公开(公告)号：US09044409B2

公开(公告)日：2015-06-02

申请号：US11869192

申请日：2007-10-09

Applicant: Christophe Carola ,  Herwig Buchholz ,  Sylvia Huber ,  Ralf Rosskopf

Inventor： Christophe Carola ,  Herwig Buchholz ,  Sylvia Huber ,  Ralf Rosskopf

IPC: A61K31/05 ,  A61K31/122 ,  A61K31/35 ,  A61K31/352 ,  A61K8/49 ,  A23L1/30 ,  A61K45/06 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q11/00 ,  A61Q19/02

CPC classification number: A61K8/498 ,  A23L33/10 ,  A61K31/05 ,  A61K31/122 ,  A61K31/35 ,  A61K31/352 ,  A61K45/06 ,  A61K2800/782 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  A61K2300/00

Abstract: The invention relates to the use of chromen-4-one derivatives of the formula I where R1 and R2 may be identical or different and are selected from H, —C(═O)—R7, —C(═O)—OR7, alkyl groups, alkenyl groups, hydroxyalkyl groups and/or cycloalkyl groups and/or cycloalkenyl groups, R3 is H or alkyl groups, R4 is H or OR8, R5 and R6 are selected from —H, —OH, alkyl groups, alkenyl groups and hydroxyalkyl groups, and R7 is H, alkyl groups, a polyhydroxyl compound, such as, preferably, an ascorbic acid radical or glycosidic radicals, and R8 is H or alkyl groups, where at least two of the substituents R1, R2 and R4-R6 are different from H or at least one substituent from R1 and R2 is —C(═O)—R7 or —C(═O)—OR7, for the care, preservation or improvement of the general state of the skin or hair.

Abstract translation: 本发明涉及式I的色烯-4-酮衍生物的用途，其中R 1和R 2可以相同或不同，并且选自H，-C（= O）-R 7，-C（= O）-OR 7， 烷基，烯基，羟基烷基和/或环烷基和/或环烯基，R3是H或烷基，R4是H或OR8，R5和R6选自-H，-OH，烷基，烯基和 羟基烷基，R7是H，烷基，多羟基化合物，例如优选抗坏血酸基团或糖苷基，R8是H或烷基，其中至少两个取代基R 1，R 2和R 4 -R 6 不同于H或R1的至少一个取代基，R2是-C（= O）-R7或-C（= O）-OR7），用于护理，保存或改善皮肤或头发的一般状态。

公开(公告)号：US20060178539A1

公开(公告)日：2006-08-10

申请号：US10549140

申请日：2004-03-20

Applicant: Sylvia Huber-Dirr ,  Michael Hesse ,  Andrea Haunert ,  Henrik Junicke

Inventor： Sylvia Huber-Dirr ,  Michael Hesse ,  Andrea Haunert ,  Henrik Junicke

IPC: C07C31/18

CPC classification number: C07C29/149 ,  B01J23/83 ,  C07C31/20

Abstract: A process for hydrogenating an organic compound which has at least one carbonyl group, in which the organic compound is brought into contact in the presence of hydrogen with a shaped article which can be produced in a process in which (i) an oxidic material comprising copper oxide, aluminum oxide and at least one of the oxides of lanthanum, tungsten, molybdenum, titanium or zirconium is prepared, (ii) powdered metallic copper, copper flakes, powdered cement, graphite or a mixture thereof is added to the oxidic material, and (iii) the mixture resulting from (ii) is shaped to a shaped article.

公开(公告)号：US07084312B1

公开(公告)日：2006-08-01

申请号：US10070275

申请日：2000-08-22

Applicant: Sylvia Huber ,  Michael Jolyon Sprague ,  Boris Breitscheidel ,  Joachim Wulff-Döring ,  Michael Hesse ,  Rolf Pinkos ,  Shelue Liang ,  Otto Kumberger ,  Marc Walter

Inventor： Sylvia Huber ,  Michael Jolyon Sprague ,  Boris Breitscheidel ,  Joachim Wulff-Döring ,  Michael Hesse ,  Rolf Pinkos ,  Shelue Liang ,  Otto Kumberger ,  Marc Walter

IPC: C07C29/136 ,  C07C29/14 ,  C07C29/141 ,  C07C29/143 ,  C07C29/147

CPC classification number: B01J23/80 ,  C07C29/149 ,  C07C31/20

Abstract: A process for the hydrogenation of an organic compound containing at least one carbonyl group comprises bringing the organic compound in the presence of hydrogen into contact with a shaped body which can be produced by a process in which (i) an oxidic material comprising copper oxide, zinc oxide and aluminum oxide is made available, (ii) pulverulent metallic copper or pulverulent cement or a mixture thereof is added to the oxidic material, and (iii) the mixture resulting from (ii) is shaped to form a shaped body.

Abstract translation: 氢化含有至少一个羰基的有机化合物的方法包括使氢存在下的有机化合物与成形体接触，成形体可以通过以下工艺制备，其中（i）包含氧化铜的氧化物， 提供氧化锌和氧化铝，（ii）将粉末状金属铜或粉状水泥或其混合物加入到氧化物中，和（iii）由（ii）得到的混合物成形为成形体。

公开(公告)号：US20050176972A1

公开(公告)日：2005-08-11

申请号：US11104408

申请日：2005-04-13

Applicant: Rolf-Hartmuth Fischer ,  Rolf Pinkos ,  Stephan Schunk ,  Joachim Wulff-Doring ,  Frank Stein ,  Thomas Nobel ,  Sylvia Huber

Inventor： Rolf-Hartmuth Fischer ,  Rolf Pinkos ,  Stephan Schunk ,  Joachim Wulff-Doring ,  Frank Stein ,  Thomas Nobel ,  Sylvia Huber

IPC: B01J21/18 ,  B01J23/656 ,  B01J23/89 ,  C07C29/17 ,  C07D307/26 ,  C07C31/18

CPC classification number: C07C29/177 ,  B01J21/18 ,  B01J23/6567 ,  B01J23/8986 ,  C07C2601/20 ,  C07C31/207 ,  C07C31/20 ,  C07C31/133

Abstract: In a process for preparing alcohols by catalytic hydrogenation of carbonyl compounds over a catalyst comprising rhenium on activated carbon, the catalyst used comprises rhenium (calculated as metal) in a weight ratio to the activated carbon of from 0.0001 to 0.5, platinum (calculated as metal) in a weight ratio to the activated carbon of from 0.0001 to 0.5 and, if appropriate, at least one further metal selected from among Zn, Cu, Ag, Au, Ni, Fe, Ru, Mn, Cr, Mo, W and V in a weight ratio to the activated carbon of from 0 to 0.25, and the activated carbon has been nonoxidatively pretreated. It is also possible to prepare ethers and lactones if the hydrogen pressure is not more than 25 bar. In this case, the activated carbon in the catalyst may also have been nonoxidatively pretreated.

Abstract translation: 在通过羰基化合物催化氢化羰基化合物的方法中，所用的催化剂包括铼在活性炭上的催化剂，所用的催化剂包括铼（以金属计）与活性炭的重量比为0.0001至0.5，铂（以金属计算 ），活性炭的重量比为0.0001〜0.5，如果合适，选自Zn，Cu，Ag，Au，Ni，Fe，Ru，Mn，Cr，Mo，W和V中的至少一种以上的金属 活性炭的重量比为0至0.25，并且活性炭已经被非氧化预处理。 如果氢气压力不超过25巴，也可制备醚和内酯。 在这种情况下，催化剂中的活性炭也可以被非氧化预处理。

公开(公告)号：US20050043398A1

公开(公告)日：2005-02-24

申请号：US10920202

申请日：2004-08-18

Applicant: Christophe Carola ,  Herwig Buchholz ,  Sylvia Huber ,  Ralf Rosskopf

Inventor： Christophe Carola ,  Herwig Buchholz ,  Sylvia Huber ,  Ralf Rosskopf

IPC: C07D311/22 ,  A23L1/30 ,  A61K8/00 ,  A61K8/33 ,  A61K8/35 ,  A61K8/37 ,  A61K8/42 ,  A61K8/49 ,  A61K31/197 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4406 ,  A61K45/06 ,  A61P1/06 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P17/12 ,  A61P17/16 ,  A61P29/00 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  C07D407/12

CPC classification number: A61K8/498 ,  A23L33/10 ,  A61K31/05 ,  A61K31/122 ,  A61K31/35 ,  A61K31/352 ,  A61K45/06 ,  A61K2800/782 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  A61K2300/00

Abstract: The invention relates to the use of chrome-4-one derivatives of the formula I where R1 and R2 may be identical or different and are selected from H, —C(═O)—R7, —C(═O)—OR7, alkyl groups, alkenyl groups, hydroxyalkyl groups and/or cycloalkyl groups and/or cycloalkenyl groups, R3 is H or alkyl groups, R4 is H or OR8, R5 and R6 are selected from —H, —OH, alkyl groups, alkenyl groups and hydroxyalkyl groups, and R7 is H, alkyl groups, a polyhydroxyl compound, such as, preferably, an ascorbic acid radical or glycosidic radicals, and R8 is H or alkyl groups, where at least two of the substituents R1, R2 and R4—R6 are different from H or at least one substituent from R1 and R2 is —C(═O)—R7 or —C(═O)—OR7, for the care, preservation or improvement of the general state of the skin or hair.

Abstract translation: 本发明涉及式I的铬-4-酮衍生物的用途，其中R 1和R 2可以相同或不同，并且选自H，-C（= O）-R 7， -C（= O）-OR 7，烷基，烯基，羟基烷基和/或环烷基和/或环烯基，R 3是H或烷基，R 4是H或OR， R 5，R 5和R 6选自-H，-OH，烷基，烯基和羟基烷基，R 7是H，烷基，多羟基化合物， 抗坏血酸基团或糖苷基，R 8是H或烷基，其中至少两个取代基R 1，R 2和R 4 -R 6不同于H或 R 1和R 2中的至少一个取代基是-C（= O）-R 7或-C（= O）-OR 7，用于保护，保存或改善一般状态 的皮肤或头发。

公开(公告)号：US06828464B2

公开(公告)日：2004-12-07

申请号：US10718795

申请日：2003-11-24

Applicant: Shelue Liang ,  Rolf-Hartmuth Fischer ,  Sylvia Huber-Dirr ,  Andrea Haunert

Inventor： Shelue Liang ,  Rolf-Hartmuth Fischer ,  Sylvia Huber-Dirr ,  Andrea Haunert

IPC: C07C4554

CPC classification number: B01J23/04 ,  C07C45/48 ,  Y02P20/582 ,  C07C49/597

Abstract: The present invention provides a process for preparing 2-cyclopentenones of the general formula: where R1 to R4 are each hydrogen atoms or are alkyl or alkenyl radicals having from 1 to 12 carbon atoms, cycloalkyl or cycloalkenyl radicals having from 5 to 7 carbon atoms, aralkylene or aryl radicals, by converting hexenedioic acids and/or their esters of the general formulae where R1 to R4 are each as defined above and R5 and R6 are each hydrogen atoms or are alkyl radicals having from 1 to 12 carbon atoms, cycloalkyl radicals having 5 or 6 carbon atoms, aralkyl or aryl radicals, at temperatures of from 150 to 450° C., over solid, oxidic catalysts, wherein the catalysts on an oxidic support material comprise from 0.01 to 5% by weight of at least one alkali metal oxide.

Abstract translation: 本发明提供一种制备以下通式的2-环戊烯酮的方法：其中R 1至R 4各自为氢原子或具有1至12个碳原子的烷基或烯基，环烷基或环烯基具有 5-7个碳原子的亚芳基或芳基，通过将通式R 1至R 4的通式所示的己烯二酸和/或它们的酯各自如上所定义，R 5和R 6各自为 氢原子或具有1至12个碳原子的烷基，具有5或6个碳原子的环烷基，芳烷基或芳基，在150-450℃的温度下，在固体，氧化催化剂上，其中催化剂在 氧化载体材料包含0.01至5重量％的至少一种碱金属氧化物。

公开(公告)号：US06291715B1

公开(公告)日：2001-09-18

申请号：US09643724

申请日：2000-08-23

Applicant: Günther Ruider ,  Karl-Heinz Ross ,  Boris Breitscheidel ,  Heike Maier ,  Gerhard Schulz ,  Sylvia Huber

Inventor： Günther Ruider ,  Karl-Heinz Ross ,  Boris Breitscheidel ,  Heike Maier ,  Gerhard Schulz ,  Sylvia Huber

IPC: C07C20984

CPC classification number: C07C213/10 ,  C07C215/08 ,  C07C215/10 ,  C07C215/14

Abstract: Preparation of alkanolamines having improved color quality by treating the alkanolamine with hydrogen in the presence of a hydrogenation catalyst at elevated temperature, by using, as hydrogenation catalyst, a heterogeneous catalyst comprising Re, Ru, Rh, Pd, Os, Ir, Pt and/or Ag and a support material chosen from the group consisting of activated carbon, alpha-aluminum oxide, zirconium dioxide and titanium dioxide, where the catalyst, in the case of activated carbon as support material, has a cutting hardness of at least 10 N, a side crushing strength of at least 30 N or a compressive strength of at least 25 N.

Abstract translation: 通过在氢化催化剂存在下，在升高的温度下，用氢处理链烷醇胺，通过使用氢化催化剂，制备包含Re，Ru，Rh，Pd，Os，Ir，Pt和/ 或Ag和选自活性炭，α-氧化铝，二氧化锆和二氧化钛的载体材料，其中在活性炭作为载体材料的情况下，催化剂具有至少10N的切割硬度， 至少30N的侧面抗压强度或至少25N的抗压强度。

公开(公告)号：US07884046B2

公开(公告)日：2011-02-08

申请号：US12608125

申请日：2009-10-29

Applicant: Sylvia Huber-Dirr ,  Michael Hesse ,  Andrea Haunert ,  Henrik Junicke

Inventor： Sylvia Huber-Dirr ,  Michael Hesse ,  Andrea Haunert ,  Henrik Junicke

IPC: B01J21/18 ,  B01J23/00 ,  B01J23/10 ,  B01J23/70 ,  B01J23/72 ,  B01J23/08 ,  B01J23/40

CPC classification number: C07C29/149 ,  B01J23/83 ,  C07C31/20

Abstract: A process for hydrogenating an organic compound which has at least one carbonyl group, in which the organic compound is hydrogenated in the presence of a shaped article which contains (i) an oxidic material comprising copper oxide, aluminum oxide and lanthanum oxide, and (ii) powdered metallic copper, copper flakes, powdered cement, graphite or a mixture thereof, is provided.

Abstract translation: 氢化具有至少一个羰基的有机化合物的方法，其中有机化合物在成型制品存在下氢化，所述成型制品包含（i）包含氧化铜，氧化铝和氧化镧的氧化物质和（ii ）粉末状金属铜，铜薄片，水泥粉末，石墨或其混合物。

公开(公告)号：US07172989B2

公开(公告)日：2007-02-06

申请号：US11104408

申请日：2005-04-13

Applicant: Rolf-Hartmuth Fischer ,  Rolf Pinkos ,  Stephan Andreas Schunk ,  Joachim Wulff-Döring ,  Frank Stein ,  Thomas Nöbel ,  Sylvia Huber

Inventor： Rolf-Hartmuth Fischer ,  Rolf Pinkos ,  Stephan Andreas Schunk ,  Joachim Wulff-Döring ,  Frank Stein ,  Thomas Nöbel ,  Sylvia Huber

IPC: B01J23/42 ,  B01J21/18 ,  B01J23/36

CPC classification number: C07C29/177 ,  B01J21/18 ,  B01J23/6567 ,  B01J23/8986 ,  C07C2601/20 ,  C07C31/207 ,  C07C31/20 ,  C07C31/133

Abstract: In a process for preparing alcohols by catalytic hydrogenation of carbonyl compounds over a catalyst comprising rhenium on activated carbon, the catalyst used comprises rhenium (calculated as metal) in a weight ratio to the activated carbon of from 0.0001 to 0.5, platinum (calculated as metal) in a weight ratio to the activated carbon of from 0.0001 to 0.5 and, if appropriate, at least one further metal selected from among Zn, Cu, Ag, Au, Ni, Fe, Ru, Mn, Cr, Mo, W and V in a weight ratio to the activated carbon of from 0 to 0.25, and the activated carbon has been nonoxidatively pretreated. It is also possible to prepare ethers and lactones if the hydrogen pressure is not more than 25 bar. In this case, the activated carbon in the catalyst may also have been nonoxidatively pretreated.

Abstract translation: 在通过羰基化合物催化氢化羰基化合物的方法中，所用的催化剂包括铼在活性炭上的催化剂，所用的催化剂包括铼（以金属计）与活性炭的重量比为0.0001至0.5，铂（以金属计算 ），活性炭的重量比为0.0001〜0.5，如果合适，选自Zn，Cu，Ag，Au，Ni，Fe，Ru，Mn，Cr，Mo，W和V中的至少一种以上的金属 活性炭的重量比为0至0.25，并且活性炭已经被非氧化预处理。 如果氢气压力不超过25巴，也可制备醚和内酯。 在这种情况下，催化剂中的活性炭也可以被非氧化预处理。

公开(公告)号：US20070027274A1

公开(公告)日：2007-02-01

申请号：US10558160

申请日：2004-05-28

Applicant: Bjorn Antelmann ,  Sylvia Huber ,  Thomas Guthner

Inventor： Bjorn Antelmann ,  Sylvia Huber ,  Thomas Guthner

IPC: C08L63/00 ,  C08G59/68

CPC classification number: C08G59/4021

Abstract: A description is given of the use of asymmetrically substituted urea derivatives of the general formula (I) where R1 and R2 each independently are a linear or branched aliphatic hydrocarbon radical having 1 to 4 carbon atoms as accelerators in combination with dicyandiamide as latent hardener for epoxy resin systems based on unhalogenated or halogenated bisphenols of type A or F and also based on resorcinol or tetrakisphenylolethane. The advangages of the inventively proposed accelerator/hardener combination are, for example, the excellent reactivity and very good storage stability. Moreover, the mechanical properties of the resins cured accordingly are likewise outstanding.

Abstract translation: 给出了使用通式（I）的不对称取代的脲衍生物，其中R 1和R 2各自独立地是具有直链或支链的脂族烃基，其具有 1至4个碳原子作为加速剂与双氰胺组合，作为基于A或F的非卤化或卤化双酚的环氧树脂体系的潜在硬化剂，也基于间苯二酚或四苯基乙基乙烷。 本发明提出的加速剂/固化剂组合的优点是例如优异的反应性和非常好的储存稳定性。 此外，相应地固化的树脂的机械性能同样突出。