公开(公告)号：US20080075742A1

公开(公告)日：2008-03-27

申请号：US10545500

申请日：2004-02-18

Applicant: Otto Westphal ,  Josette Mottier Westphal ,  Alexander Westphal ,  Thierry Walli ,  Reginald Gorczynski ,  Silke Muller ,  Jean-Pierre Mach ,  Alfred Hartman ,  Wolfgang Bessler ,  Petra Hofmann ,  Ulrich Zahringer ,  Christian Alexander ,  Ulrich vor dem Esche ,  Artur J. Ulmer ,  Antonio Verdini

Inventor： Otto Westphal ,  Josette Mottier Westphal ,  Alexander Westphal ,  Thierry Walli ,  Reginald Gorczynski ,  Silke Muller ,  Jean-Pierre Mach ,  Alfred Hartman ,  Wolfgang Bessler ,  Petra Hofmann ,  Ulrich Zahringer ,  Christian Alexander ,  Ulrich vor dem Esche ,  Artur J. Ulmer ,  Antonio Verdini

IPC: A61K39/02 ,  A61K38/17 ,  A61P31/00 ,  A61P37/00 ,  A61P35/00 ,  A61K38/52

CPC classification number: A61K35/407 ,  A23L33/10 ,  A61K35/74 ,  A61K38/42 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the γ-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition. The composition of the invention finds a variety of applications which have in common the stimulation of the immune system and the reversion in polarization of cytokines and chemokines from a Th2-directed response to a Th1-type response. The proposed applications would therefore include the treatment of allergic conditions, malignancies, chronic infections, autoimmune phenomena and age-related imbalances.

Abstract translation: 本发明涉及代表包含细菌内毒素，胎儿血红蛋白或更特别是不含血红素的衍生物或其γ链，以及任选地除了HbF之外存在于胎肝中的成分的新型免疫调节原理的药物组合物。 组合物以药学上可接受的载体和/或稀释剂递送给人。 根据本发明，惊奇地发现内毒素和胎儿血红蛋白部分结构显示出显着的协同生物医学活性。 胎儿血红蛋白及其部分结构的生物医学效应令人惊奇地不是基于作为氧转运蛋白的经典血红蛋白功能，而是与内毒素介导的生物活性的调节有关。 在口服施用组合物后，也观察到该生物医学活性。 本发明的组合物发现了各种各样的应用，其具有共同的刺激免疫系统的作用，并且从对Th1型反应的Th2导向反应的细胞因子和趋化因子的极化反转。 因此，提出的申请将包括治疗过敏性疾病，恶性肿瘤，慢性感染，自身免疫现象和年龄相关的不平衡。

公开(公告)号：US07968103B2

公开(公告)日：2011-06-28

申请号：US10545500

申请日：2004-02-18

Applicant: Otto Westphal ,  Josette Westphal, legal representative ,  Alexander Westphal, legal representative ,  Thierry Walli ,  Reginald Gorczynski ,  Silke Muller ,  Jean-Pierre Mach ,  Alfred Hartman ,  Wolfgang Bessler ,  Petra Hofmann ,  Ulrich Zahringer ,  Christian Alexander ,  Ulrich vor dem Esche ,  Artur J. Ulmer ,  Antonio Verdini

Inventor： Otto Westphal ,  Thierry Walli ,  Reginald Gorczynski ,  Silke Muller ,  Jean-Pierre Mach ,  Alfred Hartman ,  Wolfgang Bessler ,  Petra Hofmann ,  Ulrich Zahringer ,  Christian Alexander ,  Ulrich vor dem Esche ,  Artur J. Ulmer ,  Antonio Verdini

IPC: A61K39/02 ,  A61K38/17 ,  A61P31/00

CPC classification number: A61K35/407 ,  A23L33/10 ,  A61K35/74 ,  A61K38/42 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the γ-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition. The composition of the invention finds a variety of applications which have in common the stimulation of the immune system and the reversion in polarization of cytokines and chemokines from a Th2-directed response to a Th1-type response. The proposed applications would therefore include the treatment of allergic conditions, malignancies, chronic infections, autoimmune phenomena and age-related imbalances.

Abstract translation: 本发明涉及代表包含细菌内毒素，胎儿血红蛋白或更特别是不含血红素的衍生物或其γ-链以及除HbF之外存在于胎肝中的成分的新型免疫调节原理的药物组合物。 组合物以药学上可接受的载体和/或稀释剂递送给人。 根据本发明，惊奇地发现内毒素和胎儿血红蛋白部分结构显示出显着的协同生物医学活性。 胎儿血红蛋白及其部分结构的生物医学效应令人惊奇地不是基于作为氧转运蛋白的经典血红蛋白功能，而是与内毒素介导的生物活性的调节有关。 在口服施用组合物后，也观察到该生物医学活性。 本发明的组合物发现了各种各样的应用，其具有共同的刺激免疫系统的作用，并且从对Th1型反应的Th2导向反应的细胞因子和趋化因子的极化反转。 因此，提出的申请将包括治疗过敏性疾病，恶性肿瘤，慢性感染，自身免疫现象和年龄相关的不平衡。

公开(公告)号：US20050048069A1

公开(公告)日：2005-03-03

申请号：US10850562

申请日：2004-05-21

Applicant: Reginald Gorczynski ,  David Clark

Inventor： Reginald Gorczynski ,  David Clark

IPC: A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K14/70503 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2319/00 ,  C07K2319/30

Abstract: Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of an agent that inhibits CD200. Such methods are useful in treating cancer.

Abstract translation: 公开了诱导免疫抑制的方法和组合物。 所述方法包括施用有效量的CD200蛋白或编码CD200蛋白的核酸。 该方法可用于预防移植物排斥，胎儿丧失，自身免疫性疾病和过敏。 还公开了用于预防免疫抑制的方法和组合物。 所述方法包括施用有效量的抑制CD200的药剂。 这些方法可用于治疗癌症。

公开(公告)号：US20070258977A1

公开(公告)日：2007-11-08

申请号：US11753908

申请日：2007-05-25

Applicant: Reginald Gorczynski ,  David Clark

Inventor： Reginald Gorczynski ,  David Clark

IPC: A61K39/395 ,  A61K31/70 ,  A61P35/04 ,  A61K38/00

CPC classification number: C07K14/70503 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30

Abstract: Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For suppressing an immune response, an OX-2 protein or a nucleic acid encoding an OX-2 protein is administered. Such methods are useful in preventing graft rejection, fetal loss, autoimmune disease, allergies and in inducing tumor cell growth.

Abstract translation: 公开了用于调节免疫力的方法和组合物。 为了增强免疫反应，施用抑制OX-2的药剂。 这些方法可用于治疗癌症。 为了抑制免疫应答，施用OX-2蛋白或编码OX-2蛋白的核酸。 这样的方法可用于预防移植物排斥，胎儿丧失，自身免疫疾病，过敏和诱导肿瘤细胞生长。

公开(公告)号：US20050287603A1

公开(公告)日：2005-12-29

申请号：US10515332

申请日：2003-06-06

Applicant: Reginald Gorczynski

Inventor： Reginald Gorczynski

IPC: A61K31/00 ,  A61K38/17 ,  A61P19/00 ,  A61P19/10 ,  A61P37/02 ,  C07K16/28 ,  G01N33/53 ,  G01N33/567 ,  G01N33/68

CPC classification number: A61K38/1774 ,  A61K31/00 ,  A61K2039/505 ,  C07K16/28 ,  G01N33/6872 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2500/10

Abstract: Methods and compositions for modulating bone development are described.

Abstract translation: 描述了用于调节骨发育的方法和组合物。

公开(公告)号：US20050107314A1

公开(公告)日：2005-05-19

申请号：US10477525

申请日：2002-05-24

Applicant: Reginald Gorczynski ,  Philip Marsden

Inventor： Reginald Gorczynski ,  Philip Marsden

IPC: A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/705 ,  C07K16/28 ,  C12N5/08 ,  C12N15/12 ,  G01N33/50 ,  G01N33/566 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/74

CPC classification number: G01N33/505 ,  A61K38/00 ,  A61K48/00 ,  A61K2035/122 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5158 ,  C07K14/70503 ,  C07K14/70596 ,  C07K16/2803 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/5047 ,  G01N33/566 ,  G01N2500/04 ,  G01N2500/20

Abstract: The present invention relates to CD200 receptor isoforms and modulators thereof and their use in methods of immune modulation and pharmaceutical compositions.

Abstract translation: 本发明涉及CD200受体亚型及其调节剂及其在免疫调节和药物组合物的方法中的用途。

公开(公告)号：US20110189201A1

公开(公告)日：2011-08-04

申请号：US13084009

申请日：2011-04-11

Applicant: REGINALD GORCZYNSKI

Inventor： REGINALD GORCZYNSKI

IPC: A61K38/02 ,  A61K39/395 ,  A61K31/713 ,  C12Q1/02 ,  C12N5/00 ,  A61P19/10 ,  A61P19/02

CPC classification number: A61K38/1774 ,  A61K31/00 ,  A61K2039/505 ,  C07K16/28 ,  G01N33/6872 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2500/10

Abstract: Methods and compositions for modulating bone development are described.

Abstract translation: 描述了用于调节骨发育的方法和组合物。

公开(公告)号：US20090214573A1

公开(公告)日：2009-08-27

申请号：US12394621

申请日：2009-02-27

Applicant: REGINALD GORCZYNSKI

Inventor： REGINALD GORCZYNSKI

IPC: A61K39/395 ,  G01N33/53 ,  A61P19/08

CPC classification number: A61K38/1774 ,  A61K31/00 ,  A61K2039/505 ,  C07K16/28 ,  G01N33/6872 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2500/10

Abstract: Methods and compositions for modulating bone development are described.

Abstract translation: 描述了用于调节骨发育的方法和组合物。

公开(公告)号：US20070197443A1

公开(公告)日：2007-08-23

申请号：US11736632

申请日：2007-04-18

Applicant: Reginald Gorczynski ,  David Clark

Inventor： Reginald Gorczynski ,  David Clark

IPC: A61K48/00 ,  A61K38/17

CPC classification number: C07K14/70503 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2319/00 ,  C07K2319/30

Abstract: Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of an agent that inhibits CD200. Such methods are useful in treating cancer.

Abstract translation: 公开了诱导免疫抑制的方法和组合物。 所述方法包括施用有效量的CD200蛋白或编码CD200蛋白的核酸。 该方法可用于预防移植物排斥，胎儿丧失，自身免疫性疾病和过敏。 还公开了用于预防免疫抑制的方法和组合物。 所述方法包括施用有效量的抑制CD200的药剂。 这些方法可用于治疗癌症。

公开(公告)号：US20060029607A1

公开(公告)日：2006-02-09

申请号：US11192123

申请日：2005-07-29

Applicant: Reginald Gorczynski ,  David Clark

Inventor： Reginald Gorczynski ,  David Clark

IPC: A61K39/395

CPC classification number: C07K14/70503 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30

Abstract: Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For suppressing an immune response, an OX-2 protein or a nucleic acid encoding an OX-2 protein is administered. Such methods are useful in preventing graft rejection, fetal loss, autoimmune disease, allergies and in inducing tumor cell growth.