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    Methods of producing water-soluble, non-turbid copolymers of at least one water-soluble N-vinyllactam and at least one hydrophobic comonomer
    3.
    发明授权
    Methods of producing water-soluble, non-turbid copolymers of at least one water-soluble N-vinyllactam and at least one hydrophobic comonomer 有权
    制备至少一种水溶性N-乙烯基内酰胺和至少一种疏水性共聚单体的水溶性，非混浊共聚物的方法

    公开(公告)号：US07629425B2

    公开(公告)日：2009-12-08

    申请号：US11947223

    申请日：2007-11-29

    申请人： Rainer Dobrawa ,  Ralf Widmaier ,  Klaus Schnell ,  Karl-Hermann Strube ,  Jürgen Nieberle ,  Reinhold Dieing ,  Bernd de Potzolli ,  Andreas Gruber ,  Ulrich Filges ,  Martin Meister ,  Josef Neutzner ,  Wolfgang Bouquet ,  Eberhard Schupp

    发明人： Rainer Dobrawa ,  Ralf Widmaier ,  Klaus Schnell ,  Karl-Hermann Strube ,  Jürgen Nieberle ,  Reinhold Dieing ,  Bernd de Potzolli ,  Andreas Gruber ,  Ulrich Filges ,  Martin Meister ,  Josef Neutzner ,  Wolfgang Bouquet ,  Eberhard Schupp

    IPC分类号： C08F26/10

    CPC分类号： C08F2/06

    摘要： Methods of producing vinyllactam copolymers which include: providing at least one water-soluble N-vinyllactam; providing at least one hydrophobic comonomer; and subjecting the at least one water-soluble N-vinyllactam and the at least one hydrophobic comonomer to free-radical polymerization in an organic solvent in the presence of an initiator, under a combination of process measures selected from the group consisting of A and B; wherein: (A) comprises (i) polymerization under reflux, and at least two of (ii), (iii), (iv), (v), (vi), and (vii), wherein (ii) comprises an addition of at least 5 mol % of N-vinyllactam to the polymerization mixture if at least 70 mol % of the total amount of hydrophobic monomer used have completely reacted, (iii) comprises return of condensate formed in the reflux from below to the polymerization mixture, (iv) comprises introduction of the initiator in the form of a solution in an organic solvent from below into the polymerization mixture, (v) comprises addition of N-vinyllactam to the reflux, (vi) comprises distilling off a portion of the organic solvent and continuing the polymerization following conversion of 70 to 99% by weight of the N-vinyllactam used, and (vii) comprises introduction of at least one monomer from below into the polymerization mixture; and wherein (B) comprises (viii) polymerization under a superatmospheric pressure such that vaporization of the polymerization components is avoided, and at least one of (i), (ii), (iii), (iv), (v), (vi), and (vii), with the proviso that a combination of (viii) with any of (i), (iii) or (v) is carried out sequentially.

    摘要翻译： 制备乙烯基内酰胺共聚物的方法包括：提供至少一种水溶性N-乙烯基内酰胺; 提供至少一种疏水性共聚单体; 以及在引发剂存在下，使所述至少一种水溶性N-乙烯基内酰胺和所述至少一种疏水性共聚单体在有机溶剂中进行自由基聚合，所述方法选自A和B ; 其中：（A）包括（i）在回流下聚合，和（ii），（iii），（iv），（v），（vi）和（vii）中的至少两个，其中（ii） 的至少5摩尔％的N-乙烯基内酰胺加入到聚合混合物中，如果使用的疏水性单体总量的至少70摩尔％已经完全反应，（iii）包括将从回流中形成的缩合物返回到聚合混合物中， （iv）包括将引发剂以有机溶剂形式从有机溶剂中引入聚合混合物中，（v）包括向回流物中加入N-乙烯基内酰胺，（vi）包括蒸馏除去一部分有机溶剂 并且在所使用的N-乙烯基内酰胺的70至99重量％的转化后继续聚合，和（vii）包括将下述至少一种单体引入聚合混合物中; （ⅰ），（ⅱ），（ⅲ），（ⅳ），（ⅴ），（Ⅴ），（Ⅴ），（Ⅳ），（Ⅳ）， vi）和（vii），条件是（viii）与（i），（iii）或（v）中任何一个的组合依次进行。

    Thrombin-inhibitory proteins from terrestrial leeches
    7.
    发明授权
    Thrombin-inhibitory proteins from terrestrial leeches 失效
    来自陆地水蛭的凝血酶抑制蛋白

    公开(公告)号：US5455181A

    公开(公告)日：1995-10-03

    申请号：US244113

    申请日：1994-05-18

    申请人： Karl-Hermann Strube ,  Siegfried Bialojan ,  Burkhard Kroeger ,  Thomas Friedrich

    发明人： Karl-Hermann Strube ,  Siegfried Bialojan ,  Burkhard Kroeger ,  Thomas Friedrich

    IPC分类号： A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19 ,  C12N15/00 ,  C07K1/00 ,  C12P21/06

    CPC分类号： C07K14/815 ,  A61K38/00

    摘要： Novel thrombin-inhibitory proteins from terrestrial leeches of the genus Haemadipsa with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-Asp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly-Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys, or an amino-acid sequence which is obtained by C-terminal truncation of this sequence by from one to twelve amino acids, are described. The proteins are suitable for controlling diseases. Also described are the nucleic acids coding for these proteins.

    摘要翻译： PCT No.PCT / EP92 / 02661 Sec。 371日期：1994年5月18日 102（e）日期1994年5月18日PCT提交1992年11月19日PCT公布。 出版物WO93 / 11239 日期：1993年10月6日。具有氨基酸序列Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly的来自Haemadipsa属的陆地水蛭的新型凝血酶抑制蛋白 -Glu-Val-Gly-Tyr-Thr-Cys-Asp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser -Gly-Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys或氨基酸序列 描述了该序列的末端截短1至12个氨基酸。 蛋白质适用于控制疾病。 还描述了编码这些蛋白质的核酸。

    METHODS OF PRODUCING WATER-SOLUBLE, NON-TURBID COPOLYMERS OF AT LEAST ONE WATER-SOLUBLE N-VINYLLACTAM AND AT LEAST ONE HYDROPHOBIC COMONOMER
    10.
    发明申请
    METHODS OF PRODUCING WATER-SOLUBLE, NON-TURBID COPOLYMERS OF AT LEAST ONE WATER-SOLUBLE N-VINYLLACTAM AND AT LEAST ONE HYDROPHOBIC COMONOMER 有权
    生产水溶性方法，至少一种水溶性N-乙烯基甲酰胺和至少一种疏水性共聚物的非涡轮共聚物

    公开(公告)号：US20080125554A1

    公开(公告)日：2008-05-29

    申请号：US11947223

    申请日：2007-11-29

    申请人： Rainer Dobrawa ,  Ralf Widmaier ,  Klaus Schnell ,  Karl-Hermann Strube ,  Jurgen Nieberle ,  Reinhold Dieing ,  Bernd de Potzolli ,  Andreas Gruber ,  Ulrich Filges ,  Martin Meister ,  Josef Neutzner ,  Wolfgang Bouquet ,  Eberhard Schupp

    发明人： Rainer Dobrawa ,  Ralf Widmaier ,  Klaus Schnell ,  Karl-Hermann Strube ,  Jurgen Nieberle ,  Reinhold Dieing ,  Bernd de Potzolli ,  Andreas Gruber ,  Ulrich Filges ,  Martin Meister ,  Josef Neutzner ,  Wolfgang Bouquet ,  Eberhard Schupp

    IPC分类号： C08F4/36

    CPC分类号： C08F2/06

    摘要： Methods of producing vinyllactam copolymers which include: providing at least one water-soluble N-vinyllactam; providing at least one hydrophobic comonomer; and subjecting the at least one water-soluble N-vinyllactam and the at least one hydrophobic comonomer to free-radical polymerization in an organic solvent in the presence of an initiator, under a combination of process measures selected from the group consisting of A and B; wherein:(A) comprises (i) polymerization under reflux, and at least two of (ii), (iii), (iv), (v), (vi), and (vii), wherein (ii) comprises an addition of at least 5 mol % of N-vinyllactam to the polymerization mixture if at least 70 mol % of the total amount of hydrophobic monomer used have completely reacted, (iii) comprises return of condensate formed in the reflux from below to the polymerization mixture, (iv) comprises introduction of the initiator in the form of a solution in an organic solvent from below into the polymerization mixture, (v) comprises addition of N-vinyllactam to the reflux, (vi) comprises distilling off a portion of the organic solvent and continuing the polymerization following conversion of 70 to 99% by weight of the N-vinyllactam used, and (vii) comprises introduction of at least one monomer from below into the polymerization mixture; and wherein(B) comprises (viii) polymerization under a superatmospheric pressure such that vaporization of the polymerization components is avoided, and at least one of (i), (ii), (iii), (iv), (v), (vi), and (vii), with the proviso that a combination of (viii) with any of (i), (iii) or (v) is carried out sequentially.

    摘要翻译： 制备乙烯基内酰胺共聚物的方法包括：提供至少一种水溶性N-乙烯基内酰胺; 提供至少一种疏水性共聚单体; 以及在引发剂存在下，使所述至少一种水溶性N-乙烯基内酰胺和所述至少一种疏水性共聚单体在有机溶剂中进行自由基聚合，所述方法选自A和B ; 其中：（A）包括（i）在回流下聚合，和（ii），（iii），（iv），（v），（vi）和（vii）中的至少两个，其中（ii） 的至少5摩尔％的N-乙烯基内酰胺加入到聚合混合物中，如果使用的疏水性单体总量的至少70摩尔％已经完全反应，（iii）包括将从回流中形成的缩合物返回到聚合混合物中， （iv）包括将引发剂以有机溶剂形式从有机溶剂中引入聚合混合物中，（v）包括向回流物中加入N-乙烯基内酰胺，（vi）包括蒸馏除去一部分有机溶剂 并且在所使用的N-乙烯基内酰胺的70至99重量％的转化后继续聚合，和（vii）包括将下述至少一种单体引入聚合混合物中; （ⅰ），（ⅱ），（ⅲ），（ⅳ），（ⅴ），（Ⅴ），（Ⅴ），（Ⅳ），（Ⅳ）， vi）和（vii），条件是（viii）与（i），（iii）或（v）中任何一个的组合依次进行。