公开(公告)号：US5726151A

公开(公告)日：1998-03-10

申请号：US472767

申请日：1995-06-07

Applicant: Pascal Anger ,  Bertrand Bonnavaud ,  Alain Callet ,  Patrick Lefevre

Inventor： Pascal Anger ,  Bertrand Bonnavaud ,  Alain Callet ,  Patrick Lefevre

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/12 ,  A61P31/04 ,  C07K1/14 ,  C07K5/06 ,  C07K5/078 ,  C07K7/06 ,  C07K7/54 ,  C07K14/195 ,  C07K14/41 ,  C12P17/18

CPC classification number: C07K5/06182 ,  C07K5/06139 ,  C07K7/06 ,  A61K38/00

Abstract: This invention relates to a purified form of streptogramins, having of a combination of one or more group B components of streptogramins, of general formula: ##STR1## in which A.sub.1 is a radical of general formula: ##STR2## for which R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical, R is an ethyl radical or, when R' is H, R can also represent--CH.sub.3, andR.sub.1 and R.sub.2 are H, or alternatively A.sub.1 is a radical of formula: ##STR3## R is an isobutyl radical, and R.sub.1 is OH and R.sub.2 is --CH.sub.3, and one or more group A minority components of streptogramins, of general formula: ##STR4## in which R" is H or a methyl or ethyl radical, in the state of cocrystallizate, of a coprecipitate or of a physical mixture of the powders.

Abstract translation: 本发明涉及一种纯化形式的链霉素，其具有一种或多种链霉素的一种或多种B组分组合，其通式如下：其中A1是通式如下的基团：或，其中 R'是H或OH，Y是H，甲基氨基或二甲基氨基，R是乙基，或当R'是H时，R也可以表示-CH 3，R 1和R 2是H，或者A1是 式的基团：R 1是异丁基，R 1是OH，R 2是-CH 3，以及一个或多个通式为：其中R“是H的链霉素的少数成分，其中R”是H或 以共沉淀物或粉末的物理混合物的共结晶状态的甲基或乙基。

公开(公告)号：US5637565A

公开(公告)日：1997-06-10

申请号：US472768

申请日：1995-06-07

Applicant: Pascal Anger ,  Bertrand Bonnavaud ,  Alain Callet ,  Patrick Lefevre

Inventor： Pascal Anger ,  Bertrand Bonnavaud ,  Alain Callet ,  Patrick Lefevre

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/12 ,  A61P31/04 ,  C07K1/14 ,  C07K5/06 ,  C07K5/078 ,  C07K7/06 ,  C07K7/54 ,  C07K14/195 ,  C07K14/41 ,  C12P17/18 ,  A61K38/04 ,  A61K38/08 ,  C07K1/30 ,  C07K1/32

CPC classification number: C07K5/06182 ,  C07K5/06139 ,  C07K7/06 ,  A61K38/00

Abstract: This invention relates to a purified form of streptogramins, consisting of a combination of one or more group B components of streptogramins, of general formula: ##STR1## in which A.sub.1 is a radical of general formula: ##STR2## for which R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical, R is an ethyl radical or, when R' is H, R can also represent --CH.sub.3, and R.sub.1 and R.sub.2 are H, or alternatively A.sub.1 is a radical of formula: ##STR3## R is an isobutyl radical, and R.sub.1 is OH and R.sub.2 is --CH.sub.3, and one or more group A minority components of streptogramins, of general formula: ##STR4## in which R" is H or a methyl or ethyl radical, in the state of cocrystallizate, of a coprecipitate or of a physical mixture of the powders.

Abstract translation: 本发明涉及一种纯化形式的链霉素，其由一种或多种链霉素的B组分组合组成，通式如下：其中A1是通式的基团：其中R '是H或OH，Y是H，甲基氨基或二甲基氨基，R是乙基，或当R'是H时，R也可以表示-CH 3，R 1和R 2是H，或者A 1是 式的基团：其中R是异丁基，R 1是OH，R 2是-CH 3，一个或多个通式如下：其中R“是H的链霉素的A组少数成分，或 甲基或乙基，在共结晶状态下，共沉淀物或粉末的物理混合物。

公开(公告)号：US09384938B2

公开(公告)日：2016-07-05

申请号：US13825820

申请日：2011-09-23

Applicant: Dirk Zeidler ,  Thomas Kemen ,  Pascal Anger ,  Antonio Casares ,  Christof Riedesel

Inventor： Dirk Zeidler ,  Thomas Kemen ,  Pascal Anger ,  Antonio Casares ,  Christof Riedesel

IPC: H01J37/09 ,  B82Y10/00 ,  B82Y40/00 ,  H01J37/28 ,  H01J37/317

CPC classification number: H01J37/09 ,  B82Y10/00 ,  B82Y40/00 ,  H01J37/21 ,  H01J37/28 ,  H01J37/3177 ,  H01J2237/0453 ,  H01J2237/0458 ,  H01J2237/0492 ,  H01J2237/1205

Abstract: The present invention concerns a charged-particle multi-beamlet system that comprises a source of charged particles (301); a first multi-aperture plate (320) having plural apertures disposed in a charged particle beam path of the system downstream of the source; a first multi-aperture selector plate (313) having plural apertures; a carrier (340), wherein the first multi-aperture selector plate is mounted on the carrier; and an actuator (350) configured to move the carrier such that the first multi-aperture selector plate is disposed in the charged particle beam path of the system downstream of the source in a first mode of operation of the system, and such that the first multi-aperture selector plate is disposed outside of the charged particle beam path in a second mode of operation of the system. The source, the first multi-aperture plate and the carrier of the system are arranged such that a first number of charged particle beamlets is generated at a position downstream of both the first multi-aperture plate and the first multi-aperture selector plate in the first mode of operation, and that a second number of charged particle beamlets is generated at the position in the second mode of operation, wherein the first number of beamlets differs from the second number of beamlets.

Abstract translation: 本发明涉及一种带电粒子多子束系统，其包括带电粒子源（301）; 第一多孔板（320），其具有设置在所述源的下游的所述系统的带电粒子束路径中的多个孔; 具有多个孔的第一多孔选择板（313） 载体（340），其中所述第一多孔径选择器板安装在所述载体上; 以及构造成移动所述载体的致动器（350），使得所述第一多孔径选择器板在所述系统的第一操作模式中被布置在所述源的下游的系统的带电粒子束路径中，并且使得所述第一 多孔径选择器板在系统的第二操作模式中设置在带电粒子束路径的外部。 源极，第一多孔板和系统的载体被布置成使得在第一多孔径板和第一多孔径选择器板的下游位置处产生第一数量的带电粒子子束 第一操作模式，并且在第二操作模式的位置处产生第二数量的带电粒子子束，其中第一数量的子束与第二数量的子束不同。

公开(公告)号：US20130187046A1

公开(公告)日：2013-07-25

申请号：US13825820

申请日：2011-09-23

Applicant: Dirk Zeidler ,  Thomas Kemen ,  Pascal Anger ,  Antonio Casares ,  Christof Riedesel

Inventor： Dirk Zeidler ,  Thomas Kemen ,  Pascal Anger ,  Antonio Casares ,  Christof Riedesel

IPC: H01J37/09

CPC classification number: H01J37/09 ,  B82Y10/00 ,  B82Y40/00 ,  H01J37/21 ,  H01J37/28 ,  H01J37/3177 ,  H01J2237/0453 ,  H01J2237/0458 ,  H01J2237/0492 ,  H01J2237/1205

Abstract: The present invention concerns a charged-particle multi-beamlet system that comprises a source of charged particles (301); a first multi-aperture plate (320) having plural apertures disposed in a charged particle beam path of the system down-stream of the source; a first multi-aperture selector plate (313) having plural apertures; a carrier (340), wherein the first multi-aperture selector plate is mounted on the carrier; and an actuator (350) configured to move the carrier such that the first multi-aperture selector plate is disposed in the charged particle beam path of the system downstream of the source in a first mode of operation of the system, and such that the first multi-aperture selector plate is disposed outside of the charged particle beam path in a second mode of operation of the system. The source, the first multi-aperture plate and the carrier of the system are arranged such that a first number of charged particle beamlets is generated at a position downstream of both the first multi-aperture plate and the first multi-aperture selector plate in the first mode of operation, and that a second number of charged particle beamlets is generated at the position in the second mode of operation, wherein the first number of beamlets differs from the second number of beamlets.

Abstract translation: 本发明涉及一种带电粒子多子束系统，其包括带电粒子源（301）; 第一多孔板（320），其具有设置在源的系统下游的带电粒子束路径中的多个孔; 具有多个孔的第一多孔选择板（313） 载体（340），其中所述第一多孔径选择器板安装在所述载体上; 以及构造成移动所述载体的致动器（350），使得所述第一多孔径选择器板在所述系统的第一操作模式中被布置在所述源的下游的系统的带电粒子束路径中，并且使得所述第一 多孔径选择器板在系统的第二操作模式中设置在带电粒子束路径的外部。 源极，第一多孔板和系统的载体被布置成使得在第一多孔径板和第一多孔径选择器板的下游位置处产生第一数量的带电粒子子束 第一操作模式，并且在第二操作模式的位置处产生第二数量的带电粒子子束，其中第一数量的子束与第二数量的子束不同。

公开(公告)号：US06384014B1

公开(公告)日：2002-05-07

申请号：US09522949

申请日：2000-03-10

Applicant: Pascal Anger ,  Jean-Claude Barriere ,  Bertrand Bonnavaud ,  Patrick Lefevre ,  Jean-Marc Paris ,  Denis Thibaut

Inventor： Pascal Anger ,  Jean-Claude Barriere ,  Bertrand Bonnavaud ,  Patrick Lefevre ,  Jean-Marc Paris ,  Denis Thibaut

IPC: A61K3812

CPC classification number: C07K5/06182 ,  A61K38/00 ,  C07K7/06

Abstract: Purified form of streptogramines, characterised in that it contains at least one component from group B streptogramines of general formula (I), wherein R1 is Me or Et, R2 is H or OH, and R3 is substituted benzyl of general formula (III), such that 1) if R2 is H, R is NR4R5, wherein one of R4 and R5 is H or an Me radical and the other is Me, and R′ is Cl or Br, or R is (C3-5)alkenyl if R4 and R5 are Me, or 2) R is H and R′ is halogen, alkylamino or dialkylamino, an ether-oxide residue, alkylthio, (C1-3)alkyl or trihalogenomethyl, or R is halogen, (C2-4)alkylamino, (C2-4)dialkylamino or methyl ethyl amino, pyrrolidino alkenyl alkyl amino, dialkylamino, an alkyl cycloalkylmethyl amino radical or in ether-oxide residue, alkylthio, alkylthiomethyl, (C1-6)alkyl, aryl or trihalogenomethyl, and R′ is H, or R is halogen, amino, alkylamino or dialkylamino, an ether-oxide residue, an alkylthio radical, (C1-6)alkyl or trihalogenomethyl and R′ is halogen, alkylamino or dialkylamino, an ether-oxide residue or alkylthio, (C1-3)alkyl, cocrystallised with one or more minor components of group A of general formula (II) wherein R″ is H, Me or Et.

Abstract translation: 其特征在于，其含有至少一种通式（I）的B组链霉素的组分，其中R 1是Me或Et，R 2是H或OH，R 3是通式（III）的取代的苄基， 使得1）如果R 2是H，R 4是NR 4 R 5，其中R 4和R 5之一是H或Me基团，而另一个是Me，R'是Cl或Br，或R 4是（C 3-5）烯基，如果R 4 和R 5是Me，或2）R是H，R'是卤素，烷基氨基或二烷基氨基，醚氧化物残基，烷硫基，（C 1-3）烷基或三卤代甲基，或R是卤素，（C 2-4）烷基氨基， （C 2-4）二烷基氨基或甲基乙基氨基，吡咯烷基链烯基烷基氨基，二烷基氨基，烷基环烷基甲基氨基或醚氧化物残基，烷硫基，烷硫基甲基，（C 1-6）烷基，芳基或三卤代甲基，R' ，或R是卤素，氨基，烷基氨基或二烷基氨基，醚氧化物残基，烷硫基，（C 1-6）烷基或三卤代甲基，R'是卤素，烷基氨基或二烷基氨基，醚氧化物 残基或烷硫基，（C 1-3）烷基，与通式（II）的基团A的一种或多种次要组分共结晶，其中R“为H，Me或Et。