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公开(公告)号：US20120156198A1
公开(公告)日：2012-06-21
申请号：US13218293
申请日：2011-08-25
申请人： Michael Brandt , Jens Fischer , Stefan Jenewein , Klaus Kaluza , Eileen Samy , Stefan Seeber
发明人： Michael Brandt , Jens Fischer , Stefan Jenewein , Klaus Kaluza , Eileen Samy , Stefan Seeber
IPC分类号： A61K39/395 , C12N15/13 , A61P11/00 , A61P29/00 , A61P37/00 , A61P19/04 , A61P17/06 , A61P19/08 , A61P35/00 , C12P21/02 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92
摘要： The invention provides anti-IL-18R1 antibodies and methods of using the same.
摘要翻译： 本发明提供抗IL-18R1抗体及其使用方法。
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公开(公告)号：US20110165182A1
公开(公告)日：2011-07-07
申请号：US13050615
申请日：2011-03-17
申请人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
发明人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
IPC分类号： A61K39/395 , C07K19/00 , A61P31/18 , A61P31/12
CPC分类号： C07K16/2866 , C07K14/005 , C07K2319/00 , C12N2740/16122
摘要： The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.
摘要翻译： 本发明涉及包含一种或多种抗融合肽和抗CCR5抗体（mAb CCR5）的缀合物，其特征在于，一至八个抗融合肽各自与所述抗 - 抗体的重链和/或轻链的一个末端缀合， CCR5抗体和所述缀合物的药物用途。
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公开(公告)号：US07951920B2
公开(公告)日：2011-05-31
申请号：US11893899
申请日：2007-08-17
申请人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
发明人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
CPC分类号： C07K16/2866 , C07K14/005 , C07K2319/00 , C12N2740/16122
摘要： The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of the anti-CCR5 antibody and to the pharmaceutical use of the conjugate.
摘要翻译： 本发明涉及包含一种或多种抗融合肽和抗CCR5抗体（mAb CCR5）的缀合物，其特征在于，一至八个抗融合肽各自与抗-CD5抗体的重链和/或轻链的一个末端缀合， CCR5抗体和缀合物的药物用途。
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公开(公告)号：US20100197387A1
公开(公告)日：2010-08-05
申请号：US12758731
申请日：2010-04-12
申请人： Clifton Lind , Gary L. Loebig , Jefferson C. Lind , Martin Keane , Joseph R. Enzminger , John Everett Padgett , David Michael Brandt
发明人： Clifton Lind , Gary L. Loebig , Jefferson C. Lind , Martin Keane , Joseph R. Enzminger , John Everett Padgett , David Michael Brandt
IPC分类号： A63F9/24
CPC分类号： G07F17/3232 , G07F17/32
摘要： A gaming system is disclosed wherein an outcome probability is determined for each of a number of possible outcomes achievable in a wagering game. Different subsets are then associated with each different prize level in a desired prize distribution. The possible outcomes and their respective probability are assigned or mapped to the different subsets so that the probability of achieving a possible outcome included in a subset comprises a value approximating the desired probability of an award of the prize level with which the subset is associated.
摘要翻译： 公开了一种游戏系统，其中为投注游戏中可实现的多个可能结果中的每一个确定结果概率。 然后将不同的子集与期望的奖励分配中的每个不同的奖金水平相关联。 可能的结果及其各自的概率被分配或映射到不同的子集，使得包括在子集中的实现可能结果的概率包括近似该子集相关联的奖励级别的所需概率的值。
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公开(公告)号：US07661246B2
公开(公告)日：2010-02-16
申请号：US11911291
申请日：2006-04-13
申请人： Steffen Bamberger , Michael Brandt , Klaus Meyer
发明人： Steffen Bamberger , Michael Brandt , Klaus Meyer
IPC分类号： B65B61/00
CPC分类号： B65B61/26 , B65C2009/0003
摘要： The invention relates to a packaging machine for packing food products in a plastic packaging, said machine comprising a device for applying a transponder to the plastic packaging, and a system for data exchange between the transponder and a computer unit and/or a regulating unit, by which means data can be transmitted to the transponder or called therefrom.
摘要翻译： 本发明涉及一种用于在塑料包装中包装食品的包装机，所述机器包括用于将应答器应用于塑料包装的装置，以及用于应答器与计算机单元和/或调节单元之间的数据交换的系统， 通过这种方式，可以将数据发送到应答器或从中转发。
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公开(公告)号：US20090090084A1
公开(公告)日：2009-04-09
申请号：US11911291
申请日：2006-04-13
申请人： Steffen Bamberger , Michael Brandt , Klaus Meyer
发明人： Steffen Bamberger , Michael Brandt , Klaus Meyer
CPC分类号： B65B61/26 , B65C2009/0003
摘要： The invention relates to a packaging machine for packing food products in a plastic packaging, said machine comprising a device for applying a transponder to the plastic packaging, and a system for data exchange between the transponder and a computer unit and/or a regulating unit, by which means data can be transmitted to the transponder or called therefrom.
摘要翻译： 本发明涉及一种用于在塑料包装中包装食品的包装机，所述机器包括用于将应答器应用于塑料包装的装置，以及用于应答器与计算机单元和/或调节单元之间的数据交换的系统， 通过这种方式，可以将数据发送到应答器或从中转发。
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公开(公告)号：US20090028881A1
公开(公告)日：2009-01-29
申请号：US11893899
申请日：2007-08-17
申请人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
发明人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
IPC分类号： C07K16/46 , A61K39/395 , C12P21/08 , A61P31/12 , A61P31/18
CPC分类号： C07K16/2866 , C07K14/005 , C07K2319/00 , C12N2740/16122
摘要： The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.
摘要翻译： 本发明涉及包含一种或多种抗融合肽和抗CCR5抗体（mAb CCR5）的缀合物，其特征在于，一至八个抗融合肽各自与所述抗 - 抗体的重链和/或轻链的一个末端缀合， CCR5抗体和所述缀合物的药物用途。
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公开(公告)号：US20080085857A1
公开(公告)日：2008-04-10
申请号：US11869797
申请日：2007-10-10
IPC分类号： A61K38/18 , A61P35/00 , C07K1/04 , C08F283/00
CPC分类号： A61K47/60
摘要： The present invention provides a conjugate consisting essentially of a NK4 molecule and a polyethylene glycol group having a molecular weight of from about 20 to about 40 kDa. The invention also provides a composition in which the monoPEGylated conjugates comprise at least 90% of the total of pegylated NK4 molecules and unpegylated NK4 molecules in the composition. Also provided is a composition in which the monoPEGylated conjugates comprise conjugates in which the PEG groups are attached to groups randomly selected from the lysine side chains of NK4 molecules and the N-terminal amino groups of NK4 molecules. A method for the treatment of cancer by administering 1 to 30 mg monoPEGylated NK4 per kg per day is further provided.
摘要翻译： 本发明提供了基本上由NK4分子和分子量为约20至约40kDa的聚乙二醇基团组成的缀合物。 本发明还提供一种组合物，其中单聚乙二醇化缀合物包含组合物中聚乙二醇化NK4分子和未聚乙二醇化NK4分子总数的至少90％。 还提供了其中单PEG化缀合物包含缀合物的组合物，其中PEG基团连接到随机选自NK4分子的赖氨酸侧链和NK4分子的N-末端氨基的基团。 进一步提供通过每公斤施用1至30mg单PEG化的NK4来治疗癌症的方法。
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9.发明申请HIGH STRENGTH, HIGH STRESS CORROSION CRACKING RESISTANT AND CASTABLE Al-Zn-Mg-Cu-Zr ALLOY FOR SHAPE CAST PRODUCTS 审中-公开高强度，高应力腐蚀开裂耐腐蚀和可变形Al-Zn-Mg-Cu-Zr合金公开(公告)号：US20080066833A1
公开(公告)日：2008-03-20
申请号：US11856631
申请日：2007-09-17
申请人： Jen C. Lin , Xinyan Yan , Wenping Zhang , James P. Moran , John M. Newman , Ralph R. Sawtell , Gerald D. Scott , Michael Brandt , Bob R. Fors , Rick A. Borns , Moustapha Mbaye
发明人： Jen C. Lin , Xinyan Yan , Wenping Zhang , James P. Moran , John M. Newman , Ralph R. Sawtell , Gerald D. Scott , Michael Brandt , Bob R. Fors , Rick A. Borns , Moustapha Mbaye
摘要： The present invention provides an Al—Zn—Mg—Cu casting alloy that provides high strength for automotive and aerospace applications and optimized stress corrosion cracking resistance in highly corrosive and tensile environments. The inventive alloy composition includes about 3.5 wt. % to about 5.5 wt. % Zn; about 1.0 wt. % to about 3.0 wt. % Mg; about 0.5 wt. % to about 1.2 wt. % Cu; less than about 1.0 wt. % Si; less than about 0.30 wt. % Mn; less than about 0.30 wt. % Fe; and a balance of Al and incidental impurities.
摘要翻译： 本发明提供了一种Al-Zn-Mg-Cu铸造合金，其在高腐蚀性和拉伸环境中为汽车和航空航天应用提供高强度和优化的抗应力腐蚀开裂性。 本发明的合金组合物包含约3.5wt。 ％至约5.5wt。 ％Zn; 约1.0重量％ ％至约3.0wt。 ％Mg; 约0.5wt。 ％至约1.2wt。 ％Cu; 小于约1.0wt。 ％Si; 小于约0.30重量％ ％Mn; 小于约0.30重量％ ％Fe; 以及Al和杂质的平衡。
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10.发明授权Identification of human cell lines for the production of human proteins by endogenous gene activation 有权通过内源基因激活鉴定人类细胞系生产人类蛋白质公开(公告)号：US07214514B2
公开(公告)日：2007-05-08
申请号：US10982880
申请日：2004-11-08
申请人： Michael Brandt , Reinhard Franze , Ulrich Pessara
发明人： Michael Brandt , Reinhard Franze , Ulrich Pessara
IPC分类号： C12P21/02
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625
摘要： A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
摘要翻译： 通过内源基因激活选择人细胞生产人类蛋白质的方法允许以经济上可行的量和以适于生产药物组合物的形式产生人类蛋白质。 还公开了在该物质中鉴定的细胞系中产生人蛋白质的方法。
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