公开(公告)号：US20240342185A1

公开(公告)日：2024-10-17

申请号：US18578875

申请日：2022-07-13

申请人： THE SCRIPPS RESEARCH INSTITUTE ,  SHANGPHARMA INNOVATION INC.

发明人： Luke L. LAIRSON ,  Emily CHIN ,  Brett BOOKSER ,  David LAPOINTE

IPC分类号： A61K31/5377 ,  A61K31/422 ,  A61K31/454 ,  A61K31/4545 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14

CPC分类号： A61K31/5377 ,  A61K31/422 ,  A61K31/454 ,  A61K31/4545 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14

摘要： Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: (I) wherein R1, R2, R3, L, X, and Ar are defined in the present disclosure. The compounds are inhibitors of cyclic gmp-amp synthase (cGAS) or CGAS-related cGAMP production, and they are useful in treating or preventing inflammatory diseases or conditions in a subject.