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36 条记录 (耗时 0.023 秒)

    Combination therapeutic compositions and methods of use
    1.
    发明申请
    Combination therapeutic compositions and methods of use 失效
    组合治疗组合物和使用方法

    公开(公告)号：US20060035928A1

    公开(公告)日：2006-02-16

    申请号：US11258817

    申请日：2005-10-26

    申请人： Juan Jaen ,  Jin-Long Chen

    发明人： Juan Jaen ,  Jin-Long Chen

    IPC分类号： A61K31/47 ,  A61K31/165

    CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/165 ,  A61K31/47 ,  Y10S514/866 ,  A61K2300/00

    摘要： The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, α-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.

    摘要翻译： 本发明提供了使用组合疗法治疗糖尿病的药物组合物和方法。 组合物涉及式I化合物和抗糖尿病药如磺酰脲类，双胍类，格列酮，α-葡糖苷酶抑制剂，钾通道拮抗剂，醛糖还原酶抑制剂，胰高血糖素拮抗剂，RXR的激活剂，胰岛素治疗或其它抗肥胖剂。 所述方法包括施用式I化合物与抗糖尿病药物的组合，其中两种成分以同时方式递送，其中首先给予式I化合物，然后是抗糖尿病药，以及其中抗糖尿病药 首先交付，然后是式I的化合物。

    Bis-aryl thiazole derivatives
    2.
    发明申请
    Bis-aryl thiazole derivatives 失效
    双芳基噻唑衍生物

    公开(公告)号：US20050215608A1

    公开(公告)日：2005-09-29

    申请号：US10481218

    申请日：2002-06-27

    申请人： M. Amaral ,  Jin-Long Chen ,  Juan Jaen ,  David Johnston ,  Paul Rafferty

    发明人： M. Amaral ,  Jin-Long Chen ,  Juan Jaen ,  David Johnston ,  Paul Rafferty

    IPC分类号： A61K31/427 ,  C07D417/04

    CPC分类号： C07D417/04 ,  A61K31/427

    摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3. The subject compositions are particularly useful in the treatment of obesity and type II diabetes, and associated diseases.

    摘要翻译： 提供了可用于治疗或预防解偶联蛋白介导的病症或病症的化合物，组合物和方法。 特别地，本发明的化合物调节UCP3的表达和/或活性。 本发明组合物特别可用于治疗肥胖症和II型糖尿病以及相关疾病。

    Prevention of ground fault interrupts in a semiconductor processing system
    8.
    发明授权
    Prevention of ground fault interrupts in a semiconductor processing system 失效
    防止半导体处理系统中的接地故障中断

    公开(公告)号：US6110322A

    公开(公告)日：2000-08-29

    申请号：US036536

    申请日：1998-03-06

    申请人： Hong Bee Teoh ,  James Jin-Long Chen ,  Cuong C. Nguyen ,  Hanh D. Nguyen

    发明人： Hong Bee Teoh ,  James Jin-Long Chen ,  Cuong C. Nguyen ,  Hanh D. Nguyen

    IPC分类号： H05B3/00 ,  C23C16/46 ,  C23C16/511 ,  C23F1/02 ,  H01L21/00 ,  H01L21/205 ,  H01L21/68 ,  H01L21/683

    CPC分类号： H01L21/67103 ,  C23C16/4586 ,  H01L21/6719 ,  H01L21/68742 ,  H01L21/68785

    摘要： A pedestal heating system provided for heating a pedestal disposed in the processing chamber of a substrate processing system. A pedestal heating system according to the present invention includes: a heater power supply, a transformer, coupled to the heater power supply, a heater element coupled to the transformer, and an RF ground electrode. The transformer is configured to reduce leakage current from the heater element to various elements of the substrate processing system by localizing current leakage loops. The heater element and RF ground electrode are disposed within the pedestal. Preferably, the transformer is simply an isolation transformer. Where an RF energy source is used, such as in a plasma CVD processing system, an EMI filter may be coupled between the transformer and the heater element, or at another point in the power supply chain to prevent feed-through of RF energy to other of the substrate processing system's subsystems, or other sensitive electronic circuitry coupled to the facility's power supply.

    摘要翻译： 一种基座加热系统，用于加热设置在基板处理系统的处理室中的基座。 根据本发明的基座加热系统包括：耦合到加热器电源的加热器电源，变压器，耦合到变压器的加热器元件和RF接地电极。 变压器被配置为通过定位电流泄漏回路来减少从加热元件到基板处理系统的各种元件的泄漏电流。 加热器元件和RF接地电极设置在基座内。 优选地，变压器仅仅是隔离变压器。 在诸如在等离子体CVD处理系统中使用RF能量源的地方，EMI滤波器可以耦合在变压器和加热器元件之间，或者在电源链中的另一点处，以防止将RF能量馈送到其它 的衬底处理系统的子系统或耦合到设施的电源的其他敏感电子电路。

    Combination therapeutic compositions
    10.
    发明授权
    Combination therapeutic compositions 失效
    组合治疗组合物

    公开(公告)号：US07939551B2

    公开(公告)日：2011-05-10

    申请号：US11258817

    申请日：2005-10-26

    申请人： Juan C. Jaen ,  Jin-Long Chen

    发明人： Juan C. Jaen ,  Jin-Long Chen

    IPC分类号： A61K31/44 ,  A61K31/70 ,  A61K31/425 ,  A61K31/155

    CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/165 ,  A61K31/47 ,  Y10S514/866 ,  A61K2300/00

    摘要： The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, α-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.

    摘要翻译： 本发明提供了使用组合疗法治疗糖尿病的药物组合物和方法。 组合物涉及式I化合物和抗糖尿病药如磺酰脲，双胍，格列酮，α-葡糖苷酶抑制剂，钾通道拮抗剂，醛糖还原酶抑制剂，胰高血糖素拮抗剂，RXR的激活剂，胰岛素治疗或其它抗肥胖剂。 所述方法包括施用式I化合物与抗糖尿病药物的组合，其中两种成分以同时方式递送，其中首先给予式I化合物，然后是抗糖尿病药，以及其中抗糖尿病药 首先交付，然后是式I的化合物。