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公开(公告)号：US11981753B2
公开(公告)日：2024-05-14
申请号：US17726604
申请日：2022-04-22
Applicant: ShangPharma Innovation Inc.
Inventor： Yvonne Angell , Yu Wu , Yan Wang , Weimin Liu , Kin Chiu Fong , Jie Wen , Yonghan Hu
Abstract: Disclosed are a peptide compound and an application thereof, and a composition containing the peptide compound. The present invention provides a peptide compound YA-156, and a pharmaceutically acceptable salt, a tautomer, a solvate, a crystal form or a prodrug thereof. The compound has good stability and good activity for Kiss1R.
Palm-PEG8-Gly-Gly-(D-Tyr)-Hyp-Asn-Thr-Phe-azaGly-Leu-Arg (Me)-Trp-NH2-
公开(公告)号：US11643388B2
公开(公告)日：2023-05-09
申请号：US17246014
申请日：2021-04-30
Inventor： Dean Sheppard , William F. DeGrado , Aparna Sundaram , Hyunil Jo , Richard Beresis , Marc Adler
IPC: C07C275/26 , C07C275/24 , A61P11/06 , C07D205/04 , C07D213/73 , C07D217/02 , C07D217/06 , C07D239/84
CPC classification number: C07C275/26 , A61P11/06 , C07C275/24 , C07D205/04 , C07D213/73 , C07D217/02 , C07D217/06 , C07D239/84
Abstract: Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.
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公开(公告)号：US20220411366A1
公开(公告)日：2022-12-29
申请号：US17246014
申请日：2021-04-30
Inventor： Dean Sheppard , William F. DeGrado , Aparna Sundaram , Hyunil Jo , Richard Beresis , Marc Adler
IPC: C07C275/26 , A61P11/06 , C07D239/84 , C07D205/04 , C07D213/73 , C07D217/02 , C07D217/06 , C07C275/24
Abstract: Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.
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公开(公告)号：US20230339886A1
公开(公告)日：2023-10-26
申请号：US18012471
申请日：2021-06-23
Inventor： Theodore Mark Kamenecka , Kevin Greenman , Laura Solt , Yuanjun He , Mike Lizarzaburu , Brett C. Bookser
IPC: C07D401/10 , C07D401/14 , C07D209/08 , C07D209/14 , C07D471/04 , C07D403/10 , C07D401/04 , C07D413/10 , C07D405/10 , C07D403/12 , C07D417/10
CPC classification number: C07D401/10 , C07D401/14 , C07D209/08 , C07D209/14 , C07D471/04 , C07D403/10 , C07D401/04 , C07D413/10 , C07D405/10 , C07D403/12 , C07D417/10
Abstract: The present disclosure provides compounds of Formula IA and Formula IB and their pharmaceutical compositions as selective agonists of REV-ERB-α: where R1, R2, R3, R4, R5, RX1, RX2, nA, nB, X, Y, and Z are described herein. The compounds are useful in various methods and uses, such as in the treatment of diseases including hyperglycemia, dyslipidemia, atherosclerosis, and autoimmune and inflammatory disorders or diseases, and as cancer therapeutics, such as for the treatment of glioblastoma, hepatocellular carcinoma, and colorectal cancer, and for immune-oncology purposes.
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Patent Agency Ranking
公开(公告)号：US20230202974A1
公开(公告)日：2023-06-29
申请号：US17777832
申请日：2020-11-20
Inventor： Adam R. Renslo , Michelle R. Arkin , R. Jeffrey Neitz , Raymond Ng , Peter Lee
IPC: C07C311/08 , C07D209/04 , C07D401/06 , C07D401/12
CPC classification number: C07C311/08 , C07D209/04 , C07D401/06 , C07D401/12
Abstract: Disclosed herein, inter alia, are compounds and methods for inhibiting Caspase 6 and the treatment of diseases, pharmaceutical composition including a compound as described herein and a pharmaceutically acceptable excipient and methods of inhibiting human Caspase 6 protein activity, the method including: contacting the human Caspase 6 protein with a compound as described herein.
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公开(公告)号：US20230063230A1
公开(公告)日：2023-03-02
申请号：US17431111
申请日：2020-02-19
Inventor： Pamela M. England , Matthew P. Jacobson , Richard Beresis
IPC: C07D249/04 , C07D231/12 , C07D403/12 , C07F9/165 , C07D413/12 , C07D257/04 , C07C233/22 , C07C233/11 , C07D265/32 , C07C311/06 , C07C309/70 , C07C321/20 , C07C231/02 , C07D401/04 , C07D403/04 , C07F5/02 , C07D217/02 , C07C67/03 , C07C303/38 , C07C231/12 , C07D413/06 , C07D209/30 , C07C303/22 , C07C247/06 , C07C303/28 , C07F7/08 , C07D409/04
Abstract: Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.
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公开(公告)号：US12195490B2
公开(公告)日：2025-01-14
申请号：US17161275
申请日：2021-01-28
Inventor： John Gordan , Dominique Mitchell , Richard Beresis , Marc Adler
IPC: C07D241/26 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07F9/6509
Abstract: Disclosed herein, inter alia, are compounds for binding STRAD pseudokinase and uses thereof.
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公开(公告)号：US20240342185A1
公开(公告)日：2024-10-17
申请号：US18578875
申请日：2022-07-13
Inventor： Luke L. LAIRSON , Emily CHIN , Brett BOOKSER , David LAPOINTE
IPC: A61K31/5377 , A61K31/422 , A61K31/454 , A61K31/4545 , C07D413/04 , C07D413/06 , C07D413/14
CPC classification number: A61K31/5377 , A61K31/422 , A61K31/454 , A61K31/4545 , C07D413/04 , C07D413/06 , C07D413/14
Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: (I) wherein R1, R2, R3, L, X, and Ar are defined in the present disclosure. The compounds are inhibitors of cyclic gmp-amp synthase (cGAS) or CGAS-related cGAMP production, and they are useful in treating or preventing inflammatory diseases or conditions in a subject.
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公开(公告)号：US20210261587A1
公开(公告)日：2021-08-26
申请号：US17161275
申请日：2021-01-28
Inventor： John Gordan , Dominique Mitchell , Richard Beresis , Marc Adler
IPC: C07F9/6509 , C07D403/10 , C07D403/12 , C07D241/26 , C07D403/04 , C07D409/04 , C07D417/12 , C07D413/12 , C07D401/12 , C07D405/12
Abstract: Disclosed herein, inter alia, are compounds for binding STRAD pseudokinase and uses thereof.
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