公开(公告)号：US20240173359A1

公开(公告)日：2024-05-30

申请号：US18431055

申请日：2024-02-02

申请人： AOBIOME LLC

发明人： Lauren Nicole Ambrogio ,  Larry Weiss

IPC分类号： A61K35/74 ,  A61K9/00 ,  A61K45/06

CPC分类号： A61K35/74 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/0039 ,  A61K45/06

摘要： Ammonia oxidizing microorganism preparations for delivery to the urogenital system, kits including ammonia oxidizing preparations for delivery to the urogenital system, and devices for administering ammonia oxidizing preparations to the urogenital system are provided. Methods of introducing ammonia oxidizing microorganisms to the urogenital system are provided. Methods of treating disorders, including urogenital disorders and inflammatory disorders, with ammonia oxidizing microorganism preparations are provided.

公开(公告)号：US11844857B2

公开(公告)日：2023-12-19

申请号：US16875356

申请日：2020-05-15

申请人： Covidien LP

发明人： Nikolai D. Begg ,  Chad A. Pickering ,  Jordan A. Whisler ,  Rebecca D. White

IPC分类号： A61F6/16 ,  A61F6/18 ,  A61K9/00 ,  A61B17/42 ,  A61K45/06

CPC分类号： A61K9/0039 ,  A61B17/42 ,  A61F6/16 ,  A61F6/18 ,  A61B2017/4216 ,  A61K45/06

摘要： A method of treating a gynecological malignancy includes introducing an implant within a uterus of a patient and positioning the implant adjacent to an endometrium of the uterus to enable a bioactive agent supported on the implant to treat the gynecological malignancy. The implant may be one or more deployable implants including a balloon, an IUD, a stent, or combinations thereof. Such implants may be introduced by one or more surgical instruments.

公开(公告)号：US20190201418A1

公开(公告)日：2019-07-04

申请号：US16295577

申请日：2019-03-07

申请人： ARSTAT, INC.

发明人： Arkady RUBIN

IPC分类号： A61K31/575 ,  A61K31/567 ,  A61K9/00

CPC分类号： A61K31/575 ,  A61K9/0036 ,  A61K9/0039 ,  A61K9/0092 ,  A61K31/567

摘要： A method and intravaginal drug delivery device for reducing size of a uterine fibroid in a female in need thereof are provided. The method includes administering intravaginally to the female a therapeutically effective amount of an active agent, wherein the agent is delivered on a delivery device directly to uterine fibroid, wherein said amount is able to significantly reduce the size of the uterine fibroid, wherein the active agent is any one of selective progesterone receptor modulator (SPRM), an anti-progestin agent, and an anti-progestational agent.

公开(公告)号：US20190029874A1

公开(公告)日：2019-01-31

申请号：US15731767

申请日：2017-07-31

申请人： Lutrell Trumane Williams ,  Malika Manley Williams

发明人： Lutrell Trumane Williams ,  Malika Manley Williams

IPC分类号： A61F6/12 ,  A61K9/00 ,  A61F6/18

CPC分类号： A61F6/12 ,  A61F6/142 ,  A61F6/18 ,  A61K9/0039 ,  A61K9/02

摘要： Devices and methods for removing an intravaginal drug delivery ring are shown and described. In one embodiment, the device is an integral one-piece moisture impermeable structure that includes a closed end finger cot and a substantially rigid hook. Typically, the closed end finger cot includes a finger opening, a compression band, and an expandable sleeve. In some examples, the distal end of the hook is aligned substantially parallel to an axis of the finger cot to properly position the user's finger with the intravaginal drug delivery ring in the vaginal canal. The result is devices and methods to improve removal of intravaginal drug delivery rings and similar contraception prevention units.

公开(公告)号：US09949869B2

公开(公告)日：2018-04-24

申请号：US13499701

申请日：2010-09-30

申请人： Taina Tjäder ,  Ulla Calvo Alonso ,  Pirjo Inki ,  Harri Jukarainen ,  Ilkka Jutila ,  Pirjo Kortesuo ,  Juha Lehtinen ,  Eeva Lukkari-Lax ,  Heikki Lyytikäinen ,  Joachim Moede ,  Hannu Nikander ,  Pirjo Sallinen ,  Faisal Shafiq ,  Wolfgang Kaufhold ,  Christian Wamprecht

发明人： Taina Tjäder ,  Ulla Calvo Alonso ,  Pirjo Inki ,  Harri Jukarainen ,  Ilkka Jutila ,  Pirjo Kortesuo ,  Juha Lehtinen ,  Eeva Lukkari-Lax ,  Heikki Lyytikäinen ,  Joachim Moede ,  Hannu Nikander ,  Pirjo Sallinen ,  Faisal Shafiq ,  Wolfgang Kaufhold ,  Christian Wamprecht

IPC分类号： A61F6/14 ,  A61K9/00

CPC分类号： A61F6/142 ,  A61K9/0039

摘要： The present invention relates to novel intrauterine systems and to methods for manufacturing these systems. An intrauterine system according to the invention comprises a reservoir and a continuous, closed and flexible frame. The frame comprises a thermoplastic polyurethane elastomer made of a polycarbonate diol, 1,6-hexamethylenediisocyanate, and a chain extender.

公开(公告)号：US09775905B2

公开(公告)日：2017-10-03

申请号：US14766121

申请日：2014-01-31

申请人： QPHARMA AB

发明人： John Ingvar Feldtblad Kendrup

IPC分类号： A61F6/14 ,  A61K31/57 ,  A61K47/02 ,  A61K31/56 ,  A61K9/00 ,  A61F6/08 ,  A61K31/565 ,  A61K31/567 ,  A61K31/585 ,  A61K47/34

CPC分类号： A61K47/02 ,  A61F6/08 ,  A61F6/142 ,  A61K9/0039 ,  A61K31/56 ,  A61K31/565 ,  A61K31/567 ,  A61K31/57 ,  A61K31/585 ,  A61K47/34

摘要： An intrauterine device having at least one first pharmaceutically active ingredient and at least one first layer made of at least a first polymeric material, wherein between about 10 and about 60 v/v % of at least one particulate material is dispersed and/or incorporated in the first polymeric material. The presence of the particulate material will reduce the porosity of the polymer or otherwise obstruct the diffusion of the pharmaceutically active ingredient being released, thereby slowing its rate of release. In this way, it is possible to regulate the release rate and/or initial burst of the device, simply by adjusting the amount of particles/particulate material in the first layer, instead of having to adapt the size of the device to the desired release pattern, which requires expensive changes in production equipment and manufacturing processes.

公开(公告)号：US20170100332A1

公开(公告)日：2017-04-13

申请号：US15291441

申请日：2016-10-12

申请人： Sharklet Technologies, Inc. ,  University of Florida Research Foundation, Inc.

发明人： Leah Tonkin ,  Anthony B. Brennan ,  Shravanthi T. Reddy ,  Chelsea Marie Magin ,  Ethan Mann ,  Mark Spiecker ,  Bryce Stevenson

IPC分类号： A61K9/00 ,  A61K33/34 ,  A61K31/567 ,  A61K31/57 ,  C09D5/16 ,  A61K47/34

CPC分类号： A61K9/0039 ,  A61F6/144 ,  A61K31/567 ,  A61K31/57 ,  A61K33/34 ,  A61K47/34 ,  C09D5/1681

摘要： Disclosed herein is an article that includes a first plurality of spaced features. The spaced features are arranged in a plurality of groupings; the groupings of features include repeat units; the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway. The plurality of spaced features provide the article with an engineered roughness index of about 5 to about 20.

公开(公告)号：US09180040B2

公开(公告)日：2015-11-10

申请号：US14057297

申请日：2013-10-18

申请人： CONTRAMED, LLC

发明人： Michael Tal ,  Bob H. Katz ,  Mark James DeBisschop

IPC分类号： A61F6/18 ,  A61F6/14

CPC分类号： A61F6/18 ,  A61F6/06 ,  A61F6/14 ,  A61F6/142 ,  A61F6/144 ,  A61K9/0039

摘要： An intrauterine contraceptive system may include a contraceptive intrauterine device, a retrieval thread permanently attached to the intrauterine device and an insertion device for inserting the intrauterine device into a uterus. The system may also include a release thread releasably coupled with the intrauterine device. The intrauterine device may be deployable out of a distal end of the insertion device and may be configured to change from a delivery configuration when housed in the insertion device to a deployed configuration when deployed in a uterus. The retrieval thread and the optional release thread may be at least partially housed within the insertion device during insertion of the intrauterine device into the uterus. The release thread may extend from the intrauterine device through the insertion device to an attachment point at or near a proximal end of the insertion device.

摘要翻译： 子宫内避孕系统可以包括避孕宫内装置，永久地连接到子宫内装置的检索线和用于将子宫内装置插入子宫的插入装置。 该系统还可以包括与子宫内装置可释放地联接的释放线。 子宫内装置可以从插入装置的远端展开，并且可以被配置为当容纳在插入装置中时从递送配置改变为部署在子宫中时的部署配置。 在子宫内装置插入子宫期间，取出线和可选释放线可以至少部分地容纳在插入装置内。 释放螺纹可以从子宫内装置通过插入装置延伸到插入装置的近端处或附近的附接点。

公开(公告)号：US20150119372A1

公开(公告)日：2015-04-30

申请号：US14396742

申请日：2013-04-19

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Norbert Schmees ,  Lars Röse ,  Tuula Valo ,  Katja Prelle ,  Reinhard Nubbemeyer ,  Henriikka Korolainen ,  Harri Jukarainen

IPC分类号： A61K31/58

CPC分类号： A61K31/58 ,  A61K9/0039

摘要： The present invention describes intrauterine use of 18-methyl-15β,16β-methylene-19-nor-20-spirox-4-en-3-ones of the general formula (1) wherein R6 and R7 are hydrogen or a methylene group, in the treatment of menorrhagia, of uterine haemorrhages in general, and an intrauterine system for said use, comprising a compound of formula 1.

摘要翻译： 本发明描述了通式（1）的18-甲基-15β，16β-亚甲基-19-去甲代螺环-4-烯-3-酮的宫内使用，其中R 6和R 7是氢或亚甲基 组，治疗月经过多，子宫出血一般，以及所述用途的子宫内系统，其包含式1的化合物。

公开(公告)号：US20150107598A1

公开(公告)日：2015-04-23

申请号：US14057297

申请日：2013-10-18

申请人： Contramed, LLC

发明人： Michael TAL ,  Bob H. KATZ ,  Mark James DeBISSCHOP

IPC分类号： A61F6/18 ,  A61F6/14

CPC分类号： A61F6/18 ,  A61F6/06 ,  A61F6/14 ,  A61F6/142 ,  A61F6/144 ,  A61K9/0039

摘要： An intrauterine contraceptive system may include a contraceptive intrauterine device, a retrieval thread permanently attached to the intrauterine device and an insertion device for inserting the intrauterine device into a uterus. The system may also include a release thread releasably coupled with the intrauterine device. The intrauterine device may be deployable out of a distal end of the insertion device and may be configured to change from a delivery configuration when housed in the insertion device to a deployed configuration when deployed in a uterus. The retrieval thread and the optional release thread may be at least partially housed within the insertion device during insertion of the intrauterine device into the uterus. The release thread may extend from the intrauterine device through the insertion device to an attachment point at or near a proximal end of the insertion device.