公开(公告)号：US20100181475A1

公开(公告)日：2010-07-22

申请号：US12749334

申请日：2010-03-29

Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

IPC: H01J49/28

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。 捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电 或磁性）。 扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

公开(公告)号：US08198581B2

公开(公告)日：2012-06-12

申请号：US12749334

申请日：2010-03-29

Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

IPC: H01J49/28

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 Π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。 捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电 或磁性）。 扰动的幅度使得至少一些捕获的离子的绝对相位差大于零但小于2＆Pgr; 弧度超过离子检测周期Tm。

公开(公告)号：US20110147582A1

公开(公告)日：2011-06-23

申请号：US13008790

申请日：2011-01-18

Applicant: Alexander Alekseevich MAKAROV ,  Oliver LANGE ,  Stevan Roy HORNING

Inventor： Alexander Alekseevich MAKAROV ,  Oliver LANGE ,  Stevan Roy HORNING

IPC: B01D59/44 ,  H01J49/34 ,  H01J49/40

CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/14 ,  H01J49/4265

Abstract: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.

Abstract translation: 本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。 具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。 提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

公开(公告)号：US20080315080A1

公开(公告)日：2008-12-25

申请号：US10587478

申请日：2006-06-05

Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

IPC: B01D59/46

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生U'（r，phi，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。 捕获场U'（r，phi，z）是对于理想场U（r，phi，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，phi，z）的等电位，或者通过添加失真场（电或 磁性）。 扰动的幅度使得至少一些捕获的离子在离子检测周期Tm之后具有大于零但小于约2pi弧度的绝对相位扩展。

公开(公告)号：US07714283B2

公开(公告)日：2010-05-11

申请号：US10587478

申请日：2006-06-05

Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

IPC: H01J49/28

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生形式为U'（r，＆phgr，z）的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。 捕获场U'（r，＆phgr，，z）是对于理想场U（r，＆phgr;，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr，z）的等电位，或者通过添加失真场（电 或磁性）。 扰动的幅度使得至少一些捕获的离子具有大于零但小于约2的绝对相位扩展; 弧度超过离子检测周期Tm。

公开(公告)号：US07880136B2

公开(公告)日：2011-02-01

申请号：US11915735

申请日：2006-05-31

Applicant: Alexander Alekseevich Makarov ,  Oliver Lange ,  Stevan Roy Horning

Inventor： Alexander Alekseevich Makarov ,  Oliver Lange ,  Stevan Roy Horning

IPC: B01D59/44

CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/14 ,  H01J49/4265

Abstract: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.

Abstract translation: 本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。 具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。 提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

公开(公告)号：US07211794B2

公开(公告)日：2007-05-01

申请号：US10796645

申请日：2004-03-09

Applicant: Robert Malek ,  Kai Jurgen Meyer ,  Silke Seedorf ,  Stevan Roy Horning

Inventor： Robert Malek ,  Kai Jurgen Meyer ,  Silke Seedorf ,  Stevan Roy Horning

IPC: H01J49/38 ,  H01J49/26

CPC classification number: H01J49/063 ,  H01J49/38

Abstract: An improved FT-ICR Mass Spectrometer has an ion source 10 which generates ions that are transmitted through a series of multipoles 20 to an ion trap 30. Ions are ejected from the trap 30, through a series of lens and multipolar ion guide stages 40–90, and into a measurement cell 100 via an exit/gate lens 110. The measurement cell is mounted in a vacuum chamber 240 and this assembly is slideably moveable into a bore of a superconducting magnet 400 which provides the magnetic filed to cause cyclotron motion of the generated ions in the cell 100. By minimising the distance between the source 10 and cell 100, and by careful alignment of the ion optics, the ions can travel at high energies right up to the front of the measurement cell 100. The cell 100 extends in the longitudinal direction of the magnet bore and is coaxial with that. The ratio of the sectional area of the magnet bore to the sectional area of the cell volume is small (less than 3). The magnet is asymmetric and is relatively short on the ion injection side. The cell 100 is supported from in front of the cell and electrical contact is from the rear thereof.

Abstract translation: 改进的FT-ICR质谱仪具有离子源10，其产生通过一系列多极20传输到离子阱30的离子。 离子通过一系列透镜和多极离子引导台40-90从陷阱30排出，并通过出口/门镜片110进入测量单元100。 测量单元安装在真空室240中，并且该组件可滑动地移动到超导磁体400的孔中，超导磁体400提供磁场以使得所产生的离子在单元100中的回旋加速器运动。 通过使源10和电池100之间的距离最小化，并且通过离子光学器件的仔细对准，离子可以以高能量行进直到测量单元100的前方。电池单元100在磁体的纵向方向上延伸 并与之同轴。 磁体孔的截面积与电池体积的截面积的比例小（小于3）。 磁体是不对称的，并且离子注入侧相对较短。 电池单元100从电池的前面被支撑，并且电接触从其后面。