公开(公告)号：US08828200B2

公开(公告)日：2014-09-09

申请号：US12367725

申请日：2009-02-09

Applicant: Michael Marquant ,  Gregor Bainczyk

Inventor： Michael Marquant ,  Gregor Bainczyk

IPC: G01N27/327 ,  A61B5/1486 ,  A61B5/145

CPC classification number: G01N27/4166 ,  A61B5/14532 ,  A61B5/14865 ,  C25D5/48 ,  G01N27/301 ,  G01N27/327 ,  G01N27/3272 ,  G01N33/4833 ,  H01R43/16 ,  Y10T29/49204

Abstract: The invention relates to an electrochemical sensor for the determination of a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid, to an apparatus that includes the electrochemical sensor, and to a use of the electrochemical sensor, and finally to a method for producing it. The electrochemical sensor has an isolation element and at least two electrodes. The at least two electrodes comprise at least one working electrode and at least one further electrode, in particular at least one counter electrode and/or at least one reference electrode. The at least two electrodes run parallel to one another and form an electrochemical measuring cell of the electrochemical sensor.

Abstract translation: 本发明涉及一种电化学传感器，用于确定介质中的至少一种分析物，特别是身体组织和/或体液的浓度，包括电化学传感器的装置，以及使用电化学 传感器，最后是一种生产它的方法。 电化学传感器具有隔离元件和至少两个电极。 至少两个电极包括至少一个工作电极和至少一个另外的电极，特别是至少一个对电极和/或至少一个参考电极。 至少两个电极彼此平行地延伸并形成电化学传感器的电化学测量单元。

公开(公告)号：US08721544B2

公开(公告)日：2014-05-13

申请号：US12052382

申请日：2008-03-20

Applicant: Bernd Roesicke ,  Karin Obermaier ,  Stefan Lindegger ,  Andreas Menke ,  Joerg Scherer ,  Karin Schwind ,  Otto Gaa ,  Gregor Bainczyk ,  Michael Marquant ,  Sandro Niederhäuser ,  Michael Schoemaker ,  Martin Mueri

Inventor： Bernd Roesicke ,  Karin Obermaier ,  Stefan Lindegger ,  Andreas Menke ,  Joerg Scherer ,  Karin Schwind ,  Otto Gaa ,  Gregor Bainczyk ,  Michael Marquant ,  Sandro Niederhäuser ,  Michael Schoemaker ,  Martin Mueri

IPC: A61B5/145 ,  G06G7/60

CPC classification number: A61B5/0031 ,  A61B5/0002 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7232 ,  A61B5/742 ,  A61B90/98 ,  A61B2560/0209 ,  A61B2560/0219 ,  A61B2560/0481

Abstract: The analyte concentration, such as glucose, in a human or animal body is measured with an implantable sensor that generates measurement signals. The measurement signals are compressed through statistical techniques to produced compressed measurement data that can is easier to process and communicate. A base station carries the implantable sensor along with a signal processor, memory, and a transmitter. A display device is also disclosed that can receive the compressed measurement data from the base station for further processing and display.

Abstract translation: 使用可产生测量信号的可植入传感器来测量人或动物体内的分析物浓度，例如葡萄糖。 测量信号通过统计技术进行压缩，以产生可以更容易处理和通信的压缩测量数据。 基站与信号处理器，存储器和发射器一起携带可植入传感器。 还公开了可以从基站接收压缩的测量数据以进一步处理和显示的显示装置。

公开(公告)号：US08182747B2

公开(公告)日：2012-05-22

申请号：US10628042

申请日：2003-07-25

Applicant: Michael Marquant ,  Volker Unkrig ,  Fritz Hindelang

Inventor： Michael Marquant ,  Volker Unkrig ,  Fritz Hindelang

IPC: G01N27/26

CPC classification number: B01L3/502707 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0825 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N21/11 ,  G01N21/253 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/49

Abstract: The invention concerns a test device for analyzing especially a biological sample liquid comprising a composite body consisting of a plurality of layers of flat materials and a sample channel located in the composite body for transporting the sample liquid from an application site to a measuring site. According to the invention it is proposed that the composite body has a plurality of transport layers arranged in a stack-like manner between support layers for holding in each case sample channel.

Abstract translation: 本发明涉及一种用于特别分析生物样品液体的测试装置，其包括由多层扁平材料组成的复合体和位于复合体中的样品通道，用于将样品液体从施用部位输送到测量部位。 根据本发明，提出了复合体具有以堆叠方式布置在支撑层之间的多个输送层，用于在每种情况下保持样品通道。

公开(公告)号：US08142721B2

公开(公告)日：2012-03-27

申请号：US12888990

申请日：2010-09-23

Applicant: David W. Burke ,  Michael Marquant

Inventor： David W. Burke ,  Michael Marquant

IPC: G01N33/48

CPC classification number: G01N33/558 ,  G01N27/3271 ,  Y10T156/1059 ,  Y10T156/1084

Abstract: A test strip with a covering layer having a novel slot. The slot divides the inventive covering layer into two parts and provides a vent opening that allows air to escape as fluid enters a cavity or sample receiving chamber formed in the test strip. In preferred embodiments, the covering layer is clear such that the user can see through it and the slot doubles as a “fill line.” The user can thus watch the fluid sample enter the test strip, progress through the capillary cavity, and then stop at the slot or fill-line. This provides positive assurance to the user that the sample size is sufficient and the test strip has been filled properly. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.

Abstract translation: 具有新颖狭缝的覆盖层的测试条。 狭槽将本发明的覆盖层分成两部分，并提供通气口，当流体进入形成在测试条中的空腔或样品接收室时，允许空气逸出。 在优选实施例中，覆盖层是清晰的，使得用户可以看到它，并且插槽加倍为“填充线”。因此，用户可以观察流体样品进入测试条，通过毛细管腔进行，然后停止 在插槽或填充线。 这为用户提供了正确的保证，即样品尺寸足够，并且测试条已被正确填充。 本发明还提供了批量生产本发明测试条的有利方法，而不必相对于测试条横向对准槽或通风口，而不必冲压排气口。 该方法也非常适合通过辊加工技术进行批量生产。

公开(公告)号：US07892849B2

公开(公告)日：2011-02-22

申请号：US12389954

申请日：2009-02-20

Applicant: David W. Burke ,  Michael Marquant ,  Udo Zapf ,  Michael Fritz ,  Dan Mosoiu ,  Chris Wilsey

Inventor： David W. Burke ,  Michael Marquant ,  Udo Zapf ,  Michael Fritz ,  Dan Mosoiu ,  Chris Wilsey

IPC: G01N33/48

CPC classification number: G01N33/558 ,  G01N27/3271 ,  Y10T156/1059 ,  Y10T156/1084

Abstract: A test strip having a small sample-receiving chamber on the order of less than 1 microliter. The inventive test strip includes a reagent layer that extends across the width of the test strip and also extends to the sample-receiving end, such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.

Abstract translation: 具有小于1微升量级的小样品接收室的测试条。 本发明的测试条包括跨越测试条的宽度延伸并且还延伸到样品接收端的试剂层，使得试剂层的边缘与测试条的侧面和剂量接收边缘对准。 延伸到条带的配量边缘的亲水试剂促进样品的芯吸到测试条中。 试剂层的端部和侧边缘优选形成为从较大纤维网形成单独的测试条的切割过程的一部分，其导致具有均匀厚度的平滑和薄的试剂层，基本覆盖样品的整个底板 接收室 本发明的批量生产方法有助于提高试剂层的数量，位置，厚度和其他性质的再现性，从而提高了测试结果的准确性。

公开(公告)号：US07638023B2

公开(公告)日：2009-12-29

申请号：US11088305

申请日：2005-03-24

Applicant: Michael Marquant

Inventor： Michael Marquant

IPC: G01N27/327 ,  G01N21/00

CPC classification number: G01N33/48764 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502746 ,  B01L2300/0812 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L2400/0688 ,  G01N33/5438

Abstract: A capillary biosensor analysis system is provided for analyzing a liquid sample, comprising a plurality of longitudinally arranged and consecutively provided and aligned capillary biosensors having a capillary channel enclosed by at least two wall parts and containing one or more reagents, and an evaluation instrument which has a holder to position a forward-most capillary biosensor in a measurement position for performing an analysis. The plurality of capillary biosensors are implemented as a multiple capillary-biosensor strip. A multiple capillary-biosensor strip is guided and held in the holder in such a manner that one capillary biosensor of the strip at a time is located in the measurement position. The multiple capillary-biosensor strip is movable in the evaluation instrument in such a manner that consecutive capillary biosensors of the multiple capillary-biosensor strip are transported one after the other into the measurement position.

Abstract translation: 提供了用于分析液体样品的毛细管生物传感器分析系统，其包括多个纵向排列并连续提供和对准的毛细管生物传感器，其毛细管通道由至少两个壁部分包围并含有一种或多种试剂，以及评估仪器， 用于将最前面的毛细管生物传感器定位在用于进行分析的测量位置中的保持器。 多个毛细管生物传感器被实现为多毛细生物传感器条。 多个毛细管 - 生物传感器条被引导并保持在保持器中，使得一次的条带的一个毛细管生物传感器位于测量位置。 多个毛细管 - 生物传感器条可以在评估仪器中移动，使得多毛细管 - 生物传感器条的连续的毛细管生物传感器一个接一个地输送到测量位置。

公开(公告)号：US20090178923A1

公开(公告)日：2009-07-16

申请号：US12367725

申请日：2009-02-09

Applicant: Michael Marquant ,  Gregor Bainczyk

Inventor： Michael Marquant ,  Gregor Bainczyk

IPC: G01N27/26 ,  B05D5/00

CPC classification number: G01N27/4166 ,  A61B5/14532 ,  A61B5/14865 ,  C25D5/48 ,  G01N27/301 ,  G01N27/327 ,  G01N27/3272 ,  G01N33/4833 ,  H01R43/16 ,  Y10T29/49204

Abstract: The invention relates to an electrochemical sensor for the determination of a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid, to an apparatus that includes the electrochemical sensor, and to a use of the electrochemical sensor, and finally to a method for producing it. The electrochemical sensor has an isolation element and at least two electrodes. The at least two electrodes comprise at least one working electrode and at least one further electrode, in particular at least one counter electrode and/or at least one reference electrode. The at least two electrodes run parallel to one another and form an electrochemical measuring cell of the electrochemical sensor.

Abstract translation: 本发明涉及一种电化学传感器，用于确定介质中的至少一种分析物，特别是身体组织和/或体液的浓度，包括电化学传感器的装置，以及使用电化学 传感器，最后是一种生产它的方法。 电化学传感器具有隔离元件和至少两个电极。 至少两个电极包括至少一个工作电极和至少一个另外的电极，特别是至少一个对电极和/或至少一个参考电极。 至少两个电极彼此平行地延伸并形成电化学传感器的电化学测量单元。

公开(公告)号：US09101306B2

公开(公告)日：2015-08-11

申请号：US13240092

申请日：2011-09-22

Applicant: Nicole Bernini ,  Harvey B. Buck, Jr. ,  Andreas Eberhart ,  Sybille Froech ,  Otto Gaa ,  Michael Marquant ,  Juergen Rasch-Menges ,  Bernd Roesicke ,  Joerg Scherer

Inventor： Nicole Bernini ,  Harvey B. Buck, Jr. ,  Andreas Eberhart ,  Sybille Froech ,  Otto Gaa ,  Michael Marquant ,  Juergen Rasch-Menges ,  Bernd Roesicke ,  Joerg Scherer

IPC: A61B5/00 ,  A61B5/145 ,  A61N1/372

CPC classification number: G06F19/3406 ,  A61B5/0015 ,  A61B5/0024 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61B5/7271 ,  A61B5/74 ,  A61B90/98 ,  A61B2560/0406 ,  A61B2560/045 ,  A61N1/37235 ,  G06F19/00 ,  G06F21/32 ,  G06F21/445 ,  G16H40/63 ,  H04L67/12 ,  H04W4/70 ,  H04W4/80

Abstract: A medical system is disclosed, which can be useable in particular for monitoring and/or controlling at least one bodily function of a user. The medical system comprises a control device and at least one medical user element embodied separately from the control device. The medical user element and the control device are designed to exchange data wirelessly. The medical system is designed to enable an automatic assignment step, wherein an exchange of personal data between the medical user element and the control device is enabled by the automatic assignment step. The medical system is furthermore designed to automatically initiate the automatic assignment step by means of an assignment coupling between the medical user element and the control device. The medical system is furthermore designed to enable a separation of the assignment coupling for medical operation of the medical system after the assignment step.

Abstract translation: 公开了一种医疗系统，其可以特别用于监视和/或控制用户的至少一个身体功能。 医疗系统包括控制装置和与控制装置分开体现的至少一个医疗用户元件。 医疗用户元件和控制装置被设计为无线地交换数据。 医疗系统被设计成能够进行自动分配步骤，其中通过自动分配步骤来实现医疗用户元件和控制装置之间的个人数据的交换。 医疗系统还被设计成通过医疗用户元件和控制装置之间的分配耦合来自动启动自动分配步骤。 医疗系统还被设计成能够在分配步骤之后分离用于医疗系统的医疗操作的分配耦合。

公开(公告)号：US08357274B2

公开(公告)日：2013-01-22

申请号：US12177566

申请日：2008-07-22

Applicant: Michael Marquant ,  Udo Zapf ,  Gregor Bainczyk ,  Volker Unkrig ,  Mihail-Onoriu Lungu ,  Holger Kotzan

Inventor： Michael Marquant ,  Udo Zapf ,  Gregor Bainczyk ,  Volker Unkrig ,  Mihail-Onoriu Lungu ,  Holger Kotzan

IPC: G01N27/327

CPC classification number: C12Q1/001 ,  G01N27/3273 ,  G01N27/3274

Abstract: An electrochemical biosensor analysis system is provided for analyzing a sample liquid, comprising a biosensor having an electrode structure made of at least two electrodes, a test field, covering the electrode structure and capable of absorbing the sample liquid, and a defined sample application surface on the top side of the test field. The system also includes an analysis instrument comprising an evaluation unit for determining the desired analysis data. The analysis instrument comprises an AC resistance measuring device for measuring an AC resistance value between two electrodes of the electrode structure by means of an area compensation measurement. The measured AC resistance value is used, in the determination of the analysis data, as a measure of the partial area of the effective electrode structure area wetted by the sample liquid.

Abstract translation: 提供一种用于分析样品液体的电化学生物传感器分析系统，其包括具有由至少两个电极制成的电极结构的生物传感器，覆盖电极结构并能够吸收样品液体的测试场，以及定义的样品施加表面 测试领​​域的顶端。 该系统还包括分析仪器，其包括用于确定所需分析数据的评估单元。 分析仪器包括用于通过面积补偿测量来测量电极结构的两个电极之间的交流电阻值的交流电阻测量装置。 在测定分析数据时，使用测量的AC电阻值作为由样品液体润湿的有效电极结构区域的部分面积的量度。

公开(公告)号：US08119414B2

公开(公告)日：2012-02-21

申请号：US12882828

申请日：2010-09-15

Applicant: David W. Burke ,  Michael Marquant

Inventor： David W. Burke ,  Michael Marquant

IPC: G01N33/48

CPC classification number: G01N33/558 ,  G01N27/3271 ,  Y10T156/1059 ,  Y10T156/1084

Abstract: Methods of manufacturing test strips are disclosed. Embodiments include laminating a two piece covering layer over a substrate with a series of cavities, wherein the two pieces are separated by a gap, the gap forming a vent opening for the cavities. Other embodiments include covering the sample receiving chamber with a cover thinner than the cover covering the body of the test strip, the thicker body cover absorbing more force than the chamber cover to reduce the possibility of adhesives squeezing out from under the chamber cover. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.