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公开(公告)号:US20120020918A1
公开(公告)日:2012-01-26
申请号:US13225326
申请日:2011-09-02
IPC分类号: A61K38/20 , A61P29/00 , A61P37/06 , A61P1/04 , A61P17/00 , A61P11/06 , A61P11/02 , A61P19/02 , C07K14/545 , A61P17/06
CPC分类号: C07K14/545 , A61K38/00 , A61K39/00 , C07K16/245 , C07K2317/75 , C12Q1/37 , G01N2333/545 , G01N2500/02 , G01N2500/20
摘要: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
摘要翻译: 本发明提供了涉及需要蛋白质的IL-1Rrp2的组合物和方法。
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公开(公告)号:US20100266601A1
公开(公告)日:2010-10-21
申请号:US12822050
申请日:2010-06-23
IPC分类号: A61K39/395 , C07K16/00 , A61P43/00 , C12N5/07
CPC分类号: C07K14/52 , A61K38/00 , C07K14/475 , C07K14/5418 , C07K16/24 , C12N5/0636
摘要: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
摘要翻译: 本发明涉及纯化和分离的新型TSLP多肽,编码此类多肽的核酸,用于产生重组形式的此类多肽的方法,针对这些多肽产生的抗体,衍生自这些多肽的片段化肽以及上述用途。
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公开(公告)号:US20100190211A1
公开(公告)日:2010-07-29
申请号:US12716993
申请日:2010-03-03
申请人: John E. Sims , Teresa L. Born
发明人: John E. Sims , Teresa L. Born
CPC分类号: C07K14/7155 , A61K38/00 , C07K2319/00
摘要: A novel polypeptide that functions as an IL-18 receptor is disclosed. The receptor is multimeric and includes at least one AcPL polypeptide, or fragment thereof, and at least one IL-1Rrp1 polypeptide, or fraction thereof. The receptor binds IL-18 and finds use in inhibiting biological activities mediated by IL-18.
摘要翻译: 公开了用作IL-18受体的新型多肽。 受体是多聚体并且包括至少一个AcPL多肽或其片段,以及至少一种IL-1Rrp1多肽或其部分。 受体结合IL-18,可用于抑制IL-18介导的生物活性。
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公开(公告)号:US07704945B2
公开(公告)日:2010-04-27
申请号:US11699676
申请日:2007-01-29
申请人: John E. Sims , Teresa L. Born
发明人: John E. Sims , Teresa L. Born
CPC分类号: C07K14/7155 , A61K38/00 , C07K2319/00
摘要: A novel polypeptide that functions as an IL-18 receptor is disclosed. The receptor is multimeric and includes at least one AcPL polypeptide, or fragment thereof, and at least one IL-1Rrp1 polypeptide, or fraction thereof. The receptor binds IL-18 and finds use in inhibiting biological activities mediated by IL-18.
摘要翻译: 公开了用作IL-18受体的新型多肽。 受体是多聚体并且包括至少一个AcPL多肽或其片段,以及至少一种IL-1Rrp1多肽或其部分。 受体结合IL-18,可用于抑制IL-18介导的生物活性。
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公开(公告)号:US20100080804A1
公开(公告)日:2010-04-01
申请号:US12604289
申请日:2009-10-22
申请人: PATRICIA PARNET , JOHN E. SIMS
发明人: PATRICIA PARNET , JOHN E. SIMS
IPC分类号: A61K39/395 , A61P29/00
CPC分类号: C07K14/705 , A61K38/00
摘要: 2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation.
摘要翻译: 提供2F1多肽以及DNA序列,表达载体和可用于产生多肽的转化的宿主细胞。 可溶性2F1多肽用于抑制前列腺素的合成和治疗炎症。
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公开(公告)号:US20090022733A1
公开(公告)日:2009-01-22
申请号:US12074607
申请日:2008-03-04
申请人: John E. Sims , Larry F. O'Neal
发明人: John E. Sims , Larry F. O'Neal
IPC分类号: A61K39/395 , A61K38/17 , A61P3/00 , A61P3/10
CPC分类号: A61K38/1793 , Y02A50/411
摘要: The invention pertains to methods for treating medical disorders characterized by elevated levels or abnormal expression of IL-1 by administering an IL-1 antagonist, such as soluble type II IL-1 receptor.
摘要翻译: 本发明涉及通过施用IL-1拮抗剂如可溶性II型IL-1受体来治疗特征在于升高的IL-1水平或异常表达的医学病症的方法。
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公开(公告)号:US07223565B2
公开(公告)日:2007-05-29
申请号:US10843189
申请日:2004-05-10
申请人: John E. Sims , Blair R. Renshaw
发明人: John E. Sims , Blair R. Renshaw
IPC分类号: C12N15/09 , C12N15/12 , C12P21/02 , C07K14/435 , C07K14/545
CPC分类号: C07K14/545
摘要: The invention is directed to novel, purified and isolated IL-1 eta polypeptides and fragments thereof, the polynucleotides encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, peptides derived from these polypeptides, and uses thereof.
摘要翻译: 本发明涉及新颖的,纯化和分离的IL-1 eta多肽及其片段,编码此类多肽的多核苷酸,产生此类多肽的重组形式的方法,针对这些多肽产生的抗体,衍生自这些多肽的肽及其用途 。
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公开(公告)号:US06949359B1
公开(公告)日:2005-09-27
申请号:US09763498
申请日:1999-08-20
申请人: John E. Sims , Dirk E. Smith
发明人: John E. Sims , Dirk E. Smith
CPC分类号: C07K14/545 , A61K38/00
摘要: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and immune reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, and kits comprising these reagents.
摘要翻译: 本发明涉及纯化和分离的新型人IL-1ε-多肽,编码此类多肽的核酸,生产此类多肽的重组形式的方法,针对这些多肽产生的抗体,衍生自这些多肽的片段化肽,使用这些多肽 细胞和免疫反应中的多肽和片段肽以及分子量标记,使用这些多肽和片段肽作为肽断裂的对照,以及包含这些试剂的试剂盒。
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公开(公告)号:US06555520B2
公开(公告)日:2003-04-29
申请号:US09852391
申请日:2001-05-09
IPC分类号: C07K1452
CPC分类号: C07K14/52 , A61K38/00 , C07K14/475 , C07K14/5418 , C07K16/24 , C12N5/0636
摘要: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
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公开(公告)号:US06504023B1
公开(公告)日:2003-01-07
申请号:US09461908
申请日:1999-12-13
IPC分类号: C12N1506
CPC分类号: C07K14/7155 , A61K38/00
摘要: Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
摘要翻译: 公开了II型IL-1受体(II型IL-1R)蛋白,编码II型IL-1R的DNA和表达载体,以及作为重组细胞培养产物的产生II型IL-1R的方法。
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