知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

115 条记录 (耗时 0.065 秒)

    Anti-PERP recombinant antibody
    2.
    发明授权
    Anti-PERP recombinant antibody 有权
    抗PERP重组抗体

    公开(公告)号：US08093362B2

    公开(公告)日：2012-01-10

    申请号：US11634209

    申请日：2006-12-06

    申请人： Atsushi Ochiai ,  Emi Hosaka ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Yuji Ohki

    发明人： Atsushi Ochiai ,  Emi Hosaka ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Yuji Ohki

    IPC分类号： C07K16/00 ,  C12P21/08 ,  C12P21/04 ,  A61K39/395 ,  A61K39/00

    CPC分类号： C07K16/28 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/732

    摘要： An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence of an N-linked sugar chain in a variable region, specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene and binds to the extracellular region. The antibody is useful for treatment of various diseases expressing a polypeptide encoded by the PERP gene.

    摘要翻译： 需要与被认为与癌症等发生相关的人PERP（PMP-22）相关的p53凋亡效应基因编码的多肽结合的抗体。 本发明提供了在可变区中不具有N-连接糖链的共有序列的基因重组抗体，特异性地识别由PERP基因编码的多肽的细胞外区域的三维结构并结合到细胞外区域。 该抗体可用于治疗表达由PERP基因编码的多肽的各种疾病。

    Method of Enhancing of Binding Activity of Antibody Composition to FcGamma Receptor IIIa
    9.
    发明申请
    Method of Enhancing of Binding Activity of Antibody Composition to FcGamma Receptor IIIa 有权
    增强抗体组合物对Fcγ受体IIIa的结合活性的方法

    公开(公告)号：US20100092997A1

    公开(公告)日：2010-04-15

    申请号：US12550160

    申请日：2009-08-28

    申请人： Kazuyasu Nakamura ,  Kenya Shitara

    发明人： Kazuyasu Nakamura ,  Kenya Shitara

    IPC分类号： G01N33/53 ,  C07K16/00 ,  G01N33/566 ,  C12N5/10 ,  C12N1/16 ,  C12P21/04

    CPC分类号： C12P21/02 ,  A61K39/395 ,  C07K16/22 ,  C07K16/283 ,  C07K16/2866 ,  C07K16/3084 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2319/30

    摘要： A method for enhancing a binding activity of an antibody composition to Fcγ receptor IIIa, which comprises modifying a complex N-glycoside-linked sugar chain which is bound to the Fc region of an antibody molecule; a method for enhancing an antibody-dependent cell-mediated cytotoxic activity of an antibody composition; a process for producing an antibody composition having an enhanced binding activity to Fcγ receptor IIIa; a method for detecting the ratio of a sugar chain in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chain among total complex N-glycoside-linked sugar chains bound to the Fc region in an antibody composition; an Fc fusion protein composition produced by using a cell resistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain; and a process for producing the same.

    摘要翻译： 一种增强抗体组合物与Fcγ受体IIIa的结合活性的方法，其包括修饰与抗体分子的Fc区结合的复合N-糖苷连接的糖链; 用于增强抗体依赖性细胞介导的抗体组合物的细胞毒活性的方法; 制备对Fcγ受体IIIa具有增强的结合活性的抗体组合物的方法; 在抗体组合物中与Fc区结合的总复合N-糖苷连接的糖链中，检测糖链与还原末端中的岩藻糖不与N-乙酰葡糖胺结合的糖链的比例的方法; 通过使用对凝集素有抗性的细胞产生的Fc融合蛋白质组合物，所述细胞通过复合N-糖苷中的α-键识别糖链的1-位与还原末端的N-乙酰葡糖胺的6-位结合的糖链 链糖链 及其制造方法。