公开(公告)号：US20100226873A1

公开(公告)日：2010-09-09

申请号：US12719434

申请日：2010-03-08

申请人： John Hen ,  Talmadge Kelly Keene ,  Mark Travi

发明人： John Hen ,  Talmadge Kelly Keene ,  Mark Travi

IPC分类号： A61K31/74 ,  A61K33/26 ,  A61P17/02

CPC分类号： A61K33/26 ,  A61K9/0009 ,  A61K9/0014 ,  A61K31/74 ,  A61L15/42 ,  A61L2400/04 ,  A61N2/002 ,  A61K2300/00

摘要： A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound.

摘要翻译： 一种阻止血液从出血伤口流出的组合物和方法。 该组合物优选包括与有效量的不溶性阳离子交换材料和有效量的无机混合的无水高铁酸盐化合物。 可以加入聚维酮碘以提高抗菌性能。 在该方法中，将一定量的组合物磁性地附着在磁体的表面上，然后通过将粉末状化合物覆盖的表面压在伤口上足以使血液凝结的时间将粉末混合物施加到伤口上 阻止伤口进一步的血液流动。

公开(公告)号：US20120087887A1

公开(公告)日：2012-04-12

申请号：US12900170

申请日：2010-10-07

申请人： John Hen ,  John A. Thompson ,  Talmadge Kelly Keene ,  Mark Travi

发明人： John Hen ,  John A. Thompson ,  Talmadge Kelly Keene ,  Mark Travi

IPC分类号： A61K31/795 ,  B01J39/20 ,  A61P7/04

CPC分类号： A61K31/795 ,  B01J39/05 ,  B01J39/20

摘要： A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa.

摘要翻译： 用于促进出血性伤口部位愈合的组合物和方法。 该组合物优选包括基本上无水的阳离子交换树脂形式，其当在血液上施用时，提供对伤口中的浮游微生物和生物膜的抗微生物剂。 当应用足够量时，树脂还能够通过与存在于​​血液和其它体液中的阳离子进行脱水和离子交换来提供对浮游微生物和生物膜的持续和持续的抗微生物。 当树脂的浓度至少为26mg / ml时，提供MRSA，MRSE和绿脓假单胞菌生物活性降低> 3log。

公开(公告)号：US08361504B2

公开(公告)日：2013-01-29

申请号：US12421300

申请日：2009-04-09

申请人： John Hen ,  John Alfred Thompson ,  Talmadge Kelly Keene ,  Michael H. Tollon ,  Mark Travi ,  Roger Thomas

发明人： John Hen ,  John Alfred Thompson ,  Talmadge Kelly Keene ,  Michael H. Tollon ,  Mark Travi ,  Roger Thomas

IPC分类号： A61K9/14 ,  A61K33/26 ,  A61L15/00

CPC分类号： A61L15/44 ,  A61L15/60 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/602

摘要： The subject invention pertains to materials and methods for stopping or decreasing the blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a salt form of a cross-linked polyacrylic acid. In one embodiment, the composition comprises a sodium salt of a polyacrylic acid. Compositions of the invention can also optionally comprise one or more different salt ferrates, and/or a cationic exchanger resins, and/or a silver compound. In an exemplified embodiment, a composition of the invention comprises sodium polyacrylate provided in a dry powdered form. Polyacrylate compositions of the invention can be applied directly to a wound or treatment site, or they can be incorporated into a wound dressing, such as a bandage. The clot or scab formed at a wound or treatment site treated with the present invention is extremely elastic and exhibits considerable tensile strength when stretched to the breaking point. The subject invention also concerns wound and surgical site dressings and coverings, and methods of using a composition of the invention to stop blood flow from an open wound or treatment site.

摘要翻译： 本发明涉及用于从开放伤口或医疗或手术过程中停止或减少血流的材料和方法。 本发明的组合物包含交联聚丙烯酸的盐形式。 在一个实施方案中，组合物包含聚丙烯酸的钠盐。 本发明的组合物还可任选地包含一种或多种不同的高铁酸盐，和/或阳离子交换树脂和/或银化合物。 在一个示例性实施方案中，本发明的组合物包含以干燥粉末形式提供的聚丙烯酸钠。 本发明的聚丙烯酸酯组合物可以直接施用到伤口或治疗部位，或者它们可以并入伤口敷料如绷带中。 在用本发明处理的伤口或治疗部位处形成的凝块或痂是非常有弹性的，并且当拉伸到断裂点时显示出显着的拉伸强度。 本发明还涉及伤口和手术部位敷料和覆盖物，以及使用本发明的组合物来阻止来自开放伤口或治疗部位的血液流动的方法。

公开(公告)号：US20100129427A1

公开(公告)日：2010-05-27

申请号：US12626478

申请日：2009-11-25

申请人： John Hen ,  Talmadge Kelly Keene ,  Mark Travi

发明人： John Hen ,  Talmadge Kelly Keene ,  Mark Travi

IPC分类号： A61L15/16

CPC分类号： A61L15/60 ,  A61L15/24 ,  A61L15/28 ,  A61L2400/04 ,  C08L29/04 ,  C08L39/06

摘要： Hemostatic wound dressings for substantially arresting the flow of severe, life threatening bleeding from a wound by rapidly adhering to the wound site, absorbing and concentrating and thickening the blood at the dressing blood interface and accelerating the natural clot formation beneath the dressing and finally, forming a strong seal that will substantially prohibits further flow of blood out of the wound site. These hemostatic wound dressings are formed of unique combinations of hemostatic dressing aspects which achieve wound seal strengths that are significantly higher than the sum of seal strengths expected from the individual aspects alone. Some embodiments also achieve these synergistic seal strengths by combining one hemostatic dressing with a non-hemostatic device.

摘要翻译： 止血伤口敷料，用于通过快速粘附到伤口部位，大大地阻止严重的威胁生命的出血流，在敷料血液界面吸收和浓缩血液并加速敷料下面的天然凝块形成，最后形成 强烈的印章将大大禁止血液进一步流出伤口部位。 这些止血伤口敷料由止血敷料方面的独特组合形成，其实现伤口密封强度，其显着高于单独地从各个方面预期的密封强度的总和。 一些实施方案还通过将一种止血敷料与非止血装置组合来实现这些协同的密封强度。

公开(公告)号：US20090252799A1

公开(公告)日：2009-10-08

申请号：US12421300

申请日：2009-04-09

申请人： John Hen ,  John Alfred Thompson ,  Talmadge Kelly Keene ,  Michael H. Tollon ,  Mark Travi ,  Roger Thomas

发明人： John Hen ,  John Alfred Thompson ,  Talmadge Kelly Keene ,  Michael H. Tollon ,  Mark Travi ,  Roger Thomas

IPC分类号： A61K9/14 ,  A61K33/26

CPC分类号： A61L15/44 ,  A61L15/60 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/602

摘要： The subject invention pertains to materials and methods for stopping or decreasing the blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a salt form of a cross-linked polyacrylic acid. In one embodiment, the composition comprises a sodium salt of a polyacrylic acid. Compositions of the invention can also optionally comprise one or more different salt ferrates, and/or a cationic exchanger resins, and/or a silver compound. In an exemplified embodiment, a composition of the invention comprises sodium polyacrylate provided in a dry powdered form. Polyacrylate compositions of the invention can be applied directly to a wound or treatment site, or they can be incorporated into a wound dressing, such as a bandage. The clot or scab formed at a wound or treatment site treated with the present invention is extremely elastic and exhibits considerable tensile strength when stretched to the breaking point. The subject invention also concerns wound and surgical site dressings and coverings, and methods of using a composition of the invention to stop blood flow from an open wound or treatment site.

摘要翻译： 本发明涉及用于从开放伤口或医疗或手术过程中停止或减少血流的材料和方法。 本发明的组合物包含交联聚丙烯酸的盐形式。 在一个实施方案中，组合物包含聚丙烯酸的钠盐。 本发明的组合物还可任选地包含一种或多种不同的高铁酸盐，和/或阳离子交换树脂和/或银化合物。 在一个示例性实施方案中，本发明的组合物包含以干燥粉末形式提供的聚丙烯酸钠。 本发明的聚丙烯酸酯组合物可以直接施用到伤口或治疗部位，或者它们可以并入伤口敷料如绷带中。 在用本发明处理的伤口或治疗部位处形成的凝块或痂是非常有弹性的，并且当拉伸到断裂点时显示出显着的拉伸强度。 本发明还涉及伤口和手术部位敷料和覆盖物，以及使用本发明的组合物来阻止来自开放伤口或治疗部位的血液流动的方法。