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公开(公告)号：US20170285023A1
公开(公告)日：2017-10-05
申请号：US15376775
申请日：2016-12-13
IPC分类号： G01N33/564 , G01N33/558 , G01N21/75 , G01N33/543
CPC分类号： G01N33/564 , A61B5/7275 , G01N21/75 , G01N33/54386 , G01N33/6854 , G01N2021/752 , G01N2021/757 , G01N2800/24 , G01N2800/50 , G05B15/00 , G06F7/06
摘要： Portable devices for anti-drug antibodies (ADAs) testing are provided. These devices can be used in various applications, including but not restricted to the following: uniform testing of patients for ADAs; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; scientific guidance for discovering therapeutic drugs; therapeutic drug development; postmarketing surveillance of therapeutic drugs.
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公开(公告)号：US20160320405A1
公开(公告)日：2016-11-03
申请号：US15091483
申请日：2016-04-05
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/558 , A61B5/145 , A61B5/7275 , G05B15/00 , G06F7/06 , G06F19/00
摘要： Methods to estimate safety and/or efficacy of therapeutic drugs, which include portable devices for anti-drug antibody (ADA) testing and databases containing anonymized data from human and/or animal models and related analyses, are provided. These methods and compositions can be used in various applications, including but not restricted to the following: uniform testing of patients for ADA; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; scientific guidance for discovering and/or developing therapeutic drugs; postmarketing surveillance of therapeutic drugs.
摘要翻译： 提供了评估治疗药物的安全性和/或功效的方法，其包括用于抗药物抗体（ADA）测试的便携式装置和包含来自人和/或动物模型的匿名数据的数据库和相关分析。 这些方法和组合物可用于各种应用，包括但不限于以下：ADA患者的均匀测试; 选择治疗药物进行治疗; 评估需要改变治疗药物或应用耐药方案; 选择临床试验患者; 比较针对某种疾病销售的治疗药物和基因治疗; 发现和/或开发治疗药物的科学指导; 治疗药物上市后监督。
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公开(公告)号：US10725031B1
公开(公告)日：2020-07-28
申请号：US15933083
申请日：2018-03-22
IPC分类号： G01N33/00 , G01N33/543 , B01L3/00
摘要： Devices for detection of analytes in samples of various complexities are provided. The devices allow reflux of liquid into a sample-receiving member, providing for suitable analyte dilution and preventing leakage of cells or particulate material into the signal generation member. In one aspect, the devices are used to test analytes in biological samples such as blood, serum, plasma or other body fluids. In another aspect, the devices are used to test samples from tissues, such as organ tissues, tumor samples, or other body parts. In a further aspect, the devices are used to test microbial samples, food samples, or any other sample from which the analyte of interest can be captured into the reflux device.
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公开(公告)号：US09927443B2
公开(公告)日：2018-03-27
申请号：US15091483
申请日：2016-04-05
CPC分类号： G01N33/558 , A61B5/145 , A61B5/7275 , G05B15/00 , G06F7/06 , G06F19/00
摘要： Methods to estimate safety and/or efficacy of therapeutic drugs, which include portable devices for anti-drug antibody (ADA) testing and databases containing anonymized data from humans and/or animal models, and related analyses, are provided. These methods and compositions can be used in various applications, including but not restricted to the following: uniform testing of patients for ADA; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; scientific guidance for discovering and/or developing therapeutic drugs; postmarketing surveillance of therapeutic drugs.
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公开(公告)号：US09903866B2
公开(公告)日：2018-02-27
申请号：US15376775
申请日：2016-12-13
IPC分类号： G01N21/75 , G01N33/564 , G01N33/543 , G01N33/558
CPC分类号： G01N33/564 , A61B5/7275 , G01N21/75 , G01N33/54386 , G01N33/6854 , G01N2021/752 , G01N2021/757 , G01N2800/24 , G01N2800/50 , G05B15/00 , G06F7/06
摘要： Portable devices for anti-drug antibodies (ADAs) testing are provided. These devices can be used in various applications, including but not restricted to the following: uniform testing of patients for ADAs; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; scientific guidance for discovering therapeutic drugs; therapeutic drug development; postmarketing surveillance of therapeutic drugs.
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公开(公告)号：US20180031569A1
公开(公告)日：2018-02-01
申请号：US15663650
申请日：2017-07-28
CPC分类号： G01N33/6854 , A61B5/14532 , A61B5/7275 , G01N33/564 , G01N33/66 , G01N33/74 , G01N2333/62 , G01N2800/042 , G01N2800/24 , G01N2800/50 , G06F7/06
摘要： Devices for detection of antibodies against therapeutic drugs (ADAs), in which chimeric proteins facilitate immobilization and exposure of target epitopes, are described. Results can be obtained in minutes, enabling point of care testing and/or patient self-testing, and risk assessment. The data can also be used for deriving scientific knowledge in the fields of oncology, autoimmune diseases (including but not restricted to diabetes, multiple sclerosis and rheumatoid arthritis), cardiovascular diseases, rare diseases, and other diseases for which treatment comprises administration of a therapeutic drug and/or gene therapy.
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公开(公告)号：US20180031547A1
公开(公告)日：2018-02-01
申请号：US15631152
申请日：2017-06-23
IPC分类号： G01N33/543 , G01N33/531 , G01N33/53 , A61B5/145
CPC分类号： G01N33/54366 , A61B5/00 , A61B5/145 , A61B5/14546 , A61B5/41 , A61B5/4833 , A61B5/7275 , G01N33/5302 , G01N33/531 , G01N33/54386 , G01N33/558 , G01N33/6854 , G01N2800/24 , G01N2800/50 , G06F19/00
摘要： Portable devices for anti-drug antibody (ADA) testing, to estimate safety and/or efficacy of therapeutic agents are provided. These devices can be used to perform point of care risk assessment for various applications, including but not restricted to one or more of the following: selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; patient immune status prior and after vaccination; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; testing pre-existing antibodies as a risk factor; postmarketing surveillance of therapeutic drugs.
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