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    Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
    2.
    发明授权
    Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery 有权
    包含水杨酸的缓慢降解聚合物用于不延迟和持续的药物递送

    公开(公告)号：US08741317B2

    公开(公告)日：2014-06-03

    申请号：US13213843

    申请日：2011-08-19

    申请人： Kathryn E. Uhrich ,  Roselin Rosario-Meléndez

    发明人： Kathryn E. Uhrich ,  Roselin Rosario-Meléndez

    IPC分类号： A61K9/00 ,  A61K31/765 ,  C08G63/181 ,  A61K31/185 ,  C08G67/04

    CPC分类号： A61K31/185 ,  A61K31/775 ,  C08G67/04 ,  Y10T428/2982

    摘要： The invention provides polymers and methods for their use. Specifically, certain embodiments of the present invention provide a polymer that comprises a plurality of salicylic acid-adipic (SA-Adipic) units of the following formula and a plurality of salicylic acid-diethylmalonic (SA-DEM) units of the following formula Certain embodiments of the invention also provide slow degrading microspheres comprising polymers described herein for undelayed and sustained drug delivery. Certain embodiments of the present invention provide methods for treating a chronic eye disease or arthritis in a patient, comprising administering to the patient a therapeutically effective amount of a polymer or microsphere as described herein.

    摘要翻译： 本发明提供了聚合物及其使用方法。 具体地，本发明的某些实施方案提供了包含下列结构式的多种水杨酸 - 己二酸（SA-己二酸）单元和多种下式的水杨酸 - 二乙基丙二酸（SA-DEM）单元的聚合物： 本发明还提供缓慢降解的微球，其包含本文所述的聚合物用于不延迟和持续的药物递送。 本发明的某些实施方案提供了治疗患者慢性眼病或关节炎的方法，包括向患者施用治疗有效量的如本文所述的聚合物或微球。

    AMPHIPHILIC STAR-LIKE OR SCORPION-LIKE MACROMOLECULES, VARIOUS COMPOSITIONS AND USES THEREOF
    3.
    发明申请
    AMPHIPHILIC STAR-LIKE OR SCORPION-LIKE MACROMOLECULES, VARIOUS COMPOSITIONS AND USES THEREOF 审中-公开
    大分子星型或类似的大分子，各种组合物及其用途

    公开(公告)号：US20120022159A1

    公开(公告)日：2012-01-26

    申请号：US13160371

    申请日：2011-06-14

    申请人： Kathryn E. Uhrich ,  Prabhas Moghe

    发明人： Kathryn E. Uhrich ,  Prabhas Moghe

    IPC分类号： A61K31/225 ,  A61P9/10

    CPC分类号： A61K9/1275 ,  A61K31/74 ,  A61K31/785 ,  A61K31/795 ,  A61K47/6917

    摘要： Biomedical uses of amphiphilic macromolecules include the use of such macromolecules in the form of nanoparticle formulations for the sequestration and/or removal of LDL, and for the treatment and prevention of atherosclerosis and atherosclerotic development. The invention also provides the use of amphiphilic macromolecule encapsulates for treating diseases including cancer and inflammation, as well as targeted amphiphilic macromolecules and their use in therapy.

    摘要翻译： 两亲大分子的生物医学用途包括使用纳米颗粒制剂形式的大分子用于螯合和/或去除LDL，以及用于治疗和预防动脉粥样硬化和动脉粥样硬化发展。 本发明还提供了用于治疗包括癌症和炎症的疾病的两亲性大分子包封物以及靶向的两亲性大分子及其在治疗中的用途。

    Polyanhydrides with therapeutically useful degradation products
    4.
    发明授权
    Polyanhydrides with therapeutically useful degradation products 有权
    具有治疗有用的降解产物的聚酐

    公开(公告)号：US08017714B2

    公开(公告)日：2011-09-13

    申请号：US12428088

    申请日：2009-04-22

    申请人： Kathryn E. Uhrich

    发明人： Kathryn E. Uhrich

    IPC分类号： C08G64/00 ,  C08G63/02

    CPC分类号： C08G67/04 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  C08L73/02

    摘要： An aromatic polyanhydride comprising a repeating unit having the structure is disclosed, wherein Ar and R are selected so that the aromatic polyanhydride hydrolyzes to form a therapeutic salicylate, another non-steroidal anti-inflammatory, an antifibrotic aminobenzoate, or a vasoconstricting phenylethanolamine. Implantable medical devices, such as scaffolding implants for tissue reconstruction, drug delivery systems prepared from the aromatic polyanhydrides, as well as therapeutic dosage forms and treatment methods are also disclosed.

    摘要翻译： 公开了包含具有该结构的重复单元的芳族聚酐，其中选择Ar和R，使得芳族聚酐酐水解形成治疗性水杨酸盐，另一种非甾体抗炎剂，抗纤维化氨基苯甲酸盐或血管收缩苯乙醇胺。 还公开了可植入医疗装置，例如用于组织重建的脚手架植入物，由芳族聚酐制备的药物递送系统，以及治疗剂型和治疗方法。

    Synthesis of Polyanhydrides
    7.
    发明申请
    Synthesis of Polyanhydrides 审中-公开
    聚酐的合成

    公开(公告)号：US20080234235A1

    公开(公告)日：2008-09-25

    申请号：US12026925

    申请日：2008-02-06

    申请人： Kathryn E. Uhrich ,  Robert C. Schmeltzer ,  Theodore James Anastasiou

    发明人： Kathryn E. Uhrich ,  Robert C. Schmeltzer ,  Theodore James Anastasiou

    IPC分类号： A61K47/34 ,  C08G63/688 ,  C08G63/44

    CPC分类号： C08G67/04 ,  C07C67/14 ,  C07C69/86 ,  C07C69/50 ,  C07C69/63

    摘要： The present invention provides a method for forming compounds of Formula HO—C(═O)R1—X—R2—X—R1—C(═O)—O—H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R1 is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R2 is a linking group.

    摘要翻译： 本发明提供了一种形成式<β的化合物的方法，该方法包括在线式描述=“在线式”中的末端=“铅”→HO-C（ - ）R 1 - XR 2 -XR 1 -C（-O）-OH＆lt;β-in-line-formula description =“In-line Formulas”end =“tail”？>其中 化合物（I）可以聚合以提供含有治疗活性化合物的聚合物。 在本发明的化合物中，每个R 1是在聚合物水解时提供治疗活性化合物的基团; 每个X独立地是酯键或酰胺键; R 2是连接基团。

    Amphiphilic Star-Like Or Scorpion-Like Macromolecules, Various Compositions And Uses Threof
    8.
    发明申请
    Amphiphilic Star-Like Or Scorpion-Like Macromolecules, Various Compositions And Uses Threof 审中-公开
    两亲星状或蝎类大分子，各种成分和用途Threof

    公开(公告)号：US20080057026A1

    公开(公告)日：2008-03-06

    申请号：US10587678

    申请日：2005-01-31

    申请人： Kathryn E. Uhrich ,  Prabhas Moghe

    发明人： Kathryn E. Uhrich ,  Prabhas Moghe

    IPC分类号： A61K31/765 ,  A61P9/10

    CPC分类号： A61K9/1275 ,  A61K31/74 ,  A61K31/785 ,  A61K31/795 ,  A61K47/6917

    摘要： Biomedical uses of amphiphilic macromolecules include the use of such macromolecules in the form of nanoparticle formulations for the sequestration and/or removal of LDL, and for the treatment and prevention of atherosclerosis and atherosclerotic development. The invention also provides the use of amphiphilic macromolecule encapsulates for treating diseases including cancer and inflammation, as well as targeted amphiphilic macromolecules and their use in therapy.

    摘要翻译： 两亲大分子的生物医学用途包括使用纳米颗粒制剂形式的大分子用于螯合和/或去除LDL，以及用于治疗和预防动脉粥样硬化和动脉粥样硬化发展。 本发明还提供了用于治疗包括癌症和炎症的疾病的两亲性大分子包封物以及靶向的两亲性大分子及其在治疗中的用途。