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15 条记录 (耗时 0.029 秒)

    Substratum having a pattern of cell-culture controlling substance
    3.
    发明授权
    Substratum having a pattern of cell-culture controlling substance 有权
    具有细胞培养控制物质图案的底物

    公开(公告)号：US07846727B2

    公开(公告)日：2010-12-07

    申请号：US10108470

    申请日：2002-03-29

    申请人： Kenji Nishiguchi ,  Takeshi Miyazaki ,  Ryoichi Matsuda ,  Kohei Watanabe

    发明人： Kenji Nishiguchi ,  Takeshi Miyazaki ,  Ryoichi Matsuda ,  Kohei Watanabe

    IPC分类号： C12N5/07 ,  C12N11/02 ,  C12N5/00 ,  C12Q1/02 ,  C12M1/00

    CPC分类号： C12N5/0068 ,  C12N2533/30 ,  C12N2535/10

    摘要： The present invention relates to a substrate for cell culture capable of controlling at least one function selected from adhesion, proliferation, differentiation, survival, maintenance of undifferentiated state, and apoptosis of a cell. The substrate comprises an immobilization area of controlling substances involved in at least one of the functions of adhesion, proliferation, differentiation, survival, maintenance of undifferentiated state and apoptosis of cells, for example: and the areas are formed by supplying a liquid containing the controlling substances to the substrate by small microdroplet ejection means and immobilizing the controlling substance on the substrate.

    摘要翻译： 本发明涉及一种能够控制选自粘附，增殖，分化，存活，维持未分化状态和细胞凋亡中的至少一种功能的细胞培养基质。 底物包含参与粘附，增殖，分化，存活，维持未分化状态和细胞凋亡中的至少一个功能的控制物质的固定区域，例如：通过供给含有控制物质的液体形成区域 通过小微滴喷射装置将物质输送到基板上，并将控制物质固定在基板上。

    Method Of Treating Genetic Disease Caused By Nonsense Mutation
    4.
    发明申请
    Method Of Treating Genetic Disease Caused By Nonsense Mutation 审中-公开
    治疗无义突变引起的遗传病的方法

    公开(公告)号：US20100093867A1

    公开(公告)日：2010-04-15

    申请号：US12307027

    申请日：2007-07-05

    申请人： Ryoichi Matsuda ,  Masataka Shiozuka ,  Alexander MacKerell, JR.

    发明人： Ryoichi Matsuda ,  Masataka Shiozuka ,  Alexander MacKerell, JR.

    IPC分类号： A61P21/00 ,  A61K31/16 ,  C12Q1/68 ,  A01K67/00 ,  C07C237/00

    CPC分类号： A61K31/195 ,  A61K31/197 ,  A61K31/221

    摘要： An object of the present invention is to provide compounds having read-through activity for use in treatment methods of genetic diseases caused by nonsense mutation, to provide pharmaceutical compositions comprising the compound, and to provide a treatment method of genetic diseases caused by nonsense mutation comprising administering the compound.The present invention can provide a method of producing wild type normal protein in a living body of a mammal from a gene with a premature termination codon being generated by a mutation, wherein the method comprises administering a compound expressed by the following formula (VI): (wherein R1, R2, R3, R4, R5 and X1 in the formula are as defined in description) or the like to the mammal.

    摘要翻译： 本发明的目的是提供具有用于无义突变引起的遗传疾病的治疗方法的具有阅读活性的化合物，以提供包含该化合物的药物组合物，并提供由无义突变引起的遗传疾病的治疗方法，包括 给予化合物。 本发明可以提供一种由具有通过突变产生的提前终止密码子的基因在哺乳动物的活体中产生野生型正常蛋白的方法，其中所述方法包括施用下式（VI）表示的化合物： （其中式中的R1，R2，R3，R4，R5和X1如描述中所定义）等。

    Loudspeaking telephone circuit
    7.
    发明授权
    Loudspeaking telephone circuit 失效
    扬声电话电路

    公开(公告)号：US3952166A

    公开(公告)日：1976-04-20

    申请号：US511595

    申请日：1974-10-03

    申请人： Kunihiro Kato ,  Ryoichi Matsuda ,  Ryoichi Okayasu

    发明人： Kunihiro Kato ,  Ryoichi Matsuda ,  Ryoichi Okayasu

    IPC分类号： H04M1/60 ,  H04M9/08 ,  H04M9/10

    CPC分类号： H04M9/08 ,  H04M9/10

    摘要： In the loudspeaking telephone circuit, the speech signal is used as a control signal for detecting the extent of decreasing the acoustic coupling between the loudspeaker and the microphone of the telephone set and of the coupling between the transmitting and receiving circuits of an anti-sidetone circuit from an expected worst condition for which the telephone circuit has been designed thereby automatically decreasing the value of the variable loss utilized for preventing howling by an amount corresponding to said decrease. This circuit provides satisfactory speech communication with a smaller loss inserted than a prior art voice switch thus greatly improving unnatural sound as caused by the voice switch.

    摘要翻译： 在扬声电话电路中，语音信号被用作控制信号，用于检测降低扬声器与电话机的麦克风之间的声耦合的程度以及反侧音电路的发送和接收电路之间的耦合的程度 从设计电话电路的预期最差条件，从而自动将用于防止啸叫的可变损失的值减少相应于所述减小的量。 该电路提供令人满意的语音通信，其具有比现有技术的语音交换机更小的损失，因此极大地改善了由语音切换引起的不自然的声音。