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    METHOD OF FINISHING ORGANIC PIGMENTS
    2.
    发明申请
    METHOD OF FINISHING ORGANIC PIGMENTS 审中-公开
    完成有机颜料的方法

    公开(公告)号：US20100286445A1

    公开(公告)日：2010-11-11

    申请号：US12671829

    申请日：2008-07-30

    Applicant: Matthias Klueglein ,  Richard Van Gelder ,  Joachim Jesse ,  Wolfgang Best ,  Benno Sens ,  Rainer Henning

    Inventor： Matthias Klueglein ,  Richard Van Gelder ,  Joachim Jesse ,  Wolfgang Best ,  Benno Sens ,  Rainer Henning

    IPC: C07C233/76

    CPC classification number: C09B67/0017 ,  C09B67/0014 ,  C09B67/0019

    Abstract: A method of finishing an organic pigment that involves dissolving or dispersing the pigment in a mineral acid and crystallizing the pigment from the solution or dispersion by mixing with an aqueous diluent in the absence of a sulfonato-functional condensation product of an arylsulfonic acid and an aliphatic aldehyde as crystallization inhibitor, which comprises ripening the crystallized organic pigment in the presence of a surfactant or in the presence of a pigment solubility enhancer in aqueous suspension.

    Abstract translation: 一种整理有机颜料的方法，其涉及将颜料溶解或分散在无机酸中，并且在不存在芳基磺酸和脂族的磺酸根官能的缩合产物的情况下，通过与水性稀释剂混合而使溶液或分散体中的颜料结晶 醛作为结晶抑制剂，其包括在表面活性剂存在下或在水性悬浮液中存在颜料溶解度增强剂的情况下熟化结晶的有机颜料。

    PEPTIDES, PEPTIDOMIMETICS AND DERIVATIVES THEREOF, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION
    3.
    发明申请
    PEPTIDES, PEPTIDOMIMETICS AND DERIVATIVES THEREOF, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION 失效

    公开(公告)号：US20090286739A1

    公开(公告)日：2009-11-19

    申请号：US12121526

    申请日：2008-05-15

    Applicant: Peter PETZELBAUER ,  Sonja REINGRUBER ,  Waltraud PASTEINER ,  Rainer HENNING

    Inventor： Peter PETZELBAUER ,  Sonja REINGRUBER ,  Waltraud PASTEINER ,  Rainer HENNING

    IPC: A61K38/10 ,  C07K7/08 ,  A61P29/00 ,  C07K1/00

    CPC classification number: C07K14/75 ,  A61K38/00

    Abstract: Peptides, peptidomimetics and derivatives thereof of the following general formula I: (SEQ ID NO: 1) (I)H2N-GHRPX1X2X3-β-X4X5X6X7X8X9X10-X11, in which X1-X10 denote one of the 20 genetically coded amino acids, wherein X8, X9 and X10 individually or jointly may also denote a single chemical bond X11 denotes OR1 in which R1 equals hydrogen or (C1-C10)alkyl NR2R3 with R2 and R3 are equal or different and denote hydrogen, (C1-C10)alkyl or a residue —W-PEG5-60K, in which the PEG residue is attached via a suitable spacer W to the N-atom, or a residue NH—Y-Z-PEG5-60K, in which Y denotes a single chemical bond or a genetically coded amino acids from the group S, C, K or R and in which Z denotes a spacer, via which a polyethylene glycol (PEG)-residue can be attached, as well as their physiologically acceptable salts, and in which additionally β denotes an amino acid, whether genetically coded or not, or a peptidomimetic element, which have the additional property of inducing a bend or turn in the peptide backbone. Such amino acids include without limitation L-proline, D-proline, L-hydroxyproline, D-hydroxyproline, L-(O-benzyl)-hydroxyproline, D-(O-benzyl)-hydroxyproline, L-(O-tert. butyl)-hydroxyproline, 4-(O-2-naphtyl)-hydroxyproline, 4-(O-2-naphtyl-methyl)-hydroxyproline, 4-(O-phenyl)-hydroxyproline, 4-(4-phenyl-benzyl)-proline, cis-3-phenyl-proline, cis-4-phenyl-proline, trans-4-phenyl-proline, cis-5-phenyl-proline, trans-5-phenyl-proline, 4-benzyl-proline, 4-bromobenzyl-proline, 4-cyclohexyl-proline, 4-fluor-proline, L-tetrahydroisoquinoline-2-carboxylic acid (L-Tic), all diastereomers of octahydro-indole-2-carboxylic acid (Oic), and all diastereomers of 1-aza-bicyclo[3,3,0]octane-2-carboxylic acid or a residue selected from a group of peptidomimetic residues.

    PEPTIDES AND PEPTIDE DERIVATIVES AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
    4.
    发明申请
    PEPTIDES AND PEPTIDE DERIVATIVES AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 失效

    公开(公告)号：US20080039388A1

    公开(公告)日：2008-02-14

    申请号：US11678535

    申请日：2007-02-23

    Applicant: Peter Petzelbauer ,  Rainer Henning ,  Sonja Reingruber

    Inventor： Peter Petzelbauer ,  Rainer Henning ,  Sonja Reingruber

    IPC: A61K38/16 ,  A61P17/00 ,  A61P9/00 ,  C07K14/00

    CPC classification number: C07K14/75 ,  A61K38/00 ,  Y02A50/385

    Abstract: Peptides and peptide derivatives of the following general Formula I: H2H-GHRPX1X2X3X4X5X6X7X8X9X10-(I) X11PX12PPPX13X14X15X16GYR-X17, wherein: X1-X16 denote one of the 20 genetically encoded amino acids, X17 denotes OR1, with R1=hydrogen or (C1-C10-alkyl), or NR2R3, R2 and R3 being identical or different and denoting hydrogen, (C1-C10)-alkyl, or a residue -PEG5-60K, wherein the PEG-residue is linked to the N atom via a spacer, or a residue NH—Y-Z-PEG5-60K, wherein Y denotes a chemical bond or a genetically coded amino acid from among the group of S, C, K or R, and Z denotes a spacer by way of which a polyethylene glycol (PEG)-residue may be linked, as well as the physiologically acceptable salts thereof, or wherein: X15 or X16 denotes an amino acid from the group of C or K, which is linked to a residue Z-PEG5-60K via the heteroatom in the side chain, and wherein X17 denotes OR1, with R1=hydrogen or (C1-C10-alkyl), or NR2R3, R2 and R3 being identical or different and denoting hydrogen or (C1-C10)-alkyl, as well as the physiologically acceptable salts thereof.

    Method of treating cardiac insufficiency
    5.
    发明授权
    Method of treating cardiac insufficiency 失效
    治疗心功能不全的方法

    公开(公告)号：US5684016A

    公开(公告)日：1997-11-04

    申请号：US445543

    申请日：1995-05-22

    Applicant: Rainer Henning ,  Hansjorg Urbach ,  Volker Teetz ,  Rolf Geiger ,  Bernward Scholkens

    Inventor： Rainer Henning ,  Hansjorg Urbach ,  Volker Teetz ,  Rolf Geiger ,  Bernward Scholkens

    IPC: A61K38/00 ,  A61K38/55 ,  C07K5/02 ,  A61K31/47 ,  C07D217/26

    CPC classification number: C07K5/0222 ,  A61K38/556

    Abstract: The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.

    Abstract translation: 本发明涉及通过使用其中n为1或2的式I（I）的化合物治疗心功能不全的方法，R 1，R 2，R 2和R 3相同或不同，并且各自表示氢或有机基团 并且R4和R5与携带它们的原子一起形成单环，双环或三环杂环体系。 本发明还涉及式I化合物和含有这些化合物用于治疗上述疾病的药剂。

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