公开(公告)号：US20170143652A1

公开(公告)日：2017-05-25

申请号：US15428475

申请日：2017-02-09

Applicant: The University of Tennessee Research Foundation

Inventor： Charles Ryan Yates ,  Jena Steinle Smith ,  Duane Douglas Miller ,  Jordan J. Toutounchian

IPC: A61K31/191 ,  A61K9/00 ,  A61K9/107

CPC classification number: A61K31/191 ,  A61K9/0048 ,  A61K9/107 ,  A61K31/164 ,  A61K31/4453

Abstract: Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.

公开(公告)号：US10010516B2

公开(公告)日：2018-07-03

申请号：US15428475

申请日：2017-02-09

Applicant: The University of Tennessee Research Foundation

Inventor： Charles Ryan Yates ,  Jena Steinle Smith ,  Duane Douglas Miller ,  Jordan J. Toutounchian

IPC: A61K31/164 ,  A61K31/191 ,  A61K31/4453 ,  A61K9/107 ,  A61K9/00

CPC classification number: A61K31/191 ,  A61K9/0048 ,  A61K9/107 ,  A61K31/164 ,  A61K31/4453

Abstract: Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.

公开(公告)号：US09566255B2

公开(公告)日：2017-02-14

申请号：US14074457

申请日：2013-11-07

Applicant: The University of Tennessee Research Foundation

Inventor： Charles Ryan Yates ,  Jena Steinle Smith ,  Duane Douglas Miller ,  Jordan J. Toutounchian

IPC: A61K31/16 ,  A61K31/015 ,  A61K31/191 ,  A61K31/164 ,  A61K31/4453

CPC classification number: A61K31/191 ,  A61K9/0048 ,  A61K9/107 ,  A61K31/164 ,  A61K31/4453

Abstract: Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.

Abstract translation: 这里提供了一种通过向哺乳动物施用治疗有效量的奎尼酸类似物来调节哺乳动物视网膜内皮细胞活力的方法。 该方法可用于预防，治疗或治愈与放射性视网膜病变，糖尿病性视网膜病变和视网膜母细胞瘤化疗相关的视网膜内皮细胞的病理状况。

公开(公告)号：US20140094518A1

公开(公告)日：2014-04-03

申请号：US14074457

申请日：2013-11-07

Applicant: The University of Tennessee Research Foundation

Inventor： Charles Ryan Yates ,  Jena Steinle Smith ,  Duane Douglas Miller ,  Jordan J. Toutounchian

IPC: A61K31/191

CPC classification number: A61K31/191 ,  A61K9/0048 ,  A61K9/107 ,  A61K31/164 ,  A61K31/4453

Abstract: Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.

Abstract translation: 这里提供了一种通过向哺乳动物施用治疗有效量的奎尼酸类似物来调节哺乳动物视网膜内皮细胞活力的方法。 该方法可用于预防，治疗或治愈与放射性视网膜病变，糖尿病性视网膜病变和视网膜母细胞瘤化疗相关的视网膜内皮细胞的病理状况。