公开(公告)号：US20110268772A1

公开(公告)日：2011-11-03

申请号：US13141101

申请日：2009-12-24

申请人： Se-Ho Kim ,  Ji-Yeon Son ,  Muhn-Ho La ,  Sung-Won Choi ,  Min-Hyo Seo

发明人： Se-Ho Kim ,  Ji-Yeon Son ,  Muhn-Ho La ,  Sung-Won Choi ,  Min-Hyo Seo

IPC分类号： A61K31/713 ,  A61K31/7088 ,  A61P43/00 ,  A61K9/00

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K31/353 ,  A61K31/56 ,  A61K31/70 ,  A61K31/7105 ,  A61K31/711

摘要： Disclosed are an anionic drug-containing pharmaceutical composition comprising: an anionic drug as an active ingredient; a cationic lipid; and an amphiphilic block copolymer, wherein the anionic drug forms a complex with the cationic lipid, and the complex is entrapped in the micelle structure of the amphiphilic block copolymer, and a method for preparing the same. The pharmaceutical composition may increase stability of the anionic drug in blood or in a body fluid, and it may enable intracellular delivery to improve efficacy of anionic drugs.

摘要翻译： 公开了含阴离子药物的药物组合物，其包含：阴离子药物作为活性成分; 阳离子脂质; 和两亲性嵌段共聚物，其中所述阴离子药物与阳离子脂质形成络合物，并且所述复合物被截留在两亲性嵌段共聚物的胶束结构中，及其制备方法。 药物组合物可以增加阴离子药物在血液或体液中的稳定性，并且可以使细胞内递送改善阴离子药物的功效。

公开(公告)号：US20110129528A1

公开(公告)日：2011-06-02

申请号：US12674365

申请日：2008-05-29

申请人： Ji Yong Park ,  Chan Min Jeong ,  Min Kyung Lee ,  Sung Won Choi ,  Young Hee Cho ,  Hoon Ok Jeong

发明人： Ji Yong Park ,  Chan Min Jeong ,  Min Kyung Lee ,  Sung Won Choi ,  Young Hee Cho ,  Hoon Ok Jeong

IPC分类号： A61K9/48 ,  A61K47/36 ,  A61K31/7088 ,  A61K38/02 ,  A61K31/70 ,  A61K36/00 ,  A61K35/66 ,  A61K35/76 ,  C08B37/08 ,  A61K38/38 ,  A61K38/28 ,  A61K38/27 ,  A61P3/02 ,  A23L1/00 ,  A23L1/30 ,  A23L1/302 ,  A23P1/04

CPC分类号： A61K31/70 ,  A61K9/0053 ,  A61K9/5036 ,  A61K31/7088

摘要： The present invention relates to a chitosan capsule in which a soluble active ingredient is encapsulated in a matrix containing chitosan and phytic acid; a cross-linking method and materials capable of being used in preparing the capsule; and pharmaceutical, food and cosmetic compositions comprising the capsule. The chitosan capsule according to the present invention is prepared via ionic gelation of chitosan as a biodegradable polymer with phytic acid capable of rapidly and effectively forming a cross-linking reaction with the chitosan polymer. The capsule of the present invention shows high encapsulation efficiency for a soluble active ingredient and protects the soluble active ingredient from being damaged in a digestive tract, resulting in improving an in vivo delivery efficiency of a physiologically active material. Further, since the capsule of the present invention has a pH-dependent sustained-release mechanism which can minimize the release of a soluble active ingredient in the stomach and gradually release in the intestine, it is possible to regulate sustained-release of a soluble active ingredient.

摘要翻译： 本发明涉及壳聚糖胶囊，其中将可溶性活性成分包封在含有壳聚糖和植酸的基质中; 能够用于制备胶囊的交联方法和材料; 以及包含胶囊的药物，食品和化妆品组合物。 根据本发明的壳聚糖胶囊通过壳聚糖作为可生物降解聚合物的离子凝胶化制备，其中植酸能够快速且有效地与壳聚糖聚合物形成交联反应。 本发明的胶囊对可溶性活性成分显示出高的包封效率，并保护可溶性活性成分在消化道中的损伤，从而提高生理活性物质的体内递送效率。 此外，由于本发明的胶囊具有pH依赖性缓释机制，其可以使可溶性活性成分在胃中的释放最小化并在肠中逐渐释放，因此可以调节可溶性活性物质的缓释 成分。

公开(公告)号：US06946143B2

公开(公告)日：2005-09-20

申请号：US10144813

申请日：2002-05-13

申请人： Young-Ha Kim ,  Soo-Hyun Kim ,  Ki-Dong Park ,  Sung-Won Choi ,  Soo-Hong Lee ,  Il-Keun Kwon

发明人： Young-Ha Kim ,  Soo-Hyun Kim ,  Ki-Dong Park ,  Sung-Won Choi ,  Soo-Hong Lee ,  Il-Keun Kwon

IPC分类号： A61L27/18 ,  A61L27/56 ,  A61F16/00 ,  A61K9/70

CPC分类号： A61L27/56 ,  A61L27/18 ,  C08L67/04

摘要： Disclosed is a biocompatible medical material and porous scaffold for use in tissue engineering, made from a biodegradable glycolide/ε-caprolactone copolymer having a repeat unit of wherein x and y are integers greater than or equal to 18, the copolymer has an average molecular weight of about 10,000 daltons or more, and the molar ratio of glycolide: ε-caprolactone in the copolymer is about 4.0:6.0 to 6.0:4.0.

摘要翻译： 公开了一种用于组织工程的生物相容性医疗材料和多孔支架，由具有重复单元的可生物降解的乙交酯/ε-己内酯共聚物制成，其中x和y是大于或等于18的整数，共聚物的平均分子量 约10,000道尔顿或更高，共聚物中乙交酯：ε-己内酯的摩尔比为约4.0：6.0至6.0：4.0。

公开(公告)号：US20140170482A1

公开(公告)日：2014-06-19

申请号：US13333864

申请日：2011-12-21

申请人： Benjamin Park ,  Sung Won Choi ,  Ian Browne ,  William Schank

发明人： Benjamin Park ,  Sung Won Choi ,  Ian Browne ,  William Schank

IPC分类号： H01M4/64 ,  H01M10/04 ,  B32B37/14

CPC分类号： H01M4/623 ,  B32B37/203 ,  B32B2457/10 ,  H01M4/13 ,  H01M4/139 ,  H01M4/362 ,  H01M4/386 ,  H01M4/587 ,  H01M4/622 ,  H01M4/625 ,  H01M2004/021 ,  Y02E60/122 ,  Y02P70/54 ,  Y10T29/49108 ,  Y10T29/49115 ,  Y10T156/10

摘要： Electrodes and methods of forming electrodes are described herein. The electrode can be an electrode of an electrochemical cell or battery. The electrode includes a current collector and a film in electrical communication with the current collector. The film may include a carbon phase that holds the film together. The electrode further includes an electrode attachment substance that adheres the film to the current collector.

公开(公告)号：US20130266641A1

公开(公告)日：2013-10-10

申请号：US13993787

申请日：2011-12-30

申请人： Sung-Won Choi ,  Muhn-Ho La ,  Ji-Yeon Son ,  Min-Hyo Seo

发明人： Sung-Won Choi ,  Muhn-Ho La ,  Ji-Yeon Son ,  Min-Hyo Seo

IPC分类号： A61K47/16

CPC分类号： A61K47/16 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/1272 ,  A61K31/713 ,  A61K47/18 ,  A61K47/34 ,  A61K47/59 ,  A61K47/595 ,  C12N15/88

摘要： Disclosed are a carrier for delivering a negatively charged drug, comprising a cationic lipid represented by formula 1, and a preparation method thereof. Also disclosed is a pharmaceutical composition comprising a negatively charged drug and a cationic lipid represented by formula 1, wherein the negatively charged drug forms a complex with the cationic lipid. The composition can increase the in vivo stability of the negatively charged drug after local or systemic administration and allows the intracellular delivery of the negatively charged drug. Thus, the composition will be useful for improving the therapeutic effect of the negatively charged drug.

摘要翻译： 公开了用于递送带负电荷药物的载体，其包含由式1表示的阳离子脂质及其制备方法。 还公开了包含带负电荷的药物和由式1表示的阳离子脂质的药物组合物，其中带负电荷的药物与阳离子脂质形成复合物。 组合物可以在局部或全身给药后增加带负电荷的药物的体内稳定性，并允许带负电荷的药物的细胞内递送。 因此，该组合物可用于改善带负电荷的药物的治疗效果。

公开(公告)号：US07661358B2

公开(公告)日：2010-02-16

申请号：US11674398

申请日：2007-02-13

申请人： Sang-Kyong Kim ,  Sung-Won Choi ,  Jun-Young Son ,  Jong-Kyong Kim ,  Tae-Hyeon Lim ,  Byong-Sik Kang ,  Ho-Chol Chae

发明人： Sang-Kyong Kim ,  Sung-Won Choi ,  Jun-Young Son ,  Jong-Kyong Kim ,  Tae-Hyeon Lim ,  Byong-Sik Kang ,  Ho-Chol Chae

IPC分类号： B41F1/40

CPC分类号： B41M1/10 ,  B41F9/01 ,  B41F17/001

摘要： The present invention relates to an apparatus and method for forming a predetermined pattern on a substrate using a gravure offset printing method. The apparatus for forming a pattern using a gravure offset printing method comprises a gravure on which a pattern to be filled with a color resist is formed; a roller brought into contact with the gravure to transfer the pattern formed on the gravure to the roller and then to print the transferred pattern onto a substrate; a roller driving means for rotating and horizontally driving the roller to transfer the pattern formed on the gravure to the roller and then to print the transferred pattern onto the substrate as it is; and a substrate support on which the substrate is placed. Further, the roller driving means includes a rotational driving unit for rotationally driving the roller; a horizontal driving unit for horizontally driving the roller independently of the rotational driving unit; and a control unit for controlling driving speeds of the rotational and horizontal driving units.

摘要翻译： 本发明涉及使用凹版印刷法在基板上形成预定图案的装置和方法。 使用凹版胶版印刷法形成图案的装置包括形成要填充有彩色抗蚀剂的图案的凹版印刷; 与凹版接触的辊将凹版上形成的图案转印到辊上，然后将转印图案印刷在基材上; 辊驱动装置，用于旋转和水平驱动辊，将形成在凹版上的图案转印到辊上，然后将转印图案原样印刷到基板上; 以及其上放置基板的基板支撑件。 此外，辊驱动装置包括用于旋转地驱动辊的旋转驱动单元; 水平驱动单元，用于独立于旋转驱动单元水平驱动滚子; 以及用于控制旋转和水平驱动单元的驱动速度的控制单元。

公开(公告)号：US07279251B1

公开(公告)日：2007-10-09

申请号：US10276880

申请日：2000-05-19

申请人： Kyung Suk Yun ,  Byung Won Cho ,  Seong Mu Jo ,  Wha Seop Lee ,  Won Il Cho ,  Kun You Park ,  Hyung Sun Kim ,  Un Seok Kim ,  Seok Ku Ko ,  Suk Won Chun ,  Sung Won Choi

发明人： Kyung Suk Yun ,  Byung Won Cho ,  Seong Mu Jo ,  Wha Seop Lee ,  Won Il Cho ,  Kun You Park ,  Hyung Sun Kim ,  Un Seok Kim ,  Seok Ku Ko ,  Suk Won Chun ,  Sung Won Choi

IPC分类号： H01M2/16

CPC分类号： H01M10/052 ,  D01D5/0007 ,  H01M2/145 ,  H01M2/162 ,  H01M2/1673 ,  H01M4/0407 ,  H01M4/0435 ,  H01M10/0431 ,  H01M10/0436 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/058 ,  H01M2300/0091

摘要： The present invention provides a lithium secondary battery and its fabrication method. More particularly, the present invention provides a lithium secondary battery comprising a super fine fibrous porous polymer separator film and its fabrication method, wherein the porous polymer separator film is fabricated by the following process: a) melting at least one polymer or dissolving at least one polymer with organic solvents to obtain at least one polymeric melt or at least one polymeric solution; b) adding the obtained polymeric melt or polymeric solution to barrels of an electrospinning machine; and c) discharging the polymeric melt or polymeric solution onto a substrate using a nozzle to form a porous separator film. The lithium secondary battery of the present invention has the advantages of better adhesion with electrodes, good mechanical strength, better performance at low and high temperatures, better compatibility with organic electrolyte solution of a lithium secondary battery.

摘要翻译： 本发明提供一种锂二次电池及其制造方法。 更具体地说，本发明提供一种包含超细纤维多孔聚合物隔膜的锂二次电池及其制造方法，其中通过以下方法制造多孔聚合物隔膜：a）熔化至少一种聚合物或溶解至少一种 聚合物与有机溶剂以获得至少一种聚合物熔体或至少一种聚合物溶液; b）将获得的聚合物熔体或聚合物溶液加入静电纺丝机的桶中; 和c）使用喷嘴将聚合物熔体或聚合物溶液排出到基底上以形成多孔隔离膜。 本发明的锂二次电池具有电极粘附性好，机械强度高，低温高温性能好，与锂二次电池有机电解质溶液更好相容的优点。

公开(公告)号：US09613002B2

公开(公告)日：2017-04-04

申请号：US14067474

申请日：2013-10-30

申请人： Chang-Ho Han ,  Dae-Wook Kim ,  Jin-Young Lee ,  Sung-Won Choi ,  Byoung-Hoon Kim ,  Han-Hum Park ,  Sang-Jin Choi ,  Ja-Hum Ku

发明人： Chang-Ho Han ,  Dae-Wook Kim ,  Jin-Young Lee ,  Sung-Won Choi ,  Byoung-Hoon Kim ,  Han-Hum Park ,  Sang-Jin Choi ,  Ja-Hum Ku

IPC分类号： G01N37/00 ,  G06F17/18 ,  H01L21/66 ,  G03F7/20

CPC分类号： G06F17/18 ,  G03F7/70633 ,  H01L22/00 ,  H01L22/20 ,  H01L2924/0002 ,  H01L2924/00

摘要： A processing method includes processing a wafer based on initial data, measuring errors for each of the plurality of areas, calculating an error similarity of at least some of the plurality of areas as a function of a separation distance between each pair of some of the areas, selecting a first area and a plurality of second areas adjacent to the first area, calculating weight values for the second areas based on the error similarities between each pair of second areas and the error similarities between the first area and each second area, calculating an estimated error of the first area based on the measured errors of the second areas and the weight values for the second areas, and generating estimated data based on the estimated errors for each of the plurality of areas.

公开(公告)号：US09397338B2

公开(公告)日：2016-07-19

申请号：US13333864

申请日：2011-12-21

申请人： Benjamin Park ,  Sung Won Choi ,  Ian Browne ,  William Schank

发明人： Benjamin Park ,  Sung Won Choi ,  Ian Browne ,  William Schank

IPC分类号： H01M4/02 ,  H01M4/62 ,  H01M4/13 ,  H01M4/139 ,  B32B37/20 ,  H01M4/36 ,  H01M4/38 ,  H01M4/587

CPC分类号： H01M4/623 ,  B32B37/203 ,  B32B2457/10 ,  H01M4/13 ,  H01M4/139 ,  H01M4/362 ,  H01M4/386 ,  H01M4/587 ,  H01M4/622 ,  H01M4/625 ,  H01M2004/021 ,  Y02E60/122 ,  Y02P70/54 ,  Y10T29/49108 ,  Y10T29/49115 ,  Y10T156/10

摘要： Electrodes and methods of forming electrodes are described herein. The electrode can be an electrode of an electrochemical cell or battery. The electrode includes a current collector and a film in electrical communication with the current collector. The film may include a carbon phase that holds the film together. The electrode further includes an electrode attachment substance that adheres the film to the current collector.

摘要翻译： 本文描述了电极和形成电极的方法。 电极可以是电化学电池或电池的电极。 电极包括集电器和与集电器电连通的膜。 膜可以包括将膜保持在一起的碳相。 电极还包括将膜粘附到集电体的电极附着物质。

公开(公告)号：US09220779B2

公开(公告)日：2015-12-29

申请号：US13993787

申请日：2011-12-30

申请人： Sung-Won Choi ,  Muhn-Ho La ,  Ji-Yeon Son ,  Min-Hyo Seo

发明人： Sung-Won Choi ,  Muhn-Ho La ,  Ji-Yeon Son ,  Min-Hyo Seo

IPC分类号： A61K47/16 ,  A61K31/7105 ,  A61K47/48 ,  A61K9/107 ,  A61K9/127 ,  C12N15/88 ,  A61K47/18 ,  A61K47/28

CPC分类号： A61K47/16 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/1272 ,  A61K31/713 ,  A61K47/18 ,  A61K47/34 ,  A61K47/59 ,  A61K47/595 ,  C12N15/88

摘要： Disclosed are a carrier for delivering a negatively charged drug, comprising a cationic lipid represented by formula 1, and a preparation method thereof. Also disclosed is a pharmaceutical composition comprising a negatively charged drug and a cationic lipid represented by formula 1, wherein the negatively charged drug forms a complex with the cationic lipid. The composition can increase the in vivo stability of the negatively charged drug after local or systemic administration and allows the intracellular delivery of the negatively charged drug. Thus, the composition will be useful for improving the therapeutic effect of the negatively charged drug.

摘要翻译： 公开了用于递送带负电荷药物的载体，其包含由式1表示的阳离子脂质及其制备方法。 还公开了包含带负电荷的药物和由式1表示的阳离子脂质的药物组合物，其中带负电荷的药物与阳离子脂质形成复合物。 组合物可以在局部或全身给药后增加带负电荷的药物的体内稳定性，并允许带负电荷的药物的细胞内递送。 因此，该组合物可用于改善带负电荷的药物的治疗效果。