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1.发明授权Method of delivering an implantable medical device with a bioabsorbable coating 有权用生物可吸收涂层递送可植入医疗器械的方法公开(公告)号：US08313521B2
公开(公告)日：2012-11-20
申请号：US11599859
申请日：2006-11-15
申请人： Patrick H. Ruane , Waleska Perez-Segarra , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Brian L. Bates , Thomas A. Osborne
发明人： Patrick H. Ruane , Waleska Perez-Segarra , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Brian L. Bates , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/146 , A61L31/16 , A61L33/022 , A61L2300/602 , A61L2300/608 , A61L2420/08 , A61N5/1002
摘要： Methods of delivering a bioactive material to a body vessel are disclosed. The method steps can include providing an expandable medical device with a coating having a bioactive layer, and providing a second layer of a biodegradable polymer positioned over the bioactive layer. The second layer provides for controlled release of the bioactive material from the bioactive layer. The medical device is inserted into a body vessel using a catheter such that the medical device contacts the body vessel.
摘要翻译： 公开了将生物活性物质输送到身体血管的方法。 方法步骤可以包括提供具有生物活性层的涂层的可扩张医疗装置，以及提供位于生物活性层上方的生物可降解聚合物的第二层。 第二层提供生物活性物质从生物活性层的受控释放。 使用导管将医疗装置插入身体容器中，使得医疗装置接触身体容器。
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2.发明申请Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists 有权用于局部递送血管紧张素II 2型受体拮抗剂的医疗装置和方法公开(公告)号：US20090177267A1
公开(公告)日：2009-07-09
申请号：US12291593
申请日：2008-11-12
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2250/0067 , A61F2250/0068
摘要： This invention relates to medical devices and an angiotensin II type 2 (AT2) receptor antagonist compound, the medical device being adapted to release the AT2 receptor antagonist compound within a body of a patient. This invention also relates to medical devices and methods of treatment of disease, such as aneurysms and aortic dissection. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.
摘要翻译： 本发明涉及医疗装置和血管紧张素II型2型（AT2）受体拮抗剂化合物，该医疗装置适于释放患者体内的AT2受体拮抗剂化合物。 本发明还涉及医疗装置和治疗疾病的方法，例如动脉瘤和主动脉夹层。 医疗装置可以包括涂覆支架，移植物，支架移植物，气囊和导管。
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公开(公告)号：US20160296733A1
公开(公告)日：2016-10-13
申请号：US15183572
申请日：2016-06-15
申请人： David W. SNOW , Patrick H. RUANE
发明人： David W. SNOW , Patrick H. RUANE
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61F2/958 , A61M2025/105 , A61M2025/1068 , A61M2025/1081
摘要： A drug or agent coated balloon having a length which is adjustable in vivo is described herein. The balloon is configured to be coated or coatable with one or more drugs where the coating may be applied prior to advancement into a patient body or prior to balloon expansion within the patient body. The length of the expandable portion of the balloon is adjustable to approximate a length of the tissue region to be treated. Moreover, the drug-coated balloon may be used alone or it may be utilized to deploy luminal prostheses having one or more linked or otherwise coupled segments.
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公开(公告)号：US09370642B2
公开(公告)日：2016-06-21
申请号：US11771929
申请日：2007-06-29
申请人： David W. Snow , Patrick H. Ruane
发明人： David W. Snow , Patrick H. Ruane
CPC分类号： A61M25/10 , A61F2/958 , A61M2025/105 , A61M2025/1068 , A61M2025/1081
摘要： A drug or agent coated balloon having a length which is adjustable in vivo is described herein. The balloon is configured to be coated or coatable with one or more drugs where the coating may be applied prior to advancement into a patient body or prior to balloon expansion within the patient body. The length of the expandable portion of the balloon is adjustable to approximate a length of the tissue region to be treated. Moreover, the drug-coated balloon may be used alone or it may be utilized to deploy luminal prostheses having one or more linked or otherwise coupled segments.
摘要翻译： 本文描述了具有在体内可调节的长度的药物或试剂涂覆的气囊。 气囊被配置成与一种或多种药物一起涂覆或涂覆，其中涂层可以在进入患者体内之前或者在患者体内的气囊扩张之前施用。 球囊的可扩张部分的长度是可调节的，以近似待处理的组织区域的长度。 此外，药物涂覆的球囊可以单独使用，或者可以用于部署具有一个或多个连接的或以其他方式耦合的节段的管腔假体。
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5.发明授权Controlled drug delivery using a zein layer modified with levulinic acid 有权使用用乙酰丙酸修饰的玉米醇溶蛋白层进行控制药物递送公开(公告)号：US08523937B2
公开(公告)日：2013-09-03
申请号：US12273926
申请日：2008-11-19
IPC分类号： A61F2/06
CPC分类号： A61L29/085 , A61L15/44 , A61L27/34 , A61L27/54 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/426 , A61L2420/08 , C08L89/00
摘要： The disclosure relates to medical devices coated with zein admixed with levulinic acid. The medical device may further include a therapeutic agent in contact with zein admixed with levulinic acid. Zein admixed with levulinic acid allows the therapeutic agent to be retained on the device during delivery and also controls the elution rate of the therapeutic agent following implantation. The disclosure further relates to methods of delivering a therapeutic agent on said medical devices as well as their use especially in the form of stents for prevention of restenosis.
摘要翻译： 本公开涉及涂覆有与乙酰丙酸混合的玉米醇溶蛋白的医疗装置。 医疗装置还可以包括与与乙酰丙酸混合的玉米醇溶蛋白接触的治疗剂。 与乙酰丙酸混合的玉米淀粉允许治疗剂在输送期间保留在装置上，并且也控制植入后治疗剂的洗脱速率。 本公开还涉及在所述医疗装置上递送治疗剂的方法以及它们的用途，特别是以用于预防再狭窄的支架的形式。
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公开(公告)号：US08147540B2
公开(公告)日：2012-04-03
申请号：US12984733
申请日：2011-01-05
申请人： Priscilla Reyes , William F. Moore , Patrick H. Ruane , Darin G. Schaeffer , Melinda S. Morrell
发明人： Priscilla Reyes , William F. Moore , Patrick H. Ruane , Darin G. Schaeffer , Melinda S. Morrell
IPC分类号： A61F2/82 , A61F2/00 , A61K31/335 , A61M25/10
CPC分类号： A61L27/54 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61K31/337 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/416 , A61L2300/606
摘要： This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.
摘要翻译： 本公开涉及涂覆有紫杉烷治疗剂（例如紫杉醇）的可植入医疗装置，其具有不同溶解速率的一种或多种固体形式。 特别优选的涂层包括紫杉烷治疗剂的无定形和/或溶剂化固体形式，其提供耐久性涂层，其在期望的时间段内释放紫杉烷，其可以在不存在聚合物的情况下变化，通过选择固体形式的类型和量 紫杉烷治疗剂在涂层中。 其它优选实施方案涉及涂覆医疗装置的方法和治疗方法。 涂层可以在体内容器内提供紫杉烷治疗剂的持续释放而不含聚合物以达到期望的紫杉醇洗脱速率。
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公开(公告)号：US20110022148A1
公开(公告)日：2011-01-27
申请号：US12892553
申请日：2010-09-28
CPC分类号： A61L31/128 , A61F2/12 , A61F2/28 , A61F2/82 , A61F2210/0004 , A61F2210/0071 , A61F2250/0001 , A61F2250/0004 , A61F2250/0012 , A61F2250/0067 , A61K41/0028 , A61L27/44 , A61L27/54 , A61L27/58 , A61L31/148 , A61L31/16 , A61L2430/04 , B82Y30/00 , G21K5/02
摘要： An implant comprises a structure that may be implanted into tissue and that has a first material property at normal body temperature. The first material property is variable at elevated temperatures above normal body temperature. The implant also has a plurality of particles dispersed in the structure that are adapted to convert incident radiation into heat energy when irradiated with electromagnetic radiation. The particles are in thermal contact with the structure such that exposure of the particles to incident radiation raises the temperature of the structure thereby changing the first material property relative to the first material property at normal body temperature.
摘要翻译： 植入物包括可以植入组织中并且在正常体温具有第一材料性质的结构。 第一种材料性质在高于正常体温的高温下是可变的。 植入物还具有分散在结构中的多个颗粒，其适于在用电磁辐射照射时将入射的辐射转换成热能。 颗粒与结构热接触，使得颗粒暴露于入射辐射会提高结构的温度，从而在正常体温下相对于第一材料性质改变第一材料性质。
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8.发明授权Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists 有权用于局部递送血管紧张素II 2型受体拮抗剂的医疗装置和方法公开(公告)号：US07828840B2
公开(公告)日：2010-11-09
申请号：US12291593
申请日：2008-11-12
CPC分类号： A61F2/86 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2250/0067 , A61F2250/0068
摘要： This invention relates to medical devices and an angiotensin II type 2 (AT2) receptor antagonist compound, the medical device being adapted to release the AT2 receptor antagonist compound within a body of a patient. This invention also relates to medical devices and methods of treatment of disease, such as aneurysms and aortic dissection. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.
摘要翻译： 本发明涉及医疗装置和血管紧张素II型2型（AT2）受体拮抗剂化合物，该医疗装置适于释放患者体内的AT2受体拮抗剂化合物。 本发明还涉及医疗装置和治疗疾病的方法，例如动脉瘤和主动脉夹层。 医疗装置可以包括涂覆支架，移植物，支架移植物，气囊和导管。
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9.发明申请公开(公告)号：US20090258050A1
公开(公告)日：2009-10-15
申请号：US12273926
申请日：2008-11-19
IPC分类号： A61F2/82 , A61K31/337 , A61P37/00
CPC分类号： A61L29/085 , A61L15/44 , A61L27/34 , A61L27/54 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/426 , A61L2420/08 , C08L89/00
摘要： The disclosure relates to medical devices coated with zein admixed with levulinic acid. The medical device may further include a therapeutic agent in contact with zein admixed with levulinic acid. Zein admixed with levulinic acid allows the therapeutic agent to be retained on the device during delivery and also controls the elution rate of the therapeutic agent following implantation. The disclosure further relates to methods of delivering a therapeutic agent on said medical devices as well as their use especially in the form of stents for prevention of restenosis.
摘要翻译： 本公开涉及涂覆有与乙酰丙酸混合的玉米醇溶蛋白的医疗装置。 医疗装置还可以包括与与乙酰丙酸混合的玉米醇溶蛋白接触的治疗剂。 与乙酰丙酸混合的玉米淀粉允许治疗剂在输送期间保留在装置上，并且也控制植入后治疗剂的洗脱速率。 本公开还涉及在所述医疗装置上递送治疗剂的方法以及它们的用途，特别是以用于预防再狭窄的支架的形式。
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公开(公告)号：US20090105686A1
公开(公告)日：2009-04-23
申请号：US11771929
申请日：2007-06-29
申请人： David W. Snow , Patrick H. Ruane
发明人： David W. Snow , Patrick H. Ruane
CPC分类号： A61M25/10 , A61F2/958 , A61M2025/105 , A61M2025/1068 , A61M2025/1081
摘要： A drug or agent coated balloon having a length which is adjustable in vivo is described herein. The balloon is configured to be coated or coatable with one or more drugs where the coating may be applied prior to advancement into a patient body or prior to balloon expansion within the patient body. The length of the expandable portion of the balloon is adjustable to approximate a length of the tissue region to be treated. Moreover, the drug-coated balloon may be used alone or it may be utilized to deploy luminal prostheses having one or more linked or otherwise coupled segments.
摘要翻译： 本文描述了具有在体内可调节的长度的药物或试剂涂覆的气囊。 气囊被配置成与一种或多种药物一起涂覆或涂覆，其中涂层可以在进入患者体内之前或者在患者体内的气囊扩张之前施用。 球囊的可扩张部分的长度是可调节的，以近似待处理的组织区域的长度。 此外，药物涂覆的球囊可以单独使用，或者可以用于部署具有一个或多个连接的或以其他方式耦合的节段的管腔假体。
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