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公开(公告)号：US20060035928A1
公开(公告)日：2006-02-16
申请号：US11258817
申请日：2005-10-26
申请人： Juan Jaen , Jin-Long Chen
发明人： Juan Jaen , Jin-Long Chen
IPC分类号： A61K31/47 , A61K31/165
CPC分类号： A61K45/06 , A61K31/00 , A61K31/165 , A61K31/47 , Y10S514/866 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, α-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.
摘要翻译： 本发明提供了使用组合疗法治疗糖尿病的药物组合物和方法。 组合物涉及式I化合物和抗糖尿病药如磺酰脲类，双胍类，格列酮，α-葡糖苷酶抑制剂，钾通道拮抗剂，醛糖还原酶抑制剂，胰高血糖素拮抗剂，RXR的激活剂，胰岛素治疗或其它抗肥胖剂。 所述方法包括施用式I化合物与抗糖尿病药物的组合，其中两种成分以同时方式递送，其中首先给予式I化合物，然后是抗糖尿病药，以及其中抗糖尿病药 首先交付，然后是式I的化合物。
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公开(公告)号：US20050215608A1
公开(公告)日：2005-09-29
申请号：US10481218
申请日：2002-06-27
申请人： M. Amaral , Jin-Long Chen , Juan Jaen , David Johnston , Paul Rafferty
发明人： M. Amaral , Jin-Long Chen , Juan Jaen , David Johnston , Paul Rafferty
IPC分类号： A61K31/427 , C07D417/04
CPC分类号： C07D417/04 , A61K31/427
摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3. The subject compositions are particularly useful in the treatment of obesity and type II diabetes, and associated diseases.
摘要翻译： 提供了可用于治疗或预防解偶联蛋白介导的病症或病症的化合物，组合物和方法。 特别地，本发明的化合物调节UCP3的表达和/或活性。 本发明组合物特别可用于治疗肥胖症和II型糖尿病以及相关疾病。
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公开(公告)号：US20080113449A1
公开(公告)日：2008-05-15
申请号：US11971360
申请日：2008-01-09
申请人： Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
发明人： Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
IPC分类号： G01N33/566 , C07K16/28 , C07K14/705 , C07H21/04
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.
摘要翻译： 本发明提供新型受体的分离的核酸和氨基酸序列，这种受体的抗体，检测这种核酸和受体的方法，以及筛选受体调节剂的方法。
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公开(公告)号：US20070141644A1
公开(公告)日：2007-06-21
申请号：US11680133
申请日：2007-02-28
申请人： Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
发明人： Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.
摘要翻译： 本发明提供了分离的新型受体的核酸和氨基酸序列，这种受体的抗体，检测这种核酸和受体的方法，以及筛选受体调节剂的方法。
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公开(公告)号：US20060264481A1
公开(公告)日：2006-11-23
申请号：US11493131
申请日：2006-07-25
申请人： Jin-Long Chen
发明人： Jin-Long Chen
IPC分类号： A61K31/44 , A61K31/40 , A61K31/325 , A61K31/277 , A61K31/195 , A61K31/18
CPC分类号： A61K31/425 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/325 , A61K31/40 , A61K31/44 , A61K31/505
摘要： Modulators of PPARγ activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer.
摘要翻译： PPARgamma活性的调节剂用于治疗和/或预防诸如骨质疏松症，阿尔茨海默病，牛皮癣和痤疮以及癌症的病症的方法。
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公开(公告)号：US5952469A
公开(公告)日：1999-09-14
申请号：US172528
申请日：1998-10-14
申请人： Ning Zhang , M. Catherine Arnaral , Jin-Long Chen
发明人： Ning Zhang , M. Catherine Arnaral , Jin-Long Chen
IPC分类号： C12N15/09 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00
摘要： The invention provides methods and compositions relating to a novel family of UCP3 polypeptides and related nucleic acids involved in metabolic regulation. The polypeptides may be produced recombinantly from transformed host cells from the disclosed mUCP3 encoding nucleic acids or purified from mammalian cells. The invention provides isolated mUCP3 hybridization probes, knock-out/in constructs and primers capable of specifically hybridizing with the disclosed mUCP3 genes, mUCP3-specific binding agents such as specific antibodies, animals and cells modified with the subject mUCP3 nucleic acids, and methods of making and using the subject compositions in the biopharmaceutical industry.
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公开(公告)号：US06566089B1
公开(公告)日：2003-05-20
申请号：US08866942
申请日：1997-05-31
申请人： Bei Shan , R. Marc Learned , M. Catherine Amaral , Steven L. McKnight , Fabienne Charles de la Brousse , Jin-Long Chen
发明人： Bei Shan , R. Marc Learned , M. Catherine Amaral , Steven L. McKnight , Fabienne Charles de la Brousse , Jin-Long Chen
IPC分类号： C12Q132
CPC分类号： G01N33/5023 , A01K2217/072 , C12N15/8509 , C12N2510/00 , C12N2830/008 , C12Q1/6897 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N2500/00
摘要： The invention provides methods and compositions for screening for pharmacological agents which regulate gene expression in mammals. An exemplary assay involves (a) contacting a mammalian cell comprising a knock-in mutant of a targeted native allele encoding a reporter of gene expression, wherein the expression of the reporter is under the control of the gene expression regulatory sequences of the native allele, with a candidate agent under conditions whereby but for the presence of the agent, the reporter is expressed at a first expression level; and, (b) measuring the expression of the reporter to obtain a second expression level, wherein a difference between the first and second expression levels indicates that the candidate agent modulates gene expression.
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公开(公告)号：US5807740A
公开(公告)日：1998-09-15
申请号：US846012
申请日：1997-04-25
申请人： M. Catherine Amaral , Jin-Long Chen
发明人： M. Catherine Amaral , Jin-Long Chen
IPC分类号： C12N15/09 , A61K48/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/85 , C12Q1/02 , C12Q1/68 , C12N1/00 , C12N15/11 , C12N15/63
CPC分类号： C12N15/85 , C07K14/4702 , A61K48/00 , C12N2830/00 , C12N2830/85
摘要： The invention relates to regulators of UCP2 gene transcription, including novel UCP2 transcriptional promoters. UCP2 gene promoters are used in diagnosis and pharmaceutical development. In particular, transfected cells comprising UCP2 gene promoters operably linked to a reporter are used in high-throughput pharmaceutical screens.
摘要翻译： 本发明涉及UCP2基因转录调控因子，包括新型UCP2转录启动子。 UCP2基因启动子用于诊断和药物开发。 特别地，包含与报告物可操作地连接的UCP2基因启动子的转染细胞用于高通量药物筛选。
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公开(公告)号：US07358267B2
公开(公告)日：2008-04-15
申请号：US10481218
申请日：2002-06-27
IPC分类号： A61K31/427 , A61K31/428 , C07D277/50 , C07D277/82
CPC分类号： C07D417/04 , A61K31/427
摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3. The subject compositions are particularly useful in the treatment of obesity and type II diabetes, and associated diseases
摘要翻译： 提供了可用于治疗或预防解偶联蛋白介导的病症或病症的化合物，组合物和方法。 特别地，本发明的化合物调节UCP3的表达和/或活性。 本发明组合物特别可用于治疗肥胖症和II型糖尿病以及相关疾病
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公开(公告)号：US20060223109A1
公开(公告)日：2006-10-05
申请号：US11452213
申请日：2006-06-14
申请人： Hui Tian , Jiagang Zhao , Jin-Long Chen , Gene Cutler
发明人： Hui Tian , Jiagang Zhao , Jin-Long Chen , Gene Cutler
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/705 , C07K14/82 , C07K16/30
CPC分类号： C07K14/705 , A61K38/00 , C07K14/723 , G01N33/57449 , G01N2333/726 , G01N2800/04
摘要： The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.
摘要翻译： 本发明提供新型受体的分离的核酸和氨基酸序列，这种受体的抗体，检测这种核酸和受体的方法，以及筛选受体调节剂的方法。
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