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9 条记录 (耗时 0.014 秒)

    Liposomes
    2.
    发明授权
    Liposomes 失效
    脂质体

    公开(公告)号：US5676928A

    公开(公告)日：1997-10-14

    申请号：US468743

    申请日：1995-06-06

    申请人： Jo Klaveness ,  Arne Berg ,  Trond Vegard Jacobsen ,  Pal Rongved ,  Thorfinn Ege ,  Hiroshi Kikuchi ,  Kiyoto Yachi

    发明人： Jo Klaveness ,  Arne Berg ,  Trond Vegard Jacobsen ,  Pal Rongved ,  Thorfinn Ege ,  Hiroshi Kikuchi ,  Kiyoto Yachi

    IPC分类号： A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61K51/12 ,  A61K9/127

    CPC分类号： A61K49/227 ,  A61K49/0466 ,  A61K49/1812

    摘要： The invention provides a diagnostic composition for administration to human or animal subjects, the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.

    摘要翻译： 本发明提供了一种用于向人或动物受试者施用的诊断组合物，所述组合物包含多层脂质体，任选地与单层脂质体一起，所述脂质体含有至少一种成像剂并悬浮在含有所述显像剂的水性介质中，其中所述脂质体包含 中性磷脂和带电磷脂，脂质体的平均粒径为50-3000nm，填充脂质体内部的任何水相中显像剂的浓度基本上与脂质体的水性介质中相同 被暂停。 相关的造影剂通常是X射线，MRI或超声造影剂。

    Squid magnetometry using ferri-and ferromagnetic particles
    3.
    发明授权
    Squid magnetometry using ferri-and ferromagnetic particles 失效
    鱿鱼磁力计使用铁和铁磁颗粒

    公开(公告)号：US5496534A

    公开(公告)日：1996-03-05

    申请号：US199252

    申请日：1994-03-28

    申请人： Jo Klaveness ,  Thorfinn Ege ,  Scott M. Rocklage

    发明人： Jo Klaveness ,  Thorfinn Ege ,  Scott M. Rocklage

    IPC分类号： A61B5/05 ,  A61K49/00 ,  A61K49/06 ,  A61K49/18 ,  A61B5/055

    CPC分类号： A61K49/1887 ,  A61K49/18 ,  A61K49/1857 ,  Y10T436/24

    摘要： The invention provides the use of a physiologically tolerable, particulate, free or matrix-borne, ferrimagnetic or ferromagnetic material for the manufacture of a diagnostic agent for administration into the gastrointestinal tract, the reproductive tract, the urinary tract, a closed body cavity (e.g. into the synovial fluid or the vasculature) or the musculature for magnetometric imaging of the human or non-human animal body.

    摘要翻译： PCT No.PCT / EP92 / 02254 Sec。 371日期：1994年5月28日 102（e）日期1994年5月28日PCT提交1992年9月28日PCT公布。 公开号WO93 / 05818 日期1994年4月1日。本发明提供了生理上可耐受的，颗粒状，游离的或基质载体的亚铁磁性或铁磁性材料用于制造用于施用于胃肠道，生殖道，尿道 ，闭合的体腔（例如进入滑液或脉管系统）或用于人或非人动物体的磁力计成像的肌肉组织。

    Method of locating or imaging activated T-lymphocytes with a targeting polypeptide
    4.
    发明授权
    Method of locating or imaging activated T-lymphocytes with a targeting polypeptide 失效
    用靶向多肽定位或成像激活的T淋巴细胞的方法

    公开(公告)号：US4832940A

    公开(公告)日：1989-05-23

    申请号：US921061

    申请日：1986-10-21

    申请人： Thorfinn Ege

    发明人： Thorfinn Ege

    IPC分类号： G01N33/53 ,  A61K33/08 ,  A61K35/14 ,  A61K38/00 ,  A61K39/395 ,  A61K49/00 ,  A61K49/04 ,  A61K51/00 ,  A61K51/08 ,  C07K14/005 ,  C07K14/195 ,  C07K14/52 ,  C07K14/54 ,  C07K14/55 ,  C07K16/00 ,  G01N33/574

    CPC分类号： A61K51/08

    摘要： The present invention provides targeting polypeptides for use in targeting and identifying activated T-lymphocytes in the human or animal body, the targeting polypeptides being capable of binding specifically to the interleukin-2 receptors of activated T-lymphocytes or to molecules associated with the receptors and carrying one or more physiologically compatible imaging agents. Such targeting polypeptides can be used for, example, in the location of tumours and abscesses and other inflammatory conditions and in the monitoring of tissue transplants for possible rejection.

    摘要翻译： 本发明提供用于靶向和鉴定人或动物体内活化的T淋巴细胞的靶向多肽，靶向多肽能够特异性结合活化的T淋巴细胞的白细胞介素-2受体或与受体相关的分子， 携带一种或多种生理上相容的成像剂。 这样的靶向多肽可以用于例如肿瘤和脓肿以及其它炎性病症的位置以及用于可能排斥的组织移植的监测中。

    APPLICATOR, USE OF THE APPLICATOR AND METHOD FOR TOPICALLY ADMINISTERING A LIQUID BY MEANS OF THE APPLICATOR
    5.
    发明申请
    APPLICATOR, USE OF THE APPLICATOR AND METHOD FOR TOPICALLY ADMINISTERING A LIQUID BY MEANS OF THE APPLICATOR 审中-公开
    申请人，使用者的使用方法和申请人主要管理液体的方法

    公开(公告)号：US20090092438A1

    公开(公告)日：2009-04-09

    申请号：US12282775

    申请日：2007-03-09

    申请人： Thorfinn Ege ,  Oscar Rosengren ,  Christian Malm ,  Robert Axelsson

    发明人： Thorfinn Ege ,  Oscar Rosengren ,  Christian Malm ,  Robert Axelsson

    IPC分类号： B43K7/00

    CPC分类号： A45D34/041

    摘要： An applicator adapted for applying a liquid from a source of liquid to the skin of an individual subject. The applicator includes a housing delimiting a chamber, and a roller rotatably mounted in the housing with an adhesion side extending into the chamber and a transfer side extending out of the chamber. A cylinder is attached to the housing, at least one outlet and one through hole which are formed in the wall of the cylinder, is connecting the cylinder to the source of liquid and to the chamber, respectively, with the through holes axially and angularly displaced in relation to each other. A slider is arranged for sliding between first and second positions in the cylinder, a recess is formed in the slider, and the recess communicates with the source of liquid in the first position of the slider via the at least one first through hole and with the chamber in the second position of the slider via the at least one second through hole. The applicator is suitable for administering accurate and reproducible doses of easy-flowing cosmetic or medical formulations to the skin of a human being.

    摘要翻译： 适于将液体从液体源施加到个体受试者的皮肤的施加器。 施加器包括限定腔室的壳体和可旋转地安装在壳体中的辊，具有延伸到腔室中的粘附侧和延伸出腔室的传送侧。 气缸附接到壳体，形成在气缸的壁中的至少一个出口和一个通孔分别将气缸连接到液体源和腔室，通孔轴向和角位移 相互之间。 滑块布置成用于在气缸中的第一和第二位置之间滑动，在滑块中形成凹部，并且凹部经由至少一个第一通孔与滑块的第一位置中的液体源连通，并且与 通过所述至少一个第二通孔在所述滑块的第二位置。 施用器适合于向人的皮肤施用准确和可重复的剂量的容易流动的化妆品或医药制剂。