METHODS FOR DETERMINING DRUG EFFICACY FOR TREATMENT OF CANCER USING RATIOS OF CEREBLON ASSOCIATED PROTEINS
    5.
    发明申请
    METHODS FOR DETERMINING DRUG EFFICACY FOR TREATMENT OF CANCER USING RATIOS OF CEREBLON ASSOCIATED PROTEINS 审中-公开
    用于确定使用谷胱甘肽相关蛋白的比例治疗癌症的药物效果的方法

    公开(公告)号:US20160356778A1

    公开(公告)日:2016-12-08

    申请号:US15170789

    申请日:2016-06-01

    Abstract: A method of identifying a subject having cancer who is likely to be responsive to a treatment compound, comprising administering a treatment compound to a subject having cancer; obtaining a sample from the subject; determining the ratio of a first biomarker level to a second biomarker level in the sample from the subject, wherein at least one of the biomarkers is a CRBN-associated protein; and diagnosing the subject as being likely to be responsive to the treatment compound if the ratio of the biomarker levels in the sample of the subject changes as compared to a reference ratio of the biomarker levels.

    Abstract translation: 一种识别患有可能对治疗化合物有反应的癌症的受试者的方法,包括向具有癌症的受试者施用治疗化合物; 从受试者获取样本; 确定来自所述受试者的样品中第一生物标志物水平与第二生物标志物水平的比率,其中所述生物标志物中的至少一个是CRBN相关蛋白; 以及如果所述受试者样品中的生物标志物水平与所述生物标志物水平的参考比例相比变化,则将所述受试者诊断为可能对所述治疗化合物有反应。

    OVERVOLTAGE PROTECTION CIRCUIT FOR PROTECTING OVERVOLTAGE CORRESPONDING TO WIDE RANGE OF INPUT VOLTAGE

    公开(公告)号:US20190058323A1

    公开(公告)日:2019-02-21

    申请号:US16052136

    申请日:2018-08-01

    Abstract: An overvoltage protection circuit is provided which is connected between a rectifier circuit and a load including an input capacitor element connected to both ends of the load. The overvoltage protection circuit includes a semiconductor switch connected between the rectifier circuit and the load, and a control circuit controls the semiconductor switch. When the rectified voltage exceeds a predetermined value, the control circuit turns off the semiconductor switch, and detects a voltage potential difference between both ends of the semiconductor switch, and then, for an interval when the voltage potential difference is zero or a predetermined minute value, the control circuit generates a control voltage for turning on the semiconductor switch, and outputs the control voltage to a control terminal of the semiconductor switch. The overvoltage protection circuit includes a current change circuit that gradually changes a current flowing through the semiconductor switch.

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