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公开(公告)号：US07235068B2
公开(公告)日：2007-06-26
申请号：US11353842
申请日：2006-02-14
Inventor： Ben Eckenhoff, deceased
CPC classification number: A61K9/0004
Abstract: An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a protein or peptide, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmopolymer from the protein or peptide. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.
Abstract translation: 提供了具有节省空间的活塞的渗透输送系统。 外壳具有保持活塞，蛋白质或肽和渗透剂的内部。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封将渗透聚合物与蛋白质或肽分离。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂吸收来自周围环境的液体以使活塞移动，从而导致有益剂从胶囊的输送。
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公开(公告)号：US07132111B2
公开(公告)日：2006-11-07
申请号：US10443446
申请日：2003-05-21
Applicant: Michael Basara
Inventor： Michael Basara
CPC classification number: A61K8/466 , A61K31/185 , A61K31/255 , A61K45/06 , A61K2800/28 , A61Q19/00 , A61Q19/10 , A61K2300/00
Abstract: The present invention includes a method for making a formulation for treating mucosal discontinuities, comprising: providing phenolic compounds and treating the purified phenolic compounds with sulfuric acid to make sulfonic acids and sulfonate salts. The present invention also includes formulations prepared by the method.
Abstract translation: 本发明包括制备用于治疗粘膜不连续性的制剂的方法，包括：提供酚类化合物并用硫酸处理纯化的酚类化合物以制备磺酸和磺酸盐。 本发明还包括通过该方法制备的制剂。
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3.发明授权Method for the prevention and reversal of the extrinsic aging of the skin by transdermal application of selenamino acids and compositions therefore 失效因此，通过透皮施用硒氨基酸和组合物来预防和逆转皮肤的外在老化的方法
公开(公告)号：US5330757A
公开(公告)日：1994-07-19
申请号：US147902
申请日：1993-11-04
Applicant: Karen E. Burke
Inventor： Karen E. Burke
IPC: A61K8/30 , A61K8/00 , A61K8/58 , A61K8/67 , A61K31/07 , A61K31/195 , A61K31/198 , A61K31/355 , A61P3/02 , A61P17/00 , A61P43/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K13/00
CPC classification number: A61K31/195 , A61K31/355
Abstract: Provided is a method for enhancing and accelerating the repair of chronic cellular and molecular damage to skin. Also provided is a method for thinning stratum corneum of mammalian, preferably human, skin thickened by extrinsic free radicals and restoring elastic tissue damaged by extrinsic free radicals. Both methods comprise the topical administration to mammalian, preferably human, skin of a composition comprising selenoamino acids in a pharmaceutically acceptable transdermal carrier.
Abstract translation: 提供了增强和加速对皮肤的慢性细胞和分子损伤的修复的方法。 还提供了一种通过外在自由基增稠的哺乳动物，优选人类皮肤的角质层变薄并恢复由外在自由基损伤的弹性组织的方法。 两种方法包括在药学上可接受的透皮载体中向哺乳动物，优选人的皮肤局部施用包含硒氨基酸的组合物。
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公开(公告)号：US3840667A
公开(公告)日：1974-10-08
申请号：US7964670
申请日：1970-10-09
Applicant: ATLANTIC RES CORP
Inventor： HUGGETT C
CPC classification number: A62D1/0057 , A61K9/007 , Y10S514/959
Abstract: 1. A HABITABLE ATMOSPHERE WHICH DOES NOT SUPPORT COMBUSTION AND WHICH IS CAPABLE OF SUSTAINING MAMMALIAN LIFE COMPRISING: A. OXYGEN IN AN AMOUNT SUFFICIENT TO SUSTAIN MAMMALIAN LIFE, SAID AMOUNT PROVIDING AN OXYGEN PARTIAL PRESSURE WITHIN THE RANGE OF ABOUT 1.8 P.S.I.A. AND ABOUT 8.2 P.S.I.A.; B. A PERFLUOROALKANE SELECTED FROM THE GROUP CONSISTING OF PERFLUOROMETHANE, PERFLUOROETHANE, PERFLUOROPROPANE, PERFLUOROBUTANE, PERFLUOROCYCLOBUTANE, PERFLUORODIMETHYLCYCLOBUTANE, AND MIXTURES THEREOF IN AN AMOUNT SUFFICIENT TO RENDER SAID HABITABLE ATMOSPHERE SUBSTANTIALLY INCAPABLE OF SUPPORTING COMBUSTION AND IMPART TO SAID ATMOSPHERE A TOTAL HEAT CAPCAITY PER MOLE OF OXYGEN OF AT LEAST 40 CAL./*C. MEASURED AT 25* C. AND CONSTANT PRESSUE; AND C. HELIUM IN AN AMOUNT OF AT LEAST ABOUT 5 MOLE PERCENT.
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公开(公告)号：US3608066A
公开(公告)日：1971-09-21
申请号：US3608066D
申请日：1969-06-16
Applicant: EN NOM COLLECTIF SCIENCE UNION
Inventor： ILLARTEIN PAUL-ROBERT
Abstract: A pharmaceutical preparation for the treatment of infections of the respiratory tract, consisting of, in the desiccated and finely micronized state, lyophilized killed micro-organisms and their lyzates, selected from specific micro-organisms previously recognized to be responsible for such kind of infection, and also micro-organisms not previously recognized to be responsible for such kind of infection, and administered by inhalation in aerosol form.
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Patent Agency Ranking
公开(公告)号：US3594476A
公开(公告)日：1971-07-20
申请号：US3594476D
申请日：1969-05-12
Applicant: MASSACHUSETTS INST TECHNOLOGY
Inventor： MERRILL EDWARD W
CPC classification number: A61K9/0078 , A61K9/0043 , Y10S516/922
Abstract: AEROSOLS OF AQUEOUS PARTICLES OF SUBMICRON DIAMETER WHICH ARE STABLE AGAINST EVAPORATION AND SUITABLE TO BE READILY TRANSMITTED TO THE ALVEOLI OF THE LUNG BY INSPIRATION, MAY BE PREPARED FROM AQUEOUS LECITHIN DISPERSIONS NEBULIZED, AS BY AN ULTRASONIC NEBULIZER, AT TEMPERATURES GREATER THAN ABOUT 25*C. LECITHIN AEROSOLS THUS PREPARED ARE USEFUL FOR THE TREATMENT OF LUNG DISORDERS, AND MAY OPTIONALLY CONTAIN OTHER THERAPEUTIC AGENTS SUCH AS ANTIOBIOTICS.
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7.发明授权1-chloro-2,2,2-trifluoroethyl difluoromethyl ether as an anesthetic agent 失效1-氯代-2,2,2-三氟乙基二异丙基醚作为麻醉剂
公开(公告)号：US3535425A
公开(公告)日：1970-10-20
申请号：US3535425D
申请日：1969-12-18
Applicant: AIR REDUCTION
Inventor： TERRELL ROSS C
CPC classification number: C07C43/123
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公开(公告)号：US3476860A
公开(公告)日：1969-11-04
申请号：US3476860D
申请日：1966-12-08
Applicant: AIR REDUCTION
Inventor： CROIX LOUISE S , SZUR ALEX J
CPC classification number: C07C43/123
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9.发明授权Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof 有权含有聚-4-羟基丁酸酯的熔喷非织造物及其共聚物的医疗装置公开(公告)号：US08287909B2
公开(公告)日：2012-10-16
申请号：US12336755
申请日：2008-12-17
Applicant: David P. Martin , Said Rizk , Kicherl Ho , Simon F. Williams
Inventor： David P. Martin , Said Rizk , Kicherl Ho , Simon F. Williams
CPC classification number: A61L29/06 , A61L15/26 , A61L15/44 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , D04H1/4382 , D04H1/56 , Y10T442/608 , C08L67/04
Abstract: Continuous processing methods for making absorbable polymeric non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 μm to 50 μm, and thickness from 10 μm to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly-4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non-woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices.
Abstract translation: 已经开发了用于制造具有以下特性中的一种或多种的可吸收聚合非织造物的连续加工方法：高爆裂强度，平均直径为1μm至50μm的细纤维和厚度为10μm至50mm。 通过允许无纺布的纤维在网收集期间最初保持熔融，可以实现改进的纤维内聚力。 在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。 特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的无纺布，其中无纺布具有大于0.1Kgff的破裂强度，其中无纺织物通过连续熔喷法得到。 无纺布可以用于各种目的，包括制造医疗装置。
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公开(公告)号：US07163689B2
公开(公告)日：2007-01-16
申请号：US11173922
申请日：2005-07-01
Applicant: Keith R. Edwards
Inventor： Keith R. Edwards
CPC classification number: A61K31/19
Abstract: The present invention features a novel therapy for effecting acute treatment of migraine headache. The therapy involves intravenous administration of valproate and is equal to and in some respects superior to previously-known therapies for abortive treatment of prolonged moderate to severe acute migraine headache.
Abstract translation: 本发明的特征在于用于治疗偏头痛的急性治疗方法。 该治疗涉及静脉内施用丙戊酸盐，并且在某些方面等于先前已知的用于堕胎治疗长期中度至重度急性偏头痛头痛的疗法。
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