Abstract:
The present invention relates to pyrrolidine sulfonamides, pharmaceutical compositions containing them and their use as urotensin II antagonists.
Abstract:
Disclosed herein is a vortex-generating system for a moving object that has a trailing edge. The system includes a first blade coupled to the object and positioned proximate the trailing edge, a second blade coupled to the object, positioned proximate the trailing edge, and spaced apart from the first blade. The first and second blade cooperate to induce an outwardly directed vortical flow of air away from the trailing edge of the object.
Abstract:
A valve comprises a valve body having a fluid inlet and fluid outlet, a valve seat located in the valve body between the fluid inlet and a fluid outlet, a valve member movable towards and away from the valve seat for controlling the flow of fluid from the fluid inlet to the fluid outlet, and a PTC heater in thermal contact with the valve seat for heating the valve seat. The heater is integrated in the valve in a manner where the valve seat is used as an electrical conductor to facilitate operation and assembly of the valve, and a unique valve construction is provided for enabling self-draining to avoid accumulation of water or other liquid in the valve that might negatively impact performance of the valve.
Abstract:
A filter assembly includes housing enclosing a replaceable filter element. A support core is provided in the housing, and includes an extension and locking assembly. The element includes a ring of filtration media with a pair of end caps. The first end cap includes a central opening to receive the support core. The extension and locking assembly prevents the cover of the housing from being attached to the housing body without a proper filter element installed. The extension and locking assembly includes a bypass member and a locking member, which are in locking engagement when an element is absent in the housing. The second end cap includes internal protrusions which engage the locking member when the filter element is installed to disengage the bypass member from the support core, and allow the element to be inserted and the cover to be installed.
Abstract:
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
Abstract:
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
Abstract:
A filter element removably located in a housing having a central valve structure. The element has an end cap with a valve actuating portion. The valve actuating portion includes a cylindrical portion and an annular base projecting radially inward from the cylindrical portion. The valve actuating portion includes a plurality of thin, flat keys spaced around the annular base and projecting radially inward from the cylindrical portion and axially outward from the base. The keys engage the valve structure in the housing when the element is installed, and open up a flow passage through the housing.