公开(公告)号：US20160206600A1

公开(公告)日：2016-07-21

申请号：US14828418

申请日：2015-08-17

Applicant: The University of Tennessee Research Foundation

Inventor： Omran R. Abul-Khoudoud ,  Catherine Cagiannos ,  Waldemar DeRijk ,  Timothy Fabian ,  Lisa Jennings

IPC: A61K31/436

CPC classification number: A61K31/436 ,  A61L27/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  C08L27/18 ,  C08L33/10

Abstract: Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.

Abstract translation: 公开了水溶性聚合物粘合剂组合物及其作为用于在可植入装置（例如血管移植物）上携带治疗剂的递送载体的用途。 药物包被的血管移植物的使用被证明用于在体内递送治疗剂，从而抑制血管移植物的再狭窄或新内膜增生并抑制血管移植部位的感染。 还公开了形成粘合剂并制备涂覆的血管移植物的方法。

公开(公告)号：US20140112968A1

公开(公告)日：2014-04-24

申请号：US14031835

申请日：2013-09-19

Applicant: The University of Tennessee Research Foundation

Inventor： Omran R. Abul-Khoudoud ,  Catherine Cagiannos ,  Waldemar Derijk ,  Timothy C. Fabian ,  Lisa Jennings

IPC: A61L27/34 ,  A61L27/54 ,  A61K31/436

CPC classification number: A61K31/436 ,  A61L27/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  C08L27/18 ,  C08L33/10

Abstract: Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.

Abstract translation: 公开了水溶性聚合物粘合剂组合物及其作为用于在可植入装置（例如血管移植物）上携带治疗剂的递送载体的用途。 药物包被的血管移植物的使用被证明用于在体内递送治疗剂，从而抑制血管移植物的再狭窄或新内膜增生并抑制血管移植部位的感染。 还公开了形成粘合剂并制备涂覆的血管移植物的方法。

公开(公告)号：US09125970B2

公开(公告)日：2015-09-08

申请号：US14031835

申请日：2013-09-19

Applicant: The University of Tennessee Research Foundation

Inventor： Omran R. Abul-Khoudoud ,  Catherine Cagiannos ,  Waldemar Derijk ,  Timothy C. Fabian ,  Lisa Jennings

IPC: A61L27/16 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L27/34 ,  A61L33/00 ,  A61K31/436 ,  A61F2/07 ,  A61F2/82 ,  C08L27/18 ,  C08L33/10 ,  A61L31/04

CPC classification number: A61K31/436 ,  A61L27/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  C08L27/18 ,  C08L33/10

Abstract: Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.

Abstract translation: 公开了水溶性聚合物粘合剂组合物及其作为用于在可植入装置（例如血管移植物）上携带治疗剂的递送载体的用途。 药物包被的血管移植物的使用被证明用于在体内递送治疗剂，从而抑制血管移植物的再狭窄或新内膜增生并抑制血管移植部位的感染。 还公开了形成粘合剂并制备涂覆的血管移植物的方法。