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    Amino acid isomers, their production and their medicinal use
    3.
    发明授权
    Amino acid isomers, their production and their medicinal use 失效
    氨基酸异构体，其生产及其药用

    公开(公告)号：US4483853A

    公开(公告)日：1984-11-20

    申请号：US434361

    申请日：1982-10-14

    申请人： James F. Collins ,  Kenneth Curry ,  Robert Schwarcz

    发明人： James F. Collins ,  Kenneth Curry ,  Robert Schwarcz

    IPC分类号： C07F5/02 ,  A61K31/195 ,  A61K31/22 ,  A61K31/41 ,  A61P25/00 ,  A61P25/08 ,  C07C67/00 ,  C07C301/00 ,  C07C303/16 ,  C07C309/18 ,  C07D257/04 ,  C07F9/09 ,  C07F9/38 ,  C07F9/40 ,  A61K31/66 ,  A61K31/16 ,  A61K31/19

    CPC分类号： C07F9/3808 ,  C07F9/4006

    摘要： The (-)-D-isomers of compounds of the general formula ##STR1## in which X stands for an acidic radical, especially a radical of phosphonic acid, sulphonic acid, boronic acid or tetrazole,R stands for an alkylene, alkenylene or alkynylene radical with 3 or more carbon atoms, preferably 3 to 6 carbon atoms, or a C.sub.3 to C.sub.7 cycloalkyl radical, andA and B independently of each other stand for a hydrogen atom or a lipophilic radical, especially an ester radical,or salts thereof, or pharmaceutically acceptable bioprecursors thereof, especially (-)-D-aminophosphonopentanoic acid and (-)-D-aminophosphonoheptanoic acid, find use in the treatment of diseases of the central nervous system.The compound aminophosphonoheptanoic acid is also novel as a racemic mixture and the present invention also relates to that compound in racemic form which may be used in the same way as the said (-)-D-isomers.

    摘要翻译： 其中X代表酸性基团，特别是膦酸，磺酸，硼酸或四唑基团的通式为（IMA）的化合物的（ - ） - D-异构体，R代表亚烷基， 具有3个或更多个碳原子，优选3至6个碳原子或C3至C7环烷基的亚烯基或亚链炔基，A和B彼此独立地代表氢原子或亲油基团，特别是酯基，或 其盐或其药学上可接受的生物前体，特别是（ - ） - - - - - - - - - - - - - - - - - - - - 氨基膦酰基庚酸，（ - ） - D - 氨基膦酰庚酸可用于治疗中枢神经系统疾病。 化合物氨基膦酰庚酸也是新的外消旋混合物，本发明还涉及外消旋化合物，其可以以与所述（ - ） - D-异构体相同的方式使用。

    Method of Packaging and Package for Sensors
    4.
    发明申请
    Method of Packaging and Package for Sensors 审中-公开
    传感器封装方法和封装方法

    公开(公告)号：US20100293892A1

    公开(公告)日：2010-11-25

    申请号：US12624717

    申请日：2009-11-24

    申请人： Kenneth Curry ,  Todd Fjield ,  Michael J. Higgins ,  Patrick Carlin ,  Gregory J. Carlin

    发明人： Kenneth Curry ,  Todd Fjield ,  Michael J. Higgins ,  Patrick Carlin ,  Gregory J. Carlin

    IPC分类号： B65B31/00 ,  B65D85/38

    CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B2562/242 ,  B65D81/05 ,  B65D81/2061 ,  B65D81/2084

    摘要： There are provided methods of packaging and packages that prevent damage of the package contents while maintaining sterility and that limit the negative effects of sterilization on sensors such as enzyme sensors. A method of packaging an enzyme sensor includes providing an enzyme sensor such as a glucose oxidase sensor in a gas impermeable package comprising one or more of oxygen and water, removing a significant portion of the oxygen and water present in the package, and sealing the package. The resulting package comprises the enzyme sensor in an atmosphere that is substantially free of oxygen and water. The package can also include a pressure indicator that indicates when the package has exceeded a predetermined pressure.

    摘要翻译： 提供了包装和包装的方法，其防止包装内容物的损害，同时保持无菌性，并限制灭菌对诸如酶传感器的传感器的消极作用。 包装酶传感器的方法包括在包含氧和水中的一种或多种的不透气包装中提供诸如葡萄糖氧化酶传感器的酶传感器，除去存在于包装中的大部分氧气和水，并密封包装 。 所得包装包含基本上不含氧和水的气氛中的酶传感器。 该包装还可以包括一个压力指示器，指示包装何时超过预定压力。

    FLEXIBLE CIRCUIT AND METHOD FOR FORMING THE SAME
    5.
    发明申请
    FLEXIBLE CIRCUIT AND METHOD FOR FORMING THE SAME 审中-公开
    柔性电路及其形成方法

    公开(公告)号：US20100305420A1

    公开(公告)日：2010-12-02

    申请号：US12790387

    申请日：2010-05-28

    申请人： Kenneth Curry

    发明人： Kenneth Curry

    IPC分类号： A61B5/1473 ,  H01L29/66 ,  H01L21/02

    CPC分类号： G01N27/3272 ,  H01L23/4985 ,  H01L2924/0002 ,  H05K1/118 ,  H01L2924/00

    摘要： A flexible circuit is provided herein that includes conductive material on the top and bottom planar surfaces of a dielectric substrate. The flexible circuit can be used in various applications, including use as a sensor. A via is used to provide electrical communication between the top and bottom surface of the flexible circuit. A method of preparing a flexible circuit and a medical instrument including the flexible circuit are also provided.

    摘要翻译： 本文提供了一种柔性电路，其包括在电介质基底的顶部和底部平坦表面上的导电材料。 柔性电路可用于各种应用，包括用作传感器。 通孔用于在柔性电路的顶表面和底表面之间提供电连通。 还提供了制备柔性电路的方法和包括柔性电路的医疗器械。

    Xanthenyl cubane analogs with activity at the metabotropic glutamate receptors
    6.
    发明申请
    Xanthenyl cubane analogs with activity at the metabotropic glutamate receptors 审中-公开
    在代谢型谷氨酸受体上具有活性的Xanthenyl立方类似物

    公开(公告)号：US20060025471A1

    公开(公告)日：2006-02-02

    申请号：US10527955

    申请日：2003-09-12

    申请人： Kenneth Curry

    发明人： Kenneth Curry

    IPC分类号： C07D335/08 ,  C07D409/02 ,  A61K31/382 ,  A61K31/675 ,  A61K31/42 ,  A61K31/41

    CPC分类号： C07D335/20 ,  C07D311/90

    摘要： The present invention relates to therapeutically active cubane compounds, a method of preparing the same, and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating and preventing diseases of the central nervous system related to the metabotropic glutamate receptor system.

    摘要翻译： 本发明涉及治疗活性的立体化合物，其制备方法和包含该化合物的药物组合物。 该新化合物可用于治疗和预防与代谢型谷氨酸受体系统相关的中枢神经系统疾病。

    TEMPERATURE COMPENSATION FOR ENZYME ELECTRODES
    8.
    发明申请
    TEMPERATURE COMPENSATION FOR ENZYME ELECTRODES 审中-公开
    ENZYME电极温度补偿

    公开(公告)号：US20080125751A1

    公开(公告)日：2008-05-29

    申请号：US11940037

    申请日：2007-11-14

    申请人： Todd Fjield ,  Michael Higgins ,  Kenneth Curry ,  Patrick Carlin

    发明人： Todd Fjield ,  Michael Higgins ,  Kenneth Curry ,  Patrick Carlin

    IPC分类号： A61M25/00 ,  C12Q1/00

    CPC分类号： C12Q1/001 ,  C12Q1/006 ,  G01N33/5302

    摘要： A temperature compensation method for an enzyme electrode by measuring an operating temperature of the enzyme electrode, measuring the current generated by the enzyme electrode determining a deviation in measurement between the current generated and a reference current at the operating temperature, determining an enzyme concentration corresponding to the measured current, and calibrating the enzyme concentration to compensate for the deviation in measurement.

    摘要翻译： 通过测量酶电极的操作温度来测量酶电极的温度补偿方法，测量由酶电极产生的电流，确定在工作温度下产生的电流与参考电流之间的测量偏差，确定对应于 测量电流，并校准酶浓度以补偿测量的偏差。

    TARGETED CONTRAST AGENTS AND USES THEREOF
    10.
    发明申请
    TARGETED CONTRAST AGENTS AND USES THEREOF 审中-公开
    具有针对性的对照代理及其用途

    公开(公告)号：US20140065075A1

    公开(公告)日：2014-03-06

    申请号：US14112349

    申请日：2012-04-17

    申请人： Jidong Zhang ,  Kenneth Curry

    发明人： Jidong Zhang ,  Kenneth Curry

    IPC分类号： A61K49/10 ,  A61K49/08

    CPC分类号： A61K49/108 ,  A61K49/085 ,  A61K49/101 ,  A61K49/103 ,  A61K49/105 ,  A61K49/106 ,  C07D257/02

    摘要： Described herein is a contrast agent for administration to a subject. The contrast agent includes a targeting portion that includes an unchelated aminocarboxylate functional group; a metal ion bound to a metal-complexable portion; and a linker joining the targeting portion and the metal-complexable portion of the contrast agent. The portion that is not bound to a metal ion is for binding to necrotic tissue in the subject.

    摘要翻译： 本文描述了用于给予受试者的造影剂。 造影剂包括靶向部分，其包含未切割的氨基羧酸酯官能团; 与金属络合部分结合的金属离子; 以及将造影剂的靶向部分和金属可络合部分连接的接头。 不结合金属离子的部分用于结合受试者的坏死组织。