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公开(公告)号：US20110223058A1
公开(公告)日：2011-09-15
申请号：US13001478
申请日：2009-06-26
Applicant: David Whitten , Yanli Tang , Zhijun Zhou , Linnea Ista , Motokatsu Ogawa , David Keller , Brett Andrzejewski , Gabriel Lopez , Kirk Schanze
Inventor： David Whitten , Yanli Tang , Zhijun Zhou , Linnea Ista , Motokatsu Ogawa , David Keller , Brett Andrzejewski , Gabriel Lopez , Kirk Schanze
IPC: A61L2/10 , C07C229/38 , C07C211/63 , C12Q1/04 , A61K31/24 , A61K31/14 , C07H21/04
CPC classification number: C07C217/20 , A01N33/12 , A01N37/38
Abstract: Novel compounds generally referred to herein as cationic oligomeric phenylene ethynylenes (OPEs), methods of synthesizing OPEs and various uses for the OPEs are described. The compounds can be synthesized in both symmetrical (S-OPE) and non-symmetrical (N-OPE) forms. Suitable uses include sensor and biocidal applications. Reusable structures incorporating the OPEs that are able to capture and release biological species of interest are also described.
Abstract translation: 本文中通常称为阳离子低聚亚苯基乙烯基（OPE）的新型化合物，OPE的合成方法和OPE的各种用途。 这些化合物可以以对称（S-OPE）和非对称（N-OPE）的形式合成。 合适的用途包括传感器和杀菌剂应用。 还描述了结合能够捕获和释放感兴趣的生物物种的OPE的可再利用结构。
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公开(公告)号：US20060065528A1
公开(公告)日：2006-03-30
申请号：US11050424
申请日：2005-02-03
Applicant: Gabriel Lopez , Steven Brueck , Linnea Ista , Michael O'Brien
Inventor： Gabriel Lopez , Steven Brueck , Linnea Ista , Michael O'Brien
CPC classification number: B82Y30/00 , B01L3/5027 , B01L2300/0896 , B82Y15/00 , G01N27/44791
Abstract: Methods for forming an apparatus containing a nanofluidic device with a pattern having nanoscopic features includes producing a regular interference pattern in a substrate using two coherent light beams. In an embodiment, an apparatus includes a nanofluidic device having nanoscopic features in at least two dimensions. In an embodiment, a nanofludic device having nanoscopic features is formed using an ultraviolet source to generate a regular interference pattern.
Abstract translation: 用于形成包含具有纳米尺度特征的图案的纳米流体装置的装置的方法包括使用两个相干光束在衬底中产生规则的干涉图案。 在一个实施例中，一种装置包括具有至少两个维度的纳米尺度特征的纳米流体装置。 在一个实施例中，使用紫外线源形成具有纳米特征的纳米非线性器件以产生规则的干涉图案。
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公开(公告)号：US20060169587A1
公开(公告)日：2006-08-03
申请号：US10958113
申请日：2004-10-04
Applicant: Gabriel Lopez , Steve Brueck , Linnea Ista , Anthony Garcia , Dmiter Petsev , Paul Bisong , Michael O'Brien
Inventor： Gabriel Lopez , Steve Brueck , Linnea Ista , Anthony Garcia , Dmiter Petsev , Paul Bisong , Michael O'Brien
IPC: C07K1/26
CPC classification number: C07K1/26 , Y10S977/924 , Y10S977/962
Abstract: A method for separation of mixtures in fluidic systems through electrokinetic transport by use of nanochannels when the fluidic systems approach the size of an electrical double layer, thereby allowing separation based on charge. The disclosed apparatus comprises a T-chip with a nanochannel section. The method and apparatus are useful for separation of many molecular species, including peptides, proteins, and DNA.
Abstract translation: 当流体系统接近电双层的尺寸时，通过使用纳米通道的电动运输来分离流体系统中的混合物的方法，从而允许基于电荷的分离。 所公开的装置包括具有纳米通道部分的T芯片。 该方法和装置可用于分离许多分子物质，包括肽，蛋白质和DNA。
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4.发明申请公开(公告)号：US20050013988A1
公开(公告)日：2005-01-20
申请号：US10826667
申请日：2004-04-16
Applicant: Qiang Fu , Venkata Goparaju , Linnea Ista , Yang Wu , Brett Andrzejewski , Yunfeng Lu , Larry Sklar , Timothy Ward , Gabriel Lopez
Inventor： Qiang Fu , Venkata Goparaju , Linnea Ista , Yang Wu , Brett Andrzejewski , Yunfeng Lu , Larry Sklar , Timothy Ward , Gabriel Lopez
CPC classification number: C01B39/02 , C01B37/00 , C01B37/02 , C01F7/02 , C01P2006/16 , Y10T428/24694 , Y10T428/249955 , Y10T428/249956 , Y10T428/268
Abstract: The present subject matter relates generally to design, synthesis, and characterization of materials with well-defined porous networks of molecular dimensions in which the size and surface energy of the pores can be externally and reversibly controlled to dynamically modulate the adsorption and transport of molecular species.
Abstract translation: 本主题一般涉及具有明确的分子尺寸多孔网络的材料的设计，合成和表征，其中孔的尺寸和表面能可以被外部和可逆地控制以动态调节分子种类的吸附和运输 。
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公开(公告)号：US08455265B2
公开(公告)日：2013-06-04
申请号：US12529390
申请日：2008-02-29
Applicant: David G. Whitten , Sireesha Chemburu , Thomas Corbitt , Linnea Ista , Gabriel Lopez , Kirk S. Schanze , Motokatsu Ogawa , Eunkyung Ji
Inventor： David G. Whitten , Sireesha Chemburu , Thomas Corbitt , Linnea Ista , Gabriel Lopez , Kirk S. Schanze , Motokatsu Ogawa , Eunkyung Ji
IPC: G01N33/552 , G01N33/543
CPC classification number: C07K17/08 , C07K1/1077 , G01N33/542 , G01N33/54313 , Y10T436/14 , Y10T436/141111 , Y10T436/142222 , Y10T436/143333 , Y10T436/144444 , Y10T436/145555 , Y10T436/146666 , Y10T436/147777
Abstract: A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.
Abstract translation: 表面接枝共轭聚电解质（CPE）通过将CPE通过偶联部分偶联到基材的表面而形成。 衬底可以是任何形状和尺寸，并且对于表面接枝CPE的许多用途，衬底是纳米颗粒或微粒是有利的。 提出了使用二氧化硅颗粒作为底物的表面接枝CPE，其中改性的硅烷偶联剂通过一系列共价键将表面连接到CPE。 提出了两种制备表面接枝CPE的方法。 一种方法包括包含被偶联剂改性的表面，并与接枝状态的形成CPE的单体冷凝。 第二种方法包括形成具有末端基团的CPE，其与通过与偶联剂反应放置在基底表面上的官能度互补。 表面接枝的CPE也被描述为用作生物传感器和杀生物剂。
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Patent Agency Ranking
公开(公告)号：US20110159605A1
公开(公告)日：2011-06-30
申请号：US12529390
申请日：2008-02-29
Applicant: David G. Whitten , Sireesha Chemburu , Thomas Corbitt , Linnea Ista , Gabriel Lopez , Kirk S. Schanze , Motokatsu Ogawa , Eunkyung Ji
Inventor： David G. Whitten , Sireesha Chemburu , Thomas Corbitt , Linnea Ista , Gabriel Lopez , Kirk S. Schanze , Motokatsu Ogawa , Eunkyung Ji
CPC classification number: C07K17/08 , C07K1/1077 , G01N33/542 , G01N33/54313 , Y10T436/14 , Y10T436/141111 , Y10T436/142222 , Y10T436/143333 , Y10T436/144444 , Y10T436/145555 , Y10T436/146666 , Y10T436/147777
Abstract: A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.
Abstract translation: 表面接枝共轭聚电解质（CPE）通过将CPE通过偶联部分偶联到基材的表面而形成。 衬底可以是任何形状和尺寸，并且对于表面接枝CPE的许多用途，衬底是纳米颗粒或微粒是有利的。 提出了使用二氧化硅颗粒作为底物的表面接枝CPE，其中改性的硅烷偶联剂通过一系列共价键将表面连接到CPE。 提出了两种制备表面接枝CPE的方法。 一种方法包括包含被偶联剂改性的表面，并与接枝状态的形成CPE的单体冷凝。 第二种方法包括形成具有末端基团的CPE，其与通过与偶联剂反应放置在基底表面上的官能度互补。 表面接枝的CPE也被描述为用作生物传感器和杀生物剂。
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公开(公告)号：US08895321B2
公开(公告)日：2014-11-25
申请号：US13104200
申请日：2011-05-10
Applicant: Gabriel Lopez , Linnea Ista , Steven RJ Brueck , Aurelio Evangelista Lara , Mangesh Bore
Inventor： Gabriel Lopez , Linnea Ista , Steven RJ Brueck , Aurelio Evangelista Lara , Mangesh Bore
IPC: G01N33/537 , G01N27/447
CPC classification number: G01N27/44721 , G01N33/5304 , G01N33/54366 , Y10S977/92
Abstract: Device and method for detecting the presence of known or unknown toxic agents in a fluid sample. Targets in the sample are bound to releasable receptors immobilized in a reaction region of a micro- or nano-fluidic device. The receptors are selected based on their affinity for classes of known toxic agents. The receptors are freed and the bound and unbound receptors separated based on differential electrokinetic mobilities while they travel to a detection device.
Abstract translation: 用于检测流体样品中已知或未知毒物的存在的装置和方法。 样品中的靶标与固定在微流体或纳米流体装置的反应区域中的可释放受体结合。 基于它们对已知毒性剂类的亲和性来选择受体。 受体被释放，并且结合和未结合的受体在移动到检测装置的同时基于差异电动迁移率分离。
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公开(公告)号：US08753570B2
公开(公告)日：2014-06-17
申请号：US13001478
申请日：2009-06-26
Applicant: David Whitten , Yanli Tang , Zhijun Zhou , Linnea Ista , Motokatsu Ogawa , David Keller , Brett Andrzejewski , Gabriel Lopez , Kirk Schanze
Inventor： David Whitten , Yanli Tang , Zhijun Zhou , Linnea Ista , Motokatsu Ogawa , David Keller , Brett Andrzejewski , Gabriel Lopez , Kirk Schanze
IPC: A61L2/00 , A61L2/18 , A61L9/00 , C07C239/00 , C07C259/00
CPC classification number: C07C217/20 , A01N33/12 , A01N37/38
Abstract: Novel compounds generally referred to herein as cationic oligomeric phenylene ethynylenes (OPEs), methods of synthesizing OPEs and various uses for the OPEs are described. The compounds can be synthesized in both symmetrical (S-OPE) and non-symmetrical (N-OPE) forms. Suitable uses include sensor and biocidal applications. Reusable structures incorporating the OPEs that are able to capture and release biological species of interest are also described.
Abstract translation: 本文中通常称为阳离子低聚亚苯基乙烯基（OPE）的新型化合物，OPE的合成方法和OPE的各种用途。 这些化合物可以以对称（S-OPE）和非对称（N-OPE）的形式合成。 合适的用途包括传感器和杀菌剂应用。 还描述了结合能够捕获和释放感兴趣的生物物种的OPE的可再利用结构。
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9.发明申请公开(公告)号：US20140110258A1
公开(公告)日：2014-04-24
申请号：US13104200
申请日：2011-05-10
Applicant: Gabriel Lopez , Linnea Ista , Steven RJ Brueck , Aurelio Evangelista Lara , Mangesh Bore
Inventor： Gabriel Lopez , Linnea Ista , Steven RJ Brueck , Aurelio Evangelista Lara , Mangesh Bore
IPC: G01N27/447
CPC classification number: G01N27/44721 , G01N33/5304 , G01N33/54366 , Y10S977/92
Abstract: Device and method for detecting the presence of known or unknown toxic agents in a fluid sample. Targets in the sample are bound to releasable receptors immobilized in a reaction region of a micro- or nano-fluidic device. The receptors are selected based on their affinity for classes of known toxic agents. The receptors are freed and the bound and unbound receptors separated based on differential electrokinetic mobilities while they travel to a detection device.
Abstract translation: 用于检测流体样品中已知或未知毒物的存在的装置和方法。 样品中的靶标与固定在微流体或纳米流体装置的反应区域中的可释放受体结合。 基于它们对已知毒性剂类的亲和性来选择受体。 受体被释放，并且结合和未结合的受体在移动到检测装置的同时基于差异电动迁移率分离。
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公开(公告)号：US07959861B2
公开(公告)日：2011-06-14
申请号：US12102663
申请日：2008-04-14
Applicant: Gabriel Lopez , Linnea Ista , Steven R J Brueck , Aurelio Evangelista Lara , Mangesh Bore
Inventor： Gabriel Lopez , Linnea Ista , Steven R J Brueck , Aurelio Evangelista Lara , Mangesh Bore
CPC classification number: G01N27/44721 , G01N33/5304 , G01N33/54366 , Y10S977/92
Abstract: Device and method for detecting the presence of known or unknown toxic agents in a fluid sample. Targets in the sample are bound to releasable receptors immobilized in a reaction region of a micro- or nano-fluidic device. The receptors are selected based on their affinity for classes of known toxic agents. The receptors are freed and the bound and unbound receptors separated based on differential electrokinetic mobilities while they travel to a detection device.
Abstract translation: 用于检测流体样品中已知或未知毒物的存在的装置和方法。 样品中的靶标与固定在微流体或纳米流体装置的反应区域中的可释放受体结合。 基于它们对已知毒性剂类的亲和性来选择受体。 受体被释放，并且结合和未结合的受体在移动到检测装置的同时基于差异电动迁移率分离。
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