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    Methods and Compositions for Treatment of Bone Defects with Placental Cell Populations
    7.
    发明申请
    Methods and Compositions for Treatment of Bone Defects with Placental Cell Populations 有权
    用胎盘细胞群治疗骨缺损的方法和组合

    公开(公告)号：US20100047214A1

    公开(公告)日：2010-02-25

    申请号：US12546556

    申请日：2009-08-24

    申请人： Sascha D. Abramson ,  Marian Guelakis ,  Mohammad A. Heidaran ,  Kristen Labazzo ,  Shmuel Yaccoby

    发明人： Sascha D. Abramson ,  Marian Guelakis ,  Mohammad A. Heidaran ,  Kristen Labazzo ,  Shmuel Yaccoby

    IPC分类号： A61K35/50 ,  C12N5/071

    CPC分类号： A61K35/50 ,  A61K35/12 ,  C12N5/0605

    摘要： Provided herein are osteogenic placental adherent cells (OPACs), methods of using OPACs and OPAC populations, and methods of culturing, proliferating, expanding, or differentiating the OPACs. Further provided herein are methods of using the OPACs to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with OPACs and compositions comprising OPACs. Also provided herein are methods of using OPACs in the treatment and management of multiple myeloma, e.g., reducing the progression of, halting the progression of, or improving, one or more symptoms of multiple myeloma in an individual having multiple myeloma, comprising administering a plurality of OPACs to the individual.

    摘要翻译： 本文提供了成骨胎盘贴壁细胞（OPAC），使用OPAC和OPAC群体的方法，以及培养，增殖，扩增或分化OPAC的方法。 本文还提供了使用OPAC来配制适于给予受试者的可植入或可注射组合物的方法。 本文还提供了用OPAC和包含OPAC的组合物治疗骨缺损的方法。 本文还提供了在多发性骨髓瘤的治疗和管理中使用OPAC的方法，例如减少多发性骨髓瘤个体中多发性骨髓瘤的一种或多种症状的进展，停止进展或改善多发性骨髓瘤的一种或多种症状的方法，包括施用多个 的OPACs给个人。

    HIGH THROUGHPUT METHOD TO IDENTIFY LIGANDS FOR CELL ATTACHMENT
    8.
    发明申请
    HIGH THROUGHPUT METHOD TO IDENTIFY LIGANDS FOR CELL ATTACHMENT 审中-公开
    识别细胞附着配体的高通量方法

    公开(公告)号：US20080200345A1

    公开(公告)日：2008-08-21

    申请号：US12015233

    申请日：2008-01-16

    申请人： Andrea Liebmann-Vinson ,  Jonathan A. Rowley ,  Chris H. Bodily ,  Mohammad A. Heidaran

    发明人： Andrea Liebmann-Vinson ,  Jonathan A. Rowley ,  Chris H. Bodily ,  Mohammad A. Heidaran

    IPC分类号： C40B30/06

    CPC分类号： G01N33/5011 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5029 ,  G01N33/54393

    摘要： A high throughput method is provided for identifying agents capable of producing a desired biological response in whole cells. The method includes the steps of providing receptacles having a culture surface; placing different mixtures of single agents into selective ones of the receptacles according to a statistical design; and immobilizing the mixtures of single agents to the culture surface. The method further includes contacting the immobilized agents with the whole cells; and acquiring data which is indicative of a desired biological response in the contacted cells. The method also includes using statistical modeling of the acquired data to determine which mixtures of single agents and/or which single agents in these mixtures are effective in producing the desired biological response in the contacted cells.

    摘要翻译： 提供了一种高通量方法，用于鉴定能够在全细胞中产生所需生物反应的试剂。 该方法包括提供具有培养表面的容器的步骤; 根据统计设计将单一试剂的不同混合物置于选择性容器中; 并将单一试剂的混合物固定到培养表面。 该方法还包括使固定化的试剂与整个细胞接触; 并且获取指示所接触细胞中所需生物反应的数据。 该方法还包括使用获取的数据的统计建模来确定单个试剂的哪些混合物和/或这些混合物中的哪一种试剂在接触的细胞中产生所需的生物反应是有效的。

    Method of treating diseased, injured or abnormal cartilage with hyaluronic acid and growth factors
    10.
    发明授权
    Method of treating diseased, injured or abnormal cartilage with hyaluronic acid and growth factors 有权
    用透明质酸和生长因子治疗患病，损伤或异常软骨的方法

    公开(公告)号：US06645945B1

    公开(公告)日：2003-11-11

    申请号：US09298539

    申请日：1999-04-22

    申请人： Michael Radomsky ,  Mohammad A. Heidaran

    发明人： Michael Radomsky ,  Mohammad A. Heidaran

    IPC分类号： A61K31715

    CPC分类号： A61K31/728 ,  A61K31/715 ,  A61K38/1825 ,  A61K38/30 ,  A61K2300/00

    摘要： A composition is provided for treating diseased, injured or diseased cartilage comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site for a period of time sufficient to alleviate the symptoms of the disease, injury or abnormality. Preferably hyaluronic acid is used in a composition range of 0.01-4% by weight and the preferred growth factor is IGF-I, present in a concentration range of about 10−6 to 100 mg/ml.

    摘要翻译： 提供了组合物，用于治疗包含透明质酸和生长因子的患病，受伤或患病的软骨。 该组合物具有足够的粘度和生物降解性，足以在该部位持续足以减轻疾病症状，损伤或异常的时间。 透明质酸优选使用的组成范围为0.01-4重量％，优选的生长因子是IGF-I，其浓度范围约为10 -6至100mg / ml。