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1.发明申请公开(公告)号：US20070128662A1
公开(公告)日：2007-06-07
申请号：US11601591
申请日：2006-11-17
Applicant: Ehud Isacoff , Richard Kramer , Dirk Trauner , Matthew Banghart , Matthew Volgraf , Pablo Langa
Inventor： Ehud Isacoff , Richard Kramer , Dirk Trauner , Matthew Banghart , Matthew Volgraf , Pablo Langa
CPC classification number: A61K41/00 , A61K38/00 , A61N5/062 , C07K14/70571 , C12N5/0621 , C12N13/00 , C12N2529/10 , G01N33/53 , G01N2500/10
Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
Abstract translation: 本发明提供蛋白质功能的合成调节剂，该调节剂是光敏调节剂。 本发明还提供了包含受试者合成调节剂的光调节多肽。 还提供了包含受试者光调节多肽的细胞和膜。 本发明还提供调节蛋白质功能的方法，涉及使用光。 本发明还提供鉴定调节蛋白质功能的试剂的方法。
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2.发明授权公开(公告)号：US08309350B2
公开(公告)日：2012-11-13
申请号：US13364105
申请日：2012-02-01
Applicant: Ehud Y. Isacoff , Richard H. Kramer , Dirk Trauner , Matthew R. Banghart , Matthew Volgraf , Pablo Ignacio Gorostiza Langa , Katharine Borges
Inventor： Ehud Y. Isacoff , Richard H. Kramer , Dirk Trauner , Matthew R. Banghart , Matthew Volgraf , Pablo Ignacio Gorostiza Langa , Katharine Borges
CPC classification number: A61K41/00 , A61K38/00 , A61N5/062 , C07K14/70571 , C12N5/0621 , C12N13/00 , C12N2529/10 , G01N33/53 , G01N2500/10
Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
Abstract translation: 本发明提供蛋白质功能的合成调节剂，该调节剂是光敏调节剂。 本发明还提供了包含受试者合成调节剂的光调节多肽。 还提供了包含受试者光调节多肽的细胞和膜。 本发明还提供调节蛋白质功能的方法，涉及使用光。 本发明还提供鉴定调节蛋白质功能的试剂的方法。
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公开(公告)号：US20120157448A1
公开(公告)日：2012-06-21
申请号：US13302876
申请日：2011-11-22
Applicant: Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Nicholas C. Kallan , Andrew T. Metcalf , Brad Newhouse , Tony P. Tang , Allen A. Thomas , Michael Siu , Malcolm Huestis , Matthew Volgraf
Inventor： Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Nicholas C. Kallan , Andrew T. Metcalf , Brad Newhouse , Tony P. Tang , Allen A. Thomas , Michael Siu , Malcolm Huestis , Matthew Volgraf
IPC: A61K31/4439 , C07D491/20 , A61K31/527 , C07D513/10 , A61K31/444 , A61K31/424 , C07D498/10 , C07D513/20 , A61P25/28 , C07D491/107 , C07D498/20 , A61K31/547
CPC classification number: C07D498/20 , C07D491/107 , C07D491/20 , C07D498/10 , C07D513/10 , C07D513/20
Abstract: The invention provides novel tricyclic compounds of Formula I′ that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
Abstract translation: 本发明提供抑制APP分解酶切割的新颖的式I'三环化合物，并且可用作治疗神经变性疾病的治疗剂。
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Patent Agency Ranking
4.发明申请公开(公告)号：US20120190094A1
公开(公告)日：2012-07-26
申请号：US13364105
申请日：2012-02-01
Applicant: EHUD Y. ISACOFF , Richard H. Kramer , Dirk Trauner , Matthew R. Banghart , Matthew Volgraf , Pablo Ignacio Gorostiza Langa , Katharine Borges
Inventor： EHUD Y. ISACOFF , Richard H. Kramer , Dirk Trauner , Matthew R. Banghart , Matthew Volgraf , Pablo Ignacio Gorostiza Langa , Katharine Borges
CPC classification number: A61K41/00 , A61K38/00 , A61N5/062 , C07K14/70571 , C12N5/0621 , C12N13/00 , C12N2529/10 , G01N33/53 , G01N2500/10
Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
Abstract translation: 本发明提供蛋白质功能的合成调节剂，该调节剂是光敏调节剂。 本发明还提供了包含受试者合成调节剂的光调节多肽。 还提供了包含受试者光调节多肽的细胞和膜。 本发明还提供调节蛋白质功能的方法，涉及使用光。 本发明还提供鉴定调节蛋白质功能的试剂的方法。
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5.发明申请PHOTOREACTIVE REGULATOR OF GLUTAMATE RECEPTOR FUNCTION AND METHODS OF USE THEREOF 有权谷氨酸受体功能的光电稳定剂及其使用方法公开(公告)号：US20090181454A1
公开(公告)日：2009-07-16
申请号：US12338880
申请日：2008-12-18
Applicant: Dirk Trauner , Ehud Y. Isacoff , Matthew Volgraf , Pablo Ignacio Gorostiza Langa
Inventor： Dirk Trauner , Ehud Y. Isacoff , Matthew Volgraf , Pablo Ignacio Gorostiza Langa
IPC: C12N5/06 , C09B46/00 , C12N1/20 , C07K14/705
CPC classification number: C07K14/705 , C09B56/08
Abstract: The present invention provides a synthetic regulator of glutamate receptor function, which regulator is a light-sensitive (photoreactive) regulator. The present invention further provides a light-regulated glutamate receptor that includes a subject synthetic regulator non-covalently associated with the glutamate receptor. Also provided are cells and membranes comprising a subject light-regulated glutamate receptor. The present invention further provides methods of modulating glutamate receptor function, involving use of light. The present invention further provides methods of identifying agents that modulate glutamate receptor function.
Abstract translation: 本发明提供谷氨酸受体功能的合成调节剂，该调节剂是光敏（光反应）调节剂。 本发明还提供了一种光调节的谷氨酸受体，其包括与谷氨酸受体非共价结合的受试者合成调节物。 还提供了包含受试物光调节的谷氨酸受体的细胞和膜。 本发明还提供调节谷氨酸受体功能的方法，涉及使用光。 本发明还提供鉴定调节谷氨酸受体功能的试剂的方法。
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6.发明授权Photoreactive regulator of glutamate receptor function and methods of use thereof 有权谷氨酸受体功能的光反应调节剂及其使用方法公开(公告)号：US08178496B2
公开(公告)日：2012-05-15
申请号：US12338880
申请日：2008-12-18
Applicant: Dirk Trauner , Ehud Y. Isacoff , Matthew Volgraf , Pablo Ignacio Gorostiza Langa
Inventor： Dirk Trauner , Ehud Y. Isacoff , Matthew Volgraf , Pablo Ignacio Gorostiza Langa
IPC: C07C323/12 , A61A38/00
CPC classification number: C07K14/705 , C09B56/08
Abstract: The present invention provides a synthetic regulator of glutamate receptor function, which regulator is a light-sensitive (photoreactive) regulator. The present invention further provides a light-regulated glutamate receptor that includes a subject synthetic regulator non-covalently associated with the glutamate receptor. Also provided are cells and membranes comprising a subject light-regulated glutamate receptor. The present invention further provides methods of modulating glutamate receptor function, involving use of light. The present invention further provides methods of identifying agents that modulate glutamate receptor function.
Abstract translation: 本发明提供谷氨酸受体功能的合成调节剂，该调节剂是光敏（光反应）调节剂。 本发明还提供了一种光调节的谷氨酸受体，其包括与谷氨酸受体非共价结合的受试者合成调节物。 还提供了包含受试物光调节的谷氨酸受体的细胞和膜。 本发明还提供调节谷氨酸受体功能的方法，涉及使用光。 本发明还提供鉴定调节谷氨酸受体功能的试剂的方法。
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公开(公告)号：US20120065195A1
公开(公告)日：2012-03-15
申请号：US13077477
申请日：2011-03-31
Applicant: Christopher T. Clark , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Nicholas C. Kallan , Michael Siu , Allen A. Thomas , Matthew Volgraf
Inventor： Christopher T. Clark , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Nicholas C. Kallan , Michael Siu , Allen A. Thomas , Matthew Volgraf
IPC: A61K31/547 , A61K31/527 , A61K31/4439 , A61K31/423 , A61K31/4184 , C07D279/08 , C07D413/10 , C07D401/14 , C07D263/52 , C07D235/02 , C07D417/10 , A61P25/28 , C07D403/10 , C07D401/10 , C07D491/107 , A61K31/506
CPC classification number: C07D401/14 , C07D263/64 , C07D401/10 , C07D403/10 , C07D413/10 , C07D417/10
Abstract: The invention provides novel spirotetrahydronaphthalene compounds of Formula α that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
Abstract translation: 本发明提供抑制APP分解酶切割的新颖的式α的四氢四氢化合物，可用作治疗神经变性疾病的治疗剂。
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公开(公告)号：US08114843B2
公开(公告)日：2012-02-14
申请号：US11601591
申请日：2006-11-17
Applicant: Ehud Y. Isacoff , Richard H. Kramer , Dirk Trauner , Matthew Banghart , Matthew Volgraf , Pablo Ignacio Gorostiza Langa , Katharine Borges
Inventor： Ehud Y. Isacoff , Richard H. Kramer , Dirk Trauner , Matthew Banghart , Matthew Volgraf , Pablo Ignacio Gorostiza Langa , Katharine Borges
IPC: C07K14/705 , A61K38/00
CPC classification number: A61K41/00 , A61K38/00 , A61N5/062 , C07K14/70571 , C12N5/0621 , C12N13/00 , C12N2529/10 , G01N33/53 , G01N2500/10
Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
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