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1.发明授权公开(公告)号：US10429376B2
公开(公告)日：2019-10-01
申请号：US12992225
申请日：2009-05-13
摘要： Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.
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2.发明申请Microfluidic Isolation of Tumor Cells or Other Rare Cells from Whole Blood or Other Liquids 审中-公开来自全血或其他液体的肿瘤细胞或其他罕见细胞的微流控分离公开(公告)号：US20120100521A1
公开(公告)日：2012-04-26
申请号：US12992225
申请日：2009-05-13
CPC分类号： G01N33/49 , B01L3/5027 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , G01N15/1459 , G01N15/1484 , G01N33/4915 , G01N2015/1006
摘要： Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.
摘要翻译： 公开了微装置，以从诸如全血的液体中有效地，准确地并快速地分离和枚举诸如循环肿瘤细胞的稀有细胞。 该系统采用多个平行的曲折通道，其宽度为1-2个单元直径。 微型器件可以以低成本生产，可以容易地自动化，并且在许多情况下可以使用，而不需要对样品进行预处理。 它们可用于分离和枚举稀有细胞，包括例如癌症的检测和诊断，癌症分期或评估治疗干预的有效性或检测病原菌。 该装置可以可选地用于非破坏性地捕获和稍后释放靶细胞。
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公开(公告)号：US06936298B2
公开(公告)日：2005-08-30
申请号：US10257805
申请日：2001-04-13
申请人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue-Long Sun
发明人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue-Long Sun
IPC分类号： A61L15/32 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/50 , A61L33/00 , A61L33/12 , C07F9/10 , C07F9/655 , A61L27/00
CPC分类号： B82Y30/00 , A61L15/32 , A61L27/222 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/507 , A61L33/0082 , A61L33/12 , C07F9/10 , C07F9/65525 , C08L89/00
摘要： The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other implanted materials. The materials comprising bound thrombomodulin or a functionally equivalent derivative protein, provide for fewer undesirable side effects including inflammation, thromboses and neointimal hyperplasia.
摘要翻译： 本说明书描述了提供医疗假体的改进性能的材料和方法，包括血管移植材料，人造心脏瓣膜和其他植入材料。 包含结合血栓调节蛋白或功能等同衍生蛋白的材料提供较少的不良副作用，包括炎症，血栓形成和新生内膜增生。
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公开(公告)号：US07713544B2
公开(公告)日：2010-05-11
申请号：US10343408
申请日：2001-07-30
申请人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue Long Sun , Keith M. Faucher
发明人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue Long Sun , Keith M. Faucher
CPC分类号： C07F9/6552 , A61K9/1273 , A61K9/5031 , A61K9/5073 , A61L15/32 , A61L27/222 , A61L27/227 , A61L27/24 , A61L27/507 , A61L33/0082 , B82Y5/00 , B82Y30/00 , C08F220/28 , C08F220/36 , C12N1/00
摘要： A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of cells, such as islet cells, for transplantation. The surface may present exposed bioactive molecules or moieties for binding to target molecules in vivo, for modulating host response when implanted into a patient (e.g. the surface may be antithrombogenic or antiinflammatory) and the surface may have pores of selected sizes to facilitate transport of substances therethrough. An optional hydrophilic cushion or spacer between the substrate and the membrane-mimetic surface allows transmembrane proteins to extend from the surface through the hydrophilic cushion, mimicking the structure of naturally-occurring cells. An alkylated layer directly beneath the membrane-mimetic surface facilates bonding of the surface to the remainder of the biological component. Alkyl chains may extend entirely through the hydrophilic cushion when present. To facilitate binding, the substrate may optionally be treated with a polyelectrolyte or alternating layers of oppositely-charged polyelectrolytes to facilitate charged binding of the membrane-mimetic film or alkylated layer beneath the membrane-mimetic film to the substrate. The membrane-mimetic film is preferably made by in situ polymerization of phospholipid vesicles.
摘要翻译： 提供生物相容的生物组分，其包含覆盖基质的膜模拟表面膜。 合适的底物包括水合底物，例如 水凝胶，其可以含有通过膜模拟膜递送到患者的药物，或者可以由用于移植的细胞如胰岛细胞组成。 表面可以在体内呈现暴露的生物活性分子或结合靶向分子的部分，用于当植入患者时调节宿主反应（例如表面可能是抗血栓形成或抗炎性的），并且该表面可以具有选定尺寸的孔以促进物质的运输 通过。 衬底和膜模拟表面之间的可选的亲水垫或间隔物允许跨膜蛋白从表面延伸穿过亲水垫，模仿天然存在的细胞的结构。 直接在膜 - 模拟表面下面的烷基化层促进了表面与生物组分的其余部分的结合。 当存在时，烷基链可以完全延伸穿过亲水性垫。 为了便于结合，底物可以任选地用聚电解质或交替的相反电荷的聚电解质层处理，以促进膜 - 模拟膜下面的膜模拟膜或烷基化层与底物的带电结合。 膜模拟膜优选通过磷脂囊泡的原位聚合来制备。
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