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公开(公告)号：US08685895B2
公开(公告)日：2014-04-01
申请号：US13131640
申请日：2009-12-04
Applicant: Carolyn Enever , Laurent Jespers , Malgorzata Pupecka , Ian M Tomlinson
Inventor： Carolyn Enever , Laurent Jespers , Malgorzata Pupecka , Ian M Tomlinson
IPC: C40B40/10
CPC classification number: G01N33/6857 , C12Q1/37 , C40B40/10 , G01N33/6845 , G01N2500/02
Abstract: The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g., for treating disease in humans.
Abstract translation: 本公开涉及用于从文库或肽和多肽（例如，显示系统）的文库或所有组成部分中选择，分离和/或回收肽或多肽的方法，所述多肽和多肽（例如，显示系统）可通过蛋白酶例如在 血清。 通常，该方法包括提供肽或多肽的文库或谱库，在适用于蛋白酶活性的条件下用蛋白酶孵育文库或库，以及选择，分离和/或回收抗蛋白酶降解的肽或多肽 并具有所需的生物活性。 所选择的肽和多肽可用作治疗剂，例如用于治疗人类的疾病。
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公开(公告)号：US20100260763A1
公开(公告)日：2010-10-14
申请号：US12663498
申请日：2008-06-03
Applicant: Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
Inventor： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
IPC: A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , C07K14/00 , A61P11/00 , A61P31/04 , A61P19/02 , A61P1/00
CPC classification number: C07K16/2878 , A61K9/007 , A61K9/0078 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61K2039/544 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to anti-IL-1R1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
Abstract translation: 本发明涉及抗蛋白酶降解抗体的抗IL-1R1多肽和抗体单可变结构域（dAb），以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道， 以及用于治疗炎性疾病，例如关节炎或COPD。
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公开(公告)号：US20100247515A1
公开(公告)日：2010-09-30
申请号：US12663506
申请日：2008-06-04
Applicant: Michael Steward , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever , Laurent S. Jespers , Thil Dinuk Batuwangala
Inventor： Michael Steward , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever , Laurent S. Jespers , Thil Dinuk Batuwangala
IPC: A61K39/395 , C07K16/18 , A61P35/00 , A61P1/00 , A61P1/06
CPC classification number: C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
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公开(公告)号：US08398979B2
公开(公告)日：2013-03-19
申请号：US12663502
申请日：2008-06-04
Applicant: Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
Inventor： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
IPC: A61K39/395
CPC classification number: C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
Abstract translation: 本发明涉及抗TNFR1多肽和抗蛋白酶降解的抗体单可变结构域（dAb），以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道， 以及用于治疗炎性疾病，例如关节炎或COPD。
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公开(公告)号：US08357780B2
公开(公告)日：2013-01-22
申请号：US12663498
申请日：2008-06-03
Applicant: Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
Inventor： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
IPC: C07K16/00
CPC classification number: C07K16/2878 , A61K9/007 , A61K9/0078 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61K2039/544 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to anti-IL-1R1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
Abstract translation: 本发明涉及抗蛋白酶降解抗体的抗IL-1R1多肽和抗体单可变结构域（dAb），以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道， 以及用于治疗炎性疾病，例如关节炎或COPD。
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Patent Agency Ranking
公开(公告)号：US20100291103A1
公开(公告)日：2010-11-18
申请号：US12663505
申请日：2008-06-03
Applicant: Micheal Steward , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever , Laurent Jespers , Thil Dinuk Batuwangala
Inventor： Micheal Steward , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever , Laurent Jespers , Thil Dinuk Batuwangala
IPC: A61K39/395 , C07K16/22 , A61P35/00 , A61P29/00
CPC classification number: C07K16/2878 , C07K16/22 , C07K16/244 , C07K16/2866 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
Abstract translation: 本发明涉及对蛋白酶降解有抗性的抗VEGF多肽和抗体单可变结构域（dAb）以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用于肺部给药，口服给药，递送至肺部并递送至患者胃肠道，以及治疗癌症和炎性疾病如关节炎。
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公开(公告)号：US20100266616A1
公开(公告)日：2010-10-21
申请号：US12663502
申请日：2008-06-04
Applicant: Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
Inventor： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
CPC classification number: C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
Abstract translation: 本发明涉及抗TNFR1多肽和抗蛋白酶降解的抗体单可变结构域（dAb），以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道， 以及用于治疗炎性疾病，例如关节炎或COPD。
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公开(公告)号：US20100254972A1
公开(公告)日：2010-10-07
申请号：US12663491
申请日：2008-06-03
Applicant: Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
Inventor： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
CPC classification number: C07K16/2878 , A61K9/007 , A61K9/0078 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61K2039/544 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the GI tract or pulmonary tissue of a human. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, combining the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, eg for treating disease or conditions of GI tract or pulmonary tissue in humans.
Abstract translation: 本发明涉及一种用于从文库或肽和多肽（例如显示系统）的文库或组合库中选择，分离和/或回收肽或多肽的方法，所述多肽和多肽（例如，显示系统）可通过蛋白酶如蛋白酶 胃肠道或人体的肺组织。 通常，该方法包括提供肽或多肽的文库或库，在适用于蛋白酶活性的条件下将文库或库与蛋白酶组合，以及选择，分离和/或回收抗蛋白酶降解的肽或多肽 并具有所需的生物活性。 所选择的肽和多肽可用作治疗剂，例如用于治疗人类胃肠道或肺组织的疾病或病症。
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公开(公告)号：US09040668B2
公开(公告)日：2015-05-26
申请号：US13698794
申请日：2011-05-20
Applicant: Elena De Angelis , Carolyn Enever , Haiqun Liu , Oliver Schon , Malgorzata Pupecka-Swider
Inventor： Elena De Angelis , Carolyn Enever , Haiqun Liu , Oliver Schon , Malgorzata Pupecka-Swider
IPC: A61K39/395 , A61K39/00 , C12P21/08 , C07K14/765 , C07K19/00 , C07K16/46 , C07K16/18 , A61K47/48 , C07K16/28
CPC classification number: C07K16/18 , A61K47/6843 , A61K2039/505 , C07K14/765 , C07K16/2878 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/31 , C07K2319/33
Abstract: The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.
Abstract translation: 本发明涉及抗血清白蛋白免疫球蛋白单可变结构域DOM7h-11的改进变体，以及包含这些变体，组合物，核酸，载体和宿主的配体和药物偶联物。
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公开(公告)号：US20130129746A1
公开(公告)日：2013-05-23
申请号：US13698794
申请日：2011-05-20
Applicant: Elena De Angelis , Carolyn Enever , Haiqun Liu , Oliver Schon , Malgorzata Pupecka-Swider
Inventor： Elena De Angelis , Carolyn Enever , Haiqun Liu , Oliver Schon , Malgorzata Pupecka-Swider
CPC classification number: C07K16/18 , A61K47/6843 , A61K2039/505 , C07K14/765 , C07K16/2878 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/31 , C07K2319/33
Abstract: The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.
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