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    Luminescent macrocyclic lanthanide complexes
    5.
    发明授权
    Luminescent macrocyclic lanthanide complexes 有权
    发光大环镧系元素络合物

    公开(公告)号：US08729258B2

    公开(公告)日：2014-05-20

    申请号：US13460120

    申请日：2012-04-30

    申请人： Kenneth N. Raymond ,  Todd M. Corneillie ,  Jide Xu

    发明人： Kenneth N. Raymond ,  Todd M. Corneillie ,  Jide Xu

    IPC分类号： A01N55/02 ,  A61K31/40 ,  C07B47/00 ,  C07D487/22

    CPC分类号： G01N33/582 ,  G01N2458/40

    摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

    摘要翻译： 本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。 优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。 优选的化合物在其大环结构内掺入羟基间苯二酰胺部分，其特征在于与各种多肽例如抗体和蛋白质以及高动力学稳定性令人惊奇的低非特异性结合。 这些特征将它们与已知的开放结构的配体区分开来。

    Process for preparing 2,3-dihydroxybenzoic acid amides of tetraazaalkanes and cycloalkanes
    7.
    发明授权
    Process for preparing 2,3-dihydroxybenzoic acid amides of tetraazaalkanes and cycloalkanes 失效
    制备四氮杂烷烃和环烷烃的2,3-二羟基苯甲酸酰胺的方法

    公开(公告)号：US4543213A

    公开(公告)日：1985-09-24

    申请号：US64593

    申请日：1979-08-07

    申请人： Frederick L. Weitl ,  Kenneth N. Raymond

    发明人： Frederick L. Weitl ,  Kenneth N. Raymond

    IPC分类号： C07D257/02

    CPC分类号： C07D257/02

    摘要： A compound of the formula: ##STR1## wherein X is hydrogen or a conventional electron-withdrawing group, particularly --SO.sub.3 H or a salt thereof; n is 2, 3, or 4; m is 2, 3, or 4; and p is 2 or 3. The present compounds are useful as specific sequestering agents for actinide (IV) ions. Also described is a method for the 2,3-dihydroxybenzamidation of azaalkanes.

    摘要翻译： 下式的化合物：其中X为氢或常规吸电子基团，特别是-SO 3 H或其盐; n为2,3或4; m为2,3或4; 并且p为2或3.本发明化合物可用作锕系元素（IV）离子的特定螯合剂。 还描述了氮杂烷烃的2,3-二羟基苯甲酰胺化方法。

    Combination Treatment of Hydroxpyridonate Actinide/Lanthanide Decorporation Agents
    8.
    发明申请
    Combination Treatment of Hydroxpyridonate Actinide/Lanthanide Decorporation Agents 审中-公开
    羟基吡啶酮锕系元素/镧系元素的组合处理

    公开(公告)号：US20120214843A1

    公开(公告)日：2012-08-23

    申请号：US13291383

    申请日：2011-11-08

    申请人： Patricia W. Durbin-Heavey ,  Leonore Frances Heavey ,  Kenneth N. Raymond ,  Rebecca J. Abergel ,  David K. Shuh

    发明人： Patricia W. Durbin-Heavey ,  Leonore Frances Heavey ,  Kenneth N. Raymond ,  Rebecca J. Abergel ,  David K. Shuh

    IPC分类号： A61K31/444 ,  A61P39/04

    CPC分类号： A61K31/444

    摘要： The invention provides for a method for treating a subject in need of such treatment comprising administering a therapeutically effective amount of one or more pharmaceutical compositions comprising a 1,2-HOPO chelating agent and a 3,2-HOPO chelating agent to a subject in need of such treatment. The use of both 1,2-HOPO and a 3,2-HOPO chelating agents in combination is more effective than using only one chelating agent alone. The invention is especially useful when practiced on a subject that has been exposed to, have been in contact with, or contaminated by one or more known or unknown actinides and/or lanthanides, or a mixture thereof.

    摘要翻译： 本发明提供了治疗需要这种治疗的受试者的方法，其包括向需要治疗的受试者施用治疗有效量的包含1,2-HOPO螯合剂和3,2-HOPO螯合剂的一种或多种药物组合物 的这种治疗。 组合使用1,2-HOPO和3,2-HOPO螯合剂比仅使用一种螯合剂更有效。 当已经暴露于已经被一种或多种已知或未知的锕系元素和/或镧系元素或其混合物暴露于，已经接触或污染的对象上时，本发明是特别有用的。

    MACROCYCLIC HOPO CHELATORS
    9.
    发明申请
    MACROCYCLIC HOPO CHELATORS 有权
    大理石叛徒

    公开(公告)号：US20120214253A1

    公开(公告)日：2012-08-23

    申请号：US13392506

    申请日：2010-08-24

    申请人： Nathaniel G. Butlin ,  Kenneth N. Raymond ,  Jide Xu ,  Anthony D'Aleo

    发明人： Nathaniel G. Butlin ,  Kenneth N. Raymond ,  Jide Xu ,  Anthony D'Aleo

    IPC分类号： G01N21/76 ,  C07F5/00 ,  C07D401/14 ,  C07D471/22

    CPC分类号： G01N33/582 ,  C07D487/18 ,  C07D498/22 ,  G01N21/6428 ,  G01N33/533 ,  G01N2021/6432 ,  G01N2021/6439

    摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

    摘要翻译： 本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。 优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。 优选的化合物在其大环结构内包含羟基吡啶基部分，其特征在于与多种多肽如抗体和蛋白质具有惊人的低，非特异性结合以及高动力学稳定性。