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公开(公告)号：US20110237704A1
公开(公告)日：2011-09-29
申请号：US13005528
申请日：2011-01-12
Applicant: Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page , Subhabrata Bhattacharyya
Inventor： Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page , Subhabrata Bhattacharyya
CPC classification number: A61L27/46 , A61L27/446 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/406 , C08L75/04
Abstract: The present invention encompasses the finding that certain treatments (e.g., surface modifications) to particulate materials can provide surprising and unexpected benefits and/or features to composites and/or compositions as described herein. In some embodiments, such benefits and/or features may render particular composites and/or compositions particularly useful in a certain therapeutic context (e.g, for repair of tibial plateau, femoral head, craniofacial, or lateral mandibular body defects). The present invention demonstrates that certain composites and/or compositions wherein the particular material is or comprises defatted bone have surprising and beneficial attributes.
Abstract translation: 本发明包括对颗粒材料的某些处理（例如，表面改性）可以为本文所述的复合材料和/或组合物提供令人惊奇和意想不到的益处和/或特征的发现。 在一些实施方案中，这样的益处和/或特征可以使特定的复合材料和/或组合物在特定的治疗背景下特别有用（例如，用于修复胫骨平台，股骨头，颅面或侧向下颌体缺陷）。 本发明证明特定材料是或包含脱脂骨的某些复合物和/或组合物具有令人惊奇和有益的属性。
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公开(公告)号：US20070191963A1
公开(公告)日：2007-08-16
申请号：US11625119
申请日：2007-01-19
Applicant: John Winterbottom , David Kaes , Deger Tunc , Todd Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
Inventor： John Winterbottom , David Kaes , Deger Tunc , Todd Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
IPC: A61F2/28
CPC classification number: A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
Abstract translation: 一种植物复合材料，其包含多种无机材料颗粒，骨替代材料，骨衍生材料或其任何组合; 以及与颗粒结合的聚合物材料。 复合材料可以自然地模塑或流动，或者它可以是可模制的或可设定的。 植入后，可以将复合材料设置成为植入物提供机械强度。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为提供大多数矫形应用所需的机械强度。 本发明还提供了使用和制备可模制和可流动的复合材料的方法。
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公开(公告)号：US20060263279A1
公开(公告)日：2006-11-23
申请号：US11416504
申请日：2006-04-27
Applicant: Cato Laurencin , Swaminathan Sethuraman , Subhabrata Bhattacharyya , William Shoup
Inventor： Cato Laurencin , Swaminathan Sethuraman , Subhabrata Bhattacharyya , William Shoup
IPC: B01D7/00
Abstract: A sublimator device is designed where the distance between the sublimation surface and the bottom of the device to be adjusted depending on the amount of substance in the bottom of the device and the rate of sublimation without stopping the process. The device has a threaded connector on the top that allows the condenser to be advanced or receded without stopping the sublimation process. Different embodiments of the sublimator device are disclosed and indications for the use of these devices during the sublimation process are discussed.
Abstract translation: 设计升华装置，其中升华表面和装置的底部之间的距离将根据装置底部物质的量和升华速率而调整，而不停止该过程。 该设备在顶部具有螺纹连接器，允许冷凝器前进或后退，而不停止升华过程。 公开了升华装置的不同实施例，并且讨论了在升华过程中使用这些装置的指示。
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公开(公告)号：US09107751B2
公开(公告)日：2015-08-18
申请号：US11625119
申请日：2007-01-19
Applicant: John Winterbottom , David R. Kaes , Deger C. Tunc , Todd M. Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
Inventor： John Winterbottom , David R. Kaes , Deger C. Tunc , Todd M. Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
CPC classification number: A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
Abstract translation: 一种植物复合材料，其包含多种无机材料颗粒，骨替代材料，骨衍生材料或其任何组合; 以及与颗粒结合的聚合物材料。 复合材料可以自然地模塑或流动，或者它可以是可模制的或可设定的。 植入后，可以将复合材料设置成为植入物提供机械强度。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为提供大多数矫形应用所需的机械强度。 本发明还提供了使用和制备可模制和可流动的复合材料的方法。
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公开(公告)号：US09034356B2
公开(公告)日：2015-05-19
申请号：US11625086
申请日：2007-01-19
Applicant: Lawrence A. Shimp , John Winterbottom , David R. Kaes , Ryan M. Belaney , Subhabrata Bhattacharyya
Inventor： Lawrence A. Shimp , John Winterbottom , David R. Kaes , Ryan M. Belaney , Subhabrata Bhattacharyya
CPC classification number: A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46
Abstract: The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality of particles of bone-derived material, inorganic material, bone substitute material or composite material. In certain embodiments, the porous composites are prepared using a method that includes a supercritical fluid (e.g., supercritical carbon dioxide) treatment. The invention also discloses methods of using these composites as bone void fillers.
Abstract translation: 本发明涉及用于骨缺损部位以促进新骨生长的多孔复合材料。 本发明的多孔复合材料包括生物相容性聚合物和多种骨源材料，无机材料，骨替代材料或复合材料的颗粒。 在某些实施方案中，使用包括超临界流体（例如超临界二氧化碳）处理的方法制备多孔复合材料。 本发明还公开了使用这些复合材料作为骨空隙填料的方法。
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Patent Agency Ranking
公开(公告)号：US07235295B2
公开(公告)日：2007-06-26
申请号：US10938493
申请日：2004-09-10
Applicant: Cato T. Laurencin , Lakshmi Sreedharan Nair , Subhabrata Bhattacharyya , Harry R. Allcock , Jared D. Bender , Paul W. Brown , Yaser E. Greish
Inventor： Cato T. Laurencin , Lakshmi Sreedharan Nair , Subhabrata Bhattacharyya , Harry R. Allcock , Jared D. Bender , Paul W. Brown , Yaser E. Greish
CPC classification number: A61L27/50 , A61L27/18 , A61L31/10 , Y10T428/1369 , Y10T428/249924 , Y10T428/2913 , C08L85/02
Abstract: Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, either non-degradable or degradable. In a preferred embodiment demonstrated in the following examples, nanofibers are formed of biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes or with organic, inorganic/organometallic polymers as well as composite nanofibers of polyphosphazenes with nanosized particles such as hydroxyapatites.
Abstract translation: 已经开发了可用于各种医疗和其他应用的聚合物纳米纤维，例如过滤装置，医疗假体，用于组织工程的支架，伤口敷料，受控药物递送系统，化妆品皮肤面罩和防护服。 这些可以由不可降解或可降解的各种不同聚合物中的任何一种形成。 在以下实施例中证明的优选实施方案中，纳米纤维由可生物降解和不可生物降解的聚磷腈，它们与其它聚磷腈或与有机，无机/有机金属聚合物的共混物以及具有纳米尺寸颗粒如羟基磷灰石的聚磷腈的复合纳米纤维形成。
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公开(公告)号：US09333276B2
公开(公告)日：2016-05-10
申请号：US12608850
申请日：2009-10-29
Applicant: Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
Inventor： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
Abstract: Present inventions present composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. A porous composite comprises a plurality of bone particles; and polyurethanes with which the bone particles are combined. To prepare a porous composite, a composition comprise a plurality of bone particles, polyurethane precursors including polyisocyanate prepolymers and polyols, water and catalyst. A composition is either naturally moldable and/or injectable, or it can be made moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
Abstract translation: 本发明提出了骨颗粒和聚氨酯的复合材料，以及制备这种复合材料及其用途的方法。 多孔复合材料包括多个骨颗粒; 和与其结合的聚氨酯。 为了制备多孔复合材料，组合物包含多个骨颗粒，包括多异氰酸酯预聚物和多元醇的聚氨酯前体，水和催化剂。 组合物可以是天然可模塑的和/或可注射的，或者它可以是可模制的和/或可注射的。 在植入或注射后，可以将组合物设置成形成提供机械强度并支持细胞生长的多孔复合材料。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为大多数矫形应用提供机械强度。
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公开(公告)号：US20050112349A1
公开(公告)日：2005-05-26
申请号：US10938493
申请日：2004-09-10
Applicant: Cato Laurencin , Lakshmi Sreedharan Nair , Subhabrata Bhattacharyya , Harry Allcock , Jared Bender , Paul Brown , Yaser Greish
Inventor： Cato Laurencin , Lakshmi Sreedharan Nair , Subhabrata Bhattacharyya , Harry Allcock , Jared Bender , Paul Brown , Yaser Greish
CPC classification number: A61L27/50 , A61L27/18 , A61L31/10 , Y10T428/1369 , Y10T428/249924 , Y10T428/2913 , C08L85/02
Abstract: Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, either non-degradable or degradable. In a preferred embodiment demonstrated in the following examples, nanofibers are formed of biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes or with organic, inorganic/organometallic polymers as well as composite nanofibers of polyphosphazenes with nanosized particles such as hydroxyapatites.
Abstract translation: 已经开发了可用于各种医疗和其他应用的聚合物纳米纤维，例如过滤装置，医疗假体，用于组织工程的支架，伤口敷料，受控药物递送系统，化妆品皮肤面罩和防护服。 这些可以由不可降解或可降解的各种不同聚合物中的任何一种形成。 在以下实施例中证明的优选实施方案中，纳米纤维由可生物降解和不可生物降解的聚磷腈，它们与其它聚磷腈或与有机，无机/有机金属聚合物的共混物以及具有纳米尺寸颗粒如羟基磷灰石的聚磷腈的复合纳米纤维形成。
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公开(公告)号：US20100112032A1
公开(公告)日：2010-05-06
申请号：US12608850
申请日：2009-10-29
Applicant: Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
Inventor： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
Abstract: Present inventions present composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. A porous composite comprises a plurality of bone particles; and polyurethanes with which the bone particles are combined. To prepare a porous composite, a composition comprise a plurality of bone particles, polyurethane precursors including polyisocyanate prepolymers and polyols, water and catalyst. A composition is either naturally moldable and/or injectable, or it can be made moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
Abstract translation: 本发明提出了骨颗粒和聚氨酯的复合材料，以及制备这种复合材料及其用途的方法。 多孔复合材料包括多个骨颗粒; 和与其结合的聚氨酯。 为了制备多孔复合材料，组合物包含多个骨颗粒，包括多异氰酸酯预聚物和多元醇的聚氨酯前体，水和催化剂。 组合物可以是天然可模塑的和/或可注射的，或者它可以是可模制的和/或可注射的。 在植入或注射后，可以将组合物设置成形成提供机械强度并支持细胞生长的多孔复合材料。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为大多数矫形应用提供机械强度。
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公开(公告)号：US20080069852A1
公开(公告)日：2008-03-20
申请号：US11625086
申请日：2007-01-19
Applicant: Lawrence Shimp , John Winterbottom , David Kaes , Ryan Belaney , Subhabrata Bhattacharyya
Inventor： Lawrence Shimp , John Winterbottom , David Kaes , Ryan Belaney , Subhabrata Bhattacharyya
CPC classification number: A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46
Abstract: The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality of particles of bone-derived material, inorganic material, bone substitute material or composite material. In certain embodiments, the porous composites are prepared using a method that includes a supercritical fluid (e.g., supercritical carbon dioxide) treatment. The invention also discloses methods of using these composites as bone void fillers.
Abstract translation: 本发明涉及用于骨缺损部位以促进新骨生长的多孔复合材料。 本发明的多孔复合材料包括生物相容性聚合物和多种骨源材料，无机材料，骨替代材料或复合材料的颗粒。 在某些实施方案中，使用包括超临界流体（例如超临界二氧化碳）处理的方法制备多孔复合材料。 本发明还公开了使用这些复合材料作为骨空隙填料的方法。
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