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公开(公告)号：US09061904B2
公开(公告)日：2015-06-23
申请号：US13157758
申请日：2011-06-10
申请人： Minoru Miyauchi , Jianjun Miao , Trevor J. Simmons , Jong-Won Lee , Thomas V. Doherty , Jonathan S. Dordick , Robert J. Linhardt
发明人： Minoru Miyauchi , Jianjun Miao , Trevor J. Simmons , Jong-Won Lee , Thomas V. Doherty , Jonathan S. Dordick , Robert J. Linhardt
IPC分类号： B23B9/04 , B29C47/04 , D02G3/00 , B82Y30/00 , D01D5/00 , D01F1/09 , D01F8/02 , H01G9/02 , H01G11/52
CPC分类号： B82Y30/00 , D01D5/0007 , D01F1/09 , D01F2/02 , D01F8/02 , H01G9/02 , H01G11/52 , Y02E60/13 , Y10T428/2918
摘要： Embodiments of the invention provide a cellulose-sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath.
摘要翻译： 本发明的实施方案提供了一种纤维素包覆的碳纳米管纤维。 本发明的一个方面提供一种护套纳米管纤维，其包含：碳纳米管纤维; 以及沿所述碳纳米管纤维的长度的至少第一部分同轴延伸的纤维素护套。 本发明的另一方面提供了一种形成护套碳纳米管纤维的方法，所述方法包括：在纤维素溶液鞘内共同静电纺丝碳纳米管纤维凝胶芯。
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公开(公告)号：US08314078B2
公开(公告)日：2012-11-20
申请号：US12796907
申请日：2010-06-09
CPC分类号： A61K31/727 , A01N59/16 , A61K9/5115 , A61K31/726 , A61K31/728 , A61K33/38 , A61K45/06 , A61K47/6923 , A61L15/46 , A61L26/0066 , A61L27/446 , A61L27/54 , A61L29/126 , A61L29/16 , A61L31/128 , A61L31/16 , A61L2300/104 , A61L2300/236 , A61L2300/624 , A61L2400/12 , B82Y5/00 , C08B37/0075 , C08L5/08 , C08L5/10 , A01N25/34 , A01N43/16 , A01N2300/00 , A61K2300/00
摘要： A silver nanocomposite, a formation method for forming the silver nanocomposite, and an application method utilizing the silver nanocomposite. The silver nanocomposite includes a silver nanoparticle conjugated to a glycosaminoglycan (GAG) or glucose. The formation method includes chemically reacting silver nitrate with a reducing agent to form a silver nanoparticle conjugated to the reducing agent of a GAG or glucose. The application method may include topically applying the silver nanocomposite to a wound or burn as an anti-microbial with respect to an antibiotic-resistant genotype in the wound or burn, wherein the silver nanocomposite topically applied includes the silver nanoparticle conjugated to the GAG of 2,6-diaminopyridinyl heparin (DAPHP) or hyaluronan (HA). The application method may include applying the silver nanocomposite as a coating to plastic, a catheter, or a surgical tool, wherein the silver nanocomposite applied as the coating includes the silver nanoparticle conjugated to the GAG of DAPHP.
摘要翻译： 银纳米复合材料，形成银纳米复合材料的形成方法和利用银纳米复合材料的涂布方法。 银纳米复合材料包括与糖胺聚糖（GAG）或葡萄糖缀合的银纳米颗粒。 形成方法包括使硝酸银与还原剂化学反应以形成与GAG或葡萄糖的还原剂缀合的银纳米颗粒。 施用方法可以包括将伤口上的银纳米复合材料局部施用作为抗生素抗性基因型在伤口或烧伤中作为抗微生物剂，其中局部施用的银纳米复合材料包括与GAG缀合的银纳米颗粒2 ，6-二氨基吡啶基肝素（DAPHP）或透明质酸（HA）。 应用方法可以包括将银纳米复合物作为涂层施用于塑料，导管或外科工具，其中作为涂层施用的银纳米复合材料包括与DAPHP的GAG缀合的银纳米颗粒。
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公开(公告)号：US20110305903A1
公开(公告)日：2011-12-15
申请号：US13157758
申请日：2011-06-10
申请人： Minoru Miyauchi , Jianjun Miao , Trevor J. Simmons , Jong-Won Lee , Thomas V. Doherty , Jonathan S. Dordick , Robert J. Linhardt
发明人： Minoru Miyauchi , Jianjun Miao , Trevor J. Simmons , Jong-Won Lee , Thomas V. Doherty , Jonathan S. Dordick , Robert J. Linhardt
CPC分类号： B82Y30/00 , D01D5/0007 , D01F1/09 , D01F2/02 , D01F8/02 , H01G9/02 , H01G11/52 , Y02E60/13 , Y10T428/2918
摘要： Embodiments of the invention provide a cellulose-sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath.
摘要翻译： 本发明的实施方案提供了一种纤维素包覆的碳纳米管纤维。 本发明的一个方面提供一种护套纳米管纤维，其包含：碳纳米管纤维; 以及沿所述碳纳米管纤维的长度的至少第一部分同轴延伸的纤维素护套。 本发明的另一方面提供了一种形成护套碳纳米管纤维的方法，所述方法包括：在纤维素溶液鞘内共同静电纺丝碳纳米管纤维凝胶芯。
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4.再颁专利公开(公告)号：USRE41328E1
公开(公告)日：2010-05-11
申请号：US12199215
申请日：2008-08-27
申请人： Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer , Daniel L. Lohse , Robert J. Linhardt
发明人： Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer , Daniel L. Lohse , Robert J. Linhardt
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
摘要翻译： 不含裂解酶活性的纯化肝素酶I，II和III分别通过培养肝炎黄杆菌而产生，分子量分别为42,400,84,100,70,800。 已经确定了肝素酶的动力学性质以及优化其活性和稳定性的条件。
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公开(公告)号：US20100004196A1
公开(公告)日：2010-01-07
申请号：US12486272
申请日：2009-06-17
CPC分类号： C07H5/06 , A61K31/715 , A61K31/726 , A61K45/06 , G01N33/689 , G01N2400/40 , G01N2800/367 , A61K2300/00
摘要： The present invention relates to method for the preparation of glycosaminoglycan compositions, isolated glycosaminoglycan compositions obtainable therefrom, glycosaminoglycan compositions, kits and use thereof. More specifically, the present invention provides a method for isolating glycosaminoglycan compositions of the invention from human follicular fluid. The compositions, related methods and uses according to the present invention are useful in the treatment and/or prevention of thrombotic diseases, cell proliferation disorders, proteolysis and inflammation mediated cell invasion and infertility.
摘要翻译： 本发明涉及制备糖胺聚糖组合物的方法，由其获得的分离的糖胺聚糖组合物，糖胺聚糖组合物，试剂盒及其用途。 更具体地说，本发明提供了从人卵泡液中分离本发明的糖胺聚糖组合物的方法。 根据本发明的组合物，相关方法和用途可用于治疗和/或预防血栓形成疾病，细胞增殖障碍，蛋白水解和炎症介导的细胞侵袭和不育症。
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公开(公告)号：US06590110B1
公开(公告)日：2003-07-08
申请号：US09806586
申请日：2001-05-17
申请人： Robert J. Linhardt , Tulay Polat , Yuguo Du
发明人： Robert J. Linhardt , Tulay Polat , Yuguo Du
IPC分类号： C07D30706
摘要： The invention is directed to a method for synthesizing C-glycosides of ulosonic acids, as well as intermediates thereof and C-glycosides prepared by this method.
摘要翻译： 本发明涉及一种用于合成尿苷酸的C-糖苷及其中间体的方法和通过该方法制备的C-糖苷。
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公开(公告)号：US06376662B1
公开(公告)日：2002-04-23
申请号：US09142937
申请日：1998-11-17
IPC分类号： C07H704
摘要： A method for synthesizing C-glycosides of ulosonic acids such as Neu5Ac, by which diastereocontrolled synthesis of &agr;-C-glycosides of ulosonic acids is attained is disclosed. In the method of the present invention, an ulosonic acid sulfone or phosphite is reacted with an aldehyde or ketone compound in the presence of a lanthanide metal halide.
摘要翻译： 公开了用于合成诸如Neu5Ac的尿苷酸的C-糖苷的方法，通过该方法获得了关于酸性盐酸的α-C-糖苷的非对映控制合成。 在本发明的方法中，在镧系元素金属卤化物的存在下，将脲二
酸砜或亚磷酸酯与醛或酮化合物反应。-
公开(公告)号：US6121430A
公开(公告)日：2000-09-19
申请号：US298674
申请日：1999-04-23
摘要： New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants are economical to prepare and have excellent surface-active properties.
摘要翻译： 描述了新的基于葡萄糖的表面活性剂及其合成方法。 通过制备中间体葡萄糖4,6-环硫酸酯合成表面活性剂。 表面活性剂是经济的制备和具有优异的表面活性性质。
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9.发明授权
公开(公告)号：US4847338A
公开(公告)日：1989-07-11
申请号：US63170
申请日：1987-06-17
CPC分类号： C07H13/12 , C07H11/00 , C08B37/0078
摘要： There is disclosed a tetrasaccharide, a hexasaccharide, on octasaccharide and a decasaccharide all capable of inhibiting complement activation and having less tha 33% of undigested native heparin's anticoagulation activity.
摘要翻译： 公开了四糖，六糖，八糖和十糖，其能够抑制补体活化，并且具有33％的未消化的天然肝素的抗凝活性。
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公开(公告)号：US20120322114A1
公开(公告)日：2012-12-20
申请号：US13417641
申请日：2012-03-12
申请人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Eva M. Munoz , Jinghua Chen
发明人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Eva M. Munoz , Jinghua Chen
CPC分类号： C12P19/64
摘要： Heparosan is sulfated at the iduronic acid residue by providing a reaction mixture comprising C5 epimerase to convert glucuronic acid to iduronic acid, and at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS).
摘要翻译： 通过提供包含C5差向异构酶以将葡萄糖醛酸转化为艾杜糖醛酸的反应混合物和至少一种O-磺基转移酶（OST）酶和3'-磷酸腺苷5'-磷酸硫酸酯（PAPS），将Heparosan硫酸化在艾杜糖醛酸残基上。
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