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公开(公告)号：US09568424B2
公开(公告)日：2017-02-14
申请号：US11917955
申请日：2006-06-16
申请人： Chris Van Haag , Michiel Johannes Jongerius , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Ronald De Gier , Michiel De Jong , Gerhard Pross , Johannes Bacher , Andreas Boos , Gerd Luedke , Jens-Peter Seher
发明人： Chris Van Haag , Michiel Johannes Jongerius , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Ronald De Gier , Michiel De Jong , Gerhard Pross , Johannes Bacher , Andreas Boos , Gerd Luedke , Jens-Peter Seher
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Cartridge and method for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a one or more nucleic acid sequences, and the cartridge includes a generic part and one or more separate application-specific parts, which are connectable to the generic part.
摘要翻译： 用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的盒和方法。 盒包括一个或多个核酸序列，并且盒包括通用部分和一个或多个单独的应用特定部分，其可连接到通用部分。
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公开(公告)号：US20120033210A1
公开(公告)日：2012-02-09
申请号：US13273801
申请日：2011-10-14
申请人： Aleksey Kolesnychenko , Jorrit E. De Vries , Jozef C. M. Versleegers , Michiel De Jong , Theodoor B. J. Haddeman , Louis Stroucken
发明人： Aleksey Kolesnychenko , Jorrit E. De Vries , Jozef C. M. Versleegers , Michiel De Jong , Theodoor B. J. Haddeman , Louis Stroucken
IPC分类号： G01N1/10
CPC分类号： G01N21/6452
摘要： An optical detection system for monitoring real-time PCR reactions in a plurality of sample chambers with a plurality of optical units is provided. Due to a relative movement, the optical units are relative to the sample chambers, color multiplexing and space multiplexing are combined for optically detecting pathogens in a sample during the process of the PCR and delivering a quantitative result.
摘要翻译： 提供了一种用于在具有多个光学单元的多个样品室中监测实时PCR反应的光学检测系统。 由于相对运动，光学单元相对于样品室，彩色复用和空间复用被组合用于在PCR过程中光学检测样品中的病原体并递送定量结果。
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公开(公告)号：US08441629B2
公开(公告)日：2013-05-14
申请号：US13273801
申请日：2011-10-14
申请人： Aleksey Kolesnychenko , Jorrit E. De Vries , Jozef C. M. Versleegers , Michiel De Jong , Theodoor B. J. Haddeman , Louis Stroucken
发明人： Aleksey Kolesnychenko , Jorrit E. De Vries , Jozef C. M. Versleegers , Michiel De Jong , Theodoor B. J. Haddeman , Louis Stroucken
IPC分类号： G01N1/10
CPC分类号： G01N21/6452
摘要： An optical detection system for monitoring real-time PCR reactions in a plurality of sample chambers with a plurality of optical units is provided. Due to a relative movement, the optical units are relative to the sample chambers, color multiplexing and space multiplexing are combined for optically detecting pathogens in a sample during the process of the PCR and delivering a quantitative result.
摘要翻译： 提供了一种用于在具有多个光学单元的多个样品室中监测实时PCR反应的光学检测系统。 由于相对运动，光学单元相对于样品室，彩色复用和空间复用被组合用于在PCR过程中光学检测样品中的病原体并递送定量结果。
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公开(公告)号：US20120088310A1
公开(公告)日：2012-04-12
申请号：US13273677
申请日：2011-10-14
申请人： Arie R. Van Doorn , Ronald De Gier , Louis Stroucken , Marloes M. E. B. Van De Wal , Sergei Shulepov , Nicolaas B. Roozen , Contantijn W. M. Brantjes , Hendrik S. Van Damme , Michiel De Jong
发明人： Arie R. Van Doorn , Ronald De Gier , Louis Stroucken , Marloes M. E. B. Van De Wal , Sergei Shulepov , Nicolaas B. Roozen , Contantijn W. M. Brantjes , Hendrik S. Van Damme , Michiel De Jong
CPC分类号： G01N1/44
摘要： A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.
摘要翻译： 提供了一种用于接收样品载体的装置。 该装置包括用于容纳样品载体的一部分的开口和用于去除样品载体的一部分的切割器。 切割器联接到盖子，该盖子可移动以允许切割器在样品载体中进行切口，并且同时在接收到样品载体之后关闭开放的开口的至少一部分。 本公开还涉及包括这种装置的系统和用于操作这种装置的方法。
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5.发明申请CARTRIDGE, SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS 有权CARTRIDGE，SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS公开(公告)号：US20100047774A1
公开(公告)日：2010-02-25
申请号：US11917955
申请日：2006-06-16
申请人： Chris Van Haag , Michiel Johannes Jongerius , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Ronald De Gier , Michiel De Jong , Gerhard Pross , Johannes Bacher , Andreas Boos , Gerd Luedke , Jens-Peter Seher
发明人： Chris Van Haag , Michiel Johannes Jongerius , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Ronald De Gier , Michiel De Jong , Gerhard Pross , Johannes Bacher , Andreas Boos , Gerd Luedke , Jens-Peter Seher
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.
摘要翻译： 公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。 盒包括通用部分和一个或多个单独的应用特定部分，其可连接到通用部分。 还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的系统。 该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。
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公开(公告)号：US20080219889A1
公开(公告)日：2008-09-11
申请号：US12064082
申请日：2006-08-11
申请人： Danny Genius Aldegonda Schaefer , Adrianus Wihelmus Dionisius Maria Van Den Bijgaart , Michiel De Jong , Ronald Cornelis De Gier , Jacobus Frederik Molenaar , Ralph Theodorus Hubertus Maessen , Roger Maria Helmut Godfried Wehrens , Peter Hermanus Bouma , Chris Van Haag
发明人： Danny Genius Aldegonda Schaefer , Adrianus Wihelmus Dionisius Maria Van Den Bijgaart , Michiel De Jong , Ronald Cornelis De Gier , Jacobus Frederik Molenaar , Ralph Theodorus Hubertus Maessen , Roger Maria Helmut Godfried Wehrens , Peter Hermanus Bouma , Chris Van Haag
CPC分类号： G01N35/00029 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/10 , B01L2200/16 , B01L2300/021 , B01L2300/087 , B01L2400/0478 , B01L2400/0487 , B01L2400/0644 , G01N2035/00237
摘要： The invention provides a system, a processing apparatus, a sample unit, a reagent unit and a method for processing a biological sample in the inside of the sample unit. The system comprises at least a processing apparatus and a sample unit, the sample unit comprises a plurality of microfluidic elements, the processing apparatus comprises actuation means capable of actuating at the microfluidic elements such that a quick, cheap and accurate analysis of the biological sample is possible.
摘要翻译： 本发明提供了一种在样品单元内部处理生物样品的系统，处理装置，样品单元，试剂单元和方法。 所述系统至少包括处理装置和样品单元，所述样品单元包括多个微流体元件，所述处理装置包括能够致动所述微流体元件的致动装置，使得对所述生物样品进行快速，便宜且准确的分析是 可能。
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公开(公告)号：US20120034615A1
公开(公告)日：2012-02-09
申请号：US13273603
申请日：2011-10-14
申请人： Arie R. Van Doorn , Michiel De Jong
发明人： Arie R. Van Doorn , Michiel De Jong
CPC分类号： G01N1/28 , B01F11/0283 , B01J19/008 , G01N2001/2866 , G01N2035/00554 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample is provided. The apparatus includes a source and is adapted to receive a cartridge in such a way, that the apparatus focuses the HIFU waves emitted from the source onto a liquid air interface that is present within the cartridge. This focusing is performed when the cartridge is inserted into a receiving section of the apparatus.
摘要翻译： 提供了一种用于用液体样品照射具有声能以产生空化的液体样品的装置。 该装置包括源并且适于以这种方式接收盒，使得设备将从源发射的HIFU波聚焦到存在于盒内的液体空气界面上。 当墨盒插入设备的接收部分时，进行聚焦。
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公开(公告)号：US20100233682A1
公开(公告)日：2010-09-16
申请号：US12294473
申请日：2007-03-23
CPC分类号： G01F22/02 , B01F11/0071 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/10 , B01L2200/146 , B01L2300/0636 , B01L2300/0867 , B01L2300/087 , B01L2400/0481 , B01L2400/0605 , Y10T137/7837
摘要： A fluid processing system is described having at least two chambers. Each of said chambers is separated in a first and a second part by a flexible membrane, the first part, in use, comprising essentially a gas and the second part, in use comprising essentially a non-gaseous fluid, an inlet and/or an outlet means. One or more channels are provided connecting said second parts of said at least two chambers, wherein at least one of said one or more channels includes a pressure sensitive one-way valve. Further, means for exerting pressure on said first part of at least one of said at least two chambers is provided to allow transfer of a sample liquid.
摘要翻译： 描述了具有至少两个室的流体处理系统。 每个所述室在第一和第二部分通过柔性膜分离，使用中的第一部分基本上包括气体，第二部分在使用中基本上包括非气态流体，入口和/或 出口方式。 提供连接所述至少两个室的所述第二部分的一个或多个通道，其中所述一个或多个通道中的至少一个包括压敏单向阀。 此外，提供用于对所述至少两个室中的至少一个的所述第一部分施加压力的装置，以允许样品液体的转移。
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公开(公告)号：US20100151565A1
公开(公告)日：2010-06-17
申请号：US11993348
申请日：2006-06-26
申请人： Ronald Cornelis De Gier , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Chris Van Haag , Michiel De Jong
发明人： Ronald Cornelis De Gier , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Chris Van Haag , Michiel De Jong
CPC分类号： B01L3/502738 , B01L3/50273 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/04 , B01L2200/10 , B01L2300/123 , B01L2300/1827 , B01L2400/0481
摘要： The present invention relates to a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a first component and a second component being connectable to each other, the first component comprising at least a first fluid opening and a first sealing surface and the second component comprising at least a second fluid opening and a second sealing surface. Upon connection of the first and second component the first and second fluid opening are placeable in fluid communication and the first and second sealing surfaces are placeable against each other to seal the fluid communication between the first and second fluid opening. The invention is characterized in that the cartridge comprises biasing means for biasing the second sealing surface in the direction of the first sealing surface.
摘要翻译： 本发明涉及用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的盒。 所述盒包括可彼此连接的第一部件和第二部件，所述第一部件至少包括第一流体开口和第一密封表面，所述第二部件至少包括第二流体开口和第二密封表面。 在连接第一和第二部件时，第一和第二流体开口可以流体连通地放置，并且第一和第二密封表面彼此相对放置以密封第一和第二流体开口之间的流体连通。 本发明的特征在于，该盒包括用于沿第一密封表面的方向偏置第二密封表面的偏置装置。
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10.发明申请ARRAY OF SPATIAL LIGHT MODULATORS AN DMETHOD OF PRODUCTION OF A SPATIAL LIGHT MODULATOR DEVICE 审中-公开空间光调制器阵列空调光调制器的制造方法公开(公告)号：US20090040595A1
公开(公告)日：2009-02-12
申请号：US11718405
申请日：2005-11-03
申请人： Marc Andre De Samber , Michiel De Jong , Antonius Johannes Maria Nellissen , Nicolaas Johannes Anthonius Van Veen
发明人： Marc Andre De Samber , Michiel De Jong , Antonius Johannes Maria Nellissen , Nicolaas Johannes Anthonius Van Veen
CPC分类号： G03F7/70283 , G03F7/70291 , G03F7/70825 , Y10T29/49826
摘要： For the production of a SLM device, one mounts a spatial light modulator (SLM) (2) on a substrate (3) of the same material as the main material of the SLM (2) to be juxtaposed with the substrate (3). Particularly, silicon based SLMs (2) are mounted on a silicon substrate (3). This leads to arrays of SLMs (2) that maintain a high accuracy with respect to position of the SLMs (2) and planarity. To further improve the planarity, it is preferred to mount the SLMs (2) on the substrate (3) by soldering, using the self-aligning effect of solder connections (20).
摘要翻译： 为了制造SLM器件，将与空间光调制器（SLM）（2）安装在与衬底（3）并置的SLM（2）的主要材料相同材料的衬底（3）上。 特别地，硅基SLM（2）安装在硅衬底（3）上。 这导致SLM（2）的阵列相对于SLM（2）的位置和平面度保持高精度。 为了进一步提高平面性，优选使用焊料连接（20）的自对准效果通过焊接将SLM（2）安装在基板（3）上。
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