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1.发明授权公开(公告)号：US06593124B1
公开(公告)日：2003-07-15
申请号：US09213993
申请日：1998-12-16
IPC分类号： C12N121
CPC分类号： C12N15/85 , A61K38/00 , C07K14/5255 , C07K14/5403 , C07K14/55 , C07K14/57 , C07K14/70521 , C12N2830/00 , C12N2830/85
摘要： Recombinant vectors are provided that render the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, of lessened dependency on T helper cells. The vectors are comprised of a region encoding a stimulatory factor polypeptide operably linked to a heterologous transcriptional control region. Expression of the stimulatory factor polypeptide from the recombinant polynucleotide in an activated lymphocyte renders the proliferative response of less dependent on lymphocyte T helper cells. When the lymphocyte is activated by binding of its cognate antigen the transcriptional control region causes transcription of the stimulatory factor encoding region. The cells containing the vector, particularly CTLs, are of use in immunotherapy.
摘要翻译： 提供重组载体，其使活化的淋巴细胞，特别是细胞毒性T淋巴细胞的增殖反应减少对T辅助细胞的依赖性。 载体由编码可操作地连接到异源转录控制区的刺激因子多肽的区域组成。 来自重组多核苷酸的刺激因子多肽在活化淋巴细胞中的表达使得对淋巴细胞T辅助细胞较少依赖的增殖反应。 当淋巴细胞通过其同源抗原的结合而被激活时，转录控制区引起刺激因子编码区的转录。 含有载体，特别是CTL的细胞可用于免疫治疗。
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2.发明授权AAV split-packaging genes and cell lines comprising such genes for use in the production of recombinant AAV vectors 失效AAV分裂包装基因和包含用于生产重组AAV载体的这些基因的细胞系公开(公告)号：US06541258B2
公开(公告)日：2003-04-01
申请号：US08981172
申请日：1997-12-12
IPC分类号： C12N1587
CPC分类号： C12N7/00 , C12N15/86 , C12N2510/02 , C12N2750/14143 , C12N2750/14152
摘要： The present invention provides AAV “split-packaging” genes, and packaging cells comprising such genes, for use in the production of high titers of replication-incompetent recombinant AAV vectors that can be used to deliver transgenes of interest to a variety of mammalian cells.
摘要翻译： 本发明提供了AAV“分裂包装”基因，以及包含这些基因的包装细胞，用于生产可用于将感兴趣的转基因递送至多种哺乳动物细胞的高滴度复制无能的重组AAV载体。
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公开(公告)号：US5714585A
公开(公告)日：1998-02-03
申请号：US231205
申请日：1994-04-21
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N15/62 , C12N15/70 , C12N15/81 , C12N15/85 , C07K16/00
CPC分类号： C07K16/244 , C07K14/5418 , C12N15/625 , C12N15/70 , C12N15/81 , C12N15/85 , A61K38/00 , C07K2317/34 , C07K2319/02 , C07K2319/036 , C07K2319/43 , C07K2319/50 , C07K2319/75 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/005 , C12N2830/15 , C12N2830/60 , C12N2830/702 , C12N2830/704 , C12N2830/85 , C12N2840/44 , Y10S514/885
摘要： Antibodies that are immunoreactive with interleukin-7 (IL-7) proteins are provided. The anti-IL-7 antibodies may be polyclonal or monoclonal. Certain embodiments are directed to antibodies that are immunoreactive with human IL-7.
摘要翻译： 提供了与白细胞介素-7（IL-7）蛋白免疫反应的抗体。 抗IL-7抗体可以是多克隆或单克隆抗体。 某些实施方案涉及与人IL-7免疫反应的抗体。
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公开(公告)号：US06521740B1
公开(公告)日：2003-02-18
申请号：US08441893
申请日：1995-05-16
IPC分类号： C07K14705
CPC分类号： C07K14/7155 , A61K38/00
摘要： Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
摘要翻译： 公开了II型IL-1受体（II型IL-1R）蛋白，编码II型IL-1R的DNA和表达载体，以及作为重组细胞培养产物的产生II型IL-1R的方法。
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5.发明授权Use of interleukin-7 to stimulate proliferation of hematopoietic cell precursors 失效使用白细胞介素-7刺激造血细胞前体的增殖
公开(公告)号：US5965122A
公开(公告)日：1999-10-12
申请号：US871161
申请日：1997-06-09
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N15/62 , C12N15/70 , C12N15/81 , C12N15/85 , A61K38/20
CPC分类号： C07K16/244 , C07K14/5418 , C12N15/625 , C12N15/70 , C12N15/81 , C12N15/85 , A61K38/00 , C07K2317/34 , C07K2319/02 , C07K2319/036 , C07K2319/43 , C07K2319/50 , C07K2319/75 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/005 , C12N2830/15 , C12N2830/60 , C12N2830/702 , C12N2830/704 , C12N2830/85 , C12N2840/44 , Y10S514/885
摘要： Mammalian Interleukin-7 proteins (IL-7s)g DNAs and expression vectors encoding mammalian IL-7s, end processes for producing mammalian IL-7s as products of cell culture, including recombinant systems, are disclosed.
摘要翻译： 公开了哺乳动物白介素-7蛋白（IL-7s）g编码哺乳动物IL-7的DNA和表达载体，用于产生哺乳动物IL-7作为细胞培养产物的最终方法，包括重组体系。
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公开(公告)号：US06504023B1
公开(公告)日：2003-01-07
申请号：US09461908
申请日：1999-12-13
IPC分类号： C12N1506
CPC分类号： C07K14/7155 , A61K38/00
摘要： Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
摘要翻译： 公开了II型IL-1受体（II型IL-1R）蛋白，编码II型IL-1R的DNA和表达载体，以及作为重组细胞培养产物的产生II型IL-1R的方法。
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公开(公告)号：US5464937A
公开(公告)日：1995-11-07
申请号：US242211
申请日：1994-05-13
IPC分类号： A61K38/00 , C07K14/715 , C12N15/06 , C12N15/12 , C07K14/705
CPC分类号： C07K14/7155 , A61K38/00
摘要： Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
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公开(公告)号：US5328988A
公开(公告)日：1994-07-12
申请号：US957649
申请日：1992-10-06
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N15/62 , C12N15/70 , C12N15/81 , C12N15/85 , C07K13/00 , A61K37/02
CPC分类号： C12N15/85 , C07K14/5418 , C07K16/244 , C12N15/625 , C12N15/70 , C12N15/81 , A61K38/00 , C07K2317/34 , C07K2319/036 , C07K2319/43 , C07K2319/50 , C07K2319/75 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/30 , C12N2830/60 , C12N2830/702 , C12N2830/85 , Y10S930/141
摘要： Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant systems, are disclosed.
摘要翻译： 公开了哺乳动物白细胞介素-7蛋白（IL-7s），编码哺乳动物IL-7的DNA和表达载体，以及用于产生哺乳动物IL-7作为细胞培养产物的方法，包括重组体系。
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公开(公告)号：US5767064A
公开(公告)日：1998-06-16
申请号：US442043
申请日：1995-05-16
IPC分类号： A61K38/00 , C07K14/715 , C12N15/06 , C12N15/12 , A01N37/18
CPC分类号： C07K14/7155 , A61K38/00
摘要： Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed. Also disclosed are compositions and methods for regulating an IL-1 mediated immune or inflammatory response in a mammal.
摘要翻译： 公开了II型IL-1受体（II型IL-1R）蛋白，编码II型IL-1R的DNA和表达载体，以及作为重组细胞培养产物的产生II型IL-1R的方法。 还公开了用于调节哺乳动物中IL-1介导的免疫或炎症反应的组合物和方法。
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公开(公告)号：US5705149A
公开(公告)日：1998-01-06
申请号：US446908
申请日：1995-05-22
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N15/62 , C12N15/70 , C12N15/81 , C12N15/85 , A61K38/20
CPC分类号： C07K16/244 , C07K14/5418 , C12N15/625 , C12N15/70 , C12N15/81 , C12N15/85 , A61K38/00 , C07K2317/34 , C07K2319/02 , C07K2319/036 , C07K2319/43 , C07K2319/50 , C07K2319/75 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/005 , C12N2830/15 , C12N2830/60 , C12N2830/702 , C12N2830/704 , C12N2830/85 , C12N2840/44 , Y10S514/885
摘要： Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant systems, are disclosed.
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