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公开(公告)号：USD578284S1
公开(公告)日：2008-10-14
申请号：US29267418
申请日：2006-10-13
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公开(公告)号：US4891145A
公开(公告)日：1990-01-02
申请号：US823678
申请日：1986-01-29
IPC分类号： C10M145/26 , C10M145/00 , C10N30/02 , C10N40/25
CPC分类号： C10M145/00 , C10M2209/00 , C10M2209/02 , C10M2209/04 , C10M2209/06 , C10M2209/062 , C10M2209/08 , C10M2209/082 , C10M2209/084 , C10M2209/086 , C10M2209/103 , C10M2209/104 , C10M2209/105 , C10M2209/107 , C10M2209/108 , C10M2209/109
摘要： The invention concerns a lubricating oil containing less than 3 wt. % of a mixture of (1) a lubricating oil pour depressant and (2) a polyoxyalkylene ester, ether, ester/ether or mixture thereof containing one or more C.sub.10 to C.sub.30 alkyl groups and polyoxyalkylene glycol group of molecular weight 100 to 5000, the alkylene group of said polyoxyalkylene glycol containing from 1 to 4 carbon atoms. The pour depressant can for example be a vinyl acetate copolymer, a polyalkylacrylate, a polyalkylmethacrylate or an esterified olefin/maleic anhydride copolymer.
摘要翻译： 本发明涉及含有小于3wt。 （1）润滑油倾倒抑制剂和（2）含有一个或多个C 10至C 30烷基的聚氧亚烷基酯，醚，酯/醚或其混合物和分子量为100至5000的聚氧亚烷基二醇基团的混合物的％，％ 所述含有1至4个碳原子的聚氧亚烷基二醇的亚烷基。 降阻剂可以例如是乙酸乙烯酯共聚物，聚丙烯酸烷基酯，聚甲基丙烯酸烷基酯或酯化的烯烃/马来酸酐共聚物。
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公开(公告)号：US20120282215A1
公开(公告)日：2012-11-08
申请号：US13005984
申请日：2011-01-13
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/55522 , A61K2039/55533
摘要： Pharmaceutical compositions containing (i) whole autologous cancer cells, whole allogeneic cancer cells, or a combination thereof; (ii) a colony stimulating factor (CSF); (iii) an interleukin; and (iv) a pharmaceutically acceptable carrier are described which are useful for inhibiting tumor growth, progression or recurrence or to inhibit metastases formation in solid cancerous tumors, leukemias, and lymphomas.
摘要翻译： 药物组合物，其含有（i）全自体癌细胞，全同种异体癌细胞或其组合; （ii）集落刺激因子（CSF）; （iii）白介素; 描述了可用于抑制肿瘤生长，进展或复发或抑制固体癌性肿瘤，白血病和淋巴瘤中转移形成的药学上可接受的载体。
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公开(公告)号：US20110190204A1
公开(公告)日：2011-08-04
申请号：US13017173
申请日：2011-01-31
CPC分类号： A61K31/337 , A61K9/0019 , A61K38/1808 , A61K38/2257 , A61K38/38 , A61K38/40 , A61K45/06 , A61K47/42 , A61K47/44 , A61K47/48284 , A61K47/483 , A61K47/643 , A61K47/644 , A61K2300/00
摘要： Compositions comprising a taxane or taxoid, such as paclitaxel, and a protein, such as albumin or a metal-transferrin, such as gallium-transferrin, can be prepared by combining an aqueous protein solution with a second solution containing the taxane or taxoid, a non-ionic surfactant, and an alcohol; adjusting the pH of the combined solutions to between about 7.9 and about 8.3; and purifying the pH-adjusted solution to remove solutes having a molecular weight less than 10,000 Da. Such compositions can be prepared that are substantially free of non-ionic surfactants, such as Cremophor EL, and are useful in the treatment of cancers, such as breast cancer.
摘要翻译： 可以通过将蛋白质水溶液与含有紫杉烷或紫杉烷的第二溶液组合而制备包含紫杉烷或紫杉烷类如紫杉醇的组合物和蛋白质如白蛋白或金属 - 转铁蛋白如镓 - 转铁蛋白， 非离子表面活性剂和醇; 将组合溶液的pH调节至约7.9至约8.3; 并纯化pH调节的溶液以除去分子量小于10,000Da的溶质。 可以制备基本上不含非离子表面活性剂如Cremophor EL的这样的组合物，并且可用于治疗诸如乳腺癌的癌症。
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公开(公告)号：USD599994S1
公开(公告)日：2009-09-15
申请号：US29267417
申请日：2006-10-13
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6.发明授权Hydrogenated copolymers of conjugated dienes and when desired a vinyl aromatic monomer are useful as oil additives 失效共轭二烯的氢化共聚物和需要时的乙烯基芳族单体可用作油添加剂
公开(公告)号：US4073737A
公开(公告)日：1978-02-14
申请号：US678144
申请日：1976-04-19
申请人： Robert L. Elliott
发明人： Robert L. Elliott
IPC分类号： C10M143/14 , C10M157/00 , C10M161/00 , C10N20/04 , C10N30/02 , C10N40/25 , C10N60/02 , C10M1/32
CPC分类号： C10M157/00 , C10M2203/06 , C10M2205/00 , C10M2205/04 , C10M2205/06 , C10M2207/023 , C10M2207/125 , C10M2207/129 , C10M2209/04 , C10M2209/06 , C10M2209/062 , C10M2209/082 , C10M2209/084 , C10M2209/086 , C10M2215/04 , C10M2215/086 , C10M2215/26 , C10M2215/28 , C10M2217/024 , C10M2217/028 , C10M2217/042 , C10M2217/043 , C10M2217/044 , C10M2217/045 , C10M2217/046 , C10M2217/06 , C10M2219/044 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10N2210/02
摘要： A hydrogenated copolymer produced by copolymerization of from about 1 to about 10 mol percent butadiene and at least one other C.sub.5 to C.sub.12 conjugated diene, and, if desired, in order to provide a block copolymer, up to 45 mole percent of a vinyl aromatic monomer, upon addition to lubricating oils containing a pour point depressing amount of an oil-soluble polymeric pour depressant, provides viscosity modification, oxidative and shear stability with excellent low temperature viscometric properties.
摘要翻译： 通过约1至约10mol％丁二烯和至少一种其它C 5至C 12共轭二烯的共聚制备的氢化共聚物，并且如果需要，为了提供嵌段共聚物，最高达45摩尔％的乙烯基芳族单体 当加入含有倾点降低量的油溶性聚合物降压剂的润滑油时，提供粘度改性，氧化和剪切稳定性以及优异的低温粘度特性。
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7.发明授权Vaccination of cancer patients using tumor-associated antigens mixed with interleukin-2 and granulocyte-macrophage colony stimulating factor 失效使用与白介素-2和粒细胞 - 巨噬细胞集落刺激因子混合的肿瘤相关抗原的癌症患者的疫苗接种
公开(公告)号：US5478556A
公开(公告)日：1995-12-26
申请号：US202516
申请日：1994-02-28
IPC分类号： A61K39/00 , A61K45/05 , C07K14/535 , C07K14/55
CPC分类号： A61K39/0011 , Y10S530/828
摘要： A breast cancer vaccine which comprises a mixture of tumor associated antigens (TAA) with low doses of recombinant interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF).
摘要翻译： 包括与低剂量重组白细胞介素-2（IL-2）和粒细胞巨噬细胞集落刺激因子（GM-CSF）的肿瘤相关抗原（TAA）的混合物的乳腺癌疫苗。
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公开(公告)号：US5179182A
公开(公告)日：1993-01-12
申请号：US532105
申请日：1990-05-30
IPC分类号： C08F2/06 , C08F20/12 , C10L1/196 , C10L1/197 , C10M145/14 , C10M145/16
CPC分类号： C10M145/16 , C08F2/06 , C08F20/12 , C10L1/1963 , C10L1/1973 , C10M145/14 , C10M2207/028 , C10M2209/062 , C10M2209/084 , C10M2209/086 , C10M2219/046 , C10M2223/045 , C10N2210/02
摘要： The reaction cycle time for the copolymerization of unsaturated esters such as alkyl fumarates and vinyl acetate, and for the polymerization of methacrylates and acrylates may be dramatically reduced by carrying out the polymerization at elevated temperatures and pressures. An additional feature is the addition of initiator during polymerization which leads to improved products especially for lubricating oil pour depressants and fuel and crude oil flow improvers.
摘要翻译： 通过在升高的温度和压力下进行聚合，可以显着降低不饱和酯如富马酸烷基酯和乙酸乙烯酯的共聚反应循环时间和甲基丙烯酸酯和丙烯酸酯的聚合反应时间。 另外的特征是在聚合期间加入引发剂，这导致改进的产品，特别是对于润滑油倾倒抑制剂和燃料和原油流动改进剂。
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9.发明授权Oil compositions containing oil-soluble, oxidatively and mechanically degraded ethylene copolymers 失效含有油溶性，氧化和机械降解的乙烯共聚物的油组合物
公开(公告)号：US4372863A
公开(公告)日：1983-02-08
申请号：US81050
申请日：1979-10-02
IPC分类号： C08F8/32 , C10M143/02 , C10M143/18 , C10M159/12 , C10M1/32
CPC分类号： C10M159/12 , C08F8/32 , C10M143/02 , C10M143/18 , C08F2800/20 , C10M2205/00 , C10M2205/02 , C10M2205/022 , C10M2205/06 , C10M2205/10 , C10M2205/22 , C10M2209/04 , C10M2209/06 , C10M2209/062 , C10M2209/084 , C10M2209/086 , C10M2215/04 , C10M2215/042 , C10M2215/22 , C10M2215/221 , C10M2215/224 , C10M2215/225 , C10M2215/226 , C10M2215/26 , C10M2215/30 , C10M2217/046 , C10M2217/06 , C10M2219/044 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2223/045 , C10N2210/02 , C10N2220/02 , C10N2240/02 , C10N2240/102 , C10N2240/103
摘要： A lubricating oil composition comprising a major amount of lubricating oil and a viscosity index improving amount of an oil-soluble polymer composition comprising an ethylene copolymer, preferably an oxidatively and mechanically degraded ethylene copolymer, having an ethylene content of 26-79 weight percent (35-85 mole percent), a C.sub.3 to C.sub.18 higher alpha-olefin and from about 1-25 weight percent of an alkyl norbornene having from about 8 to 28 carbons, preferably ethyl norbornene and preferably at least a pour point depressing amount of a lubricating oil pour point depressant, e.g. an alkyl fumarate vinyl acetate copolymer, whereby superior low temperature viscometrics is provided to said lubricating oil composition.
摘要翻译： 一种润滑油组合物，其包含主要量的润滑油和粘度指数改进量的油溶性聚合物组合物，其包含乙烯含量为26-79重量％的乙烯共聚物，优选氧化和机械降解的乙烯共聚物（35 -85摩尔％），C3至C18高级α-烯烃和约1-25重量％的具有约8至28个碳原子的烷基降冰片烯，优选乙基降冰片烯，优选至少一种润滑油的倾点降低量 倾点抑制剂，例如 富马酸烷基酯乙酸乙烯酯共聚物，由此向所述润滑油组合物提供优异的低温粘度。
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10.发明授权Oil-soluble addition products of an ethylene-propylene copolymer and anionically polymerizable monomer having utility as multifunctional V.I. improver for lubricating oils 失效乙烯 - 丙烯共聚物和阴离子聚合单体的油溶性加成产物，可用作多功能V.I. 润滑油改良剂
公开(公告)号：US4098710A
公开(公告)日：1978-07-04
申请号：US696786
申请日：1978-06-16
IPC分类号： C08F8/12 , C10M149/02 , C10M159/12 , C10M1/32
CPC分类号： C10M159/12 , C08F8/14 , C10M149/02 , C08F2800/20 , C08F2810/30 , C10M2203/10 , C10M2205/12 , C10M2207/021 , C10M2207/027 , C10M2207/125 , C10M2207/129 , C10M2207/144 , C10M2207/146 , C10M2207/16 , C10M2209/00 , C10M2209/02 , C10M2209/04 , C10M2209/06 , C10M2209/062 , C10M2209/08 , C10M2209/084 , C10M2209/086 , C10M2209/10 , C10M2211/06 , C10M2213/02 , C10M2213/062 , C10M2215/04 , C10M2215/042 , C10M2215/22 , C10M2215/221 , C10M2215/225 , C10M2215/226 , C10M2215/26 , C10M2215/30 , C10M2217/00 , C10M2217/02 , C10M2217/022 , C10M2217/023 , C10M2217/024 , C10M2217/026 , C10M2217/028 , C10M2217/04 , C10M2217/042 , C10M2217/043 , C10M2217/046 , C10M2217/06 , C10M2219/044 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2221/00 , C10M2221/02 , C10M2223/045 , C10M2223/121 , C10M2225/00 , C10M2225/02 , C10M2227/00 , C10M2227/061 , C10N2210/00 , C10N2210/02 , C10N2210/03 , C10N2270/02
摘要： An oil-soluble addition product of a catalyzed condensation reaction of an anionically polymerizable monomer, preferably an ethylenically unsaturated nitrogen-containing monomer, e.g. acrylonitrile, with an oxidized copolymer of ethylene and at least one C.sub.3 to C.sub.50 alpha monoolefin, e.g. propylene, said addition product in its preferred form containing from about 0.005 to 2% by weight nitrogen and having a number average molecular weight of from about 1000 to 500,000, has utility as a multifunctional V.I. improver or dispersant for lubricating oils.
摘要翻译： 阴离子聚合性单体，优选烯键式不饱和含氮单体的催化缩合反应的油溶性加成产物。 丙烯腈，具有乙烯和至少一种C 3至C 50α-单烯烃的氧化共聚物，例如。 丙烯，其优选形式的所述加成产物含有约0.005至2重量％的氮并且具有约1000至500,000的数均分子量，具有多功能V.I。 润滑油的改进剂或分散剂。
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