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公开(公告)号：US11779716B2
公开(公告)日：2023-10-10
申请号：US16635657
申请日：2018-08-01
IPC分类号： A61M15/00 , B05D7/14 , B05D7/00 , C08G65/336 , C08G75/20
CPC分类号： A61M15/0066 , B05D7/14 , B05D7/52 , C08G65/336 , C08G75/20 , A61M2205/0238 , B05D2202/15 , B05D2202/25 , B05D2506/10 , B05D2518/00 , C08G2650/48
摘要： Methods of making components for a medicinal delivery device are described, in which a base composition comprising a polysulphone is applied to the surface of a component to create a base layer, a primer composition comprising a silane having two or more reactive silane groups separated by an organic linker group is applied to the base layer to create primed surface, and a coating composition comprising an at least partially fluorinated compound is applied to the primed surface. Corresponding coated components and a medicinal delivery device are disclosed.
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公开(公告)号：US11771878B2
公开(公告)日：2023-10-03
申请号：US16909723
申请日：2020-06-23
CPC分类号： A61M37/0015 , A61M5/14248 , A61M5/322 , A61M5/3297 , A61M2037/0023 , A61M2037/0061
摘要： A microneedle injection and infusion apparatus, and a method of using same. The apparatus can include a housing, a microneedle array holder for holding a microneedle array, and a shuttle that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.
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公开(公告)号：US20230285697A1
公开(公告)日：2023-09-14
申请号：US18018365
申请日：2021-07-28
申请人： Andrew Robert Cooper , Christopher George Blatchford , Stephen Howgill , Barzin Gavtash , Benjamin James Myatt , Hendrik Versteeg , Kerry Ward , Lee Michael Hodges , Sam Oladele Apoola , John Paul Bunting , KINDEVA DRUG DELIVERY L.P.
发明人： Andrew Robert Cooper , Christopher George Blatchford , Stephen Howgill , Barzin Gavtash , Benjamin James Myatt , Hendrik Versteeg , Kerry Ward , Lee Michael Hodges , Sam Oladele Apoola , John Paul Bunting
CPC分类号： A61M15/08 , A61M15/0065 , A61M15/0086
摘要： Various embodiments of a device for delivery of a medicament and a method of utilizing such device are disclosed. The device can include a canister and an actuator. The actuator includes a housing receiving the canister; a valve block receiving a metering valve of the canister, the valve block defining an expansion chamber for passage of propellant and medicament expelled from the canister; and a nosepiece for insertion into a user's nostril, the nosepiece including a fluid passage and a delivery opening for expulsion of the propellant and medicament into the user's nostril. A flow path is defined through the actuator for passage of propellant and medicament from the canister and includes the expansion chamber, the fluid passage and the delivery opening. Further, the cross-sectional area of the flow path is greater than the lowest cross-sectional area of the metering valve at all points along the flow path.
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公开(公告)号：US20230165723A1
公开(公告)日：2023-06-01
申请号：US17921774
申请日：2021-04-27
发明人： Adam S. Cantor , Daniel H. Carlson , John R. Fenton , John R. Hart , Glen A. Jerry , Gordon P. Knutson , Jonathan J. O'Hare , Mikhail L. Pekurovsky , Timothy A. Peterson , Karl K. Stensvad
CPC分类号： A61F13/00063 , A61F13/025 , A61F13/0253 , A61F13/0289 , A61K9/7061 , A61F2013/0071 , A61F2013/0296
摘要： Various embodiments of an adhesive article and a method of forming such article are disclosed. The adhesive article includes an active pharmaceutical ingredient; a substrate having a first surface and a second surface including a first area and a second area; and a first adhesive layer disposed on the first area of the second surface of the substrate. The active pharmaceutical ingredient is present in the first adhesive layer at a first concentration. The adhesive article also includes a second adhesive layer having a first portion that is in contact with the first adhesive layer and a second portion that is disposed in the second area of the substrate. The active pharmaceutical ingredient is present in the second adhesive layer at a second concentration. The second concentration is less than the first concentration.
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公开(公告)号：US11577900B2
公开(公告)日：2023-02-14
申请号：US17420918
申请日：2020-01-07
发明人： Peter P. Evanson
摘要： A packaging system for microarrays, such as microarrays of microneedles, comprising inner and outer pouches (500, 5000).
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公开(公告)号：US11497866B2
公开(公告)日：2022-11-15
申请号：US16331213
申请日：2017-09-05
发明人： Stephen J. Howgill
IPC分类号： A61M15/00
摘要： A breath-responsive metered dose inhaler having a trigger mechanism for triggering delivery of a medicament and a trigger mechanism chassis for locating the trigger mechanism within the inhaler, the trigger mechanism including a breath responsive member moveable upon inhalation of the user from a primed position in which the inhaler is prevented from delivering medicament, to a triggered position in which the medicament is delivered to the user, a spring which is flexible along its longitudinal axis, wherein the spring is configured to bias the breath responsive member from its triggered position to its primed position by flexure along its longitudinal axis.
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公开(公告)号：US20220008352A1
公开(公告)日：2022-01-13
申请号：US17482871
申请日：2021-09-23
IPC分类号： A61K9/70 , A61K31/4468 , A61K9/00 , A61K31/44
摘要： A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.
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公开(公告)号：US20210260310A1
公开(公告)日：2021-08-26
申请号：US16973863
申请日：2019-06-26
摘要： A metered dose inhaler equipped with a metering valve and having an aerosol canister containing a pharmaceutical composition comprising propellant, ethanol, citric acid, and tiotropium or a pharmaceutically acceptable salt or solvate thereof dissolved in the composition, wherein the aerosol canister has an internal surface that is a non-metal material that is in contact with the pharmaceutical composition.
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公开(公告)号：US20210228119A1
公开(公告)日：2021-07-29
申请号：US17054253
申请日：2019-05-13
发明人： Chin-Yee NG , Scott A. Burton , Kandyce M. Bohannon , Chu Yi
IPC分类号： A61B5/1486 , A61B5/00 , A61B5/145
摘要： Device with probe located within hollow microneedles and having a ping to protect the probe from damage, and method of using the same to detect analyte.
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公开(公告)号：US20210215616A1
公开(公告)日：2021-07-15
申请号：US15734013
申请日：2019-06-13
摘要： A process of making a microneedle array comprising providing a microneedle array having a plurality of microneedles of a desired shape, illuminating at least a portion of said microneedle array that comprises at least one microneedle, capturing an observed image of said at least one microneedle using an optical device, electronically processing said observed image and determining at least one shape parameter for said at least one microneedle, accepting said microneedle array if said at least one shape parameter is within an acceptable range, thereby providing a microneedle array that comprises a known shape of the plurality of microneedles.
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