公开(公告)号：US20200048468A1

公开(公告)日：2020-02-13

申请号：US16534064

申请日：2019-08-07

Applicant: Michael Milbocker

Inventor： Michael Milbocker

IPC: C09B69/10 ,  A61K8/87 ,  A61Q5/10

Abstract: A polymeric hair colorant composition that may cure at ambient temperature, and is self-curable, may be obtained by attaching a protein bonding group to a polymeric backbone comprising chromophores. The protein bonding group may be an isocyanate or epoxy group pendant on the polymer backbone. The application of this self-curable polymeric hair colorant composition has neither organic solvent emission nor energy needed for curing.

公开(公告)号：US07044982B2

公开(公告)日：2006-05-16

申请号：US09939863

申请日：2001-08-27

Applicant: Michael Milbocker

Inventor： Michael Milbocker

IPC: A61F2/02

CPC classification number: A61L27/50 ,  A61F2/0036 ,  A61L27/18 ,  C08L75/04

Abstract: A method for repairing a defect in living mammalian tissue comprising: covering a tissue defect and surrounding tissue with a prosthetic by placing the prosthetic over the defect and against the surrounding tissue. The method includes applying a surgical adhesive to the prosthetic on the surrounding tissue on at least one location on the prosthetic and the surrounding tissue so that surrounding tissue and the prosthetic adhere to each other.

公开(公告)号：US20110196189A1

公开(公告)日：2011-08-11

申请号：US12702788

申请日：2010-02-09

Applicant: Michael Milbocker

Inventor： Michael Milbocker

IPC: A61M1/12

CPC classification number: A61M1/106 ,  A61M1/1008 ,  A61M1/1068 ,  A61M1/1086 ,  A61M1/12

Abstract: A device for extra-cardiac actuation for the support of a failing heart is provided that utilizes the inertial component of a driving fluid to provide separately adjustable quantities of supportive energy to the left and right ventricles. By partitioning the inertial and baric forms of energy delivered to a single chamber, heart encircling assist device, and by localizing the heart to minimize lateral and axial displacement a device and method for achieving balanced left-right flow is disclosed that restores the Frank-Starling mechanism to a failing heart and assists recovery by enabling the heart to achieve physiologic cardiovascular equilibrium.

Abstract translation: 提供了一种用于支持心脏失败的心脏外心脏的装置，其利用驱动流体的惯性分量向左心室和右心室分别提供可调节量的支撑能量。 通过分配传递到单个腔室，心脏环绕辅助装置的惯性和杠杆形式的能量，并且通过定心心脏以最小化侧向和轴向位移，公开了用于实现平衡的左右流动的装置和方法，其恢复了Frank-Starling 机制失败的心脏，并通过使心脏达到生理心血管平衡来帮助恢复。

公开(公告)号：US20060233852A1

公开(公告)日：2006-10-19

申请号：US11406553

申请日：2006-04-19

Applicant: Michael Milbocker

Inventor： Michael Milbocker

IPC: A61F13/00

CPC classification number: A61C8/0006

Abstract: A process for the manufacture of a prosthetic sheet with improved tissue healing characteristics useful in reinforcing tissue defects is disclosed. Generally the prosthetic may be comprised of any material that does not promote fibrosis and inflammation. In particular, the prosthetic may be comprised of non-absorbable hydrogel reinforced with fiber, so that the fiber reinforcement is encapsulated and shielded from interaction with tissue. The prosthetic may contain pores that pass through it to encourage tissue through-growth. These pores may be made by removing material from a sheet of reinforced hydrogel or the reinforcement means may contain a porosity around which the hydrogel is formed and the porosity is maintained.

Abstract translation: 公开了一种用于制造具有改善组织愈合特征的辅助片材的方法，该特征可用于加强组织缺陷。 通常，假体可以由不促进纤维化和炎症的任何材料组成。 特别地，假体可以由用纤维增强的不可吸收的水凝胶组成，使得纤维增强物被包封和屏蔽以免与组织的相互作用。 假体可能含有通过它的孔，以促进组织通过生长。 这些孔可以通过从增强的水凝胶片上除去材料来制造，或者加强装置可以包含孔隙率，在其周围形成水凝胶并保持孔隙率。

公开(公告)号：US20130052236A1

公开(公告)日：2013-02-28

申请号：US13597821

申请日：2012-08-29

Applicant: Joerg Tessmar ,  Eva Esser ,  Lukas Bluecher ,  Michael Milbocker

Inventor： Joerg Tessmar ,  Eva Esser ,  Lukas Bluecher ,  Michael Milbocker

IPC: A61K9/00 ,  A61F13/00 ,  A61K38/44

CPC classification number: A61L31/10 ,  A61L31/022 ,  A61L31/048 ,  A61L31/06 ,  C08L67/04 ,  C08L5/04

Abstract: The present disclosure provides a medical assembly comprising a surgical barrier aspect comprising polylactic acid, and a hydrophilic mucoadhesive aspect, wherein the surgical barrier aspect is provided on a first side of the assembly and the mucoadhesive aspect is provided on a second side of the assembly. The disclosure also relates to a medical assembly comprising a surgical barrier aspect, a short term mucoadhesive aspect, an intermediate term protein polymerization adhesive aspect, and a long term tissue ingrowth implant localization aspect. The aforementioned medical assemblies may be provided as layered sheet structures. Also provided are methods for preparing a medical assembly.

Abstract translation: 本公开提供了一种医疗组件，其包括包含聚乳酸的外科屏障方面和亲水性粘膜粘附方面，其中手术屏障方面设置在组件的第一侧上，并且粘膜粘附方面设置在组件的第二侧上。 本公开还涉及包括手术屏障方面，短期粘膜粘附方面，中间术语蛋白质聚合粘合剂方面和长期组织向内生长定位方面的医疗组合件。 上述医疗组件可以设置为层状片结构。 还提供了用于制备医疗组件的方法。

公开(公告)号：US20090248048A1

公开(公告)日：2009-10-01

申请号：US12482495

申请日：2009-06-11

Applicant: Michael Milbocker

Inventor： Michael Milbocker

IPC: A61B17/08 ,  A61F2/02

CPC classification number: A61C8/0006

Abstract: A process for the manufacture of a prosthetic sheet with improved tissue healing characteristics useful in reinforcing tissue defects is disclosed. Generally the prosthetic may be comprised of any material that does not promote fibrosis and inflammation. In particular, the prosthetic may be comprised of non-absorbable hydrogel reinforced with fiber, so that the fiber reinforcement is encapsulated and shielded from interaction with tissue. The prosthetic may contain pores that pass through it to encourage tissue through-growth. These pores may be made by removing material from a sheet of reinforced hydrogel or the reinforcement means may contain a porosity around which the hydrogel is formed and the porosity is maintained.

Abstract translation: 公开了一种用于制造具有改善组织愈合特征的辅助片材的方法，该特征可用于加强组织缺陷。 通常，假体可以由不促进纤维化和炎症的任何材料组成。 特别地，假体可以由用纤维增强的不可吸收的水凝胶组成，使得纤维增强物被包封和屏蔽以免与组织的相互作用。 假体可能含有通过它的孔，以促进组织通过生长。 这些孔可以通过从增强的水凝胶片上除去材料来制造，或者加强装置可以包含孔隙率，在其周围形成水凝胶并保持孔隙率。

公开(公告)号：US20050187429A1

公开(公告)日：2005-08-25

申请号：US11062779

申请日：2005-02-22

Applicant: Dix Poppas ,  Michael Milbocker

Inventor： Dix Poppas ,  Michael Milbocker

IPC: A61B17/12 ,  A61B17/42 ,  A61F2/02 ,  A61L24/00

CPC classification number: A61B17/12 ,  A61B17/42 ,  A61L24/0042

Abstract: A tissue reinforcement therapy to make the vaginal vault smaller and possibly increase and/or restore sexual gratification is described. The therapy involves augmenting the distal third of the vagina, the orgasmic platform, the external vaginal opening and the perineal area with an injectable in situ polymerizing liquid.

Abstract translation: 描述了一种使阴道穹顶更小并可能增加和/或恢复性满足的组织加强治疗。 该疗法包括用可注射的原位聚合液体增加阴道的远端三分之一，高血压平台，外阴道开口和会阴区域。

公开(公告)号：US09289279B2

公开(公告)日：2016-03-22

申请号：US11863222

申请日：2007-09-27

Applicant: Jeffrey A. Wilson ,  Michael Milbocker

Inventor： Jeffrey A. Wilson ,  Michael Milbocker

IPC: A61B19/00 ,  A61F2/00 ,  A61L31/12

CPC classification number: A61F2/0063 ,  A61B2090/0816 ,  A61L31/129

Abstract: A composite prosthesis and method for limiting the incidence of postoperative adhesions. The composite includes a non-inflammatory or coated mesh and a barrier material which prevents exposure of tissue elsewhere in the body to tissue covered by the composite prosthesis. The barrier material is absorbable which allows tissue through-growth and localization of the composite prosthetic. In use, the composite prosthesis is positioned over the tissue defect and may be positioned with the barrier material oriented against the tissue defect or repair site.

Abstract translation: 一种复合假体和方法，用于限制术后粘连的发生率。 该复合材料包括非炎性或涂层的网状物和阻挡材料，其阻止身体其他部位的组织暴露于由复合假体覆盖的组织上。 阻隔材料是可吸收的，其允许复合假体的组织通过生长和定位。 在使用中，复合假体位于组织缺损处，并且可以将阻挡材料定位成抵抗组织缺损或修复部位定位。

公开(公告)号：US20130095161A1

公开(公告)日：2013-04-18

申请号：US13645941

申请日：2012-10-05

Applicant: Lukas Bluecher ,  Michael Milbocker

Inventor： Lukas Bluecher ,  Michael Milbocker

IPC: A61K31/785

CPC classification number: A61K31/785 ,  C08G18/10 ,  C08G18/12 ,  C08G18/4277 ,  C08G18/6484 ,  C08G18/66 ,  C08G18/6633 ,  C08G18/6666 ,  C08G18/755 ,  C08G18/3206 ,  C08G18/4837

Abstract: The present disclosure relates to compositions A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker, wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof. The disclosure further relates to medical devices comprising the aforementioned compositions, and to methods of using the compositions and devices. More particularly, the compositions, devices and methods described herein are useful for preventing protein adhesions in vivo, particularly the Vroman effect.

Abstract translation: 本公开内容涉及组合物包含阴离子多糖，二异氰酸酯和接头的聚合产物的组合物，其中所述连接体包含i）醚基团，酯基团或其组合，和ii）扩链剂，其包含 羟基，硫醇基，胺基或其组合。 本公开还涉及包含上述组合物的医疗装置，以及使用组合物和装置的方法。 更具体地，本文所述的组合物，装置和方法可用于预防体内蛋白质粘连，特别是Vroman效应。

公开(公告)号：US20080086216A1

公开(公告)日：2008-04-10

申请号：US11863222

申请日：2007-09-27

Applicant: Jeffrey A. Wilson ,  Michael Milbocker

Inventor： Jeffrey A. Wilson ,  Michael Milbocker

IPC: A61F2/02

CPC classification number: A61F2/0063 ,  A61B2090/0816 ,  A61L31/129

Abstract: A composite prosthesis and method for limiting the incidence of postoperative adhesions. The composite includes a non-inflammatory or coated mesh and a barrier material which prevents exposure of tissue elsewhere in the body to tissue covered by the composite prosthesis. The barrier material is absorbable which allows tissue through-growth and localization of the composite prosthetic. In use, the composite prosthesis is positioned over the tissue defect and may be positioned with the barrier material oriented against the tissue defect or repair site.

Abstract translation: 一种复合假体和方法，用于限制术后粘连的发生率。 该复合材料包括非炎性或涂层的网状物和阻挡材料，其阻止身体其他部位的组织暴露于由复合假体覆盖的组织上。 阻隔材料是可吸收的，其允许复合假体的组织通过生长和定位。 在使用中，复合假体位于组织缺损处，并且可以将阻挡材料定位成抵抗组织缺损或修复部位定位。