公开(公告)号：US20240409578A1

公开(公告)日：2024-12-12

申请号：US18273957

申请日：2022-01-26

Applicant: UNIVERSITY OF COPENHAGEN

Inventor： Kristian STRØMGAARD ,  Matthias Manfred HERTH ,  Andreas KJÆR ,  Eduardo Felipe Alves FERNANDES ,  Line Bruhn Schneider KNUDSEN

IPC: C07K1/13

Abstract: The invention regards a method for 18F-labeling of a peptide.

公开(公告)号：US20240336661A1

公开(公告)日：2024-10-10

申请号：US18564398

申请日：2022-06-02

Applicant: University of Copenhagen

Inventor： Oluf Pedersen ,  Yong Fan

IPC: C07K14/195 ,  A61K38/00 ,  A61P3/04 ,  A61P3/10 ,  A61P19/00

CPC classification number: C07K14/195 ,  A61P3/04 ,  A61P3/10 ,  A61P19/00 ,  A61K38/00

Abstract: The present invention relates to polypeptides derived from Ruminococcus torques, and polypeptide fragments and variants thereof useful for treatment and/or prevention of metabolic disorders, muscle disorders and injuries, and bone disorders, and host cells comprising said polypeptides, polypeptide fragments or variants thereof for use as a probiotic or as a Live Biopharmaceutical Product (LBP).

公开(公告)号：US20240191396A1

公开(公告)日：2024-06-13

申请号：US18285099

申请日：2022-03-31

Applicant: University of Copenhagen ,  Danmarks Tekniske Universitet

Inventor： Joachim Elbeshausen Sestoft ,  Thomas Kanne Nordqvist ,  Mikelis Marnauza ,  Aske Nørskov Gejl ,  Dags Olsteins ,  Kasper Grove-Rasmussen ,  Jesper Nygård

IPC: C30B29/60 ,  C30B11/12 ,  C30B29/40 ,  C30B29/66 ,  H01L29/06 ,  H01L29/20 ,  H01L29/66 ,  H01L29/76 ,  H01L31/0352 ,  H01L33/06 ,  H10N60/12

CPC classification number: C30B29/605 ,  C30B11/12 ,  C30B29/40 ,  C30B29/66 ,  H01L29/0665 ,  H01L29/20 ,  H01L29/66977 ,  H01L29/7613 ,  H01L31/035227 ,  H01L33/06 ,  H10N60/12

Abstract: The present disclosure relates to a method of manufacturing a transferable lamella comprising interconnected nanostructures, the method comprising the steps of: a) providing a substrate such as a planar substrate; b) forming at least one superstructure on the substrate, said superstructure comprising a plurality of elongated nanostructures (formed e.g. by growth, deposition, and/or etching); wherein the elongated nanostructures are formed such that at least two of said nanostructures are conductively interconnected, and/or wherein at least a first layer is grown or deposited to conductively interconnect or insulate at least a part of the elongated nanostructures; c) encapsulating at least a portion of said superstructure in an encapsulating material, said portion comprising at least two interconnected nanostructures; and d) cutting the encapsulating material in a direction that intersects at least two interconnected nanostructures, thereby manufacturing a transferable lamella comprising interconnected nanostructures. The present disclosure further relates to an electronic device manufactured from one or more of the lamellas provided by the method.

公开(公告)号：US20230407377A1

公开(公告)日：2023-12-21

申请号：US18038044

申请日：2021-12-03

Applicant: University of Copenhagen

Inventor： Morten Frödin ,  Yiyuan Niu ,  Catarina Ferreira A. Azevedo ,  Claus Storgaard Sørensen

IPC: C12Q1/6827 ,  C12N15/10 ,  C12N9/22

CPC classification number: C12Q1/6827 ,  C12N15/102 ,  C12N9/22 ,  C12N2310/20

Abstract: The present disclosure relates to methods for assessing the effects of a mutation of interest in a cell. Herein are also disclosed systems for assessing the effects of a mutation of interest in a cell. The disclosure also provides host cells and host cell populations comprising the system.

公开(公告)号：US20230346948A1

公开(公告)日：2023-11-02

申请号：US17905660

申请日：2021-03-05

Applicant: University of Copenhagen

Inventor： Kenneth L. Madsen ,  Ulrik Gether ,  Nikolaj Riis Christensen

IPC: A61K47/54 ,  A61K47/60 ,  A61K38/08 ,  A61P25/00 ,  A61K47/69

CPC classification number: A61K47/542 ,  A61K47/60 ,  A61K38/08 ,  A61P25/00 ,  A61K47/6907

Abstract: The present disclosure relates to a lipid conjugated bivalent peptide ligand which bind to Protein Interacting with C Kinase-1 (PICK1) and thereby inhibit PICK1. The PICK1 inhibitors of the present disclosure comprise a peptide portion comprising two peptide ligands of PICK1, and a non-peptide portion comprising a linker, linking the two peptide ligands, and a lipid. The disclosure furthermore relates to therapeutic and diagnostic use of said PICK1 inhibitor for treatment of diseases or disorders associated with maladaptive plasticity.

公开(公告)号：US11793752B2

公开(公告)日：2023-10-24

申请号：US17147957

申请日：2021-01-13

Applicant: University of Copenhagen

Inventor： Daniel Bar-Shalom ,  Jette Jacobsen ,  Kasper Dalby ,  Anne Marie Lynge Pedersen ,  Peter Vilmann

IPC: A61K9/06 ,  A61K47/10 ,  A61K47/38 ,  A61K9/00 ,  A61K31/167 ,  A61K31/245 ,  A61K31/439 ,  A61K31/445 ,  A61K31/47 ,  A61K45/06

CPC classification number: A61K9/06 ,  A61K9/006 ,  A61K9/0034 ,  A61K31/167 ,  A61K31/245 ,  A61K31/439 ,  A61K31/445 ,  A61K31/47 ,  A61K45/06 ,  A61K47/10 ,  A61K47/38

Abstract: An aqueous gel composition comprising a) water, at least one polysaccharide and at least one high molecular weight polyethylene oxide, wherein the water content is at least 90% by weight of the composition, and b) a local anaesthetic agent or an analgesic agent, for use as a local anaesthetic or analgesic. The aqueous gel shows transparency, lubricity, stringiness, elongation, extensiveness, and cohesiveness while being devoid of taste and smell and non-tacky or non-sticky.

公开(公告)号：US20230277600A1

公开(公告)日：2023-09-07

申请号：US18047758

申请日：2022-10-19

Applicant: University of Rochester ,  University of Copenhagen

Inventor： Steven A. Goldman ,  Ricardo da Costa Barbedo Vieira

IPC: A61K35/30 ,  A61P25/28

CPC classification number: A61K35/30 ,  A61P25/28

Abstract: The present application relates to alleviating adverse effects of oligodendrocyte loss, astrocyte loss, or white matter loss, including age-related oligodendrocyte loss, age-related astrocyte loss, or age-related white matter loss, in the brain of a subject. The present application also relates to rejuvenating a glial progenitor cell or a progeny thereof, or to enhancing the development potential of a glial progenitor cell or a progeny thereof.

公开(公告)号：US11680250B2

公开(公告)日：2023-06-20

申请号：US15742737

申请日：2016-07-14

Applicant: University of Copenhagen

Inventor： Claus Felby ,  David Cannella ,  Klaus Benedikt Möllers

IPC: C12N9/02 ,  C12P19/14 ,  C12N13/00 ,  C12P7/04

CPC classification number: C12N9/0071 ,  C12N9/0004 ,  C12N13/00 ,  C12P7/04 ,  C12P19/14 ,  C12Y114/00

Abstract: The present disclosure relates to a light-driven system which is able to chemically modify an organic substrate with high efficiency and in a cost-effective manner. Also provided are methods for chemically modifying an organic substrate using the present systems and methods for manufacturing such systems.

公开(公告)号：US20230004850A1

公开(公告)日：2023-01-05

申请号：US17781389

申请日：2020-12-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  UNIVERSITY OF COPENHAGEN

Inventor： Yuval OREG ,  Gal SHAVIT ,  Omri LESSER ,  Erez BERG ,  Adiel STERN ,  Karsten FLENSBERG

IPC: G06N10/40 ,  H01L39/12 ,  H01L39/22

Abstract: Provided is a quantum computing device comprising a carbon nanotube, a superconducting substrate in quantum proximity to the nanotube and being in a superconducting state having a pairing correlation matrix with a substantial spin-triplet component in a direction perpendicular to the nanotube, and a magnet arranged to provide a longitudinal magnetic field along a longitudinal axis of the nanotube. Further provided is a quantum computing device comprising at least three substrates made of a superconductor material and each in a superconducting state, and a non-superconducting structure made of a material in which the electrons' closed trajectories experience strong spin-orbit coupling interactions and being in quantum proximity to the substrates. The sum of the phase differences between the order parameters of all of the substrates is at least π.

公开(公告)号：US11490621B2

公开(公告)日：2022-11-08

申请号：US16638769

申请日：2018-08-28

Applicant: Kemira Oyj ,  University of Copenhagen

Inventor： Jaakko Simell ,  Marko Kolari ,  Michael Givskov ,  Tim Tolker-Nielsen ,  Morten Levin Rybtke ,  Jens Bo Andersen

IPC: A01N43/78 ,  A01N41/10

Abstract: Disclosed is a method for controlling a biofilm, for removing a formed biofilm and/or for controlling a growth of microorganisms, preferably bacteria, in an aqueous environment of an industrial manufacturing process including cellulosic fibre material. In the method, a composition including a compound selected from a group consisting of 3-[(4-methylphenyl)sulphonyl]-2-propenenitrile and 4-amino-N-2-thiazolyl-benzenesulphonamide is administered to the aqueous environment of the process.