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公开(公告)号：US11513078B2
公开(公告)日：2022-11-29
申请号：US17086782
申请日：2020-11-02
摘要： Distributed fiber optic sensors formed by covering the fibers with tubing are provided. The tubing including responsive materials formulated or configured to, responsive to exposure to one of a target chemical species and a target radiation particle, change a relative size and generate a localized effect on or in the optical fiber.
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公开(公告)号：US11371943B2
公开(公告)日：2022-06-28
申请号：US17060253
申请日：2020-10-01
IPC分类号： G01N21/77 , C03C25/1065 , G01M3/04 , G01T3/06 , G02B6/036
摘要： Distributed fiber optic chemical and radiation sensors formed by coating the fibers with certain types of response materials are provided. For distributed chemical sensors, the coatings are reactive with the targets; the heat absorbed or released during a reaction will cause a local temperature change on the fiber. For distributed radiation sensors, coating a fiber with a scintillator enhances sensitivity toward thermal neutrons, for example, by injecting light into the fiber. The luminescent components in these materials are taken from conjugated polymeric and oligomeric dyes, metal organic frameworks with sorbed dyes, and two-photon-absorbing semiconductors. The compositions may exhibit strong gamma rejection. Other scintillators combining luminescent materials with neutron converters are available. With a multiple-layer coating, it may be possible to identify the presence of both neutrons and gamma rays, for example. Coatings may be applied during manufacture or in the field.
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3.发明申请ADHESIVE COMPOSITION FOR CARRYING THERAPEUTIC AGENTS AS DELIVERY VEHICLE ON COATING APPLIED TO VASCULAR GRAFTS 审中-公开用于运输治疗剂的粘合剂组合物作为用于血管植入物的涂料的交付车辆公开(公告)号：US20160206600A1
公开(公告)日：2016-07-21
申请号：US14828418
申请日：2015-08-17
发明人： Omran R. Abul-Khoudoud , Catherine Cagiannos , Waldemar DeRijk , Timothy Fabian , Lisa Jennings
IPC分类号： A61K31/436
CPC分类号： A61K31/436 , A61L27/16 , A61L27/34 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/42 , C08L27/18 , C08L33/10
摘要： Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.
摘要翻译： 公开了水溶性聚合物粘合剂组合物及其作为用于在可植入装置（例如血管移植物）上携带治疗剂的递送载体的用途。 药物包被的血管移植物的使用被证明用于在体内递送治疗剂，从而抑制血管移植物的再狭窄或新内膜增生并抑制血管移植部位的感染。 还公开了形成粘合剂并制备涂覆的血管移植物的方法。
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公开(公告)号：US11375929B2
公开(公告)日：2022-07-05
申请号：US15989765
申请日：2018-05-25
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
发明人： Edward Chaum , Erno Lindner
IPC分类号： A61B5/1468 , A61B5/145 , A61B5/053 , A61B5/00 , A61M5/172 , A61M5/142 , A61M5/145 , A61B5/1459 , G01N27/49 , A61M25/00 , A61M31/00 , G01N27/403 , G01N33/00
摘要： The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.
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公开(公告)号：US11202850B2
公开(公告)日：2021-12-21
申请号：US16298891
申请日：2019-03-11
申请人： THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION , THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
发明人： Gary L. Bowlin , Allison E. Fetz , Marko Z. Radic
IPC分类号： A61L27/18 , A61L27/54 , A61L27/58 , A61L27/56 , A61P29/00 , C08L67/04 , C08G63/06 , D01F6/62 , D01D5/00 , D01F1/10 , C08K5/29
摘要： As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).
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公开(公告)号：US09566255B2
公开(公告)日：2017-02-14
申请号：US14074457
申请日：2013-11-07
IPC分类号： A61K31/16 , A61K31/015 , A61K31/191 , A61K31/164 , A61K31/4453
CPC分类号： A61K31/191 , A61K9/0048 , A61K9/107 , A61K31/164 , A61K31/4453
摘要： Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.
摘要翻译： 这里提供了一种通过向哺乳动物施用治疗有效量的奎尼酸类似物来调节哺乳动物视网膜内皮细胞活力的方法。 该方法可用于预防，治疗或治愈与放射性视网膜病变，糖尿病性视网膜病变和视网膜母细胞瘤化疗相关的视网膜内皮细胞的病理状况。
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7.发明申请COMPOSITIONS AND METHODS FOR PROTECTING COLONIC EPITHELIAL BARRIER FUNCTION 审中-公开用于保护上髁上障碍功能的组合物和方法公开(公告)号：US20170007559A1
公开(公告)日：2017-01-12
申请号：US15207907
申请日：2016-07-12
IPC分类号： A61K31/164 , A61K45/06
CPC分类号： A61K45/06 , A61K31/198
摘要： Disclosed are compositions and methods for treating or preventing colonic barrier dysfunction in a human by administering to the human in need thereof a pharmaceutically effective amount of an LPA2 receptor agonist or N-Acetyl L-Cysteine.
摘要翻译： 公开了通过向有需要的人施用药学有效量的LPA2受体激动剂或N-乙酰基L-半胱氨酸来治疗或预防人类结肠屏障功能障碍的组合物和方法。
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8.发明授权Adhesive composition for carrying therapeutic agents as delivery vehicle on coating applied to vascular grafts 有权用于将治疗剂作为施用于血管移植物的涂层上的递送载体的粘合剂组合物公开(公告)号：US09125970B2
公开(公告)日：2015-09-08
申请号：US14031835
申请日：2013-09-19
发明人： Omran R. Abul-Khoudoud , Catherine Cagiannos , Waldemar Derijk , Timothy C. Fabian , Lisa Jennings
IPC分类号： A61L27/16 , A61L27/54 , A61L31/10 , A61L31/16 , A61L27/34 , A61L33/00 , A61K31/436 , A61F2/07 , A61F2/82 , C08L27/18 , C08L33/10 , A61L31/04
CPC分类号： A61K31/436 , A61L27/16 , A61L27/34 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/42 , C08L27/18 , C08L33/10
摘要： Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.
摘要翻译： 公开了水溶性聚合物粘合剂组合物及其作为用于在可植入装置（例如血管移植物）上携带治疗剂的递送载体的用途。 药物包被的血管移植物的使用被证明用于在体内递送治疗剂，从而抑制血管移植物的再狭窄或新内膜增生并抑制血管移植部位的感染。 还公开了形成粘合剂并制备涂覆的血管移植物的方法。
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公开(公告)号：US20140094518A1
公开(公告)日：2014-04-03
申请号：US14074457
申请日：2013-11-07
IPC分类号： A61K31/191
CPC分类号： A61K31/191 , A61K9/0048 , A61K9/107 , A61K31/164 , A61K31/4453
摘要： Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.
摘要翻译： 这里提供了一种通过向哺乳动物施用治疗有效量的奎尼酸类似物来调节哺乳动物视网膜内皮细胞活力的方法。 该方法可用于预防，治疗或治愈与放射性视网膜病变，糖尿病性视网膜病变和视网膜母细胞瘤化疗相关的视网膜内皮细胞的病理状况。
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公开(公告)号：US20170143652A1
公开(公告)日：2017-05-25
申请号：US15428475
申请日：2017-02-09
IPC分类号： A61K31/191 , A61K9/00 , A61K9/107
CPC分类号： A61K31/191 , A61K9/0048 , A61K9/107 , A61K31/164 , A61K31/4453
摘要： Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.
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