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公开(公告)号：US20090252799A1
公开(公告)日：2009-10-08
申请号：US12421300
申请日：2009-04-09
申请人： John Hen , John Alfred Thompson , Talmadge Kelly Keene , Michael H. Tollon , Mark Travi , Roger Thomas
发明人： John Hen , John Alfred Thompson , Talmadge Kelly Keene , Michael H. Tollon , Mark Travi , Roger Thomas
CPC分类号： A61L15/44 , A61L15/60 , A61L26/0066 , A61L26/008 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/602
摘要： The subject invention pertains to materials and methods for stopping or decreasing the blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a salt form of a cross-linked polyacrylic acid. In one embodiment, the composition comprises a sodium salt of a polyacrylic acid. Compositions of the invention can also optionally comprise one or more different salt ferrates, and/or a cationic exchanger resins, and/or a silver compound. In an exemplified embodiment, a composition of the invention comprises sodium polyacrylate provided in a dry powdered form. Polyacrylate compositions of the invention can be applied directly to a wound or treatment site, or they can be incorporated into a wound dressing, such as a bandage. The clot or scab formed at a wound or treatment site treated with the present invention is extremely elastic and exhibits considerable tensile strength when stretched to the breaking point. The subject invention also concerns wound and surgical site dressings and coverings, and methods of using a composition of the invention to stop blood flow from an open wound or treatment site.
摘要翻译： 本发明涉及用于从开放伤口或医疗或手术过程中停止或减少血流的材料和方法。 本发明的组合物包含交联聚丙烯酸的盐形式。 在一个实施方案中，组合物包含聚丙烯酸的钠盐。 本发明的组合物还可任选地包含一种或多种不同的高铁酸盐，和/或阳离子交换树脂和/或银化合物。 在一个示例性实施方案中，本发明的组合物包含以干燥粉末形式提供的聚丙烯酸钠。 本发明的聚丙烯酸酯组合物可以直接施用到伤口或治疗部位，或者它们可以并入伤口敷料如绷带中。 在用本发明处理的伤口或治疗部位处形成的凝块或痂是非常有弹性的，并且当拉伸到断裂点时显示出显着的拉伸强度。 本发明还涉及伤口和手术部位敷料和覆盖物，以及使用本发明的组合物来阻止来自开放伤口或治疗部位的血液流动的方法。
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公开(公告)号：US08361504B2
公开(公告)日：2013-01-29
申请号：US12421300
申请日：2009-04-09
申请人： John Hen , John Alfred Thompson , Talmadge Kelly Keene , Michael H. Tollon , Mark Travi , Roger Thomas
发明人： John Hen , John Alfred Thompson , Talmadge Kelly Keene , Michael H. Tollon , Mark Travi , Roger Thomas
CPC分类号： A61L15/44 , A61L15/60 , A61L26/0066 , A61L26/008 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/602
摘要： The subject invention pertains to materials and methods for stopping or decreasing the blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a salt form of a cross-linked polyacrylic acid. In one embodiment, the composition comprises a sodium salt of a polyacrylic acid. Compositions of the invention can also optionally comprise one or more different salt ferrates, and/or a cationic exchanger resins, and/or a silver compound. In an exemplified embodiment, a composition of the invention comprises sodium polyacrylate provided in a dry powdered form. Polyacrylate compositions of the invention can be applied directly to a wound or treatment site, or they can be incorporated into a wound dressing, such as a bandage. The clot or scab formed at a wound or treatment site treated with the present invention is extremely elastic and exhibits considerable tensile strength when stretched to the breaking point. The subject invention also concerns wound and surgical site dressings and coverings, and methods of using a composition of the invention to stop blood flow from an open wound or treatment site.
摘要翻译： 本发明涉及用于从开放伤口或医疗或手术过程中停止或减少血流的材料和方法。 本发明的组合物包含交联聚丙烯酸的盐形式。 在一个实施方案中，组合物包含聚丙烯酸的钠盐。 本发明的组合物还可任选地包含一种或多种不同的高铁酸盐，和/或阳离子交换树脂和/或银化合物。 在一个示例性实施方案中，本发明的组合物包含以干燥粉末形式提供的聚丙烯酸钠。 本发明的聚丙烯酸酯组合物可以直接施用到伤口或治疗部位，或者它们可以并入伤口敷料如绷带中。 在用本发明处理的伤口或治疗部位处形成的凝块或痂是非常有弹性的，并且当拉伸到断裂点时显示出显着的拉伸强度。 本发明还涉及伤口和手术部位敷料和覆盖物，以及使用本发明的组合物来阻止来自开放伤口或治疗部位的血液流动的方法。
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公开(公告)号：US20100129427A1
公开(公告)日：2010-05-27
申请号：US12626478
申请日：2009-11-25
申请人： John Hen , Talmadge Kelly Keene , Mark Travi
发明人： John Hen , Talmadge Kelly Keene , Mark Travi
IPC分类号： A61L15/16
摘要： Hemostatic wound dressings for substantially arresting the flow of severe, life threatening bleeding from a wound by rapidly adhering to the wound site, absorbing and concentrating and thickening the blood at the dressing blood interface and accelerating the natural clot formation beneath the dressing and finally, forming a strong seal that will substantially prohibits further flow of blood out of the wound site. These hemostatic wound dressings are formed of unique combinations of hemostatic dressing aspects which achieve wound seal strengths that are significantly higher than the sum of seal strengths expected from the individual aspects alone. Some embodiments also achieve these synergistic seal strengths by combining one hemostatic dressing with a non-hemostatic device.
摘要翻译： 止血伤口敷料，用于通过快速粘附到伤口部位，大大地阻止严重的威胁生命的出血流，在敷料血液界面吸收和浓缩血液并加速敷料下面的天然凝块形成，最后形成 强烈的印章将大大禁止血液进一步流出伤口部位。 这些止血伤口敷料由止血敷料方面的独特组合形成，其实现伤口密封强度，其显着高于单独地从各个方面预期的密封强度的总和。 一些实施方案还通过将一种止血敷料与非止血装置组合来实现这些协同的密封强度。
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公开(公告)号：US20110245868A1
公开(公告)日：2011-10-06
申请号：US12750168
申请日：2010-03-30
IPC分类号： A61B17/04
CPC分类号： A61B17/0466 , A61B2017/0496 , A61L26/0061 , A61L2400/04
摘要： A wound sealing system and method for closing a vascular access site. The method invisions suturing a single continuous Z-stitch into a skin area around a wound and wound tract while the catheter remains within the vessel; covering the wound and suture holes with a hemostatic powder; tightening and knotting the ends of the suture together in an X configuration, applying finger pressure against the hemostatic powder as the catheter is removed; and twisting the suture ends together to tension the Z-stitch, pulling the skin area into inversion. The wound sealing system includes a powder containment device (PCD) which surrounds wound and catheter and a suture twisting member configured with the PCD to tension the Z-stitch closing the wound and arresting blood flow. The hole in the PCD holds a quantity of the hemostatic agent sufficient to cover the wound and suture holes.
摘要翻译： 用于闭合血管通路部位的伤口密封系统和方法。 该方法在导管保留在容器内时，将单个连续的Z-缝合缝合到伤口和伤口处周围的皮肤区域中; 用止血粉覆盖伤口和缝合孔; 以X构型将缝合线的端部紧固并打结在一起，在取出导管时将手指压力施加到止血粉末上; 并将缝线端部扭曲在一起，以拉紧Z形针迹，将皮肤区域拉回。 伤口密封系统包括围绕伤口和导管的粉末容纳装置（PCD），以及配置有PCD的缝合线扭绞构件，以张紧闭合伤口的Z向缝合并阻止血液流动。 PCD中的孔保持一定量的止血剂足以覆盖伤口和缝合孔。
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公开(公告)号：US20110020425A1
公开(公告)日：2011-01-27
申请号：US12924547
申请日：2010-09-29
CPC分类号： A61K33/26 , A61K31/715 , A61K31/717 , A61K31/718 , A61K31/722 , A61K31/729 , A61K31/731 , A61K31/734 , A61K31/74 , A61K31/79 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/32 , A61K33/34 , A61K33/38 , A61K45/06 , A61L15/18 , A61L15/44 , A61L2300/102 , A61L2300/104 , A61L2300/404
摘要： The subject invention pertains to methods and compositions for wound treatment. The methods and compositions provide for promoting and accelerating wound healing; provide for inhibition of microbial infection; provide for a protective scab-like covering on a wound; and/or for arresting the flow of blood or body fluids from an open wound. The methods and compositions can be used to increase granulation and epithelialization in a wound. In one embodiment, a substantially anhydrous compound of a salt ferrate and a cation exchange material is provided. Compositions of the invention can also include silver compounds. In use, compositions of the invention are preferably applied as a dry dressing to an exuding chronic wound site. If the chronic wound site is dry, the wound site may be wetted with a suitable liquid or aqueous media prior to applying the dressing in dry form.
摘要翻译： 本发明涉及伤口治疗的方法和组合物。 所述方法和组合物用于促进和加速伤口愈合; 提供抑制微生物感染; 在伤口上提供防护性的scab状覆盖物; 和/或用于阻止血液或体液从开口伤口流出。 方法和组合物可用于增加伤口中的造粒和上皮形成。 在一个实施方案中，提供了基本上无水的高铁酸盐和阳离子交换材料的化合物。 本发明的组合物还可以包括银化合物。 在使用中，优选将本发明的组合物作为干燥敷料施用于渗出性慢性伤口部位。 如果慢性伤口部位干燥，则在施用干燥形式的敷料之前，可以用合适的液体或水性介质润湿伤口部位。
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公开(公告)号：US20100226873A1
公开(公告)日：2010-09-09
申请号：US12719434
申请日：2010-03-08
申请人： John Hen , Talmadge Kelly Keene , Mark Travi
发明人： John Hen , Talmadge Kelly Keene , Mark Travi
CPC分类号： A61K33/26 , A61K9/0009 , A61K9/0014 , A61K31/74 , A61L15/42 , A61L2400/04 , A61N2/002 , A61K2300/00
摘要： A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound.
摘要翻译： 一种阻止血液从出血伤口流出的组合物和方法。 该组合物优选包括与有效量的不溶性阳离子交换材料和有效量的无机混合的无水高铁酸盐化合物。 可以加入聚维酮碘以提高抗菌性能。 在该方法中，将一定量的组合物磁性地附着在磁体的表面上，然后通过将粉末状化合物覆盖的表面压在伤口上足以使血液凝结的时间将粉末混合物施加到伤口上 阻止伤口进一步的血液流动。
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7.发明申请Composition and Method for Arresting Blood Flow and for Forming a Persistent Microbial Barrier 审中-公开阻止血液流动和形成持久性微生物屏障的组成和方法公开(公告)号：US20120087887A1
公开(公告)日：2012-04-12
申请号：US12900170
申请日：2010-10-07
申请人： John Hen , John A. Thompson , Talmadge Kelly Keene , Mark Travi
发明人： John Hen , John A. Thompson , Talmadge Kelly Keene , Mark Travi
IPC分类号： A61K31/795 , B01J39/20 , A61P7/04
CPC分类号： A61K31/795 , B01J39/05 , B01J39/20
摘要： A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa.
摘要翻译： 用于促进出血性伤口部位愈合的组合物和方法。 该组合物优选包括基本上无水的阳离子交换树脂形式，其当在血液上施用时，提供对伤口中的浮游微生物和生物膜的抗微生物剂。 当应用足够量时，树脂还能够通过与存在于血液和其它体液中的阳离子进行脱水和离子交换来提供对浮游微生物和生物膜的持续和持续的抗微生物。 当树脂的浓度至少为26mg / ml时，提供MRSA，MRSE和绿脓假单胞菌生物活性降低> 3log。
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