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1.发明授权公开(公告)号：US07597016B2
公开(公告)日：2009-10-06
申请号：US11556479
申请日：2006-11-03
CPC分类号： G01N17/00 , G01N17/043 , Y10T436/100833
摘要： A method of using an exhaust flow simulation system to test the effects of exhaust system conditions on various materials. A typical exhaust flow simulator is a burner-based system, in which exhaust from burner combustion is exhausted through an exhaust line. A “test coupon” of the material may be placed at an appropriate location in the flow line, and tested to determine how it is affected by the exhaust resulting from various fuels and additives.
摘要翻译： 一种使用排气流动模拟系统来测试排气系统条件对各种材料的影响的方法。 典型的排气流模拟器是基于燃烧器的系统，其中来自燃烧器燃烧的排气通过排气管线排出。 材料的“试样”可以放置在流线中的适当位置，并进行测试以确定它是如何受到各种燃料和添加剂产生的排气的影响。
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2.发明授权Controlled low strength flowable fill composition with iron chelating compounds 有权控制低强度可流动填充组合物与铁螯合化合物公开(公告)号：US07582158B2
公开(公告)日：2009-09-01
申请号：US12075931
申请日：2008-03-14
申请人： Jerry Setliff , Scott F. Timmons , Clinton W. Pike
发明人： Jerry Setliff , Scott F. Timmons , Clinton W. Pike
IPC分类号： C04B18/06
CPC分类号： C04B28/021 , Y02W30/92 , Y02W30/94 , Y10S106/01 , C04B14/06 , C04B18/08 , C04B22/064 , C04B24/122 , C04B14/28 , C04B22/08 , C04B24/2652 , C04B14/185 , C04B16/08 , C04B24/04 , C04B2103/0086 , C04B14/10 , C04B14/108 , C04B14/16 , C04B14/18 , C04B18/06 , C04B18/141
摘要： A rapid setting, controlled low strength composition of Class C fly ash is provided having a quantity of hydrated lime and an iron chelating compound in an amount sufficient to accelerate the hydration and set time of the fly ash. In some examples, a filler material is added. A method for acceleration of the hydration and set time of a cementitious mixture is provided wherein hydrated lime is added to the cementitious mixture in an amount in the range of 0.1% to 15% by weight and an iron chelating compound in an amount in the range of 0.01% to 5.0% by weight of the cementitious material. Further, a calcium source and an iron chelating compound may be added to a Class C fly ash to accelerate the hydration and set time of the ash.
摘要翻译： 提供了具有一定量的熟石灰和铁螯合化合物的快速凝固，控制的低强度组合C级粉煤灰，其量足以加速水合和设定飞灰的时间。 在一些实例中，加入填料。 提供了一种用于加速水泥混合物的水化和凝固时间的方法，其中将熟石灰以0.1重量％至15重量％的量加入水泥混合物中，铁螯合化合物的量在该范围内 为水泥质材料的0.01〜5.0重量％。 此外，可以向C类飞灰中加入钙源和铁螯合化合物以加速水合并设定灰分时间。
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3.发明授权Keratin-based hydrogel for biomedical applications and method of production 有权用于生物医学应用的角蛋白基水凝胶和生产方法公开(公告)号：US06379690B2
公开(公告)日：2002-04-30
申请号：US09736957
申请日：2000-12-12
IPC分类号： A61F1300
CPC分类号： C08H1/06 , A61K8/042 , A61K8/65 , A61K38/1709 , A61K38/39 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/52 , A61L27/60 , A61L31/047 , A61L31/10 , A61Q19/00 , C07K14/4741 , Y10S514/944 , Y10S530/842 , C08L89/04 , C08L89/00
摘要： A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.
摘要翻译： 可用作伤口敷料和细胞脚手架的角蛋白水凝胶。 通过部分氧化显着百分比的二硫键以形成半胱氨酸基团，由干净的洗涤毛发形成角蛋白水凝胶，而一些二硫键保持完整。 用还原剂处理部分氧化的毛发，从而将大部分剩余的二硫键连接到半胱氨酸 - 巯基乙酸酯二硫化物和半胱氨酸基团。 收集毛发的可溶性部分并进行氧化，使得还原的硫基团能够改性二硫键，从而将角蛋白结合在一起。 残留的半胱氨酸基团，在水凝胶内提供亲水部位。 较高程度的部分氧化导致水凝胶中亲水性半胱氨酸基团的丰度较大。
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公开(公告)号：US6159496A
公开(公告)日：2000-12-12
申请号：US365699
申请日：1999-08-02
IPC分类号： A61K38/17 , A61K38/39 , A61L26/00 , A61L27/22 , A61L27/34 , A61L27/52 , A61L27/60 , A61L31/04 , A61L31/10 , C07K14/47 , C08H1/06 , A61L15/00 , A61F13/00 , A61K9/70 , A61K38/00
CPC分类号： C08H1/06 , A61K38/1709 , A61K38/39 , A61K8/042 , A61K8/65 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/52 , A61L27/60 , A61L31/047 , A61L31/10 , A61Q19/00 , C07K14/4741 , Y10S514/944 , Y10S530/842
摘要： A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.
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公开(公告)号：US5980699A
公开(公告)日：1999-11-09
申请号：US957181
申请日：1997-10-24
IPC分类号： C04B35/589 , C04B35/628 , C04B35/80 , C04B35/83 , C01B53/00 , C01B25/00
CPC分类号： C04B35/584 , C04B35/589 , C04B35/6267 , C04B35/62873 , C04B35/64 , C04B35/806 , C04B35/83 , C04B2235/32 , C04B2235/3804 , C04B2235/3817 , C04B2235/3821 , C04B2235/3826 , C04B2235/3852 , C04B2235/386 , C04B2235/3873 , C04B2235/3882 , C04B2235/3891 , C04B2235/422 , C04B2235/428 , C04B2235/465 , C04B2235/5244 , C04B2235/5248 , C04B2235/667 , C04B2235/766 , C04B2235/80
摘要： A method of producing silicon nitride ceramics and silicon nitride ceramic composites. A mixture comprising a polysilazane and an additive effective to increase coupling between the mixture and electromagnetic energy is converted to a preceramic intermediate. The preceramic intermediate is treated with electromagnetic energy and thereby converted to a silicon nitride ceramic and/or a silicon nitride ceramic composite.
摘要翻译： 一种生产氮化硅陶瓷和氮化硅陶瓷复合材料的方法。 包含聚硅氮烷和有效增加混合物和电磁能之间的偶联剂的添加剂的混合物被转化成陶瓷中间体。 用电磁能处理前陶瓷中间体，从而转化为氮化硅陶瓷和/或氮化硅陶瓷复合材料。
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公开(公告)号：US07344592B2
公开(公告)日：2008-03-18
申请号：US10552345
申请日：2004-03-10
申请人： Jerry Setliff , Scott F. Timmons , Clinton W. Pike
发明人： Jerry Setliff , Scott F. Timmons , Clinton W. Pike
IPC分类号： C04B18/06
CPC分类号： C04B28/021 , Y02W30/92 , Y02W30/94 , Y10S106/01 , C04B14/06 , C04B18/08 , C04B22/064 , C04B24/122 , C04B14/28 , C04B22/08 , C04B24/2652 , C04B14/185 , C04B16/08 , C04B24/04 , C04B2103/0086 , C04B14/10 , C04B14/108 , C04B14/16 , C04B14/18 , C04B18/06 , C04B18/141
摘要： A rapid setting, controlled low strength composition of Class C fly ash is provided having a quantity of hydrated lime and an iron chelating compound in an amount sufficient to accelerate the hydration and set time of the fly ash. In some examples, a filler material is added. A method for acceleration of the hydration and set time of a cementitious mixture is provided wherein hydrated lime is added to the cementitious mixture in an amount in the range of 0.1% to 15% by weight and an iron chelating compound in an amount in the range of 0.01% to 5.0% by weight of the cementitious material. Further, a calcium source and an iron chelating compound may be added to a Class C fly ash to accelerate the hydration and set time of the ash.
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公开(公告)号：US06544548B1
公开(公告)日：2003-04-08
申请号：US09638643
申请日：2000-08-14
申请人： Arlene J. Siller-Jackson , Mark E. Van Dyke , Scott F. Timmons , Cheryl R. Blanchard , Robert A. Smith
发明人： Arlene J. Siller-Jackson , Mark E. Van Dyke , Scott F. Timmons , Cheryl R. Blanchard , Robert A. Smith
IPC分类号： A61F1300
CPC分类号： A61K8/042 , A61F2013/530481 , A61F2013/530613 , A61K8/65 , A61K9/0024 , A61K9/06 , A61K9/146 , A61K9/2063 , A61K9/7007 , A61K38/015 , A61K38/17 , A61K47/42 , A61K47/6953 , A61L15/32 , A61L15/60 , A61L27/227 , A61L27/52 , A61Q19/00
摘要： A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel can be used as a biocompatible viscoelastic filler for implant applications. Another use for the absorbent keratin and keratin hydrogel is as an excipient in pharmaceutical and cosmetic applications.
摘要翻译： 可以通过将毛发角蛋白二硫键部分氧化成磺酸残基并使磺酸残基与阳离子反应来制备能够吸收大量过量水分的可水合的高吸收性角蛋白固体纤维或粉末。 中和的悬浮液可以过滤，洗涤和干燥，留下角蛋白固体，将其切成纤维并进一步研磨成粉末。 向固体中加入水产生水凝胶。 粉末或水凝胶可用作吸收材料，作为皮肤的治疗剂或赋形剂。 角蛋白材料可以并入无纺膜中。 水凝胶可用作植入物应用的生物相容性粘弹性填料。 吸收性角蛋白和角蛋白水凝胶的另一用途是作为药物和化妆品应用中的赋形剂。
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公开(公告)号：US6159495A
公开(公告)日：2000-12-12
申请号：US362244
申请日：1999-07-28
IPC分类号： A61K9/70 , A61K35/36 , A61K38/17 , A61K38/39 , A61L15/32 , A61L26/00 , A61L27/22 , A61L27/34 , A61L27/60 , A61L31/04 , A61L31/10 , C07K14/47 , C08H1/06 , C12N5/00 , A61K13/00 , A61K38/00 , C08G63/48
CPC分类号： C12N5/0068 , A61K35/36 , A61K38/1709 , A61K38/39 , A61K9/70 , A61L15/32 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/60 , A61L31/047 , A61L31/10 , C07K14/4741 , C08H1/06 , C12N2533/50 , Y10S530/842
摘要： Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCl, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film. The film may be used as a wound dressing, a tissue-engineering scaffold, a diffusion membrane, a coating for implantable devices, and as a cell encapsulant. In another method, the keratin solution thus formed is concentrated, poured into a mold, and allowed to air dry into a three dimensional keratin product. The resulting bulk product can be used as a cross-linked implantable biomaterial for soft and hard tissue replacement. In another method, a keratin solution is emulsified and freeze dried, forming a porous, open cell keratin material.
摘要翻译： 用于生产薄角蛋白薄膜，片材和散装材料的方法以及使用这些方法形成的产品。 一种方法包括提供毛发，减少头发，使得二硫键断裂，形成游离的半胱氨酸硫醇基团，在溶液中分离出更可溶的角蛋白级分，从较可溶级分形成薄层，并将角蛋白级分空气干燥 氧的存在，从而形成新的二硫键，赋予所得薄的角蛋白薄膜强度。 一种方法包括通过在氮气下在氢氧化铵和巯基乙酸铵溶液中加热头发，然后离心并收集含有较可溶性角蛋白级分的上清液来减少头发。 该方法中较易溶解的角蛋白用HCl沉淀，除去，再悬浮于氢氧化铵中。 将如此形成的角蛋白溶液倒入平坦表面，并使其干燥成薄的角蛋白膜。 该膜可以用作伤口敷料，组织工程支架，扩散膜，用于可植入装置的涂层，以及作为细胞密封剂。 在另一种方法中，将如此形成的角蛋白溶液浓缩，倒入模具中，并使其风干至三维角蛋白产品。 所得到的散装产品可用作用于软组织和硬组织置换的交联可植入生物材料。 在另一种方法中，将角蛋白溶液乳化并冷冻干燥，形成多孔的开放细胞角蛋白材料。
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公开(公告)号：US6110487A
公开(公告)日：2000-08-29
申请号：US198998
申请日：1998-11-24
IPC分类号： A61K9/70 , A61K35/36 , A61K38/17 , A61K38/39 , A61L15/32 , A61L26/00 , A61L27/22 , A61L27/34 , A61L27/60 , A61L31/04 , A61L31/10 , C07K14/47 , C08H1/06 , C12N5/00 , A61K9/00 , A61K38/00 , C08G63/48
CPC分类号： C12N5/0068 , A61K35/36 , A61K38/1709 , A61K38/39 , A61K9/70 , A61L15/32 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/60 , A61L31/047 , A61L31/10 , C07K14/4741 , C08H1/06 , C12N2533/50 , Y10S530/842
摘要： Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCl, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film. The film may be used as a wound dressing, a tissue-engineering scaffold, a diffusion membrane, a coating for implantable devices, and as a cell encapsulant. In another method, the keratin solution thus formed is concentrated, poured into a mold, and allowed to air dry into a three dimensional keratin product. The resulting bulk product can be used as a cross-linked implantable biomaterial for soft and hard tissue replacement. In another method, a keratin solution is emulsified and freeze dried, forming a porous, open cell keratin material.
摘要翻译： 用于生产薄角蛋白薄膜，片材和散装材料的方法以及使用这些方法形成的产品。 一种方法包括提供毛发，减少头发，使得二硫键断裂，形成游离的半胱氨酸硫醇基团，在溶液中分离出更可溶的角蛋白级分，从较可溶级分形成薄层，并将角蛋白级分空气干燥 氧的存在，从而形成新的二硫键，赋予所得薄的角蛋白薄膜强度。 一种方法包括通过在氮气下在氢氧化铵和巯基乙酸铵溶液中加热头发，然后离心并收集含有较可溶性角蛋白级分的上清液来减少头发。 该方法中较易溶解的角蛋白用HCl沉淀，除去，再悬浮于氢氧化铵中。 将如此形成的角蛋白溶液倒入平坦表面，并使其干燥成薄的角蛋白膜。 该膜可以用作伤口敷料，组织工程支架，扩散膜，用于可植入装置的涂层，以及作为细胞密封剂。 在另一种方法中，将如此形成的角蛋白溶液浓缩，倒入模具中，并使其风干至三维角蛋白产品。 所得到的散装产品可用作用于软组织和硬组织置换的交联可植入生物材料。 在另一种方法中，将角蛋白溶液乳化并冷冻干燥，形成多孔的开放细胞角蛋白材料。
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公开(公告)号：US5948432A
公开(公告)日：1999-09-07
申请号：US979526
申请日：1997-11-26
IPC分类号： A61K9/70 , A61K35/36 , A61K38/39 , A61L15/32 , A61L26/00 , A61L27/22 , A61L27/34 , A61L27/60 , A61L31/04 , A61L31/10 , C08H1/06 , C12N5/00 , A61K38/00 , A01N25/34 , A61L15/00
CPC分类号： C12N5/0068 , A61K35/36 , A61K38/39 , A61K9/70 , A61L15/32 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/60 , A61L31/047 , A61L31/10 , C08H1/06 , C12N2533/50 , Y10S530/842
摘要： A sheet wound dressing formed of cross linked keratin. An insoluble, largely Beta keratin fraction from human hair is acidified to a low pH, preferably less than about 3, which partially solubilizes the keratin by weakening hydrogen bonds. The suspension is added to base, such as ammonium hydroxide, forming a slurry. The slurry is cast directly onto a flat surface, allowing the re-formation of cross-links including hydrogen bonds and disulfide bonds. The resulting cross-linked keratin sheet can be used as a sheet wound dressing or as a scaffolding for growth of cells. The insoluble keratin can be derived from human hair which is washed, rinsed, dried, chopped and treated with peracetic acid to break some accessible disulfide linkages. The treated hair is filtered, rinsed, dried, and ground into a keratin powder. The keratin powder is suspended in a mixture of ammonium hydroxide and ammonium thioglycollate and heated sufficiently to dissolve the soluble keratin fraction, followed by cooling and centrifugation to concentrate the insoluble, largely Beta keratin fraction.
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