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    MARKER FOR DIAGNOSIS OF BREAST CANCER, TEST METHOD, AND TEST KIT
    1.
    发明申请
    MARKER FOR DIAGNOSIS OF BREAST CANCER, TEST METHOD, AND TEST KIT 审中-公开
    乳腺癌诊断标记，测试方法和测试包

    公开(公告)号：US20130012412A1

    公开(公告)日：2013-01-10

    申请号：US13618415

    申请日：2012-09-14

    申请人： Masahiko KURODA ,  Masami TANAKA ,  Kosuke OIKAWA ,  Takayuki MIZUTANI ,  Masakatsu TAKANASHI

    发明人： Masahiko KURODA ,  Masami TANAKA ,  Kosuke OIKAWA ,  Takayuki MIZUTANI ,  Masakatsu TAKANASHI

    IPC分类号： C40B30/04

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/178

    摘要： An embodiment of the present invention provides a marker, a test method, and a test kit which can detect the onset of breast cancer that cannot be detected by palpation or mammography examination or breast cancer in an early stage (clinical stage 0), which are simple, and which have high reliability.A marker associated with breast cancer of an embodiment of the present invention is characterized by being a micro-RNA that is found in serum or plasma. More specifically, the marker contains at least a micro-RNA that is present in the serum or the plasma at a significantly reduced level after the onset of breast cancer, or during or after an early stage (during or after clinical stage 0) of breast cancer compared with that before the onset of breast cancer or before the early stage (before clinical stage 0) of breast cancer.

    摘要翻译： 本发明的一个实施方案提供了可以检测在早期阶段（临床阶段0）不能通过触诊或乳房X线照相检查或乳腺癌检测到的乳腺癌发作的标志物，测试方法和测试试剂盒，其为 简单，可靠性高。 与本发明实施方案的乳腺癌相关的标志物的特征在于是在血清或血浆中发现的微RNA。 更具体地，标记物在乳腺癌发作后或在乳腺早期（临床阶段0期间或之后）期间或之后存在于血清或血浆中存在的至少一种微RNA，其显着降低水平 与乳腺癌发病前或乳腺癌早期（临床阶段0之前）癌症相比较。

    CANCER CELL IDENTIFICATION MARKER AND CANCER CELL PROLIFERATION INHIBITOR
    6.
    发明申请
    CANCER CELL IDENTIFICATION MARKER AND CANCER CELL PROLIFERATION INHIBITOR 有权
    癌细胞鉴定标记和癌细胞增殖抑制剂

    公开(公告)号：US20130172400A1

    公开(公告)日：2013-07-04

    申请号：US13613626

    申请日：2012-09-13

    申请人： Masahiko KURODA ,  Masakatsu Takanashi ,  Kosuke Oikawa

    发明人： Masahiko KURODA ,  Masakatsu Takanashi ,  Kosuke Oikawa

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/57496

    摘要： Disclosed is an identification marker which can be utilized for detection of various human cancer cells and whose expression closely relates to malignant alteration of cells, and compositions for human cancer treatment which are based on suppression of cancer cell proliferation through inhibition of expression of the identification marker. The marker is human heterochromatin protein 1γ (HP1γ), and the compositions for cancer treatment comprises one or more agents which suppresses the expression of human HP1γ gene, such as siRNAs to human HP1γ.

    摘要翻译： 公开了可用于检测各种人类癌细胞并且其表达与细胞的恶性改变密切相关的鉴定标记物，以及基于通过抑制识别标志物表达抑制癌细胞增殖的人类癌症治疗用组合物 。 该标记物是人异染色质蛋白质1gamma（HP1gamma），并且用于癌症治疗的组合物包含一种或多种抑制人HP1gamma基因（例如人HP1gamma的siRNA）表达的试剂。

    MARKER FOR DIAGNOSIS OF BREAST CANCER, TEST METHOD, AND TEST KIT
    7.
    发明申请
    MARKER FOR DIAGNOSIS OF BREAST CANCER, TEST METHOD, AND TEST KIT 审中-公开
    乳腺癌诊断标记，测试方法和测试包

    公开(公告)号：US20110028332A1

    公开(公告)日：2011-02-03

    申请号：US12934948

    申请日：2009-03-27

    申请人： Masahiko Kuroda ,  Masami Tanaka ,  Kosuke Oikawa ,  Takayuki Mizutani ,  Masakatsu Takanashi

    发明人： Masahiko Kuroda ,  Masami Tanaka ,  Kosuke Oikawa ,  Takayuki Mizutani ,  Masakatsu Takanashi

    IPC分类号： C40B30/00 ,  C07H21/02 ,  C40B40/06

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/178

    摘要： An embodiment of the present invention provides a marker, a test method, and a test kit which can detect the onset of breast cancer that cannot be detected by palpation or mammography examination or breast cancer in an early stage (clinical stage 0), which are simple, and which have high reliability.A marker associated with breast cancer of an embodiment of the present invention is characterized by being a micro-RNA that is found in serum or plasma. More specifically, the marker contains at least a micro-RNA that is present in the serum or the plasma at a significantly reduced level after the onset of breast cancer, or during or after an early stage (during or after clinical stage 0) of breast cancer compared with that before the onset of breast cancer or before the early stage (before clinical stage 0) of breast cancer.

    摘要翻译： 本发明的一个实施方案提供了可以检测在早期阶段（临床阶段0）不能通过触诊或乳房X线照相检查或乳腺癌检测到的乳腺癌发作的标志物，测试方法和测试试剂盒，其为 简单，可靠性高。 与本发明实施方案的乳腺癌相关的标志物的特征在于是在血清或血浆中发现的微RNA。 更具体地，标记物在乳腺癌发作后或在乳腺早期（临床阶段0期间或之后）期间或之后存在于血清或血浆中存在的至少一种微RNA，其显着降低水平 与乳腺癌发病前或乳腺癌早期（临床阶段0之前）癌症相比较。