公开(公告)号：US20240124577A1

公开(公告)日：2024-04-18

申请号：US18363113

申请日：2023-08-01

申请人： Kyowa Kirin Co., Ltd. ,  KAGOSHIMA UNIVERSITY

发明人： Nobuaki Takahashi ,  Ryosuke NAKANO ,  Sayaka MAEDA ,  Yuji ITO

IPC分类号： C07K16/28 ,  A61K47/10 ,  A61K47/36 ,  C12N5/12 ,  G01N33/563

CPC分类号： C07K16/2803 ,  A61K47/10 ,  A61K47/36 ,  C12N5/12 ,  G01N33/563 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565

摘要： The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

公开(公告)号：US11701440B2

公开(公告)日：2023-07-18

申请号：US17047859

申请日：2019-04-15

申请人： NIHON MEDI-PHYSICS CO., LTD. ,  National University Corporation Kagoshima University ,  National University Corporation Chiba University

发明人： Shota Komoto ,  Yu Ogawa ,  Yoshinari Shoyama ,  Tadashi Hatano ,  Yuji Ito ,  Yasushi Arano ,  Hiroyuki Suzuki ,  Tomoya Uehara

IPC分类号： A61K47/68 ,  A61K51/10 ,  C07K5/065 ,  C07K5/087 ,  A61K51/04 ,  A61K51/08 ,  C07D257/02 ,  C07K7/08 ,  C07K16/32

CPC分类号： A61K51/1093 ,  A61K47/6887 ,  A61K47/6889 ,  A61K51/0482 ,  A61K51/088 ,  A61K51/1096 ,  C07D257/02 ,  C07K5/06078 ,  C07K5/0812 ,  C07K7/08 ,  C07K16/32 ,  C07K2317/21

摘要： Described is a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH (SEQ ID NO: 2) wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.

公开(公告)号：US20230210967A1

公开(公告)日：2023-07-06

申请号：US17996866

申请日：2021-04-21

申请人： BRIGHTPATH BIOTHERAPEUTICS CO., LTD. ,  KAGOSHIMA UNIVERSITY

发明人： Yukie SASAKURA ,  Norihiro NAKAMURA ,  Yuji MISHIMA ,  Noriko MATSUMOTO ,  Fumiko ISODA ,  Yuji ITO

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K47/64 ,  A61K47/68 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K39/12 ,  A61K47/64 ,  A61K47/68 ,  A61P35/00 ,  A61K2039/505 ,  A61K2039/5154

摘要： A peptide vaccine complexed so that the peptide vaccine can be delivered specifically to the surface of specific immune cells and a method for delivering a peptide vaccine specifically to the surface of specific immune cells. The peptide vaccine is combined with an IgG binding peptide capable of binding to an IgG that is an agonist against molecules on the surface of specific immune cells such as dendritic cells.

公开(公告)号：US20220033432A1

公开(公告)日：2022-02-03

申请号：US17473635

申请日：2021-09-13

申请人： DAIKIN INDUSTRIES, LTD. ,  KAGOSHIMA UNIVERSITY

发明人： Tomohito HAMADA ,  Hideyuki IKEUCHI ,  Kanako INOO ,  Yosuke KISHIKAWA ,  Masanori IKEDA ,  Midori TAKEDA

IPC分类号： C07H19/16 ,  A61K31/7076 ,  A61P1/16 ,  A61P35/00 ,  A61P31/20

摘要： The present disclosure aims to provide an anti-hepatitis B virus agent, and a prophylactic or therapeutic agent for a hepatitis B virus-related disease, each comprising a nucleic acid analogue as an active ingredient.
The above object can be attained by an anti-hepatitis B virus agent, or a prophylactic or therapeutic agent for a hepatitis B virus-related disease, each comprising, as an active ingredient, a compound represented by the following formula (1): wherein R is a halogen atom, an amino group, a methoxy group, or a cyano group, or its prodrug, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

公开(公告)号：US11186613B2

公开(公告)日：2021-11-30

申请号：US16461871

申请日：2017-11-17

申请人： Kagoshima University ,  Daicel Corporation

发明人： Yuji Ito ,  Seiichi Uchimura

IPC分类号： C07K7/04 ,  C07K17/00 ,  C07K1/22 ,  C07K16/00 ,  G01N30/88 ,  C12N15/09 ,  C07K7/08 ,  C07K1/16 ,  C07K17/08 ,  C07K17/10

摘要： The present invention provides an IgG-binding peptide which can be used for the purification of IgG and has excellent stability, e.g., alkali stability. The present invention also provides a method for purifying IgG using the IgG-binding peptide. Specifically, the present invention relates to a solid-phase support including an IgG-binding peptide, an IgG separation column including the solid-phase support, a kit including the solid-phase support or the column, and a method for purifying IgG using the solid-phase support or the column.

公开(公告)号：US20210188841A1

公开(公告)日：2021-06-24

申请号：US16650133

申请日：2018-09-27

申请人： KAGOSHIMA UNIVERSITY ,  SHOWA UNIVERSITY

发明人： Takashi KURIHARA ,  Ichiro TAKASAKI ,  Naoki TOYOOKA ,  Hiroaki GOUDA

IPC分类号： C07D471/04 ,  C07D403/14

摘要： This invention relates to an analgesic drug comprising a compound represented by the following formula (I) or (II), wherein R1 is a C1-6-alkoxy group or a C1-6-haloalkoxy group; R2 is a hydrogen atom; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

公开(公告)号：US10987372B2

公开(公告)日：2021-04-27

申请号：US16083762

申请日：2017-03-10

申请人： KAGOSHIMA UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY ,  DAIKIN INDUSTRIES, LTD.

发明人： Masanori Ikeda ,  Midori Takeda ,  Masanori Baba ,  Nobuyuki Kato

IPC分类号： A61K31/7076 ,  A61P1/16 ,  A61P31/20 ,  A61P31/14 ,  A61P35/00

摘要： It is an object of the present invention to provide a novel therapeutic agent for hepatoma viruses. Specifically, the present invention relates to an anti-hepatoma virus agent, containing as an active ingredient a compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: (wherein R1 is fluorine or hydrogen).

公开(公告)号：US20210008134A1

公开(公告)日：2021-01-14

申请号：US16758019

申请日：2018-11-08

申请人： KAGOSHIMA UNIVERSITY

发明人： Ken-ichiro KOSAI ,  Nobuhiro IJICHI

IPC分类号： A61K35/761 ,  A61K47/55 ,  C12N15/86 ,  A61P35/04

摘要： The present invention is based on a novel concept for finding the optimum expression level of a therapeutic gene for inducing the largest therapeutic effect without any adverse reaction. An object of the present invention is to develop an immuno-viral therapeutic vector exerting the optimal therapeutic effect while ensuring high safety. The present invention provides, for example, an oncolytic virus comprising an immunity-inducing gene operably linked to the downstream of E2F promoter or a promoter having an activity equivalent thereto, wherein at least one promoter for nucleic acids encoding an element essential for viral replication or assembly is replaced with a promoter for an organ specific highly expressed factor or with a promoter for a cancer cell specific highly expressed factor.

公开(公告)号：US20190352397A1

公开(公告)日：2019-11-21

申请号：US16473482

申请日：2017-12-25

申请人： Kyowa Hakko Kirin Co., Ltd. ,  KAGOSHIMA UNIVERSITY

发明人： Nobuaki TAKAHASHI ,  Ryosuke NAKANO ,  Sayaka MAEDA ,  Yuji ITO

IPC分类号： C07K16/28 ,  A61K47/10 ,  A61K47/36 ,  C12N5/12 ,  G01N33/563

摘要： The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

公开(公告)号：US10227383B2

公开(公告)日：2019-03-12

申请号：US15575138

申请日：2016-05-20

申请人： KAGOSHIMA UNIVERSITY

发明人： Yuji Ito

IPC分类号： C07K7/08 ,  A61K47/64 ,  C07K16/00 ,  A61K39/395 ,  C07K19/00 ,  A61K38/00

摘要： This invention relates to an IgG-binding peptide, an IgG-binding peptide modified with a cross-linking agent, a conjugate of the IgG-binding peptide modified with a cross-linking agent and IgG, and a method for producing the conjugate, etc.