-
1.发明授权Methods for identifying human cell lines useful for endogenous gene activation, isolated human cell lines identified thereby, and uses thereof 有权用于鉴定可用于内源基因激活的人细胞系的方法，由此鉴定的分离的人细胞系及其用途公开(公告)号：US07214532B2
公开(公告)日：2007-05-08
申请号：US10351397
申请日：2003-01-27
申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
发明人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
IPC分类号： C12N15/00
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625 , C12P21/005
摘要： The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
摘要翻译： 本发明涉及由于内源性人EPO基因的活化能够产生足够数量和纯度的EPO以使作为药物制剂的人EPO成本有效的生产的人细胞。 此外，本发明涉及生产这种人EPO产生细胞的方法，用于激活人细胞内源性EPO基因的DNA构建体以及在人细胞中大规模生产EPO的方法。
-
2.发明申请Identification of human cell lines for the production of human proteins by endogenous gene activation 有权通过内源基因激活鉴定人类细胞系生产人类蛋白质公开(公告)号：US20050090007A1
公开(公告)日：2005-04-28
申请号：US10982880
申请日：2004-11-08
申请人： Michael Brandt , Reinhard Franze , Ulrich Pessara
发明人： Michael Brandt , Reinhard Franze , Ulrich Pessara
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625
摘要： A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
摘要翻译： 通过内源基因激活选择人细胞生产人类蛋白质的方法允许以经济上可行的量和以适于生产药物组合物的形式产生人类蛋白质。 还公开了在该物质中鉴定的细胞系中产生人蛋白质的方法。
-
公开(公告)号：US06846673B2
公开(公告)日：2005-01-25
申请号：US10112755
申请日：2002-04-02
申请人： Michael Brandt , Reinhard Franze , Ulrich Pessara
发明人： Michael Brandt , Reinhard Franze , Ulrich Pessara
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625
摘要： A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
-
4.发明授权Methods for identifying human cell lines useful for endogenous gene activation isolated human cell lines identified thereby, and uses thereof 有权用于鉴定用于内源基因激活的人细胞系分离鉴定的人细胞系的方法及其用途公开(公告)号：US06555373B1
公开(公告)日：2003-04-29
申请号：US09607277
申请日：2000-06-30
申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
发明人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
IPC分类号： C12N502
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625 , C12P21/005
摘要： The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
摘要翻译： 本发明涉及由于内源性人EPO基因的活化能够产生足够数量和纯度的EPO以使作为药物制剂的人EPO成本有效的生产的人细胞。 此外，本发明涉及生产这种人EPO产生细胞的方法，用于激活人细胞内源性EPO基因的DNA构建体以及在人细胞中大规模生产EPO的方法。
-
5.发明授权Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof 失效用于鉴定可用于内源基因激活的人细胞系的方法，由此鉴定的分离的人系及其用途公开(公告)号：US06548296B1
公开(公告)日：2003-04-15
申请号：US09113692
申请日：1998-07-10
申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
发明人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
IPC分类号： C12P2106
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625 , C12P21/005
摘要： The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
摘要翻译： 本发明涉及由于内源性人EPO基因的活化能够产生足够数量和纯度的EPO以使作为药物制剂的人EPO成本有效的生产的人细胞。 此外，本发明涉及生产这种人EPO产生细胞的方法，用于激活人细胞内源性EPO基因的DNA构建体以及在人细胞中大规模生产EPO的方法。
-
6.发明授权Identification of human cell lines for the production of human proteins by endogenous gene activation 有权通过内源基因激活鉴定人类细胞系生产人类蛋白质公开(公告)号：US07214514B2
公开(公告)日：2007-05-08
申请号：US10982880
申请日：2004-11-08
申请人： Michael Brandt , Reinhard Franze , Ulrich Pessara
发明人： Michael Brandt , Reinhard Franze , Ulrich Pessara
IPC分类号： C12P21/02
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625
摘要： A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
摘要翻译： 通过内源基因激活选择人细胞生产人类蛋白质的方法允许以经济上可行的量和以适于生产药物组合物的形式产生人类蛋白质。 还公开了在该物质中鉴定的细胞系中产生人蛋白质的方法。
-
公开(公告)号：US06395484B1
公开(公告)日：2002-05-28
申请号：US09463339
申请日：2000-05-30
申请人： Michael Brandt , Reinhard Franze , Ulrich Pessara
发明人： Michael Brandt , Reinhard Franze , Ulrich Pessara
IPC分类号： C12P2106
CPC分类号： C12N15/63 , A61K38/00 , C07K14/505 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625
摘要： A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
-
8.发明申请公开(公告)号：US20050238529A1
公开(公告)日：2005-10-27
申请号：US11111585
申请日：2005-04-21
申请人： Jen Lin , Cagatay Yanar , Michael Brandt , Xinyan Yan , Wenping Zhang
发明人： Jen Lin , Cagatay Yanar , Michael Brandt , Xinyan Yan , Wenping Zhang
IPC分类号： C22C21/10
CPC分类号： C22C21/10
摘要： A heat treatable aluminum alloy for shaped castings includes from about 3.5-5.5% Zn, from about 1-1.5% Mg, less than about 1% Si, less than about 0.30% Mn, and less than about 0.3% Fe and other incidental impurities.
摘要翻译： 用于成型铸件的可热处理的铝合金包括约3.5-5.5％的Zn，约1-1.5％的Mg，小于约1％的Si，小于约0.30％的Mn和小于约0.3％的Fe和其他附带的杂质 。
-
公开(公告)号：US06544748B2
公开(公告)日：2003-04-08
申请号：US09985357
申请日：2001-11-02
申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
发明人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
IPC分类号： C12Q168
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625 , C12P21/005
摘要： The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.
-
公开(公告)号：US06391633B1
公开(公告)日：2002-05-21
申请号：US09463380
申请日：2000-01-21
申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
发明人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
IPC分类号： C12N506
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625 , C12P21/005
摘要： The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO inhuman cells, and a method for the large technical production of EPO in human cells.
摘要翻译： 本发明涉及能够以内源性人EPO基因的活化为基础的以足够量和纯度生产EPO的人细胞，从而使作为药物制剂的人EPO成本有效地生产成为可能。 本发明还涉及制备这种人EPO产生细胞的方法，用于激活内源性EPO非人细胞的DNA构建体，以及人细胞中大量技术生产EPO的方法。
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.031 秒)
