公开(公告)号：US20060154291A1

公开(公告)日：2006-07-13

申请号：US11348129

申请日：2006-02-06

申请人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  John Russell ,  Stephen Stroupe

发明人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  John Russell ,  Stephen Stroupe

IPC分类号： C12Q1/68 ,  A61K48/00 ,  A61K38/17 ,  C07H21/04 ,  C07K14/82 ,  C07K16/30

CPC分类号： C07K14/47 ,  C07K16/3015 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS322 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS322-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS322 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases

摘要翻译： 描述了一组连续且部分重叠的cDNA序列和由此编码的多肽，命名为BS322并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BS322编码的多肽或蛋白质的抗体以及预防组织特异性BS322多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤

公开(公告)号：US20050255519A1

公开(公告)日：2005-11-17

申请号：US11185111

申请日：2005-07-20

申请人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe ,  Hong Yu

发明人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe ,  Hong Yu

IPC分类号： A61K38/00 ,  C07K16/30 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K16/3069 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N2500/04

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为PS108并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS108编码的多肽或蛋白质的抗体，以及预防组织特异性PS108多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US20050208567A1

公开(公告)日：2005-09-22

申请号：US11122741

申请日：2005-05-05

申请人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Michael Klass ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe

发明人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Michael Klass ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe

IPC分类号： C12P19/34 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS123, and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate such as prostate cancer. Also provided are antibodies which specifically bind to PS123-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS123 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组由其编码的连续和部分重叠的RNA序列和多肽，命名为PS123，并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对诸如前列腺癌的前列腺疾病和病症的倾向。 还提供了特异性结合PS123编码的多肽或蛋白质的抗体，以及预防组织特异性PS123多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US20050158753A1

公开(公告)日：2005-07-21

申请号：US11007835

申请日：2004-12-08

申请人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Mark Hayden ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  John Russell ,  Stephen Stroupe

发明人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Mark Hayden ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  John Russell ,  Stephen Stroupe

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C12P19/34

CPC分类号： C07K16/3046 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：US20050153373A1

公开(公告)日：2005-07-14

申请号：US10991681

申请日：2004-11-18

申请人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe

发明人： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/574 ,  C07K14/705 ,  C12N5/06

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4748 ,  C07K16/3015 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57415

摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：USD473670S1

公开(公告)日：2003-04-22

申请号：US29137588

申请日：2001-02-23

申请人： Victor Kelmelis ,  Maurice Cohen

设计人： Victor Kelmelis ,  Maurice Cohen

公开(公告)号：US06538119B2

公开(公告)日：2003-03-25

申请号：US09193881

申请日：1998-11-18

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Edward N. Granados ,  Michael R. Klass ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C07H2102

CPC分类号： C07K14/47

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS249 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS249-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS249 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases

摘要翻译： 描述了一组由此编码的连续和部分重叠的cDNA序列和多肽，命名为BS249并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BS249编码的多肽或蛋白质的抗体，以及预防组织特异性BS249多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤

公开(公告)号：US06485626B1

公开(公告)日：2002-11-26

申请号：US09423925

申请日：2000-01-31

申请人： Samuele Bottani ,  Rainer Siebert ,  Hans Rebscher ,  Maurice Cohen-Solal ,  Luc Valentin

发明人： Samuele Bottani ,  Rainer Siebert ,  Hans Rebscher ,  Maurice Cohen-Solal ,  Luc Valentin

IPC分类号： G01N2726

CPC分类号： G01N27/44782 ,  G01N27/44704

摘要： The invention concerns a multiple capillary electrophoresis device comprising a plurality of juxtaposed capillaries, means for generating inside the capillaries an electric field ensuring electrophoretic migration, at least one source for emitting a beam dsigned to exite the molecules at the capillary output, means for detecting the fluorescence of the molecules excited by said beam. The invention also comprises means for generating another electric field, called confinement electric field, which is regularly distributed around said capillaries and which is substantially parallel thereto, said electric field confining the electrophoretic migration field and forcing the molecules to move substantially without divergence in the axis of said capillaries.

摘要翻译： 本发明涉及一种多毛细管电泳装置，其包括多个并置的毛细管，用于在毛细管内产生确保电泳迁移的电场的装置，至少一个用于发射被排斥以在毛细管输出处排出分子的束的源，用于检测 由所述光束激发的分子的荧光。 本发明还包括用于产生称为限制电场的另一电场的装置，其被规则地分布在所述毛细管周围并且基本上与其平行，所述电场限制了电泳迁移场，并迫使分子基本上在轴线上没有发散 的毛细血管。

公开(公告)号：US06368792B1

公开(公告)日：2002-04-09

申请号：US09049698

申请日：1998-03-27

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K16/3046 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS193 and transcribed from GI tract tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS193-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS193 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：US06183952B2

公开(公告)日：2001-02-06

申请号：US08912276

申请日：1997-08-15

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  Y10S435/81

摘要： A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

摘要翻译： 描述了称为BU101的蛋白质的子宫肌血清蛋白家族的新成员。 BU101由一组从乳腺组织转录的连续和部分重叠的RNA序列以及由此编码的多肽来定义。 还公开了表示BU101的最长连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合BU101编码的多肽或蛋白质的抗体，以及预防组织特异性BU101多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。