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    Ocular therapeutic system with selected membranes for administering ophthalmic drug
    2.
    发明授权
    Ocular therapeutic system with selected membranes for administering ophthalmic drug 失效
    眼科治疗系统具有选择的用于给药眼药物的膜

    公开(公告)号：US4057619A

    公开(公告)日：1977-11-08

    申请号：US705470

    申请日：1976-07-15

    申请人： Takeru Higuchi ,  Anwar Hussain

    发明人： Takeru Higuchi ,  Anwar Hussain

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0051

    摘要： An ocular therapeutic system for releasing a drug to the eye at a controlled and continuous rate for a prolonged period of time is disclosed. The system is shaped, sized and adapted for insertion and retention in the eye. The system contains an ophthalmically acceptable drug and it is formed of a polymeric material permeable to the passage of drug by diffusion. The material is an ethylene-vinyl ester copolymer of the general formula: ##STR1## WHEREIN R is hydrogen, alkyl of 2 to 7 carbons, or aryl, m is (4 to 80)% by weight and n is (100 - m)% by weight.

    摘要翻译： 公开了一种用于以长期控制和连续的速率将药物释放到眼睛的眼部治疗系统。 该系统的形状，尺寸和适用于插入和保留在眼睛中。 该系统含有眼睛可接受的药物，并且由可通过扩散通过药物的聚合物材料形成。 该材料是下列通式的乙烯 - 乙烯基酯共聚物：其中R为氢，2-7个碳原子的烷基或芳基，m为（4-80）重量％，n为（100-m） 重量％。

    Vaginal drug dispensing device
    3.
    发明授权
    Vaginal drug dispensing device 失效
    阴道药物分配装置

    公开(公告)号：US4016251A

    公开(公告)日：1977-04-05

    申请号：US582131

    申请日：1975-05-30

    申请人： Takeru Higuchi ,  Anwar Hussain

    发明人： Takeru Higuchi ,  Anwar Hussain

    IPC分类号： A61F6/14 ,  A61F9/00 ,  A61K9/00 ,  A61K9/70 ,  A61M31/00 ,  A61K47/00

    CPC分类号： A61K9/7084 ,  A61F6/14 ,  A61F6/142 ,  A61F9/0017 ,  A61K9/0004 ,  A61K9/0036 ,  A61K9/0039 ,  A61M31/002

    摘要： Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.

    摘要翻译： 用于以连续和受控的速率长时间释放药物的药物递送装置由含有药学上可接受的药物并且可透过药物通过扩散而可渗透的成形体的聚合材料构成。 聚合物材料是乙酸乙烯酯含量为约4-80重量％，熔体指数为约0.1-1000克/ 10分钟的乙烯 - 乙酸乙烯酯共聚物。

    Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
    4.
    发明授权
    Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient 失效
    渗透式分配器具有响应于渗透梯度分配活性剂的装置

    公开(公告)号：US3995631A

    公开(公告)日：1976-12-07

    申请号：US291686

    申请日：1972-09-25

    申请人： Takeru Higuchi ,  Harold M. Leeper

    发明人： Takeru Higuchi ,  Harold M. Leeper

    IPC分类号： A01G7/06 ,  A61D7/00 ,  A61K9/00 ,  B01J4/04 ,  B65D1/04 ,  A61M31/00 ,  B65D35/28

    CPC分类号： A61D7/00 ,  A01G7/06 ,  A61K9/0004 ,  B01J4/04 ,  B65D1/04

    摘要： An osmotic active agent dispenser is comprised of a chamber having controlled permeability to an external fluid, i.e., water, and containing an osmotically effective solute which, in solution, exhibits an osmotic pressure gradient against said external fluid, said chamber housing a flexible bag of relatively impervious material containing an active agent and provided with means or dispensing head for releasing said active agent to the exterior of the dispenser. The flexible bag is disposed within the said housing chamber such that as the, e.g., water permeates from the external environment through the permeable walls of the chamber and migrates or diffuses by osmosis into the solution contained therein, same increases in volume thereby generating mechanical compressing or deflating force on the flexible bag, which force in turn ejects the active agent out of the apparatus at an osmotically controlled rate over a prolonged period of time.

    摘要翻译： 渗透活性剂分配器包括具有对外部流体（即水）具有受控渗透性的腔室，并且含有渗透性有效的溶质，其在溶液中对所述外部流体显示出渗透压梯度，所述腔容纳柔性袋 相对不透水的材料含有活性剂并且具有用于将所述活性剂释放到分配器外部的装置或分配头。 柔性袋设置在所述容纳室内，使得例如水从外部环境通过室的可渗透壁渗透并通过渗透迁移或扩散到其中包含的溶液中，同样增加体积从而产生机械压缩 或在柔性袋上的放气力，该力随后在更长的时间内以渗透控制的速率将活性剂排出设备。

    Lipid osmotic pump
    7.
    发明授权
    Lipid osmotic pump 失效
    脂质渗透泵

    公开(公告)号：US4685918A

    公开(公告)日：1987-08-11

    申请号：US697105

    申请日：1985-02-01

    申请人： Gordon L. Amidon ,  Takeru Higuchi ,  Jennifer B. Dressman

    发明人： Gordon L. Amidon ,  Takeru Higuchi ,  Jennifer B. Dressman

    IPC分类号： B01J4/04 ,  A61K9/00 ,  A61K9/22 ,  A61K9/32 ,  A61K9/50 ,  A61M1/00

    CPC分类号： A61K9/5042 ,  A61K9/0004

    摘要： The instant invention is directed to a lipid osmotic pump, comprising:(A) a core, comprising:(i) a beneficial amount of at least one substantially water insoluble active agent which is lipid soluble and/or lipid wettable;(ii) a sufficient amount of at least one water immiscible lipid carrier, which is liquid at the temperature of intended use, to dissolve and/or suspend said active agent; and(iii) a sufficient amount of at least one osmotic agent to ensure release of said lipid carrier from the pump; and(B) surrounded by a water insoluble wall:(i) having a thickness of about 1 to 1000 microns;(ii) which is preferentially wetted by said lipid carrier over an aqueous solution of said osmotic agent;(iii) having a water permeability of about 1.times.10.sup.-18 to 4.times.10.sup.-15 cm.sup.3 sec/g;(iv) prepared from at least one polymer permeable to water but substantially impermeable to said osmotic agent; and(v) having a means for said active agent and lipid carrier to be released through said water insoluble wall.

    摘要翻译： 本发明涉及脂质渗透泵，其包含：（A）核心，其包含：（i）有益量的至少一种基本上不溶于水的活性剂，其是脂溶性和/或脂质可湿性的; （ii）足够量的至少一种在预期使用温度下为液体的与水不混溶的脂质载体溶解和/或悬浮所述活性剂; 和（iii）足够量的至少一种渗透剂以确保从泵中释放所述脂质载体; 和（B）由水不溶性壁包围：（i）具有约1至1000微米的厚度; （ii）优选地由所述脂质载体润湿所述渗透剂的水溶液; （iii）具有约1×10 18至4×10 15 cm 3 sec / g的透水性; （iv）由至少一种可渗透水的聚合物制备，但基本上不渗透所述渗透剂; 和（v）具有用于所述活性剂和脂质载体通过所述水不溶性壁释放的装置。

    Intrauterine system embracing selected copolymeric membranes for administering beneficial agent
    9.
    发明授权
    Intrauterine system embracing selected copolymeric membranes for administering beneficial agent 失效
    子宫内系统包含用于施用有益剂的选择的共聚膜

    公开(公告)号：US4188951A

    公开(公告)日：1980-02-19

    申请号：US826928

    申请日：1977-08-22

    申请人： Takeru Higuchi ,  Anwar A. Hussain

    发明人： Takeru Higuchi ,  Anwar A. Hussain

    IPC分类号： A61F6/14 ,  A61K9/00 ,  A61K9/70 ,  A61M31/00 ,  A61M7/00

    CPC分类号： A61M31/002 ,  A61F6/14 ,  A61F6/142 ,  A61K9/0039 ,  A61K9/0092

    摘要： An intrauterine system for releasing beneficial agent to the uterus at a controlled and continuous rate for a prolonged period of time is disclosed. The system is shaped, sized and adapted for insertion and retention in the uterus. The system contains a beneficial agent and it is formed of a copolymeric material permeable to the passage of agent by diffusion. The material is an ethylene-vinyl ester polymer of the general formula: ##STR1## wherein R is hydrogen, alkyl of 2 to 7 carbons, or aryl, m is (4 to 80)% by weight and n is (100-m)% by weight.

    摘要翻译： 公开了一种子宫内系统，用于以有控制和连续的速率长时间地将有益剂释放到子宫。 该系统的形状，尺寸和适用于插入和保留在子宫中。 该系统含有有益剂，并且由可通过扩散剂通过的共聚材料形成。 该材料是下列通式的乙烯 - 乙烯基酯聚合物：其中R是氢，2至7个碳原子的烷基或芳基，m是（4-80）重量％，n是（100-m） 重量％。